Gustavo dos Santos Fernandes
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View article: Perfil e motivos dos hipoutilizadores duma unidade de saúde familiar do Porto
Perfil e motivos dos hipoutilizadores duma unidade de saúde familiar do Porto Open
Introdução: A não utilização dos cuidados de saúde primários é problemática, especialmente pela ausência de vigilância do hipoutilizador. Reduzida frequência em consultas com o médico de família impede realização de rastreios, deteção prec…
View article: MUCINOUS AND SIGNET RING CELL RECTAL ADENOCARCINOMA WITH ISOLATED BONE MARROW DISSEMINATION: A CASE REPORT
MUCINOUS AND SIGNET RING CELL RECTAL ADENOCARCINOMA WITH ISOLATED BONE MARROW DISSEMINATION: A CASE REPORT Open
View article: Impact of COVID-19 vaccination on mortality from COVID-19 severe acute respiratory syndrome (SRAG-Covid) in Brazilian municipalities in 2021
Impact of COVID-19 vaccination on mortality from COVID-19 severe acute respiratory syndrome (SRAG-Covid) in Brazilian municipalities in 2021 Open
Population Medicine considers the following types of articles:• Research Papers -reports of data from original research or secondary dataset analyses.• Review Papers -comprehensive, authoritative, reviews within the journal's scope.These i…
View article: Supplementary Data from Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
Supplementary Data from Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy Open
Supplementary Methods and Supplementary Table 1
View article: Data from Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
Data from Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy Open
Purpose:Evaluate response of mismatch repair–deficient (dMMR) rectal cancer to neoadjuvant chemotherapy.Experimental Design:dMMR rectal tumors at Memorial Sloan Kettering Cancer Center (New York, NY) were retrospectively reviewed for chara…
View article: Supplementary Data from Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
Supplementary Data from Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy Open
Supplementary Methods and Supplementary Table 1
View article: Data from Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
Data from Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy Open
Purpose:Evaluate response of mismatch repair–deficient (dMMR) rectal cancer to neoadjuvant chemotherapy.Experimental Design:dMMR rectal tumors at Memorial Sloan Kettering Cancer Center (New York, NY) were retrospectively reviewed for chara…
View article: Patterns of immune-related adverse events in patients treated with immune checkpoint inhibitors: a Brazilian real-world analysis
Patterns of immune-related adverse events in patients treated with immune checkpoint inhibitors: a Brazilian real-world analysis Open
Objectives: To report real-world data of a cohort of patients treated with immune-checkpoint inhibitors in Brazil, with focus in immune-related adverse events. Material and Methods: In this retrospective study, we analyzed a cohort of pati…
View article: What can we learn from more than 1,000 Brazilian patients at risk of hereditary cancer?
What can we learn from more than 1,000 Brazilian patients at risk of hereditary cancer? Open
Background Identifying individuals at a higher risk of developing cancer is a major concern for healthcare providers. Cancer predisposition syndromes are the underlying cause of cancer aggregation and young-onset tumors in many families. G…
View article: Survey NEN / Inquérito NEN
Survey NEN / Inquérito NEN Open
Introduction: Although new treatments and diagnostic methods for Neuroendocrine Neoplasms (NEN) have been introduced, the level of access to them needs somehow to be further investigated. Objectives: to understand the aspects that influenc…
View article: Updated Brazilian guidelines for the management of immune-related adverse events associated with checkpoint inhibitors - edition 2.0
Updated Brazilian guidelines for the management of immune-related adverse events associated with checkpoint inhibitors - edition 2.0 Open
Immunotherapy (IT) in the form of monoclonal antibodies targeting coreceptors involved in the modulation of the immune synapse represents a standard of care for patients with distinct malignancies. Over the past years, evidences supporting…
