Guruprasad P. Aithal
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View article: Efficacy and Toxicity Profile of Carboplatin/Gemcitabine Chemotherapy in Locally Advanced or Metastatic Biliary Tract Cancer: A Single UK Centre Experience
Efficacy and Toxicity Profile of Carboplatin/Gemcitabine Chemotherapy in Locally Advanced or Metastatic Biliary Tract Cancer: A Single UK Centre Experience Open
Background/Objectives: Biliary tract cancers (BTCs) refer to an invasive group of malignancies consisting of gallbladder cancer, ampullary cancer, and cholangiocarcinoma (CCA). BTCs are often diagnosed at advanced stages, leading to poor p…
View article: Diabetes mellitus in alcohol-associated liver disease: Prevalence and outcomes
Diabetes mellitus in alcohol-associated liver disease: Prevalence and outcomes Open
Background: Alcohol associated liver disease (ALD) is a common condition that is a significant global cause of morbidity and mortality. Diabetes mellitus (DM) increases the risk of adverse outcomes in other types of steatotic liver disease…
View article: Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies
Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies Open
In the management of cholangiocarcinoma, effective biliary drainage and accurate diagnosis are vital to allow further treatment. Confirmation of tissue diagnosis and molecular characterization is also required to guide future treatment opt…
View article: Investigating hepatic fibrosis heterogeneity by three-dimensional imaging in metabolic dysfunction-associated steatotic liver disease
Investigating hepatic fibrosis heterogeneity by three-dimensional imaging in metabolic dysfunction-associated steatotic liver disease Open
Although liver biopsy is a well-established technique to assess fibrosis it has several limitations, including invasive nature, semi-quantitative assessment methods, significant sampling and observer variability, making precise assessment …
View article: Advanced Technologies to Address Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma
Advanced Technologies to Address Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma Open
In the management of cholangiocarcinoma, effective biliary drainage and accurate diagnosis are vital to allow further treatment. Confirmation of tissue diagnosis and molecular characterization is also required to guide future treatment opt…
View article: Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis
Chronic pancreatitis and extra pancreatic cancers- A systematic review and meta analysis Open
Patients with CP have an increased risk of developing EP cancers compared to patients without CP, in particular lung and liver cancer which had the highest relative risk. Shared risk factor modifications, such as smoking cessation and alco…
View article: Mapping the hemodynamic effects of terlipressin in patients with hepatorenal syndrome using advanced magnetic resonance imaging
Mapping the hemodynamic effects of terlipressin in patients with hepatorenal syndrome using advanced magnetic resonance imaging Open
View article: Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury
Transcriptomic and proteomic characterization of cell and protein biomarkers of checkpoint inhibitor-induced liver injury Open
View article: Incidence and predictors of non-hepatic cancers in biopsy-proven alcohol-related liver disease
Incidence and predictors of non-hepatic cancers in biopsy-proven alcohol-related liver disease Open
NHC is common and frequently fatal. However, NHC is an infrequent cause of morbidity or mortality in ALD compared to liver-related outcomes.
View article: Assessing brodalumab in the treatment of primary sclerosing cholangitis (SABR-PSC pilot study): protocol for a single-arm, multicentre, pilot study
Assessing brodalumab in the treatment of primary sclerosing cholangitis (SABR-PSC pilot study): protocol for a single-arm, multicentre, pilot study Open
Introduction Primary sclerosing cholangitis (PSC) is a rare immune-mediated hepatobiliary disease, characterised by progressive biliary fibrosis, cirrhosis, and end-stage liver disease. As yet, no licensed pharmacological therapy exists. W…
View article: Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury
Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury Open
Predicting which drugs might have the potential to cause drug-induced liver injury (DILI) is highly complex and the current methods, 2D cell-based models and animal tests, are not sensitive enough to prevent some costly failures in clinica…
View article: The association between fibrotic diseases and treatment-resistant hypertension in England
The association between fibrotic diseases and treatment-resistant hypertension in England Open
Aims Multimorbidity has been identified as a research priority in recent years; fibrosis (progressive organ scarring) is one mechanism that may underpin multimorbidity. Some studies suggest hypertension could be fibrotic, particularly seve…
View article: The development of a food-group, tree classification method and its use in exploring dietary associations with metabolic dysfunction-associated Steatotic liver disease (MASLD) and other health-related outcomes in a UK population
The development of a food-group, tree classification method and its use in exploring dietary associations with metabolic dysfunction-associated Steatotic liver disease (MASLD) and other health-related outcomes in a UK population Open
View article: Chronic pancreatitis: a case ascertainment study
Chronic pancreatitis: a case ascertainment study Open
Background Chronic pancreatitis (CP) is a debilitating condition, characterised by chronic inflammation and fibrosis of the pancreas. The population frequency of CP is poorly understood. Therefore, we used a broad pragmatic approach to est…
View article: In Vivo Hepatic Glutathione Synthesis Flux Measurement by 13c Magnetic Resonance Spectroscopy and Metabolic Modelling: A Tool for Assessing Hepatic Redox Balance and Oxidative Stress
