Guowei Huang
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View article: Establishing reference intervals for venous whole blood micronutrients in the healthy older Chinese population via dried blood spot technology
Establishing reference intervals for venous whole blood micronutrients in the healthy older Chinese population via dried blood spot technology Open
This study presents venous whole blood micronutrient parameters that can facilitate nutrition-related epidemiological research and inform personalized intervention strategies, thereby enhancing the quality of healthcare for elderly individ…
View article: A collaborative large language model for drug analysis
A collaborative large language model for drug analysis Open
Large language models (LLMs), such as ChatGPT, have substantially helped in understanding human inquiries and generating textual content with human-level fluency. However, directly using LLMs in healthcare applications faces several proble…
View article: The impact of influence tactics on brand message sharing
The impact of influence tactics on brand message sharing Open
View article: Association of whole blood multi-micronutrients with mild cognitive impairment in Chinese older adults: a matched case–control study
Association of whole blood multi-micronutrients with mild cognitive impairment in Chinese older adults: a matched case–control study Open
View article: Reducing cardiometabolic disease risk dietary pattern in the Chinese population with dyslipidemia: a single-center, open-label, randomized, dietary intervention study
Reducing cardiometabolic disease risk dietary pattern in the Chinese population with dyslipidemia: a single-center, open-label, randomized, dietary intervention study Open
This trial was registered at Chinese Clinical Trial Registry as ChiCTR2300072472 (https://www.chictr.org.cn/showproj.html?proj=198618).
View article: Effect Of Levocarnitine Plus Iron Sucrose On Nutritional Status And Life Cycle In Uremic Patients With Renal Anemia
Effect Of Levocarnitine Plus Iron Sucrose On Nutritional Status And Life Cycle In Uremic Patients With Renal Anemia Open
Research team believes that Levocarnitine (L-carnitine) combined with Iron sucrose (IS) has a more significant positive effect on the nutritional status and lifespan of uremic patients with renal anemia and has carried out research and dem…
View article: Information disclosure and funding success of green crowdfunding campaigns: a study on GoFundMe
Information disclosure and funding success of green crowdfunding campaigns: a study on GoFundMe Open
Crowdfunding has become important in increasing financial support for the development of green technologies. Self-disclosed information significantly affects supporters’ decisions and is important for the success of green project funding. …
View article: Enocyanin promotes osteogenesis and bone regeneration by inhibiting MMP9
Enocyanin promotes osteogenesis and bone regeneration by inhibiting MMP9 Open
Enocyanin (ENO), an anthocyanin extracted from grapes, has been shown to exert inhibitory effects on acid phosphatase and inflammation; however, its role in osteogenesis and bone formation is currently unknown. The present study aimed to i…
View article: A Risk Correlative Model for Sleep Disorders in Chinese Older Adults Based on Blood Micronutrient Levels: A Matched Case-Control Study
A Risk Correlative Model for Sleep Disorders in Chinese Older Adults Based on Blood Micronutrient Levels: A Matched Case-Control Study Open
Background: The physical abilities of older adults decline with age, making them more susceptible to micronutrient deficiency, which may affect their sleep quality. Objectives: This study aimed to construct a risk correlative model for sle…
View article: Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial
Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial Open
This food supplement containing phosphatidylserine could improve different cognitive functions of MCI patients, especially short-term memory, and increase serum n-3 PUFAs and neurotransmitters levels. Serum ALA level might play a mediation…
View article: 18F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol
18F-Fluorodeoxyglucose positron emission tomography/computed tomography imaging reveals the protective effect of docosahexaenoic acid on glucose metabolism by reducing brain 27-hydroxycholesterol Open
Total cholesterol (TC) and the cholesterol oxidation product 27-hydroxycholesterol (27-OHC) are both increased in the elderly. Accumulating evidence has linked 27-OHC to glucose metabolism in the brain, while docosahexaenoic acid (DHA) has…
View article: A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
The policies regarding the mandatory fortification of food with folic acid (FA) may impact the effectiveness of folate-based B vitamin treatment on cognitive function in older adults. We critically and systematically review the literature …
View article: Medium-chain triglycerides combined with DHA improve cognitive function by inhibiting neurocyte apoptosis of the brain in SAMP8 mice
Medium-chain triglycerides combined with DHA improve cognitive function by inhibiting neurocyte apoptosis of the brain in SAMP8 mice Open
Medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA, Cn-3, 22:6) are essential in improving cognitive function and protecting neurocytes. This study explored the effects of the combined intervention of MCTs and DHA o…
View article: Socioeconomic disparities and green space associated with myopia among Chinese school-aged students: A population-based cohort study
Socioeconomic disparities and green space associated with myopia among Chinese school-aged students: A population-based cohort study Open
Exposure to green spaces could play a crucial role in slowing the progression of myopia among school-aged students. Myopia control policies should prioritise young populations residing in low SES areas with limited access to green spaces, …
View article: LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation
LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation Open
Breast phyllodes tumor (PT) is a rare fibroepithelial neoplasm with potential malignant behavior. Long non-coding RNAs (lncRNAs) play multifaceted roles in various cancers, but their involvement in breast PT remains largely unexplored. In …
View article: Mental health difficulties and related factors in Chinese children and adolescents during the COVID-19 pandemic: a cross-sectional study
