Guosheng Gu
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View article: Effect of rapid carbapenemase detection-directed antimicrobial therapy on clinical response in patients with intra-abdominal infections (RAPID): protocol for a randomised controlled trial
Effect of rapid carbapenemase detection-directed antimicrobial therapy on clinical response in patients with intra-abdominal infections (RAPID): protocol for a randomised controlled trial Open
Introduction Infections caused by carbapenemase-producing organisms have become a major problem during the treatment of secondary bloodstream infection in patients with severe intra-abdominal infection (sIAI). Early detection and identific…
View article: Identification of Cuproptosis‐Related Patterns Predict Prognosis and Immunotherapy Response in Hepatocellular Carcinoma
Identification of Cuproptosis‐Related Patterns Predict Prognosis and Immunotherapy Response in Hepatocellular Carcinoma Open
A novel copper‐dependent mode of death, cuproptosis, has been newly identified. This study developed a cuproptosis score (CS) based on the cuproptosis model to analyse the association of CS with prognosis, immune cell infiltration, drug se…
View article: Development a risk prediction nomogram for multidrug−resistant bacterial and fungal infection in gastrointestinal fistula patients during the perioperative period
Development a risk prediction nomogram for multidrug−resistant bacterial and fungal infection in gastrointestinal fistula patients during the perioperative period Open
Background This study aims to develop a risk prediction model for multidrug-resistant bacterial and fungal infections in patients with gastrointestinal fistulas during the perioperative period. Methods A retrospective cohort study was cond…
View article: Predictive value of triglyceride glucose index in acute kidney injury in patients with severe traumatic brain injury
Predictive value of triglyceride glucose index in acute kidney injury in patients with severe traumatic brain injury Open
View article: Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression
Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression Open
The design of chimeric antigen receptors (CAR) significantly enhances the antitumor efficacy of T cells. Although some CAR-T products have been approved by FDA in treating hematological tumors, adoptive immune therapy still faces many diff…
View article: Smart implants: 4D-printed shape-morphing scaffolds for medical implantation
Smart implants: 4D-printed shape-morphing scaffolds for medical implantation Open
Biomedical implants have recently shown excellent application potential in tissue repair and replacement. Applying three-dimensional (3D) printing to implant scaffold fabrication can help to address individual needs more precisely. Fourdim…
View article: Subphenotyping heterogeneous patients with chronic critical illness to guide individualised fluid balance treatment using machine learning: a retrospective cohort study
Subphenotyping heterogeneous patients with chronic critical illness to guide individualised fluid balance treatment using machine learning: a retrospective cohort study Open
View article: Transcatheter arterial embolization of the common hepatic artery for pseudoaneurysm after a laparoscopic‐assisted pancreaticoduodenectomy: A case report
Transcatheter arterial embolization of the common hepatic artery for pseudoaneurysm after a laparoscopic‐assisted pancreaticoduodenectomy: A case report Open
Common hepatic artery pseudoaneurysm is a rare and potentially life‐threatening complication after pancreaticoduodenectomy, and the possible cause is unclear. We report a case of intraperitoneal hemorrhage after pancreaticoduodenectomy who…
View article: Self‐Healing Supramolecular Hydrogels with Antibacterial Abilities for Wound Healing
Self‐Healing Supramolecular Hydrogels with Antibacterial Abilities for Wound Healing Open
Wound healing due to skin defects is a growing clinical concern. Especially when infection occurs, it not only leads to impair healing of the wound but even leads to the occurrence of death. In this study, a self‐healing supramolecular hyd…
View article: Transcatheter arterial embolization of the common hepatic artery for pseudoaneurysm after a laparoscopic-assisted pancreaticoduodenectomy: A case report
Transcatheter arterial embolization of the common hepatic artery for pseudoaneurysm after a laparoscopic-assisted pancreaticoduodenectomy: A case report Open
Common hepatic artery (CHA) pseudoaneurysm is a rare and potentially life-threatening complication after pancreaticoduodenectomy, and the possible cause is unclear. We report a case of intraperitoneal hemorrhage after pancreaticoduodenecto…
View article: 4D-printed bilayer hydrogel with adjustable bending degree for enteroatmospheric fistula closure
4D-printed bilayer hydrogel with adjustable bending degree for enteroatmospheric fistula closure Open
Recently, four-dimensional (4D) shape-morphing structures, which can dynamically change shape over time, have attracted much attention in biomedical manufacturing. The 4D printing has the capacity to fabricate dynamic construction conformi…
View article: Trocar Puncture With a Sump Drain for Crohn's Disease With Intra-Abdominal Abscess: A 10-Year Retrospective Cohort Study
Trocar Puncture With a Sump Drain for Crohn's Disease With Intra-Abdominal Abscess: A 10-Year Retrospective Cohort Study Open
Background Traditional percutaneous catheter drainage (PCD) and surgical intervention could not always achieve satisfactory results for patients with Crohn's disease (CD) who have complications with intra-abdominal abscess. We proposed a t…
View article: Author Correction: Released mitochondrial DNA following intestinal ischemia reperfusion induces the inflammatory response and gut barrier dysfunction
Author Correction: Released mitochondrial DNA following intestinal ischemia reperfusion induces the inflammatory response and gut barrier dysfunction Open
4, where the images in panel (a) for the Sham group, Jejunuum and the I/R group, Ileum are incorrect.The correct Figure 4 and accompanying legend appear below.
