Guozhi Wang
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View article: The geochemical differences of bitumens in paleo-oil/gas reservoirs on the northern- northwestern margin of the Sichuan Basin and their indicative significances for differential enrichments of various Pb-Zn deposits
The geochemical differences of bitumens in paleo-oil/gas reservoirs on the northern- northwestern margin of the Sichuan Basin and their indicative significances for differential enrichments of various Pb-Zn deposits Open
View article: A3: Android Agent Arena for Mobile GUI Agents
A3: Android Agent Arena for Mobile GUI Agents Open
AI agents have become increasingly prevalent in recent years, driven by significant advancements in the field of large language models (LLMs). Mobile GUI agents, a subset of AI agents, are designed to autonomously perform tasks on mobile d…
View article: AMEX: Android Multi-annotation Expo Dataset for Mobile GUI Agents
AMEX: Android Multi-annotation Expo Dataset for Mobile GUI Agents Open
View article: Transcriptome-wide association studies identify candidate genes for carcass and meat traits in meat rabbits
Transcriptome-wide association studies identify candidate genes for carcass and meat traits in meat rabbits Open
Meat rabbits are a small herbivorous livestock and have been popularly raised in China for producing high-quality meat. Therefore, it is economically important to genetically improve both carcass performance and meat quality in meat rabbit…
View article: Enhanced Immune Responses in Mice by Combining the Mpox Virus B6R-Protein and Aluminum Hydroxide-CpG Vaccine Adjuvants
Enhanced Immune Responses in Mice by Combining the Mpox Virus B6R-Protein and Aluminum Hydroxide-CpG Vaccine Adjuvants Open
Novel adjuvants and innovative combinations of adjuvants (Adjuvant Systems) have facilitated the development of enhanced and new vaccines against re-emerging and challenging pathogenic microorganisms. Nonetheless, the efficacy of adjuvants…
View article: Radiographic chest wall abnormalities in primary spontaneous pneumothorax identified by artificial intelligence
Radiographic chest wall abnormalities in primary spontaneous pneumothorax identified by artificial intelligence Open
View article: Different effects of inspiratory duration and expiratory duration on heart rate deceleration capacity and heart rate asymmetry
Different effects of inspiratory duration and expiratory duration on heart rate deceleration capacity and heart rate asymmetry Open
View article: Long-read sequencing-based transcriptomic landscape in longissimus dorsi and transcriptome-wide association studies for growth traits of meat rabbits
Long-read sequencing-based transcriptomic landscape in longissimus dorsi and transcriptome-wide association studies for growth traits of meat rabbits Open
Rabbits are an attractive meat livestock species that can efficiently convert human-indigestible plant biomass, and have been commonly used in biological and medical researches. Yet, transcriptomic landscape in muscle tissue and associatio…
View article: Comparison of the Immune Responses to Different Formulations of BC02-Adjuvanted HPV Types 16 and 18 Bivalent Vaccines in Mice
Comparison of the Immune Responses to Different Formulations of BC02-Adjuvanted HPV Types 16 and 18 Bivalent Vaccines in Mice Open
To achieve maximum efficacy, vaccines, such as subunit, recombinant, and conjugate vaccines, necessitate the incorporation of immunostimulators/adjuvants. Adjuvants play a vital role in bolstering and extending the strength of the immune r…
View article: A genome-wide association study of coat color in Chinese Rex rabbits
A genome-wide association study of coat color in Chinese Rex rabbits Open
Coat color is an important phenotypic characteristic of the domestic rabbit ( Oryctolagus cuniculus ) and has specific economic importance in the Rex rabbit industry. Coat color varies considerably among different populations of rabbits, a…
View article: Novel BC02 Compound Adjuvant Enhances Adaptive and Innate Immunity Induced by Recombinant Glycoprotein E of Varicella-Zoster Virus
Novel BC02 Compound Adjuvant Enhances Adaptive and Innate Immunity Induced by Recombinant Glycoprotein E of Varicella-Zoster Virus Open
Both adaptive and innate immunity responses are necessary for the efficient elimination of different pathogens. However, the magnitude, quality and desired type of immune response specific to the co-administered antigen is largely determin…
View article: High accuracy of recombinant fusion protein early secretory antigenic target protein 6‐culture filtrate protein 10 skin test for the detection of tuberculosis infection: a phase III, multi‐centered, double‐blind, hospital‐based, randomized controlled trial
High accuracy of recombinant fusion protein early secretory antigenic target protein 6‐culture filtrate protein 10 skin test for the detection of tuberculosis infection: a phase III, multi‐centered, double‐blind, hospital‐based, randomized controlled trial Open
The diagnostic performance of the ECST was close to the T-SPOT.TB assay in the detection of TB infection and indicated good potential for clinical application in common scenarios.
