Guorui Xie
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View article: IgA nephropathy with monotypic IgA-κ deposits: a case report and literature review
IgA nephropathy with monotypic IgA-κ deposits: a case report and literature review Open
IgA nephropathy (IgAN) is an immune complex-mediated glomerulonephritis characterized by predominant IgA deposition in the mesangial region, typically exhibiting polyclonal IgA deposits (co-dominance of κ and λ light chains). However, a fe…
View article: Severe pneumonia caused by Nocardia otitidiscaviarum in a patient with bronchiectasis and IgA nephropathy: a case report
Severe pneumonia caused by Nocardia otitidiscaviarum in a patient with bronchiectasis and IgA nephropathy: a case report Open
Background Nocardia species are rare opportunistic pathogens in the clinic, with strong invasiveness and dissemination, that can cause serious pulmonary infection, especially in immunocompromised patients, chronic lung diseases and hormone…
View article: Subsets of Tissue CD4 T Cells Display Different Susceptibilities to HIV Infection and Death: Analysis by CyTOF and Single Cell RNA-seq
Subsets of Tissue CD4 T Cells Display Different Susceptibilities to HIV Infection and Death: Analysis by CyTOF and Single Cell RNA-seq Open
CD4 T lymphocytes belong to diverse cellular subsets whose sensitivity or resistance to HIV-associated killing remains to be defined. Working with lymphoid cells from human tonsils, we characterized the HIV-associated depletion of various …
View article: Additional file 2 of No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells
Additional file 2 of No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells Open
Additional file 2: Supplemental Table 1. List of enriched gene sets amongst PBMC cell types as determined by GSEA for 8-donor PBMC scRNA-seq dataset. Supplemental Table 2. List of enriched gene sets amongst PBMC cell types as determined by…
View article: MAVS Is Essential for Primary CD4 + T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection
MAVS Is Essential for Primary CD4 + T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection Open
The use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been the major focus of research in individual vaccine development. West Nile virus (WNV) nonstructural (NS) 4B-P38G mutant has several feat…
View article: No detectable alloreactive transcriptional responses during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells
No detectable alloreactive transcriptional responses during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells Open
Single-cell RNA sequencing (scRNA-seq) provides high-dimensional measurement of transcript counts in individual cells. However, high assay costs limit the study of large numbers of samples. Sample multiplexing technologies such as antibody…
View article: Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection
Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection Open
The E3 ubiquitin ligase Pellino 1 (Peli1) is a microglia-specific mediator of autoimmune encephalomyelitis. Its role in neurotropic flavivirus infection is largely unknown. Here, we report that mice deficient in Peli1 (Peli1-/-) were more …
View article: MAVS Is Essential for Primary CD4<sup>+</sup>T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection
MAVS Is Essential for Primary CD4<sup>+</sup>T Cell Immunity but Not for Recall T Cell Responses following an Attenuated West Nile Virus Infection Open
The use of pathogen recognition receptor (PRR) agonists and the molecular mechanisms involved have been the major focus of research in individual vaccine development. West Nile virus (WNV) nonstructural (NS) 4B-P38G mutant has several feat…
View article: Erratum: Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation
Erratum: Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation Open
View article: Dysregulation of Toll-Like Receptor 7 Compromises Innate and Adaptive T Cell Responses and Host Resistance to an Attenuated West Nile Virus Infection in Old Mice
Dysregulation of Toll-Like Receptor 7 Compromises Innate and Adaptive T Cell Responses and Host Resistance to an Attenuated West Nile Virus Infection in Old Mice Open
The elderly are known to have enhanced susceptibility to infections and an impaired capacity to respond to vaccination. West Nile virus (WNV), a mosquito-borne flavivirus, has induced severe neurological symptoms, mostly in the elderly pop…
View article: A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells
A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells Open