Explanipedia

A Pan-Indian survey on the interpretation of intestinal biopsies in inflammatory bowel disease, and differentiating intestinal tuberculosis and Crohn’s disease from a pathologist’s perspective Open

Jayati Sarangi, Sagir Akhtar, Subham Bhowmik, Lalita Mehra, Puja Sakhuja , et al. · 2025

Background: The incidence of inflammatory bowel disease (IBD) is rising in India, particularly that of Crohn’s disease (CD). Histological examination is essential for disease evaluation. Materials and Methods: This national survey invited …

Correlation between intestinal stem cell niche changes and small bowel crypt failure in patients with treatment-naïve celiac disease Open

Prasenjit Das, Sudha Battu, Lalita Mehra, Alka Singh, Muzaffar Ahmad , et al. · 2024

Objectives: We hypothesized that crypt failure in the small bowel results in villous flattening in patients with celiac disease (CeD). We investigated whether alterations in the stem cell niche (ISC) are responsible for this phenomenon. Ma…

Pancreatic Mass Characterization Using IVIM-DKI MRI and Machine Learning-Based Multi-Parametric Texture Analysis Open

Archana Malagi, Sivachander Shivaji, Devasenathipathy Kandasamy, Raju Sharma, Pramod Kumar Garg , et al. · 2023

Non-invasive characterization of pancreatic masses aids in the management of pancreatic lesions. Intravoxel incoherent motion-diffusion kurtosis imaging (IVIM-DKI) and machine learning-based texture analysis was used to differentiate pancr…

Impact of Cytomegalovirus Infection on Short-Term Clinical Outcomes and Operative Histopathology in Infants with Biliary Atresia Open

Gayatri Munghate, Sachit Anand, Veereshwar Bhatnagar, Sandeep Agarwala, Siddhartha Datta Gupta · 2022

Background: There is limited information on the impact of cytomegalovirus (CMV) infection on clinical outcomes and operative histopathology in children with biliary atresia (BA). We hypothesized that CMV infection is associated with greate…

Expression analysis of oncogene transcript in human Aberrant Crypt foci, in comparison to the normal colonic mucosa and colorectal carcinoma from formalin-fixed paraffin-embedded tissue samples: A Pilot Study Open

Mohamed Sulaiman, Jayati Sarangi, Aijaz Ahmed, Shouriyo Ghosh, Lailta Mehra , et al. · 2022

Purpose: Aberrant Crypt Foci (ACF) are microscopic preneoplastic lesions in human colon detectable by magnified chromoendoscopy. Our aim was to analyze the expression of a chosen gene transcript in harvested colonic ACF, corresponding colo…

Erratum to ‘Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure’ [J Clin Exp Hepatol 10 (2020) 477-517] Open

Anil C. Anand, Bhaskar Nandi, Subrat Kumar Acharya, Anil Arora, Sethu Babu , et al. · 2022

Histologic Changes in Core-Needle Liver Biopsies From Patients With Acute-on-Chronic Liver Failure and Independent Histologic Predictors of 28-Day Mortality Open

Vandana Baloda, Abhinav Anand, Rajni Yadav, Lalita Mehra, Madhu Rajeshwari , et al. · 2021

Context.— The histologic features in patients with acute-on-chronic liver failure (ACLF) are evolving, and histologic indicators of patients' poor prognosis are not yet fully established. Objective.— To evaluate the independent histologic …

Inhibition of the neuromuscular acetylcholine receptor with atracurium activates FOXO/DAF‐16‐induced longevity Open

Rebecca L. McIntyre, Simone Denis, Rashmi Kamble, Marte Molenaars, Michael Petr , et al. · 2021

Transcriptome‐based drug screening is emerging as a powerful tool to identify geroprotective compounds to intervene in age‐related disease. We hypothesized that, by mimicking the transcriptional signature of the highly conserved longevity …

Long‐term outcomes of anti‐tumor necrosis factor therapy and surgery in nonperianal fistulizing Crohn's disease Open

Sudheer K. Vuyyuru, Devendra Desai, Saurabh Kedia, Pavan Dhoble, Pabitra Sahu , et al. · 2021