View article: Past, Present and Future of Bacillus Calmette-Guérin Vaccine Use in China
Past, Present and Future of Bacillus Calmette-Guérin Vaccine Use in China Open
The BCG vaccine is prepared from a weakened strain of Mycobacterium bovis (M. bovis), a bacterium closely related to Mycobacterium tuberculosis (MTB), which causes tuberculosis (TB). The vaccine was developed over 13 years, from 1908 to 19…
View article: Enhanced Potency and Persistence of Immunity to Varicella-Zoster Virus Glycoprotein E in Mice by Addition of a Novel BC02 Compound Adjuvant
Enhanced Potency and Persistence of Immunity to Varicella-Zoster Virus Glycoprotein E in Mice by Addition of a Novel BC02 Compound Adjuvant Open
Herpes zoster (HZ) is one of two distinct syndromes caused by Varicella-zoster virus (VZV). A primary infection with VZV causes varicella in susceptible young children. After resolution of the primary infection, VZV establishes a lifelong …
View article: High Efficacy of Recombinant Fusion Protein ESAT6-CFP10 as a Skin Test Reagent for Adult Tuberculosis: A Phase III, Multi-Centered, Double-Blind, Hospital-Based, Randomized Controlled Trial
High Efficacy of Recombinant Fusion Protein ESAT6-CFP10 as a Skin Test Reagent for Adult Tuberculosis: A Phase III, Multi-Centered, Double-Blind, Hospital-Based, Randomized Controlled Trial Open
View article: Sensitivity, Specificity, and Safety of a Novel ESAT6-CFP10 Skin Test for Tuberculosis Infection in China: 2 Randomized, Self-Controlled, Parallel-Group Phase 2b Trials
Sensitivity, Specificity, and Safety of a Novel ESAT6-CFP10 Skin Test for Tuberculosis Infection in China: 2 Randomized, Self-Controlled, Parallel-Group Phase 2b Trials Open
Background Diagnostics to identify tuberculosis infection are limited. We aimed to assess the diagnostic accuracy and safety of ESAT6-CFP10 (EC) skin test for tuberculosis infection in Chinese adults. Methods We conducted 2 randomized, par…
View article: Biohazard levels and biosafety protection for Mycobacterium tuberculosis strains with different virulence
Biohazard levels and biosafety protection for Mycobacterium tuberculosis strains with different virulence Open
View article: Tuberculosis vaccine development: from classic to clinical candidates
Tuberculosis vaccine development: from classic to clinical candidates Open
View article: Sensitivity, Specificity and Safety of a Novel Skin Test (ESAT6-CFP10) for Tuberculosis Infection in China: Randomized, Blinded, Self-Controlled, Parallel-Group Phase 2b Trials
Sensitivity, Specificity and Safety of a Novel Skin Test (ESAT6-CFP10) for Tuberculosis Infection in China: Randomized, Blinded, Self-Controlled, Parallel-Group Phase 2b Trials Open
View article: Unmethylated CpG motif-containing genomic DNA fragment of <i>Bacillus calmette-guerin</i> promotes macrophage functions through TLR9-mediated activation of NF-<b>κ</b>B and MAPKs signaling pathways
Unmethylated CpG motif-containing genomic DNA fragment of <i>Bacillus calmette-guerin</i> promotes macrophage functions through TLR9-mediated activation of NF-<b>κ</b>B and MAPKs signaling pathways Open
The potency of synthetic CpG-oligo-deoxynucleotides (CpG-ODNs) adjuvants in modulating the immune cell functions through the TLR pathway has been tested and reported previously. However, the cellular signaling involved in the stimulation o…
View article: Ag85b/ESAT6-CFP10 adjuvanted with aluminum/poly-IC effectively protects guinea pigs from latent mycobacterium tuberculosis infection
Ag85b/ESAT6-CFP10 adjuvanted with aluminum/poly-IC effectively protects guinea pigs from latent mycobacterium tuberculosis infection Open
View article: Current status of new tuberculosis vaccine in children
Current status of new tuberculosis vaccine in children Open
Pediatric tuberculosis contributes significantly to the burden of TB disease worldwide. In order to achieve the goal of eliminating TB by 2050, an effective TB vaccine is urgently needed to prevent TB transmission in children. BCG vaccinat…