Guoqiang Jiang
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View article: Substrate tunnel regulates substrate specificity switching in hyaluronan synthase
Substrate tunnel regulates substrate specificity switching in hyaluronan synthase Open
Hyaluronic acid (HA), a ubiquitous linear polysaccharide in the extracellular matrix of vertebrates and the capsule of certain pathogenic bacteria, is characterized by its unique structure of alternating β-1,3- N -acetylglucosamine and β-1…
View article: Ex-vivo biomechanical evaluation of the application of a novel annulus closure device to closure of annulus fibrosus
Ex-vivo biomechanical evaluation of the application of a novel annulus closure device to closure of annulus fibrosus Open
Objective To investigate the technical feasibility of applying a simple suture guide device to close the annulus fibrosus (AF) of the intervertebral discs (IVD). Methods 30 sheep functional discal units (FDUs) were obtained and subjected t…
View article: Anionic Cardiolipin Stabilizes the Transmembrane Region of Hyaluronan Synthase and Promotes Catalysis-Relevant Dynamics
Anionic Cardiolipin Stabilizes the Transmembrane Region of Hyaluronan Synthase and Promotes Catalysis-Relevant Dynamics Open
View article: Risk factors for spinal subdural hematoma after minimally invasive transforaminal lumbar Interbody Fusion (MI-TLIF): a multivariate analysis
Risk factors for spinal subdural hematoma after minimally invasive transforaminal lumbar Interbody Fusion (MI-TLIF): a multivariate analysis Open
View article: A Case Study of Synchrosqueezing Wavelet Transform to Conventional Logging
A Case Study of Synchrosqueezing Wavelet Transform to Conventional Logging Open
In this paper, the synchronous squeezing wavelet transform (SSWT) is used to process the conventional logging curve, and the spectral characteristics of logging signal are obtained. The results show that the spectral characteristics of SSW…
View article: Recent advances in the repair of degenerative intervertebral disc for preclinical applications
Recent advances in the repair of degenerative intervertebral disc for preclinical applications Open
The intervertebral disc (IVD) is a load-bearing, avascular tissue that cushions pressure and increases flexibility in the spine. Under the influence of obesity, injury, and reduced nutrient supply, it develops pathological changes such as …
View article: Bone cement distribution may significantly affect the efficacy of percutaneous vertebroplasty in treating symptomatic Schmorl’s nodes
Bone cement distribution may significantly affect the efficacy of percutaneous vertebroplasty in treating symptomatic Schmorl’s nodes Open
View article: Bioactive mineralized small intestinal submucosa acellular matrix/PMMA bone cement for vertebral bone regeneration
Bioactive mineralized small intestinal submucosa acellular matrix/PMMA bone cement for vertebral bone regeneration Open
Polymethylmethacrylate (PMMA) bone cement extensively utilized for the treatment of osteoporotic vertebral compression fractures due to its exceptional handleability and mechanical properties. Nevertheless, the clinical application of PMMA…
View article: Identification of Prognostic Biomarkers of Glioblastoma Based on Multidatabase Integration and Its Correlation with Immune-Infiltration Cells
Identification of Prognostic Biomarkers of Glioblastoma Based on Multidatabase Integration and Its Correlation with Immune-Infiltration Cells Open
Background. Glioblastoma (GBM) is the most malignant of all known intracranial tumors; meanwhile, most patients have a poor prognosis. In order to improve the poor prognosis of GBM patients as much as possible, it is specifically significa…
View article: Biomechanical comparison of vertebral augmentation and cement discoplasty for the treatment of symptomatic Schmorl’s node: a finite element analysis
Biomechanical comparison of vertebral augmentation and cement discoplasty for the treatment of symptomatic Schmorl’s node: a finite element analysis Open
Percutaneous vertebral augmentation (PVA) and percutaneous cement discoplasty (PCD) are two relatively new minimally invasive surgeries for symptomatic Schmorl's reported in recent decade. However, the clinical evidence for the effectivene…
View article: Fluid Identification Based on NMR Apparent Free Water Porosity Inversion: A Case Study of Paleozoic Tight Sandstone Gas Reservoirs in Western Ordos
