Guoqiang Yuan
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View article: Cost‐Effectiveness and Cost‐Utility Analysis of Tongxinluo Capsules Compared With Conventional Therapy for the Treatment of Acute Myocardial Infarction
Cost‐Effectiveness and Cost‐Utility Analysis of Tongxinluo Capsules Compared With Conventional Therapy for the Treatment of Acute Myocardial Infarction Open
Aim Tongxinluo (TXL) capsule, a traditional Chinese medicine compound, has proven effective in acute myocardial infarction (AMI), but its cost‐effectiveness is unclear. Methods This economic evaluation utilized individual data from clinica…
View article: A comprehensive analysis of transcription factors identified TCF3 as a prognostic target for glioma
A comprehensive analysis of transcription factors identified TCF3 as a prognostic target for glioma Open
Transcription factors (TFs) are pivotal in tumor initiation and progression, regulating downstream gene expression and modulating cellular processes. In this study, we conducted a comprehensive analysis of TF gene sets to define the molecu…
View article: Molecular typing of gliomas on the basis of integrin family genes and a functional study of ITGA7
Molecular typing of gliomas on the basis of integrin family genes and a functional study of ITGA7 Open
Gliomas are highly malignant tumors of the central nervous system, and their complex molecular heterogeneity poses major therapeutic challenges. Integrins are important members of the class of cell adhesion molecules (CAMs), consisting of …
View article: KCNE3 Facilitates M1 Macrophage Polarization by Suppressing the Wnt/β‐Catenin Pathway, Inhibiting Glioma Proliferation, Migration, and Invasion
KCNE3 Facilitates M1 Macrophage Polarization by Suppressing the Wnt/β‐Catenin Pathway, Inhibiting Glioma Proliferation, Migration, and Invasion Open
The glioma microenvironment is critical for tumor growth, where reprogramming M2‐polarized tumor‐associated macrophages/microglia (TAMs) to an antitumor M1 phenotype represents a promising therapeutic strategy. While the potassium channel …
View article: Machine learning unravels the mysteries of glioma typing and treatment
Machine learning unravels the mysteries of glioma typing and treatment Open
Gliomas, which are complex primary malignant brain tumors known for their heterogeneous and invasive nature, present substantial challenges for both treatment and prognosis. Recent advancements in whole-genome studies have opened new avenu…
View article: Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review)
Transitioning from molecular methods to therapeutic methods: An in‑depth analysis of glioblastoma (Review) Open
Glioblastoma (GBM) is the most aggressive primary brain tumour, characterised by high heterogeneity, aggressiveness and resistance to conventional therapies, leading to poor prognosis for patients. In recent years, with the rapid developme…
View article: Polymeric Polylactic Acid–Glycolic Acid-Based Nanoparticles Deliver Nintedanib Across the Blood–Brain Barrier to Inhibit Glioblastoma Growth
Polymeric Polylactic Acid–Glycolic Acid-Based Nanoparticles Deliver Nintedanib Across the Blood–Brain Barrier to Inhibit Glioblastoma Growth Open
The aim of this study was to investigate the inhibitory effect of nintedanib (BIBF) on glioblastoma (GBM) cells and its mechanism of action and to optimize a drug delivery strategy to overcome the limitations posed by the blood–brain barri…
View article: Staged microsurgical treatment of a complex scalp arteriovenous fistula combined with type C sAVF and cirsoid aneurysm: a case report and literature review
Staged microsurgical treatment of a complex scalp arteriovenous fistula combined with type C sAVF and cirsoid aneurysm: a case report and literature review Open
Scalp arteriovenous fistula (sAVF) is a rare disease caused by a congenital defect or exogenous injury, but no standard treatment exists. In this article, we report a rare case of sAVF combined with type C sAVF and cirsoid aneurysm (CA), w…
View article: Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest
Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest Open
Glioma is a common primary nervous system malignant tumor with poor overall cure rate and low survival rate, yet successful treatment still remains a challenge. Here, we demonstrated that amantadine (AMT) exhibits the powerful anti-glioma …