View article: The addition of PD-1/PD-L1 axis blockade to BRAF and MEK inhibition for advanced melanoma patients harboring BRAF mutations: a systematic review and meta-analysis
The addition of PD-1/PD-L1 axis blockade to BRAF and MEK inhibition for advanced melanoma patients harboring BRAF mutations: a systematic review and meta-analysis Open
Objectives: Immune-checkpoint inhibitors (ICI) and targeted-therapies (TT) have become standard options for BRAF-V600 metastatic melanomas (MM). Recently, randomized trials (RCT) addressed the efficacy of combined approaches, with conflict…
View article: Association of genomic profiles and survival in early onset and screening‐age colorectal cancer patients with liver metastases resected over 15 years
Association of genomic profiles and survival in early onset and screening‐age colorectal cancer patients with liver metastases resected over 15 years Open
Background This study explores whether genomic profiles of colorectal liver metastasis (CRLM) patients with early onset (EO, < 50 years old) and screening age (SA) primary diagnosis are associated with overall survival (OS). Methods All pa…
View article: BRAZILIAN CONSENSUS FOR MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 3: CONTROVERSIES AND UNRESECTABLE METASTASES
BRAZILIAN CONSENSUS FOR MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 3: CONTROVERSIES AND UNRESECTABLE METASTASES Open
In the last module of this consensus, controversial topics were discussed. Management of the disease after progression during first line chemotherapy was the first discussion. Next, the benefits of liver resection in the presence of extra-…
View article: Fluorouracil Bolus Use in Infusional Regimens Among Oncologists—A Survey by Brazilian Group of Gastrointestinal Tumors
Fluorouracil Bolus Use in Infusional Regimens Among Oncologists—A Survey by Brazilian Group of Gastrointestinal Tumors Open
PURPOSE The utility of administering fluorouracil (5-FU) in bolus in regimens of infusional 5-FU has been questioned. We aimed to quantify the use of 5-FU bolus in infusional regimens for gastrointestinal malignancies among Brazilian oncol…
View article: Implementing somatic mutation testing in clinical setting: recommendations from a panel of experts.
Implementing somatic mutation testing in clinical setting: recommendations from a panel of experts. Open
There has been a rapid increase in the volume of genomic data gathered from different cancers, this has helped to develop new tumor classifications as well as to select better tailored therapies for the patients. Some of the genomic marker…
View article: Identification of the<i>TP53</i>p.R337H Variant in Tumor Genomic Profiling Should Prompt Consideration of Germline Testing for Li-Fraumeni Syndrome
Identification of the<i>TP53</i>p.R337H Variant in Tumor Genomic Profiling Should Prompt Consideration of Germline Testing for Li-Fraumeni Syndrome Open
PURPOSE Li-Fraumeni syndrome (LFS) is rare in the worldwide population, but it is highly prevalent in the Brazilian population because of a founder mutation, TP53 p.R337H, accounting for 0.3% of south and southeastern population. Clinical …
View article: A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers
A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers Open
Background The causative factors for the recent increase in early-onset colorectal cancer (EO-CRC) incidence are unknown. We sought to determine if early-onset disease is clinically or genomically distinct from average-onset colorectal can…
View article: P-47 5-fluorouracil bolus use in infusional regimens among oncologists: A survey by Brazilian Group of Gastrointestinal Tumors
P-47 5-fluorouracil bolus use in infusional regimens among oncologists: A survey by Brazilian Group of Gastrointestinal Tumors Open
View article: Germline molecular data in hereditary breast cancer in Brazil: Lessons from a large single-center analysis
Germline molecular data in hereditary breast cancer in Brazil: Lessons from a large single-center analysis Open
Brazil is the largest country in South America and the most genetically heterogeneous. The aim of the present study was to determine the prevalence of germline pathogenic variants (PVs) in Brazilian patients with breast cancer (BC) who und…