Background Unlike perianal fistula, long‐term outcomes of nonperianal fistulae (NPF) in Crohn's disease (CD) are not clear. We aimed to compare the outcomes of medical and surgical therapies in patients with NPF. Methods We retrospectively…

Role of Whole body PET/CT and Examination under anesthesia with multi-site biopsy in evaluating CUP Open

Anupam Kanodia, Chirom Amit Singh, Pirabu Sakthivel, Shamim Ahmad Shamim, Kapil Sikka , et al. · 2021

Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis Open

Anil C. Anand, Bhaskar Nandi, Subrat Kumar Acharya, Anil Arora, Sethu Babu , et al. · 2020

Indian National Association for the Study of Liver Consensus Statement on Acute Liver Failure (Part-2): Management of Acute Liver Failure Open

Anil C. Anand, Bhaskar Nandi, Subrat Kumar Acharya, Anil Arora, Sethu Babu , et al. · 2020

Rheology of complex fluids and kinematics of complex flows Open

Siddhartha Datta Gupta · 2019

Complex fluids are key to commercial and biological applications, exhibiting diverse flow kinematics such as elongational flows, polymer-induced purely elastic instability, slip and shear banding. Accurate measurement of such complex flow …

Holographic shear rheology of viscoelastic fluids Open

Siddhartha Datta Gupta, Siva A. Vanapalli · 2019

In this study, we report the use of digital holography microscopy (DHM) for 3D-resolved flow kinematics and shear rheometry of viscoelastic polymeric fluids. We computationally reconstruct the recorded holograms to visualize the tracer imb…

2019 Update of Indian National Association for Study of the Liver Consensus on Prevention, Diagnosis, and Management of Hepatocellular Carcinoma in India: The Puri II Recommendations Open

Ashish Kumar, Subrat Kumar Acharya, Shivaram Prasad Singh, Anil Arora, Radha K. Dhiman , et al. · 2019

Sa1530 – Celiac Disease Associated Liver Dysfunction: Study of the Histological Features and Co-Localisation Patterns of Iga and Igg Anti-Tissue Transglutaminase Antibody in Liver Biopsies Open

Rimlee Dutta, Asif Iqbal, Prasenjit Das, Alka Singh, Siddhartha Datta Gupta , et al. · 2019

Quantitative histology-based classification system for assessment of the intestinal mucosal histological changes in patients with celiac disease Open

Prasenjit Das, Gaurav PS Gahlot, Alka Singh, Vandana Baloda, Ramakant Rawat , et al. · 2019

Quantitative assessment increases the reliability of the histological assessment of mucosal biopsies in patients with CeD. Such a classification system may be used for clinical trials in patients with CeD. (Intest Res, Published online).

Detection of Solitary Axillary Lymph Node Metastases from Hürthle Cell Carcinoma of the Thyroid on 18F-FDG PET/CT Open

Meghana Prabhu, Deepali Jain, Siddhartha Datta Gupta, Chandrasekhar Bal, Rakesh Kumar · 2018

Objective Scoring of Extent of Steatosis and Fibrosis Using Computer Assisted Image Analysis System in Liver Biopsy Of Non-alcoholic steatohepatitis Patients Open

Prateek Kinra, Prasenjit Das, Rajni Yadav, Saumyaranjan Mallik, S. Shalimar , et al. · 2018

Background: The histological grading/staging system for Non-alcoholic steatohepatitis (NASH) encompasses the following criteria: extent of steatosis, lobular-inflammation, ballooning hepatocytes and extent of fibrosis. The existing scoring…

Modification and Assessment of a Residential Summer Program for High School Women Open

Aimée Cloutier, Guo Zheng Yew, Siddhartha Datta Gupta, Kalpani Dissanayake, Paula Monaco , et al. · 2018

The importance of reducing the gender gap in engineering programs by recruiting and retaining female students is well recognized. Although women hold roughly half of all jobs in the United States, only 24% of STEM jobs are occupied by wome…

Modification and Assessment of a Residential Summer Program for High School Women (Evaluation) Open