Mental health difficulties and related factors in Chinese children and adolescents during the COVID-19 pandemic: a cross-sectional study Open
View article: Protocol for evaluating the effects of the Reducing Cardiometabolic Diseases Risk dietary pattern in the Chinese population with dyslipidaemia: a single-centre, open-label, dietary intervention study
Protocol for evaluating the effects of the Reducing Cardiometabolic Diseases Risk dietary pattern in the Chinese population with dyslipidaemia: a single-centre, open-label, dietary intervention study Open
Introduction Cardiometabolic disease (CMD) is the leading cause of mortality in China. A healthy diet plays an essential role in the occurrence and development of CMD. Although the Chinese heart-healthy diet is the first diet with cardiova…
View article: Physical exercise frequency and cognition: a multicenter cross-sectional cohort study
Physical exercise frequency and cognition: a multicenter cross-sectional cohort study Open
Background and aims Dementia imposes a heavy burden on society and families, therefore, effective drug treatments, exploring and preventing factors associated with dementia, are paramount. To provide reference points for the best frequency…
View article: Efficacy of MUC1-targeted CAR-NK cells against human tongue squamous cell carcinoma
Efficacy of MUC1-targeted CAR-NK cells against human tongue squamous cell carcinoma Open
Introduction The clinical efficacy of CAR-NK cells against CD19-expressing blood cancers has been demonstrated, and they have shown potential for treating solid tumors as well. However, the efficacy of CAR-NK cells for treating human oral …
View article: Protein Kinase A Is a Master Regulator of Physiological and Pathological Cardiac Hypertrophy
Protein Kinase A Is a Master Regulator of Physiological and Pathological Cardiac Hypertrophy Open
BACKGROUND: The sympathoadrenergic system and its major effector PKA (protein kinase A) are activated to maintain cardiac output coping with physiological or pathological stressors. If and how PKA plays a role in physiological cardiac hype…
View article: Methodological Validation of the Dried Blood Spot Technique for the Determination of Magnesium, Copper, Iron, Zinc and Selenium Levels in Whole Blood
Methodological Validation of the Dried Blood Spot Technique for the Determination of Magnesium, Copper, Iron, Zinc and Selenium Levels in Whole Blood Open
View article: Interaction between parental myopia and children lifestyle on the incidence of myopia among children aged 6–18 years: a cross-sectional study in Tianjin, China
Interaction between parental myopia and children lifestyle on the incidence of myopia among children aged 6–18 years: a cross-sectional study in Tianjin, China Open
Objectives This study aimed to explore the influence of the interaction between parental myopia and lifestyle on myopia among school-age children. Design Cross-sectional study. Setting This study used data from the Tianjin Child and Adoles…
View article: IGFBP5, as a Prognostic Indicator Promotes Tumor Progression and Correlates with Immune Microenvironment in Glioma
IGFBP5, as a Prognostic Indicator Promotes Tumor Progression and Correlates with Immune Microenvironment in Glioma Open
Background: Insulin-like growth factor binding protein 5 (IGFBP5) is highly expressed in multiple human cancers, including glioma. Despite this, it remains unclear what role it plays in glioma. The aim of the present study was to an…
View article: Calcaneal tuberosity avulsion fractures – A review
Calcaneal tuberosity avulsion fractures – A review Open
View article: RETRACTED: DrugGPT: A Knowledge-Grounded Collaborative Large Language Model for Evidence-based Drug Analysis
RETRACTED: DrugGPT: A Knowledge-Grounded Collaborative Large Language Model for Evidence-based Drug Analysis Open
The authors have requested that this preprint be removed from Research Square.
View article: Supplementation of Medium-Chain Triglycerides Combined with Docosahexaenoic Acid Inhibits Amyloid Beta Protein Deposition by Improving Brain Glucose Metabolism in APP/PS1 Mice
Supplementation of Medium-Chain Triglycerides Combined with Docosahexaenoic Acid Inhibits Amyloid Beta Protein Deposition by Improving Brain Glucose Metabolism in APP/PS1 Mice Open
The deterioration of brain glucose metabolism predates the clinical onset of Alzheimer’s disease (AD). Medium-chain triglycerides (MCTs) and docosahexaenoic acid (DHA) positively improve brain glucose metabolism and decrease the expression…
View article: SAM/SAH Mediates Parental Folate Deficiency-Induced Neural Cell Apoptosis in Neonatal Rat Offspring: The Expression of Bcl-2, Bax, and Caspase-3
SAM/SAH Mediates Parental Folate Deficiency-Induced Neural Cell Apoptosis in Neonatal Rat Offspring: The Expression of Bcl-2, Bax, and Caspase-3 Open
Research demonstrated that folate deficiency in either the mother or father could impact the biological functions of the offspring’s of neural cells. Folate deficiency can also impair the methionine cycle, thus contributing to the conversi…
View article: Recent progress on 3D-printed gelatin methacrylate-based biomaterials for articular cartilage repair
Recent progress on 3D-printed gelatin methacrylate-based biomaterials for articular cartilage repair Open
The structure and composition of articular cartilage is complex, and its self-healing ability is limited, and thus, it is difficult to achieve ideal healing once the articular cartilage is damaged. Recently, three-dimensional (3D) printing…
View article: Association of Unhealthy Lifestyle and Genetic Risk Factors With Mild Cognitive Impairment in Chinese Older Adults
Association of Unhealthy Lifestyle and Genetic Risk Factors With Mild Cognitive Impairment in Chinese Older Adults Open
Importance Apolipoprotein E polymorphism ε4 ( APOE ε4) and methylenetetrahydrofolate reductase ( MTHFR ) TT genotype are genetic risk factors of mild cognitive impairment (MCI), but whether this risk can be changed by modifiable lifestyle …
View article: Prevalence of myopia among children and adolescents aged 6–16 during COVID-19 pandemic: a large-scale cross-sectional study in Tianjin, China
Prevalence of myopia among children and adolescents aged 6–16 during COVID-19 pandemic: a large-scale cross-sectional study in Tianjin, China Open
Purpose This study aimed to determine the prevalence of myopia among children and adolescents aged 6–16 years during COVID-19 pandemic in Tianjin, China. Methods This was a cross-sectional study using data from the Tianjin Child and Adoles…