View article: Immunotherapy and Targeted Therapy for Hepatocellular Carcinoma: A Literature Review and Treatment Perspectives
Immunotherapy and Targeted Therapy for Hepatocellular Carcinoma: A Literature Review and Treatment Perspectives Open
Advanced hepatocellular carcinoma is a prevalent and potentially aggressive disease. For more than a decade, treatment with sorafenib has been the only approved therapeutic approach. Moreover, no agent has been proven to prolong survival f…
View article: Diretriz Brasileira de Cardio-oncologia – 2020
Diretriz Brasileira de Cardio-oncologia – 2020 Open
1. Introdução Atualmente, doenças cardiovasculares (DCV) e câncer são as principais causas de mortalidade em todo o mundo e no Brasil.– As transições demográfica e epidemiológica ocorridas recentemente no nosso país resultaram no aumento d…
View article: Author Correction: Epidemiological and Clinical Patterns of Newly Diagnosed Hepatocellular Carcinoma in Brazil: the Need for Liver Disease Screening Programs Based on Real-World Data
Author Correction: Epidemiological and Clinical Patterns of Newly Diagnosed Hepatocellular Carcinoma in Brazil: the Need for Liver Disease Screening Programs Based on Real-World Data Open
View article: Epidemiological and Clinical Patterns of Newly Diagnosed Hepatocellular Carcinoma in Brazil: the Need for Liver Disease Screening Programs Based on Real-World Data
Epidemiological and Clinical Patterns of Newly Diagnosed Hepatocellular Carcinoma in Brazil: the Need for Liver Disease Screening Programs Based on Real-World Data Open
Purpose Describe sociodemographic and clinical characteristics of patients with hepatocellular carcinoma (HCC) and establish their history in the Brazilian public health system. Methods Retrospective observational study was conducted using…
View article: Evidence-based recommendations for gastrointestinal cancers during the COVID-19 pandemic by the Brazilian Gastrointestinal Tumours Group
Evidence-based recommendations for gastrointestinal cancers during the COVID-19 pandemic by the Brazilian Gastrointestinal Tumours Group Open
Our recommendations emphasise the importance of treating cancer patients, using the best evidence available, while simultaneously taking into consideration the world-wide health resource hyperutilisation to treat non-cancer COVID-19 patien…
View article: Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy Open
Purpose: Evaluate response of mismatch repair–deficient (dMMR) rectal cancer to neoadjuvant chemotherapy. Experimental Design: dMMR rectal tumors at Memorial Sloan Kettering Cancer Center (New York, NY) were retrospectively reviewed for ch…
View article: Regorafenib in Combination with First-Line Chemotherapy for Metastatic Esophagogastric Cancer
Regorafenib in Combination with First-Line Chemotherapy for Metastatic Esophagogastric Cancer Open
Background Angiogenesis is critical to gastroesophageal adenocarcinoma growth and metastasis. Regorafenib is a multikinase inhibitor targeting angiogenic and stromal receptor tyrosine kinases. We evaluated whether regorafenib augments the …
View article: Year in Review 2018 by the Brazilian Gastrointestinal Tumors Group - GTG: Gastrointestinal Tumors
Year in Review 2018 by the Brazilian Gastrointestinal Tumors Group - GTG: Gastrointestinal Tumors Open
In 2018, there were some important trials presented over multiple international meetings. The objective of this article is to summarize the most important and practice changing studies in gastrointestinal oncology this year. Some studies i…
View article: Treatment choices in metastatic colorectal cancer according to sidedness and RAS/BRAF status: a national survey by the Brazilian Gastrointestinal Tumors Group (GTG)
Treatment choices in metastatic colorectal cancer according to sidedness and RAS/BRAF status: a national survey by the Brazilian Gastrointestinal Tumors Group (GTG) Open
Objectives: Tumor sidedness and RAS/BRAF status have changed the treatment landscape of metastatic colorectal cancer (mCRC). This study was performed to understand the first line choices of Brazilian oncologists for patients with mCRC, esp…
View article: Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial
Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): a randomised, open-label, controlled, phase 3 trial Open