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View article: Impact of bleeding and thrombosis on outcome of 945 COVID-19 VV-ECMO cases from a German registry
Impact of bleeding and thrombosis on outcome of 945 COVID-19 VV-ECMO cases from a German registry Open
Bleeding and thromboembolic events (BTE) increase the mortality of COVID-19 acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO). The current analysis aimed to assess frequency and determinants…
View article: Transfer of Veno-venous Extracorporeal Membrane Oxygenation Patients With COVID-19 Associated Acute Respiratory Distress Syndrome
Transfer of Veno-venous Extracorporeal Membrane Oxygenation Patients With COVID-19 Associated Acute Respiratory Distress Syndrome Open
Interhospital transport of acute respiratory distress syndrome (ARDS) patients bears transport-associated risks. It is unknown how interhospital extracorporeal membrane oxygenation (ECMO) transfer of COVID-19 patients by mobile ECMO units …
View article: Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia
Plasma Metabolome Alterations Discriminate between COVID-19 and Non-COVID-19 Pneumonia Open
Pneumonia is a common cause of morbidity and mortality and is most often caused by bacterial pathogens. COVID-19 is characterized by lung infection with potential progressive organ failure. The systemic consequences of both disease on the …
View article: Respiratory Physiology of COVID-19 and Influenza Associated Acute Respiratory Distress Syndrome
Respiratory Physiology of COVID-19 and Influenza Associated Acute Respiratory Distress Syndrome Open
Background: There is ongoing debate whether lung physiology of COVID-19-associated acute respiratory distress syndrome (ARDS) differs from ARDS of other origin. Objective: The aim of this study was to analyze and compare how critically ill…
View article: Comparison of immersive and non-immersive virtual reality videos as substitute for in-hospital teaching during coronavirus lockdown: a survey with graduate medical students in Germany
Comparison of immersive and non-immersive virtual reality videos as substitute for in-hospital teaching during coronavirus lockdown: a survey with graduate medical students in Germany Open
As a consequence of the continued Covid-19 lockdown in Germany, in-hospital teaching for medical students was impossible. While lectures and other theoretical training were relatively easily converted into online sessions using platforms s…
View article: Awake Extracorporeal Membrane Oxygenation for COVID-19–induced Acute Respiratory Distress Syndrome
Awake Extracorporeal Membrane Oxygenation for COVID-19–induced Acute Respiratory Distress Syndrome Open
International audience
View article: Statistical power boost for broadly applicable host immune response-based tools
Statistical power boost for broadly applicable host immune response-based tools Open
COVID-19 is a diversely manifested and potentially deadly disease. This is challenging for patient management and development of evidence-based tools, especially considering SARS-CoV-2 evolution and variable pandemic mitigation strategies.…
View article: 32. Host Immune-Protein Signature Combining TRAIL, IP-10 and CRP for Early and Accurate Prediction of Severe COVID-19 Outcome
32. Host Immune-Protein Signature Combining TRAIL, IP-10 and CRP for Early and Accurate Prediction of Severe COVID-19 Outcome Open
Background Accurately identifying COVID-19 patients at-risk to deteriorate remains challenging. Dysregulated immune responses impact disease progression and development of life-threatening complications. Tools integrating host immune-prote…
View article: Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19
Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19 Open
Hyperinflammation is frequently observed in patients with severe COVID-19. Inadequate and defective IFN type I responses against SARS-CoV-2, associated with autoantibodies in a proportion of patients, lead to severe courses of disease. In …
View article: Distinct Patterns of Blood Cytokines Beyond a Cytokine Storm Predict Mortality in COVID-19
Distinct Patterns of Blood Cytokines Beyond a Cytokine Storm Predict Mortality in COVID-19 Open
Several newly identified blood markers were significantly increased in patients with severe COVID-19 (AAT, EN-RAGE, myoglobin, SAP, TIMP-1, vWF, decorin) or in patients that died (IL-1ra, IL-8, IL-10, MCP-1, SCF, CA-9). The use of establis…
View article: An immune-protein signature combining TRAIL, IP-10 and CRP for accurate prediction of severe COVID-19 outcome
An immune-protein signature combining TRAIL, IP-10 and CRP for accurate prediction of severe COVID-19 outcome Open
