Gurmit Singh
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View article: Risk Factors for Sacroiliac Joint Fusion after Instrumented Spinal Fusion
Risk Factors for Sacroiliac Joint Fusion after Instrumented Spinal Fusion Open
Study Design Retrospective Cohort Study. Objective To identify risk factors for sacroiliac (SI) joint fusion after instrumented spinal fusion. Methods Patients were identified from the PearlDiver BiscayneBay database. Patients who underwen…
View article: Computational modeling to study the impact of changes in Nav1.8 sodium channel on neuropathic pain
Computational modeling to study the impact of changes in Nav1.8 sodium channel on neuropathic pain Open
Objective Nav1.8 expression is restricted to sensory neurons; it was hypothesized that aberrant expression and function of this channel at the site of injury contributed to pathological pain. However, the specific contributions of Nav1.8 t…
View article: Doxycycline-Induced Changes in Circulating MMP or TIMP2 Levels Are Not Associated with Skeletal-Related Event-Free or Overall Survival in Patients with Bone Metastases from Breast Cancer
Doxycycline-Induced Changes in Circulating MMP or TIMP2 Levels Are Not Associated with Skeletal-Related Event-Free or Overall Survival in Patients with Bone Metastases from Breast Cancer Open
Doxycycline is often used as a promoter of inducible gene expression in preclinical models; however, it can also have direct effects on tumor growth and survival. This is due in part to its ability to inhibit cell invasion and regulate mat…
View article: Is chronic pain as an autoimmune disease?
Is chronic pain as an autoimmune disease? Open
Autoimmune diseases frequently occur in females, and a parallel sexually dimorphic suffering is observed in individuals who suffer chronic pain. Though perception and environment influence the chronicity of pain, this review illustrates ex…
View article: Differences and Similarities in Spontaneous Activity Between Animal Models of Cancer-Induced Pain and Neuropathic Pain
Differences and Similarities in Spontaneous Activity Between Animal Models of Cancer-Induced Pain and Neuropathic Pain Open
Thus, SFL may result from SA activity in C-fiber neurons in CIP and NEP rats. The differences and similarities in spontaneous pain between CIP and NEP rats is related to the proportion and rate of SA in C-fibers, respectively.
View article: A systematic review of the literature on the relationship between ace2 and sars-cov infection in animal models
A systematic review of the literature on the relationship between ace2 and sars-cov infection in animal models Open
Background: similar to the severe acute respiratory syndrome coronavirus (SARS-CoV), research suggests severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts with angiotensin-converting enzyme 2 (ACE2) to gain entry into ce…
View article: Evaluation of the preclinical analgesic efficacy of naturally derived, orally administered oil forms of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and their 1:1 combination
Evaluation of the preclinical analgesic efficacy of naturally derived, orally administered oil forms of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and their 1:1 combination Open
Chronic neuropathic pain (NP) is a growing clinical problem for which effective treatments, aside from non-steroidal anti-inflammatory drugs and opioids, are lacking. Cannabinoids are emerging as potentially promising agents to manage neur…
View article: <p>Applying Serum Cytokine Levels to Predict Pain Severity in Cancer Patients</p>
Applying Serum Cytokine Levels to Predict Pain Severity in Cancer Patients Open
Exploratory analyses such as the ones presented here will be a beneficial tool to expand insights into potential cancer-specific nociceptive mechanisms and to develop novel therapeutics.
