Guy Brock
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View article: An AI-Based Chatbot to Support Health-Related Social Needs among Pediatric Primary Care Population: Protocol for a Pilot Randomized Controlled Trial
An AI-Based Chatbot to Support Health-Related Social Needs among Pediatric Primary Care Population: Protocol for a Pilot Randomized Controlled Trial Open
Unmet health-related social needs (HRSNs) are major drivers of poor health outcomes in early childhood. Children with unmet HRSNs are at greater risk for developmental delays, caregiver stress, and increased healthcare utilization, yet cur…
View article: Externalizing behaviors in children living near coal-fired power plants
Externalizing behaviors in children living near coal-fired power plants Open
View article: Cross‐Sectional Association of Physical Activity With Life’s Simple 7 Metrics in Community‐Dwelling Black Men
Cross‐Sectional Association of Physical Activity With Life’s Simple 7 Metrics in Community‐Dwelling Black Men Open
Background Black men are burdened by a higher prevalence of cardiovascular risk factors than non‐Hispanic White and Hispanic American men and women. Physical activity may improve other modifiable cardiovascular risk factors, but this relat…
View article: Design of Black Impact: A Randomized Controlled Trial Evaluating the Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention
Design of Black Impact: A Randomized Controlled Trial Evaluating the Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health Intervention Open
Background Lower attainment of cardiovascular health (CVH), indicated by lower scores on the American Heart Association's Life's Essential 8 metrics, is a major contributor to Black men having the shortest life expectancy of any nonindigen…
View article: Association between concussion and risk of suicide among youth and young adults
Association between concussion and risk of suicide among youth and young adults Open
View article: Predictors of antitumor necrosis factor primary nonresponse and drug durability in pediatric inflammatory bowel disease
Predictors of antitumor necrosis factor primary nonresponse and drug durability in pediatric inflammatory bowel disease Open
Objectives Antitumor necrosis factor (anti‐TNF) therapies are first‐line therapies for children with inflammatory bowel disease (IBD) (Crohn's disease [CD], ulcerative colitis [UC] and IBD‐unclassified [IBD‐U]). Limited studies describing …
View article: Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial
Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial Open
Introduction Targeted oxygenation protocols in mechanically ventilated patients are critical in avoiding the deleterious effects of hypoxaemia and hyperoxaemia. Peripheral oxygen saturation (SpO2) is a practical metric that commonly drives…
View article: Joint modeling of multistate survival processes with informative examination scheme: application to progressions in diabetes
Joint modeling of multistate survival processes with informative examination scheme: application to progressions in diabetes Open
Our joint model offers a framework for analyzing multistate survival processes while accounting for the dependence between disease progression and examination frequency. Unlike traditional MSMs that estimate only transition intensities, ou…
View article: Plasma proteomic profiles correlate with organ dysfunction in COVID‐19 ARDS
Plasma proteomic profiles correlate with organ dysfunction in COVID‐19 ARDS Open
Severe COVID‐19 is often complicated by hypoxemic respiratory failure and acute respiratory distress syndrome (ARDS). Mechanisms governing lung injury and repair in ARDS remain poorly understood. We hypothesized that plasma proteomics may …
View article: Comparison of crisis response planning and treatment as usual for active duty service members at risk for suicide: Study protocol for a stepped-wedge cluster randomized trial in a military treatment facility
Comparison of crisis response planning and treatment as usual for active duty service members at risk for suicide: Study protocol for a stepped-wedge cluster randomized trial in a military treatment facility Open
NCT05795764.