BACKGROUND Accurately identifying COVID-19 patients at-risk to deteriorate remains challenging. Tools integrating host-protein expression have proven useful in determining infection etiology and hold potential for prognosticating disease s…
View article: Acute Respiratory Distress Syndrome due to Mycoplasma pneumoniae Misinterpreted as SARS-CoV-2 Infection
Acute Respiratory Distress Syndrome due to Mycoplasma pneumoniae Misinterpreted as SARS-CoV-2 Infection Open
Background. In 2020, a novel coronavirus caused a global pandemic with a clinical picture termed COVID-19, accounting for numerous cases of ARDS. However, there are still other infectious causes of ARDS that should be considered, especiall…
View article: Respiratory physiology of COVID-19 and Influenza associated Acute Respiratory Distress Syndrome
Respiratory physiology of COVID-19 and Influenza associated Acute Respiratory Distress Syndrome Open
Background: There is ongoing debate whether lung physiology of COVID-19 associated acute respiratory distress syndrome (ARDS) differs from ARDS of other origin.Objective: The aim of this study was to analyze and compare how critically ill …
View article: Distinct patterns of blood cytokines beyond a cytokine storm predict mortality in COVID-19
Distinct patterns of blood cytokines beyond a cytokine storm predict mortality in COVID-19 Open
Background COVID-19 comprises several severity stages ranging from oligosymptomatic disease to multi-organ failure and fatal outcomes. The mechanisms why COVID-19 is a mild disease in some patients and progresses to a severe multi-organ an…
View article: Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19
Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19 Open
STRUCTURED ABSTRACT Hyperinflammation is frequently observed in patients with severe COVID-19. Inadequate and defective IFN type I responses against SARS-CoV-2, associated with autoantibodies in a proportion of patients, lead to severe cou…
View article: Therapeutic application of alpha-1-antitrypsin in COVID-19
Therapeutic application of alpha-1-antitrypsin in COVID-19 Open
Rationale The treatment options for COVID-19 patients are sparse and do not show sufficient efficacy. Alpha-1-antitrypsin (AAT) is a multi-functional host-defense protein with anti-proteolytic and anti-inflammatory activities. Objectives T…
View article: Conservative management of COVID-19 associated hypoxaemia
Conservative management of COVID-19 associated hypoxaemia Open
This correspondence argues that data presented previously cannot justify a novel approach for treating hypoxic patients with severe #COVID19 https://bit.ly/3dLaPlk.
View article: Extracorporeal life support in COVID‐19‐related acute respiratory distress syndrome: A EuroELSO international survey
Extracorporeal life support in COVID‐19‐related acute respiratory distress syndrome: A EuroELSO international survey Open
Extracorporeal life support (ECLS) is a means to support patients with acute respiratory failure. Initially, recommendations to treat severe cases of pandemic coronavirus disease 2019 (COVID‐19) with ECLS have been restrained. In the meant…
View article: SARS-CoV-2 Infection is a frequent cause of pulmonary failure in 2020, but not the only one – a case report
SARS-CoV-2 Infection is a frequent cause of pulmonary failure in 2020, but not the only one – a case report Open
Background In 2020, a novel coronavirus caused a global pandemic with a clinical picture termed COVID-19 accounting for numerous cases of ARDS. However, there are still other infectious causes of ARDS that should be considered, especially,…
View article: Pulmonary Hemodynamics and Ventilation in Patients With COVID-19-related Respiratory Failure and ARDS
Pulmonary Hemodynamics and Ventilation in Patients With COVID-19-related Respiratory Failure and ARDS Open
Background: It has been suggested that COVID-19-associated severe respiratory failure (CARDS) might differ from usual acute respiratory distress syndrome (ARDS) due to failing auto-regulation of pulmonary vessels and higher shunt. We sough…
View article: <i>Pneumocystis jirovecii</i> Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Coinfection in a Patient With Newly Diagnosed HIV-1 Infection
<i>Pneumocystis jirovecii</i> Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Coinfection in a Patient With Newly Diagnosed HIV-1 Infection Open
from anti-inflammatory therapies such as steroids.In the work by Fadel et al, it is difficult to ascertain which was the time from the onset of symptoms to initiation of steroid treatment.The fact that a large proportion of patients in the…