View article: Research progress on S-palmitoylation modification mediated by the ZDHHC family in glioblastoma
Research progress on S-palmitoylation modification mediated by the ZDHHC family in glioblastoma Open
S-Palmitoylation has been widely noticed and studied in a variety of diseases. Increasing evidence suggests that S-palmitoylation modification also plays a key role in Glioblastoma (GBM). The zDHHC family, as an important member of S-palmi…
View article: Identification of Metabolites in Muscles of Lueyang Black-Bone Chickens: A Comparative Analysis of Caged and Cage-Free Rearing Modes Using Untargeted Metabolomic Techniques
Identification of Metabolites in Muscles of Lueyang Black-Bone Chickens: A Comparative Analysis of Caged and Cage-Free Rearing Modes Using Untargeted Metabolomic Techniques Open
The Lueyang black-bone chicken is a specific native chicken strain in China. This study aimed to investigate the effects of different rearing systems on the meat quality of Lueyang black-bone chickens. Six hundred Lueyang black-bone hens w…
View article: Association of M2 macrophages with EMT in glioma identified through combination of multi-omics and machine learning
Association of M2 macrophages with EMT in glioma identified through combination of multi-omics and machine learning Open
View article: Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways Open
View article: Case report: a case report of excision of giant lipoma in the posterior neck
Case report: a case report of excision of giant lipoma in the posterior neck Open
Lipomas, benign tumors originating from the anomalous proliferation of adipocytes, predominantly emerge in regions rich in adipose tissue. However, their presence in the head and neck areas remains rare, constituting approximately 13% of a…
View article: Neutrophils in glioma microenvironment: from immune function to immunotherapy
Neutrophils in glioma microenvironment: from immune function to immunotherapy Open
Glioma is a malignant tumor of the central nervous system (CNS). Currently, effective treatment options for gliomas are still lacking. Neutrophils, as an important member of the tumor microenvironment (TME), are widely distributed in circu…
View article: Role of Melatonin-Related Signatures in the Prognosis of Glioblastoma
Role of Melatonin-Related Signatures in the Prognosis of Glioblastoma Open
Background Melatonin (MT) can have a direct or indirect impact on the expression of numerous crucial genes in cancer cells. Consequently, this paper strived to investigate MT-associated prognostic genes in Glioblastoma (GBM) and their mech…
View article: Bisphenol A: Unveiling Its Role in Glioma Progression and Tumor Growth
Bisphenol A: Unveiling Its Role in Glioma Progression and Tumor Growth Open
Gliomas represent the most common and lethal category of primary brain tumors. Bisphenol A (BPA), a widely recognized endocrine disruptor, has been implicated in the progression of cancer. Despite its established links to various cancers, …
View article: Exploring the therapeutic mechanisms and prognostic targets of Biochanin A in glioblastoma via integrated computational analysis and in vitro experiments
Exploring the therapeutic mechanisms and prognostic targets of Biochanin A in glioblastoma via integrated computational analysis and in vitro experiments Open
Glioblastoma (GBM) is the most aggressive brain tumor and is characterized by a poor prognosis and high recurrence and mortality rates. Biochanin A (BCA) exhibits promising clinical anti-tumor effects. In this study, we aimed to explore th…
View article: DIRAS3 might function as a diagnostic biomarker and be related to immune infiltration in gliomas
DIRAS3 might function as a diagnostic biomarker and be related to immune infiltration in gliomas Open
Gliomas are not composed of mere tumour cells, but a complex ecosystem with an internal immune-related component called the tumour immune microenvironment, which is closely related to the development of the tumour itself. In order to devel…
View article: Exploring the Role of the Plant Actin Cytoskeleton: From Signaling to Cellular Functions
Exploring the Role of the Plant Actin Cytoskeleton: From Signaling to Cellular Functions Open
The plant actin cytoskeleton is characterized by the basic properties of dynamic array, which plays a central role in numerous conserved processes that are required for diverse cellular functions. Here, we focus on how actins and actin-rel…