View article: Educational Method to Promote Recognition, Diagnosis, and Treatment of Eating Disorders: A Cluster-Randomized Study of the Effects of Retrieval Practice Amongst Medical Trainees
Educational Method to Promote Recognition, Diagnosis, and Treatment of Eating Disorders: A Cluster-Randomized Study of the Effects of Retrieval Practice Amongst Medical Trainees Open
View article: Externalizing Behavior Problems in Children Aged 6 to 14 years-old Living Near Coal-Fired Power Plants
Externalizing Behavior Problems in Children Aged 6 to 14 years-old Living Near Coal-Fired Power Plants Open
View article: A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome
A Multicenter Training and Interrater Reliability Study of the BASED Score for Infantile Epileptic Spasms Syndrome Open
Purpose: The best possible outcomes in infantile epileptic spasms syndrome require electroclinical remission; however, determining electrographic remission is not straightforward. Although the determination of hypsarrhythmia has inadequate…
View article: Improved Gut Health by a Green Tea Extract Confection in Metabolic Syndrome and Healthy Adults Occurred Without Affecting Short-Chain Fatty Acids and Microbiota Diversity
Improved Gut Health by a Green Tea Extract Confection in Metabolic Syndrome and Healthy Adults Occurred Without Affecting Short-Chain Fatty Acids and Microbiota Diversity Open
View article: MDB-83. OUTCOMES OF INFANTS AND YOUNG CHILDREN WITH NEWLY DIAGNOSED SHH MEDULLOBLASTOMA TREATED ON THE NEXT CONSORTIUM “HEAD START” 4 PROTOCOL
MDB-83. OUTCOMES OF INFANTS AND YOUNG CHILDREN WITH NEWLY DIAGNOSED SHH MEDULLOBLASTOMA TREATED ON THE NEXT CONSORTIUM “HEAD START” 4 PROTOCOL Open
BACKGROUND Infants and young children with SHH medulloblastoma were demonstrated to have a favorable outcome on “Head Start (HS)” III clinical trial utilizing five cycles of induction followed by one myeloablative high-dose chemotherapy (H…
View article: The Association of Adiposity and RAAS With Incident Diabetes in African Americans: The Jackson Heart Study
The Association of Adiposity and RAAS With Incident Diabetes in African Americans: The Jackson Heart Study Open
Background The renin-angiotensin-aldosterone system (RAAS) and adiposity measures are independently associated with the development of diabetes in African American adults. However, studies have not examined the combined interaction between…
View article: SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure
SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure Open
View article: Association of Socioeconomic Status With Life's Essential 8 in the National Health and Nutrition Examination Survey: Effect Modification by Sex
Association of Socioeconomic Status With Life's Essential 8 in the National Health and Nutrition Examination Survey: Effect Modification by Sex Open
Background Higher scores for the American Heart Association Life's Essential 8 (LE8) metrics, blood pressure, cholesterol, glucose, body mass index, physical activity, smoking, sleep, and diet, are associated with lower risk of chronic dis…
View article: A green tea extract confection decreases circulating endotoxin and fasting glucose by improving gut barrier function but without affecting systemic inflammation: A double-blind, placebo-controlled randomized trial in healthy adults and adults with metabolic syndrome
A green tea extract confection decreases circulating endotoxin and fasting glucose by improving gut barrier function but without affecting systemic inflammation: A double-blind, placebo-controlled randomized trial in healthy adults and adults with metabolic syndrome Open
Anti-inflammatory activities of catechin-rich green tea extract (GTE) in obese rodents protect against metabolic endotoxemia by decreasing intestinal permeability and absorption of gut-derived endotoxin. However, translation to human healt…
View article: PREDICTORS OF PRIMARY NON-RESPONSE AND DRUG DURABILITY FOR ADALIMUMAB AND INFLIXIMAB IN PEDIATRIC INFLAMMATORY BOWEL DISEASE
PREDICTORS OF PRIMARY NON-RESPONSE AND DRUG DURABILITY FOR ADALIMUMAB AND INFLIXIMAB IN PEDIATRIC INFLAMMATORY BOWEL DISEASE Open
BACKGROUND Anti-tumor necrosis factor (anti-TNF) therapies have become first-line therapy for children with inflammatory bowel disease (IBD). Studies describing drug durability and loss of response to anti-TNF therapies are limited in chil…
