Guy Chowers
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View article: Elucidating Mechanisms of Hypomorphic WDR19-Related Kidney Failure
Elucidating Mechanisms of Hypomorphic WDR19-Related Kidney Failure Open
Our study validates the pathogenic role of the WDR19 hypomorphic variant in adult-onset renal failure and highlights how hypomorphic pathogenic variants disrupt kidney development. These findings underscore the critical role of cilia in re…
View article: Multiethnic prevalence of the <i>APOL1</i> G1 and G2 variants among the Israeli dialysis population
Multiethnic prevalence of the <i>APOL1</i> G1 and G2 variants among the Israeli dialysis population Open
Background and hypothesis The two apolipoprotein L1 (APOL1) variants, G1 and G2, are common in populations of sub-Saharan African ancestry. Individuals with two of these alleles (G1 or G2) have an increased risk for a spectrum of non-diabe…
View article: Conditioning Regimen-Specific Patterns and Determinants of Acute Severe Organ Toxicity Following Allogeneic Transplantation
Conditioning Regimen-Specific Patterns and Determinants of Acute Severe Organ Toxicity Following Allogeneic Transplantation Open
BackgroundIn recipients of allogeneic hematopoietic stem cell transplantation (HSCT), organ toxicity is a barrier to administering high-intensity conditioning. We hypothesized that determinants of acute organ toxicity are specific to indiv…
View article: Course of Sodium Iodate–Induced Retinal Degeneration in Albino and Pigmented Mice
Course of Sodium Iodate–Induced Retinal Degeneration in Albino and Pigmented Mice Open
A single IP injection of 50 mg/kg SI leads to severe RPE injury followed by vision impairment, dysfunction, and loss of photoreceptors in both BALB/c and C57Bl/6J mice. This easily induced and reproducible noninherited model may serve as a…