Guoyan Mo
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View article: Multi-Response Au-Nanohybrid Composite Triggered NIR-Light for Effective Anti-Tumor Therapy in Animal Model
Multi-Response Au-Nanohybrid Composite Triggered NIR-Light for Effective Anti-Tumor Therapy in Animal Model Open
This nanohybrid system represents a promising strategy for improving the efficacy of chemotherapy and reducing toxicity in cancer treatment. It enhances drug enrichment and release in tumor tissues while minimizing the impact on normal tis…
View article: Color-induced changes in Chrysanthemum morifolium: an integrative transcriptomic and metabolomic analysis of petals and non-petals
Color-induced changes in Chrysanthemum morifolium: an integrative transcriptomic and metabolomic analysis of petals and non-petals Open
Chrysanthemum morifolium (CM), renowned for its diverse and vibrant varieties, holds significant ornamental and medicinal value. Despite this, the core regulatory mechanisms underlying its coloration, especially in non-petal tissues (i.e.,…
View article: Metabolomics integrated network pharmacology reveals the mechanism of Ma-Mu-Ran Antidiarrheal Capsules on acute enteritis mice
Metabolomics integrated network pharmacology reveals the mechanism of Ma-Mu-Ran Antidiarrheal Capsules on acute enteritis mice Open
Acute enteritis (AE) is a type of digestive disease caused by biochemical factors that irritate the intestinal tract or pathogenic bacteria that infect it. In China, Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) have been applied against diarrh…
View article: Mechanism of Shiliu Buxue Syrup for anemia using integrated metabolomics and network pharmacology
Mechanism of Shiliu Buxue Syrup for anemia using integrated metabolomics and network pharmacology Open
For many years, Shiliu Buxue Syrup (SLBXS) has been used in the treatment of anemia in Xinjiang, China. However, the potential therapeutic mechanism of SLBXS in the treatment of anemia remains unclear. We qualitatively analyzed the ingredi…
View article: Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome
Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome Open
Nephrotic syndrome (NS) is a clinical syndrome resulting from abnormal glomerular permeability, mainly manifesting as edema and proteinuria. Qingrekasen granule (QRKSG), a Chinese Uyghur folk medicine, is a single-flavor preparation made f…
View article: Genome‐Wide Regulation of Electroacupuncture and Treadmill Exercise on Diet‐Induced Obese Rats
Genome‐Wide Regulation of Electroacupuncture and Treadmill Exercise on Diet‐Induced Obese Rats Open
Acupuncture has been widely used for obesity treatment, but its mechanism is still unclear. To investigate the molecular mechanisms, we applied electroacupuncture (EA) at the Zusanli (ST36) acupoint and treadmill exercise (TE) in a diet‐in…
View article: Tumor-mediated shape-transformable nanogels with pH/redox/enzymatic-sensitivity for anticancer therapy
Tumor-mediated shape-transformable nanogels with pH/redox/enzymatic-sensitivity for anticancer therapy Open
Background Delivery of anticancer drug(s) throughout tumor tissues is critical for cancer therapy. However, most current nanomedicines lack sufficient tumor permeability due to their bulky size (100 ~ 200 nm), which is a main reason for cl…
View article: <p>Triterpenoid Saponins from <em>Anemone flaccida</em> Suppress Tumor Cell Proliferation by Regulating MAPK, PD1/PDL1, and STAT3 Signaling Pathways and Altering Cancer Metabolism</p>
Triterpenoid Saponins from <em>Anemone flaccida</em> Suppress Tumor Cell Proliferation by Regulating MAPK, PD1/PDL1, and STAT3 Signaling Pathways and Altering Cancer Metabolism Open
The findings suggested that triterpenoid saponins interfered with multiple signaling cascades involved in tumorigenesis and tumor metabolism and have potential applications in HCC therapy.
View article: Association between circadian gene CLOCK and cisplatin resistance in ovarian cancer cells: A preliminary study
Association between circadian gene CLOCK and cisplatin resistance in ovarian cancer cells: A preliminary study Open
The present study aimed to observe the expression of circadian gene clock circadian regulator (CLOCK) in ovarian cancer cells and the effects of circadian gene CLOCK on cis-dichlorodiamine platinum (cisplatin) resistance in ovarian cancer …
View article: Acupuncture and Related Therapies for Obesity: A Network Meta‐Analysis
Acupuncture and Related Therapies for Obesity: A Network Meta‐Analysis Open
Obesity is a worldwide public health problem. Currently, increasing evidence suggests acupuncture and related therapies are effective for obesity. This network meta‐analysis (NMA) was performed to compare the effectiveness of different acu…
View article: Targeting the eIF4E/β-catenin axis sensitizes cervical carcinoma squamous cells to chemotherapy.
Targeting the eIF4E/β-catenin axis sensitizes cervical carcinoma squamous cells to chemotherapy. Open
Chemotherapy has improved the clinical outcomes of cervical cancer patients. However, patients develop chemoresistance, whose underlying mechanisms are not well understood. In this study, we investigated the phosphorylation levels of eukar…
View article: Triterpenoid saponin flaccidoside II from Anemone flaccida triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors via the MAPK-HO-1 pathway
Triterpenoid saponin flaccidoside II from Anemone flaccida triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors via the MAPK-HO-1 pathway Open
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft tissue neoplasms that are extremely rare and are frequently associated with neurofibromatosis type 1 patients. MPNSTs are typically fatal, and there is no effecti…