Fluid Identification Based on NMR Apparent Free Water Porosity Inversion: A Case Study of Paleozoic Tight Sandstone Gas Reservoirs in Western Ordos Open
Tight sandstone reservoirs are affected by various factors such as pore structure, formation water salinity, and siliceous cementation, which lead to the abnormal phenomenon of high-resistivity water layers and increase the difficulty in i…
View article: Diagnosis of Hypersensitivity Induced by Antituberculosis Drugs
Diagnosis of Hypersensitivity Induced by Antituberculosis Drugs Open
Objective. To explore the clinical value of the specific plasma cell detection and specific T lymphocyte detection test in diagnosing hypersensitivity caused by antituberculosis drugs. Methods. A total of 266 patients with pulmonary tuberc…
View article: Anti-inflammatory Effects of Hydrogen in LPS-induced RAW264.7 Cells via Inhibiting NF-κB and MAPKs Signaling Pathways
Anti-inflammatory Effects of Hydrogen in LPS-induced RAW264.7 Cells via Inhibiting NF-κB and MAPKs Signaling Pathways Open
Hydrogen (H 2 ), a new type of medical gas molecule, which has significant preventive effect on numerous diseases and its anti-inflammatory properties has been proven in previous studies. However, the mechanisms of H 2 anti-inflammatory ac…
View article: Identification of Biomarkers Related to Prognosis of Glioblastoma and Their Correlation with Immune Infiltration Cells
Identification of Biomarkers Related to Prognosis of Glioblastoma and Their Correlation with Immune Infiltration Cells Open
Glioblastoma (GBM) is the most malignant of all known intracranial tumors, meanwhile most patients have a poor prognosis. In order to improve the poor prognosis of GBM patients as much as possible, it is specifically significant to identif…
View article: Effect of pedicle-screw rod fixation on oblique lumbar interbody fusion in patients with osteoporosis: a retrospective cohort study
Effect of pedicle-screw rod fixation on oblique lumbar interbody fusion in patients with osteoporosis: a retrospective cohort study Open
View article: Biomechanical Comparison of Vertebral Augmentation and Cement Discoplasty for the Treatment of Symptomatic Schmorl’s Node Combined With Modic Change: Finite Element Analyses
Biomechanical Comparison of Vertebral Augmentation and Cement Discoplasty for the Treatment of Symptomatic Schmorl’s Node Combined With Modic Change: Finite Element Analyses Open
Study design : Finite element simulation study. Objective : To compare the biomechanical effects of percutaneous vertebral augmentation (PVA) and percutaneous cement discoplasty (PCD) in patients with symptomatic Schmorl’s node combined wi…
View article: Osteoporosis Delimit the Indication for Additional Fixation in Oblique Lumbar Interbody Fusion
Osteoporosis Delimit the Indication for Additional Fixation in Oblique Lumbar Interbody Fusion Open
Study design : A retrospective cohort study. Objective : To detect the boundary of indications of fixation in OLIF surgery. Methods : Review patients undergoing stand-alone or combined OLIF. Measure the disc height increment (ΔDH), foramin…
View article: Modified poly(methyl methacrylate) bone cement in the treatment of Kümmell disease
Modified poly(methyl methacrylate) bone cement in the treatment of Kümmell disease Open
Kümmell disease (KD) causes serious vertebral body collapse in patients. However, only a few case reports have been conducted and the number of patients with KD investigated was limited. Additionally, the frequently used poly(methyl methac…
View article: Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene
Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene Open
Dihydrotanshinone I (DHTS), extracted from Salvia miltiorrhiza, was found to be the most effective compound of tanshen extracts against cancer cells in our previous studies. However, the therapeutic benefits and underlying mechanisms of DH…
View article: Needle-Guided Suture Technique for Lumbar Annular Fiber Closure in Microendoscopic Discectomy: A Technical Note and Case Series
Needle-Guided Suture Technique for Lumbar Annular Fiber Closure in Microendoscopic Discectomy: A Technical Note and Case Series Open
BACKGROUND Annular fiber closure techniques have been proven effective in reducing short-term recurrence after discectomy. However, annular fiber closure devices are expensive and still fail at a low rate. We present a novel suture method,…