View article: Evidence for the Association Between Adverse Childhood Family Environment, Child Abuse, and Caregiver Warmth and Cardiovascular Health Across the Lifespan: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Evidence for the Association Between Adverse Childhood Family Environment, Child Abuse, and Caregiver Warmth and Cardiovascular Health Across the Lifespan: The Coronary Artery Risk Development in Young Adults (CARDIA) Study Open
BACKGROUND: This study aimed to quantify the association between childhood family environment and longitudinal cardiovascular health (CVH) in adult CARDIA (Coronary Artery Risk Development in Young Adults) Study participants. We further in…
View article: Improving mental health in black men through a 24-week community-based lifestyle change intervention: the black impact program
Improving mental health in black men through a 24-week community-based lifestyle change intervention: the black impact program Open
Background Poor mental health is a leading cause of morbidity and mortality among Black men in the United States. Efforts to improve mental health among Black men have been hampered by a lack of access and utilization of mental health serv…
View article: Racial and Ethnic Disparities in the Diagnosis and Early Treatment of First-Episode Psychosis
Racial and Ethnic Disparities in the Diagnosis and Early Treatment of First-Episode Psychosis Open
Background Despite recognition that early intervention for first-episode psychosis (FEP) improves outcomes, Black youth with FEP continue to experience critical disparities in care. A historical lack of scientific focus on racial and ethni…
View article: Is There a Spot for Remote Pediatric Stroke Evaluation in the World of Telestroke Networks? A Pilot Feasibility Study of Performing the Pednihss Over Televideo
Is There a Spot for Remote Pediatric Stroke Evaluation in the World of Telestroke Networks? A Pilot Feasibility Study of Performing the Pednihss Over Televideo Open
View article: Role of Sex in the Association of Socioeconomic Status With Cardiovascular Health in Black Americans: The Jackson Heart Study
Role of Sex in the Association of Socioeconomic Status With Cardiovascular Health in Black Americans: The Jackson Heart Study Open
Background Socioeconomic status (SES) is associated with cardiovascular health (CVH). Potential differences by sex in this association remain incompletely understood in Black Americans, where SES disparities are posited to be partially res…
View article: Exome sequencing in the pediatric neuromuscular clinic leads to more frequent diagnosis of both neuromuscular and neurodevelopmental conditions
Exome sequencing in the pediatric neuromuscular clinic leads to more frequent diagnosis of both neuromuscular and neurodevelopmental conditions Open
Introduction/Aims Exome sequencing (ES) has proven to be a valuable diagnostic tool for neuromuscular disorders, which often pose a diagnostic challenge. The aims of this study were to investigate the clinical outcomes associated with util…
View article: Association of Socioeconomic Status With Life's Essential 8 Varies by Race and Ethnicity
Association of Socioeconomic Status With Life's Essential 8 Varies by Race and Ethnicity Open
Background The American Heart Association's Life's Essential 8 (LE8) are 8 risk factors for cardiovascular disease, with poor attainment across all racial, ethnic, and socioeconomic groups. Attainment is lowest among Americans of low socio…
View article: P03-087-23 Green Tea Extract Confection Alleviates Endotoxemia Without Affecting Systemic Inflammation in Healthy Adults and Those With Metabolic Syndrome
P03-087-23 Green Tea Extract Confection Alleviates Endotoxemia Without Affecting Systemic Inflammation in Healthy Adults and Those With Metabolic Syndrome Open
View article: Plasma Thermogram Parameters Differentiate Status and Overall Survival of Melanoma Patients
Plasma Thermogram Parameters Differentiate Status and Overall Survival of Melanoma Patients Open
Melanoma is the fifth most common cancer in the United States and the deadliest of all skin cancers. Even with recent advancements in treatment, there is still a 13% two-year recurrence rate, with approximately 30% of recurrences being dis…
View article: Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case–control study
Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case–control study Open