View article: Exploring the Therapeutic Mechanisms and Prognostic Targets of Biochanin A in Glioblastoma via Network Pharmacology and Bioinformatics Analysis
Exploring the Therapeutic Mechanisms and Prognostic Targets of Biochanin A in Glioblastoma via Network Pharmacology and Bioinformatics Analysis Open
Purpose Glioblastoma (GBM) is the most malignant type of brain tumor, characterized by a poor prognosis and high recurrence and mortality rates. Biochanin A (BCA) has demonstrated promising clinical antitumor effects. This study aimed to e…
View article: SUPPRESSOR OF MAX2 LIKE 6, 7, and 8 Interact with DDB1 BINDING WD REPEAT DOMAIN HYPERSENSITIVE TO ABA DEFICIENT 1 to Regulate the Drought Tolerance and Target SUCROSE NONFERMENTING 1 RELATED PROTEIN KINASE 2.3 to Abscisic Acid Response in Arabidopsis
SUPPRESSOR OF MAX2 LIKE 6, 7, and 8 Interact with DDB1 BINDING WD REPEAT DOMAIN HYPERSENSITIVE TO ABA DEFICIENT 1 to Regulate the Drought Tolerance and Target SUCROSE NONFERMENTING 1 RELATED PROTEIN KINASE 2.3 to Abscisic Acid Response in Arabidopsis Open
SUPPRESSOR OF MAX2-LIKE 6, 7, and 8 (SMXL6,7,8) function as repressors and transcription factors of the strigolactone (SL) signaling pathway, playing an important role in the development and stress tolerance in Arabidopsis thaliana. Howeve…
View article: Efficacy of TTFields in high-grade gliomas: a protocol for systematic review and meta-analysis
Efficacy of TTFields in high-grade gliomas: a protocol for systematic review and meta-analysis Open
Introduction Despite their recent FDA(Food and Drug Administration) approval, tumour treatment fields (TTFields) have not seen acceptance as part of standard of care (SOC) for the treatment of high-grade gliomas (HGGs). Few studies have re…
View article: EEF1E1 promotes glioma proliferation by regulating cell cycle through PTEN/AKT signaling pathway
EEF1E1 promotes glioma proliferation by regulating cell cycle through PTEN/AKT signaling pathway Open
The cell cycle, a pivotal regulator of cell proliferation, can be significantly influenced by the phosphatase and tensin homolog (PTEN)/AKT signaling pathway's modulation of cyclin‐related proteins. In our study, we discovered the crucial …
View article: Circ_103128 is associated with the tumorigenesis of medulloblastoma
Circ_103128 is associated with the tumorigenesis of medulloblastoma Open
View article: Methyltransferase like 21C interaction with Hsc70 affects chicken myoblast differentiation
Methyltransferase like 21C interaction with Hsc70 affects chicken myoblast differentiation Open
Skeletal muscle has an essential role in boiler production, which depends on the muscle fibre development during the embryonic stage. Whereas the posttranslational modifications of both histone and non-histone proteins are known to regulat…
View article: Mechanism of SOX9 nuclear translocation induced by NF1 mutation promoting neurofibroma proliferation and collagen secretion
Mechanism of SOX9 nuclear translocation induced by NF1 mutation promoting neurofibroma proliferation and collagen secretion Open
Neurofibromatosis type 1 (NF1) is caused by NF1 gene mutations. Patients with NF1 often have complications with tumors, such as neurofibroma. In order to investigate the pathogenesis of human neurofibroma, a systematic comparison of protei…
View article: Regulation of glioblastoma proliferation and migration by Nova1
Regulation of glioblastoma proliferation and migration by Nova1 Open
Purpose: The aim of this study was to investigate the regulation of proliferation and migration of glioblastoma (GBM) cells by Nova1. Methods: We used a bioinformatics approach to analyze RNA sequencing data from the cerebral cortex of Nov…
View article: Regulation of LARP4 in malignant biological behavior of GBM
Regulation of LARP4 in malignant biological behavior of GBM Open
Background Glioblastoma (GBM) is the most prevalent form of primary brain cancer. La-related protein 4 (LARP4) is known to play a crucial role in various types of cancer. Nevertheless, the expression and function of LARP4 in GBM have not b…
View article: CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas
CASP4 can be a diagnostic biomarker and correlated with immune infiltrates in gliomas Open
Background Gliomas are the most common and invasive malignant tumors that originate in the central nervous system. Currently, the primary treatment modality for gliomas is maximum surgical resection, supplemented by radiotherapy and chemot…