View article: An evaluation of the anti‐hyperalgesic effects of cannabidiolic acid‐methyl ester in a preclinical model of peripheral neuropathic pain
An evaluation of the anti‐hyperalgesic effects of cannabidiolic acid‐methyl ester in a preclinical model of peripheral neuropathic pain Open
Background and Purpose Chronic neuropathic pain (NEP) is associated with growing therapeutic cannabis use. To promote quality of life without psychotropic effects, cannabinoids other than Δ9‐tetrahydrocannabidiol, including cannabidiol and…
View article: Bone cancer-induced pain is associated with glutamate signalling in peripheral sensory neurons
Bone cancer-induced pain is associated with glutamate signalling in peripheral sensory neurons Open
We previously identified that several cancer cell lines known to induce nociception in mouse models release glutamate in vitro. Although the mechanisms of glutamatergic signalling have been characterized primarily in the central nervous sy…
View article: Response to pregabalin and progesterone differs in male and female rat models of neuropathic and cancer pain
Response to pregabalin and progesterone differs in male and female rat models of neuropathic and cancer pain Open
Background: Cancer pain involves nervous system damage and pathological neurogenesis. Neuropathic pain arises from damage to the nervous system and is driven by ectopic signaling. Both progesterone and pregabalin are neuroprotective in ani…
View article: <p>Effect of glutaminase inhibition on cancer-induced bone pain</p>
Effect of glutaminase inhibition on cancer-induced bone pain Open
Adaptation to metabolic disturbances may explain the failure of CB-839 to exhibit any significant effects in vivo and the metabolic flexibility of the cell line tested should be considered for future investigations studying the metabolic e…
View article: 3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion
3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion Open
Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatit…
View article: STAT3 Inhibition in a Murine Model of Human Breast Cancer-Induced Bone Pain Delays Onset of Nociception
STAT3 Inhibition in a Murine Model of Human Breast Cancer-Induced Bone Pain Delays Onset of Nociception Open
Introduction/Aim: Alterations in extracellular glutamate levels have been previously found to contribute to cancer-induced bone pain (CIBP). Increased activity of system xc-, a cystine-glutamate membrane antiporter, has been previously imp…
View article: Spinal microglia contribute to cancer-induced pain through system xC −-mediated glutamate release
Spinal microglia contribute to cancer-induced pain through system xC −-mediated glutamate release Open
Introduction: Microglial cells, the resident macrophages of the central nervous system, are a key contributor to the generation and maintenance of cancer-induced pain (CIP). In healthy organisms, activated microglia promote recovery throug…
View article: Evaluating the efficacy of cannabidiol to manage surgically induced neuropathic pain in a preclinical rat model: Are T cells a sexually dimorphic target?
Evaluating the efficacy of cannabidiol to manage surgically induced neuropathic pain in a preclinical rat model: Are T cells a sexually dimorphic target? Open
Background: Considering the poorly understood etiology and complex symptoms of chronic neuropathic pain (NP), the lack of effective treatments, and sex-dependent differences in the neuroimmune system as well as in antinociceptive responses…
View article: <p>Activation of hippocampal microglia in a murine model of cancer-induced pain</p>
Activation of hippocampal microglia in a murine model of cancer-induced pain Open
This is the first experimental evidence to demonstrate the effects of peripheral tumor-induced nociception on hippocampal microglial activation. The increase in hippocampal microglia observed in the present study may reflect the emotional …
View article: xCT knockdown in human breast cancer cells delays onset of cancer-induced bone pain
xCT knockdown in human breast cancer cells delays onset of cancer-induced bone pain Open
Cancers in the bone produce a number of severe symptoms including pain that compromises patient functional status, quality of life, and survival. The source of this pain is multifaceted and includes factors secreted from tumor cells. Malig…
View article: Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception
Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception Open
Aggressive breast cancer subtypes utilize system x c − , a membrane antiporter, to import cystine for glutathione synthesis and maintenance of redox homeostasis, in turn releasing glutamate as a metabolic pro-nociceptive by-product. Metast…
View article: Biological Mechanisms of Cancer-Induced Depression
Biological Mechanisms of Cancer-Induced Depression Open
Patients with cancer are more likely to develop depression than the general population, which negatively impacts their quality of life and prognosis. In order to identify effective antidepressants catered toward cancer patients, the biolog…
View article: Cancer pain and neuropathic pain are associated with A <b> <i>β</i> </b> sensory neuronal plasticity in dorsal root ganglia and abnormal sprouting in lumbar spinal cord
Cancer pain and neuropathic pain are associated with A <b> <i>β</i> </b> sensory neuronal plasticity in dorsal root ganglia and abnormal sprouting in lumbar spinal cord Open
Evidence suggests that there are both nociceptive and neuropathic components of cancer-induced pain. We have observed that changes in intrinsic membrane properties and excitability of normally non-nociceptive Aβ sensory neurons are consist…
View article: Functional effects of TrkA inhibition on system x<sub>C</sub><sup>−</sup>-mediated glutamate release and cancer-induced bone pain
Functional effects of TrkA inhibition on system x<sub>C</sub><sup>−</sup>-mediated glutamate release and cancer-induced bone pain Open
Breast cancer cells release the signalling molecule glutamate via the system x C − antiporter, which is upregulated to exchange extracellular cystine for intracellular glutamate to protect against oxidative stress. Here, we demonstrate tha…