In Vivo Hepatic Glutathione Synthesis Flux Measurement by 13c Magnetic Resonance Spectroscopy and Metabolic Modelling: A Tool for Assessing Hepatic Redox Balance and Oxidative Stress Open
View article: Identification of Distinguishing Features of Drug-Induced Liver Injury and Liver Injury Associated with Sepsis
Identification of Distinguishing Features of Drug-Induced Liver Injury and Liver Injury Associated with Sepsis Open
View article: Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink
Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Research Datalink Open
Objective To develop and validate a prognostic model for risk-stratified monitoring of 5-aminosalicylate nephrotoxicity. Methods This UK retrospective cohort study used data from the Clinical Practice Research Datalink Aurum and Gold for m…
View article: Utility of Bio-Degradable Bile Duct Stents Following Bile Leaks and Pre-Operative Stone Clearance: International, Prospective, Multi-Centre, Observational Cohort Study
Utility of Bio-Degradable Bile Duct Stents Following Bile Leaks and Pre-Operative Stone Clearance: International, Prospective, Multi-Centre, Observational Cohort Study Open
View article: Screening for Alcohol Use Disorder Among Hospitalised Patients: Learning from a Retrospective Cohort Study in Secondary Care
Screening for Alcohol Use Disorder Among Hospitalised Patients: Learning from a Retrospective Cohort Study in Secondary Care Open
Background: Excessive alcohol consumption is among the leading causes of hospitalisation in high-income countries and contributes to over 200 medical conditions. We aimed to determine the prevalence and characteristics of alcohol use disor…
View article: The Midlands Liver Research Alliance - A partnership to optimise obesity-related liver disease research: targeting areas of high incidence and underserved communities
The Midlands Liver Research Alliance - A partnership to optimise obesity-related liver disease research: targeting areas of high incidence and underserved communities Open
Background The prevalence of liver disease is rising in the United Kingdom (UK), with obesity underpinning surging metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD is associated with an increased cardiometabolic risk…
View article: Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK
Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK Open
Introduction Acute liver failure (ALF) has no effective treatment other than liver transplantation and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. Alternatively-activated macrophages (AAM…
View article: Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review
Association between glucagon-like peptide-1 receptor agonists use and change in alcohol consumption: a systematic review Open
View article: 150P Prevalence of DPYD variants in 1478 cancer patients receiving fluoropyrimidine chemotherapy: A real-world data analysis
150P Prevalence of DPYD variants in 1478 cancer patients receiving fluoropyrimidine chemotherapy: A real-world data analysis Open
View article: Structuring white rice with gellan gum reduces the glycemic response in healthy humans
Structuring white rice with gellan gum reduces the glycemic response in healthy humans Open
White rice has a high glycemic index and its consumption has been linked to an increased risk of developing type-2 diabetes mellitus, increased diabetes associated complications and obesity. In recent in vitro studies we have shown that ad…
View article: Glycated haemoglobin is a major predictor of disease severity in patients with NAFLD
Glycated haemoglobin is a major predictor of disease severity in patients with NAFLD Open
View article: Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training
Greater hepatic lipid saturation is associated with impaired glycaemic regulation in men with metabolic dysfunction‐associated steatotic liver disease but is not altered by 6 weeks of exercise training Open
Aims To examine the impact of impaired glycaemic regulation (IGR) and exercise training on hepatic lipid composition in men with metabolic dysfunction‐associated steatotic liver disease (MASLD). Materials and Methods In Part A (cross‐secti…
View article: Macrophage Therapy for Acute Liver Injury (MAIL): a Phase 1 Randomised, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages in Patients with Paracetamol-induced Acute Liver Injury
Macrophage Therapy for Acute Liver Injury (MAIL): a Phase 1 Randomised, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages in Patients with Paracetamol-induced Acute Liver Injury Open
Introduction Acute Liver Failure (ALF) has no effective treatment other than liver transplantation, and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. Alternatively activated macrophages (AA…
View article: A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry
A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry Open
Background: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-associated cirrhosis by comparing …
View article: Health professional attitudes and perceptions of prehabilitation and nutrition before haematopoietic cell transplantation
Health professional attitudes and perceptions of prehabilitation and nutrition before haematopoietic cell transplantation Open
Background Nutritional prehabilitation may improve haematopoietic cell transplantation (HCT) outcomes, although little evidence exists. The present study aimed to understand healthcare professional (HCP) perceptions of prehabilitation and …
View article: Vascular adhesion protein-1 blockade in primary sclerosing cholangitis: Open-label, multicenter, single-arm, phase II trial
Vascular adhesion protein-1 blockade in primary sclerosing cholangitis: Open-label, multicenter, single-arm, phase II trial Open
Background: Primary sclerosing cholangitis is a progressive inflammatory liver disease characterized by biliary and liver fibrosis. Vascular adhesion protein-1 (VAP-1) is important in the inflammatory process driving liver fibrosis. We eva…