Guy Elisha
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View article: Modeling based insights into mechanical dysfunction in esophageal motility disorders
Modeling based insights into mechanical dysfunction in esophageal motility disorders Open
Esophageal motility arises from the continuous coupling between enteric neural activity and the organ’s mechanical response, yet the structure of this coupling remains poorly understood. Esophageal motility disorders represent mechanical d…
View article: Musculoskeletal simulation of limb movement biomechanics in Drosophila melanogaster
Musculoskeletal simulation of limb movement biomechanics in Drosophila melanogaster Open
Computational models are critical to advance our understanding of how neural, biomechanical, and physical systems interact to orchestrate animal behaviors. Despite the availability of near-complete reconstructions of the Drosophila melanog…
View article: Direct and Retrograde Wave Propagation in Unidirectionally Coupled Wilson-Cowan Oscillators
Direct and Retrograde Wave Propagation in Unidirectionally Coupled Wilson-Cowan Oscillators Open
Some biological systems exhibit both direct and retrograde propagating signal waves despite unidirectional coupling. To explain this phenomenon, we study a chain of unidirectionally coupled Wilson-Cowan oscillators. Surprisingly, we find t…
View article: Mechanophysiology of endometriosis: a non-dimensional physiomarker to detect retrograde flow
Mechanophysiology of endometriosis: a non-dimensional physiomarker to detect retrograde flow Open
Endometriosis affects a significant portion of fertile-age women, often leading to infertility and a substantial decline in quality of life. Despite its prevalence, current diagnostic methods are limited, focusing on assessing the presence…
View article: Direct and retrograde signal propagation in unidirectionally coupled Wilson-Cowan oscillators
Direct and retrograde signal propagation in unidirectionally coupled Wilson-Cowan oscillators Open
Certain biological systems exhibit both direct and retrograde propagating wave signals, despite unidirectional neural coupling. However, there is no model to explain this. Therefore, the underlying physics of reversing the signal's directi…
View article: Neurological disorders leading to mechanical dysfunction of the esophagus: an emergent behavior of a neuromechanical dynamical system
Neurological disorders leading to mechanical dysfunction of the esophagus: an emergent behavior of a neuromechanical dynamical system Open
An understanding how neurological disorders lead to mechanical dysfunction of the esophagus requires knowledge of the neural circuit of the enteric nervous system. Historically, this has been elusive. Here, we present an empirically guided…
View article: A Mechanics-Based Perspective on the Function of Human Sphincters During Functional Luminal Imaging Probe Manometry
A Mechanics-Based Perspective on the Function of Human Sphincters During Functional Luminal Imaging Probe Manometry Open
Functional luminal imaging probe (FLIP) is used to measure cross-sectional area (CSA) and pressure at sphincters. It consists of a catheter surrounded by a fluid filled cylindrical bag, closed on both ends. Plotting the pressure-CSA hyster…
View article: Assessing mechanical function of peristalsis with functional lumen imaging probe panometry: Contraction power and displaced volume
Assessing mechanical function of peristalsis with functional lumen imaging probe panometry: Contraction power and displaced volume Open
Background and Aims The distal contractile integral (DCI) quantifies the contractile vigor of primary peristalsis on high‐resolution manometry (HRM), whereas no such metric exists for secondary peristalsis on functional lumen imaging probe…
View article: A mechanics-based perspective on the pressure-cross-sectional area loop within the esophageal body
A mechanics-based perspective on the pressure-cross-sectional area loop within the esophageal body Open
Introduction: Plotting the pressure-cross-sectional area (P-CSA) hysteresis loops within the esophagus during a contraction cycle can provide mechanistic insights into esophageal motor function. Pressure and cross-sectional area during sec…
View article: A mechanics--based perspective on the function of human sphincters during functional luminal imaging probe manometry
A mechanics--based perspective on the function of human sphincters during functional luminal imaging probe manometry Open
Functional luminal imaging probe (FLIP) is used to measure cross-sectional area (CSA) and pressure at sphincters. It consists of a catheter surrounded by a fluid filled cylindrical bag, closed on both ends. Plotting the pressure-CSA hyster…
View article: Pressure-area loop based phenotypic classification and mechanics of the esophagogastric junction physiology
Pressure-area loop based phenotypic classification and mechanics of the esophagogastric junction physiology Open
The esophagogastric junction (EGJ) is located at the distal end of the esophagus and acts as a valve allowing swallowed food to enter the stomach and preventing acid reflux. Irregular weakening or stiffening of the EGJ muscles results in c…
View article: Pressure -- area loop based phenotypic classification and mechanics of esophagogastric junction physiology
Pressure -- area loop based phenotypic classification and mechanics of esophagogastric junction physiology Open
The esophagogastric junction (EGJ) is located at the distal end of the esophagus and acts as a valve allowing swallowed materials to enter the stomach and preventing acid reflux. Irregular weakening or stiffening of the EGJ muscles result …
View article: Peristaltic regimes in esophageal transport
Peristaltic regimes in esophageal transport Open
A FLIP device gives cross-sectional area along the length of the esophagus and one pressure measurement, both as a function of time. Deducing mechanical properties of the esophagus including wall material properties, contraction strength, …
View article: Fluid-structure instability forecasts thoracic aortic aneurysm progression
Fluid-structure instability forecasts thoracic aortic aneurysm progression Open
The basic mechanism driving aneurysm growth is unknown. Currently, clinical diagnosis of an aneurysm is mainly informed by retrospective tracking of its size and growth rate. However, aneurysms can rupture before reactive criteria are met …
View article: Esophageal virtual disease landscape using mechanics-informed machine learning
Esophageal virtual disease landscape using mechanics-informed machine learning Open
The pathogenesis of esophageal disorders is related to the esophageal wall mechanics. Therefore, to understand the underlying fundamental mechanisms behind various esophageal disorders, it is crucial to map the esophageal wall mechanics-ba…
View article: A fluid-structure instability driven physiomarker for aneurysm growth
A fluid-structure instability driven physiomarker for aneurysm growth Open
Currently, the diagnosis and treatment of an aneurysm are informed by correlative guidelines on its size and growth rate, along with a holistic consideration of associated symptoms and pathologies. However, aneurysms can exhibit significan…