Aimée Cloutier, Guo Zheng Yew, Siddhartha Datta Gupta, Cheryl Dissanayake, Paula Monaco , et al. · 2018

Modification and Assessment of a Residential Summer Program for High School Women (Evaluation) The importance of reducing the gender gap in engineering programs by recruiting and retaining female students is well recognized. Although women…

Acute Traumatic Endotheliopathy in Isolated Severe Brain Injury and Its Impact on Clinical Outcome Open

Venencia Albert, Arulselvi Subramanian, Deepak Agrawal, Hara Prasad Pati, Siddhartha Datta Gupta , et al. · 2018

Study design: Prospective observational cohort. Objective: To investigate the difference in plasma levels of syndecan-1 (due to glycocalyx degradation) and soluble thrombomodulin (due to endothelial damage) in isolated severe traumatic bra…

Selective M1 macrophage polarization in granuloma-positive and granuloma-negative Crohn's disease, in comparison to intestinal tuberculosis Open

Prasenjit Das, Ritika Rampal, Sonakshi Udinia, Tarun Kumar, Sucharita Pilli , et al. · 2018

Proinflammatory M1_φ polarization was more common in colonic mucosa of CD patients, especially in the presence of mucosal granulomas. Further characterization of the innate immune system could help in clarifying the pathology of …

Topographic, histological and molecular study of aberrant crypt foci identified in human colon in different clinical groups Open

Shouriyo Ghosh, Brijnandan Gupta, P. Verma, Sreenivas Vishnubathla, Sujoy Pal , et al. · 2018

Left colonic ACF appear to be high-risk based on their morphological and prototypic tumor marker signature. ACF identified in different clinical groups do not show significant genotypic or topographic differences. Further detailed genetic …

Cathepsin L and B as Potential Markers for Liver Fibrosis: Insights From Patients and Experimental Models Open

Mansi Manchanda, Prasenjit Das, Gaurav Pratap Singh Gahlot, Ratnakar Singh, Elke Roeb , et al. · 2017

Our data demonstrate the overexpression of CTSL and CTSB in patients and experimental mouse models, suggesting their potential as diagnostic biomarkers for chronic liver diseases.

Microfluidic viscometers for shear rheology of complex fluids and biofluids Open

Siddhartha Datta Gupta, William S. Wang, Siva A. Vanapalli · 2016

The rich diversity of man-made complex fluids and naturally occurring biofluids is opening up new opportunities for investigating their flow behavior and characterizing their rheological properties. Steady shear viscosity is undoubtedly th…

Proteome analysis of the macroscopically affected colonic mucosa of Crohn’s disease and intestinal tuberculosis Open

Lokesh Rukmangadachar, Govind Makharia, Asha Mishra, Prasenjit Das, Gururao Hariprasad , et al. · 2016

Demographic profile, host, disease & viral predictive factors of response in patients with chronic hepatitis C virus infection at a tertiary care hospital in north India Open

Sreejith Vasudevan, Amit Kavimandan, Nancy Kalra, Baibaswata Nayak, Bhaskar Thakur , et al. · 2016

Background & objectives: Standard of care for chronic hepatitis C (CHC) in India is peginterferon and ribavirin (RBV). The response to treatment in real life stetting is unclear. The objectives of this study were to evaluate the demographi…

Cancer stem cells in hepatocellular carcinomas Open

Prasenjit Das, Siddhartha Datta Gupta · 2015

There are currently two major schools of thought or theories that explain the formation of tumours. According to the classical stochastic theory or clonal-evolution model of carcinogenesis, it is believed that a cancer cell develops as a r…

Correlation of pre- and post-operative liver function, duct diameter at porta hepatis, and portal fibrosis with surgical outcomes in biliary atresia Open

Veereshwar Bhatnagar, Rajib Ray Baruah, Sandeep Agarwala, Siddhartha Datta Gupta · 2015

Following KP, jaundice persisted in 40% patients; it disappeared in 60% patients but reappeared in half of these patients 6 months postoperatively. The duct size at the porta hepatis did not correlate with age or surgical outcome. Serum bi…

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