View article: Correction: Engineering an adhesive based on photosensitive polymer hydrogels and silver nanoparticles for wound healing
Correction: Engineering an adhesive based on photosensitive polymer hydrogels and silver nanoparticles for wound healing Open
Correction for ‘Engineering an adhesive based on photosensitive polymer hydrogels and silver nanoparticles for wound healing’ by Qinqing Tang et al. , J. Mater. Chem. B , 2020, 8 , 5756–5764, DOI: 10.1039/d0tb00726a.
View article: Corrigendum to: Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn’s Disease
Corrigendum to: Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn’s Disease Open
View article: Intestinal mucosa-derived DNA methylation signatures in the penetrating intestinal mucosal lesions of Crohn’s disease
Intestinal mucosa-derived DNA methylation signatures in the penetrating intestinal mucosal lesions of Crohn’s disease Open
View article: CCL4‐mediated targeting of spleen tyrosine kinase (Syk) inhibitor using nanoparticles alleviates inflammatory bowel disease
CCL4‐mediated targeting of spleen tyrosine kinase (Syk) inhibitor using nanoparticles alleviates inflammatory bowel disease Open
Inflammatory bowel disease (IBD) has emerged a global disease and the ascending incidence and prevalence is accompanied by elevated morbidity, mortality, and substantial healthcare system costs. However, the current typical one‐size‐fits‐a…
View article: Early Enteral Nutrition Preserves Intestinal Barrier Function through Reducing the Formation of Neutrophil Extracellular Traps (NETs) in Critically Ill Surgical Patients
Early Enteral Nutrition Preserves Intestinal Barrier Function through Reducing the Formation of Neutrophil Extracellular Traps (NETs) in Critically Ill Surgical Patients Open
Background. The gut was suggested as the driver of critical illness and organ injury. Recently, excessive formation of neutrophil extracellular traps (NETs) was associated with mucosal inflammation. Direct investigation of intestinal mucos…
View article: Nutritional Management of Patients With Enterocutaneous Fistulas: Practice and Progression
Nutritional Management of Patients With Enterocutaneous Fistulas: Practice and Progression Open
The management of enterocutaneous fistulas (ECF) can be challenging because of massive fluid loss, which can lead to electrolyte imbalance, severe dehydration, malnutrition and sepsis. Nutritional support plays a key role in the management…
View article: Current progress of source control in the management of intra-abdominal infections
Current progress of source control in the management of intra-abdominal infections Open
View article: Hesperidin Protects Against Intestinal Inflammation by Restoring Intestinal Barrier Function and Up‐Regulating Treg Cells
Hesperidin Protects Against Intestinal Inflammation by Restoring Intestinal Barrier Function and Up‐Regulating Treg Cells Open
In the initially published article, the representative images of the +hesperidin (40 mg/kg) group in the bottom panel of Figure 3B and the images of the control group in the first panel are mistakenly identical.Figure 3B is corrected to th…
View article: Clinical parameters and outcomes of necrotizing soft tissue infections secondary to gastrointestinal fistulas
Clinical parameters and outcomes of necrotizing soft tissue infections secondary to gastrointestinal fistulas Open
Trauma is the main cause of GI fistulas associated NSTIs. Sepsis continues to be the most important factor related to mortality. Our data may assist providing enlightenment for quality improvement in these special populations.
View article: LINC01106 Drives Colorectal Cancer Growth and Stemness Through a Positive Feedback Loop to Stimulate Hedgehog Activation
LINC01106 Drives Colorectal Cancer Growth and Stemness Through a Positive Feedback Loop to Stimulate Hedgehog Activation Open
View article: Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing
Microfluidic Electrospray Niacin Metal-Organic Frameworks Encapsulated Microcapsules for Wound Healing Open
Niacin metal-organic frameworks (MOFs) encapsulated microcapsules with alginate shells and copper-/zinc-niacin framework cores were in situ synthesized by using a microfluidic electrospray approach for wound healing. As the alginate shells…
View article: Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction
Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction Open
View article: The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway
The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway Open
Disruption of the mucosal barrier following intestinal ischemia reperfusion (I/R) is life threatening in clinical practice. Mitochondrial dysfunction and oxidative stress significantly contribute to the early phase of I/R injury and amplif…
View article: Impaired Coagulation Status in the Crohn's Disease Patients Complicated with Intestinal Fistula
Impaired Coagulation Status in the Crohn's Disease Patients Complicated with Intestinal Fistula Open
Intestinal fistula was significantly associated with impaired coagulation status in patients complicated with CD. Coagulation status could be improved after intestinal fistula resections.
View article: Urinary Mitochondrial DNA Identifies Renal Dysfunction and Mitochondrial Damage in Sepsis‐Induced Acute Kidney Injury
Urinary Mitochondrial DNA Identifies Renal Dysfunction and Mitochondrial Damage in Sepsis‐Induced Acute Kidney Injury Open
Background . Recent animal studies have shown that mitochondrial dysfunction initiates and accelerates renal injury in sepsis, but its role in sepsis remains unknown. Mitochondrial stress or dying cells can lead to fragmentation of the mit…
View article: Delayed Diagnosis is Associated with Early and Emergency Need for First Crohn’s Disease-Related Intestinal Surgery
Delayed Diagnosis is Associated with Early and Emergency Need for First Crohn’s Disease-Related Intestinal Surgery Open
BACKGROUND Increasing evidence suggests that delayed diagnosis in Crohn's disease is associated with a complicated disease course. The aim of this study was to explore the association between delayed diagnosis and the timing of the first C…
View article: Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption
Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption Open