View article: Poly(methyl methacrylate) bone cement composited with mineralized collagen for osteoporotic vertebral compression fractures in extremely old patients
Poly(methyl methacrylate) bone cement composited with mineralized collagen for osteoporotic vertebral compression fractures in extremely old patients Open
To examine the clinical effects of a new bone cement composed of poly(methyl methacrylate) (PMMA) and mineralized collagen (MC) compared with pure PMMA bone cement in treating osteoporotic vertebral compression fractures (OVCFs) in patient…
View article: Bioactive poly (methyl methacrylate) bone cement for the treatment of osteoporotic vertebral compression fractures
Bioactive poly (methyl methacrylate) bone cement for the treatment of osteoporotic vertebral compression fractures Open
Rationale: Poly (methyl methacrylate) (PMMA) bone cement is one of the most commonly used biomaterials for augmenting/stabilizing osteoporosis-induced vertebral compression fractures (OVCFs), such as percutaneous vertebroplasty (PVP…
View article: Accurate location and minimally invasive treatment of lumbar lateral recess stenosis with combined SNRB and PTED
Accurate location and minimally invasive treatment of lumbar lateral recess stenosis with combined SNRB and PTED Open
Objective To establish a management strategy for multi-segment lumbar lateral recess stenosis. Methods A retrospective study was performed in patients in whom suspected responsible nerve roots underwent sequential selective nerve root bloc…
View article: Preparation and Corrosion Behavior of Chemically Bonded Ceramic Coatings Reinforced by Functionalized Graphene Oxide
Preparation and Corrosion Behavior of Chemically Bonded Ceramic Coatings Reinforced by Functionalized Graphene Oxide Open
View article: <p>Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules &lt;10 mm in the maximum diameter: does size matter?</p>
Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules <10 mm in the maximum diameter: does size matter? Open
For thyroid nodules of TIRADS category 4-6, the diagnostic efficacy of US-FNAB is similar for thyroid nodules either smaller or greater than 10 mm in their maximum diameter.
View article: Down-regulation of GADD45A enhances chemosensitivity in melanoma
Down-regulation of GADD45A enhances chemosensitivity in melanoma Open
View article: Biodegradable macroporous scaffold with nano-crystal surface microstructure for highly effective osteogenesis and vascularization
Biodegradable macroporous scaffold with nano-crystal surface microstructure for highly effective osteogenesis and vascularization Open
We report the construction of a biodegradable macroporous scaffold with a nano-crystal surface microstructure capable of releasing bioactive ions for highly effective osteogenesis and vascularization.
View article: Osteogenesis, vascularization and osseointegration of a bioactive multiphase macroporous scaffold in the treatment of large bone defects
Osteogenesis, vascularization and osseointegration of a bioactive multiphase macroporous scaffold in the treatment of large bone defects Open
We report a segmental radial bone defect model used to evaluate the osteogenesis, vascularization and osseointegration of a bioactive multiphase macroporous scaffold with nano-crystal surface microstructures that can release bioactive ions.
View article: Functional characterization of a novel transcript of ERCC1 in chemotherapy resistance of ovarian cancer
Functional characterization of a novel transcript of ERCC1 in chemotherapy resistance of ovarian cancer Open
Approximately 15-20% of ovarian cancer patients receiving platinum-based chemotherapy are primary platinum-resistant. Identification of these patients and transfer to other more effective therapy could reduce the morbidity of ovarian cance…
View article: Medium-term effects of Dynesys dynamic stabilization versus posterior lumbar interbody fusion for treatment of multisegmental lumbar degenerative disease
Medium-term effects of Dynesys dynamic stabilization versus posterior lumbar interbody fusion for treatment of multisegmental lumbar degenerative disease Open
Objective To compare the medium-term clinical and radiographic outcomes of Dynesys dynamic stabilization and posterior lumbar interbody fusion (PLIF) for treatment of multisegmental lumbar degenerative disease. Methods Fifty-seven patients…