Guy H. Carpenter
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View article: Analysis of the association between salivary proteins and oral mucositis in patients with head and neck cancer undergoing IMRT: a longitudinal study
Analysis of the association between salivary proteins and oral mucositis in patients with head and neck cancer undergoing IMRT: a longitudinal study Open
Introduction This longitudinal study assessed the association between salivary protein composition and the clinical onset/severity of oral mucositis (OM) in patients with head and neck tumours treated with intensity-modulated-radiotherapy …
View article: Role of salivary proteins on radiation-related caries onset in head and neck cancer patients treated with radiotherapy - a longitudinal study.
Role of salivary proteins on radiation-related caries onset in head and neck cancer patients treated with radiotherapy - a longitudinal study. Open
Objective Longitudinal assessment of the role of specific proteins on radiotherapy caries (RC) onset in head and neck cancer patients (HNC)up to one-year post intensity-modulated radiation therapy (IMRT). Methods Dental status/salivary pro…
View article: Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications
Recent Developments in Engineering Non-Paralytic Botulinum Molecules for Therapeutic Applications Open
This review discusses the expanding application of botulinum neurotoxin in treating neurological conditions. The article specifically explores novel approaches to using non-paralytic botulinum molecules. These new molecules, such as BiTox …
View article: Intensity-modulated radiotherapy prevents lasting damage to salivary glands but not oral mucositis.
Intensity-modulated radiotherapy prevents lasting damage to salivary glands but not oral mucositis. Open
Objective : This study aimed to assess the salivary protein composition variations in head and neck cancer patients (HNC) undergoing Intensity-Modulated Radiotherapy (IMRT) and examined the correlation with the clinical onset/severity of o…
View article: Comparison of the Metabolic Profile between Unstimulated and Stimulated Saliva Samples from Pregnant Women with/without Obesity and Periodontitis
Comparison of the Metabolic Profile between Unstimulated and Stimulated Saliva Samples from Pregnant Women with/without Obesity and Periodontitis Open
This study aimed to compare the metabolic profile of unstimulated (US) and stimulated (SS) saliva samples from pregnant women with/without obesity and periodontitis. Ninety-six pregnant women were divided into: obesity + periodontitis (OP …
View article: The influence of ions on the lubricative abilities of mucin and the role of sialic acids
The influence of ions on the lubricative abilities of mucin and the role of sialic acids Open
Mucus reduces friction between epithelial surfaces by providing lubrication in the boundary and mixed regime. Mucins, the main macromolecule, are heavily glycosylated proteins that polymerise and retain water molecules, resulting in a hydr…
View article: Novel bacterial proteolytic and metabolic activity associated with dental erosion-induced oral dysbiosis
Novel bacterial proteolytic and metabolic activity associated with dental erosion-induced oral dysbiosis Open
Background Dental erosion is a disease of the oral cavity where acids cause a loss of tooth enamel and is defined as having no bacterial involvement. The tooth surface is protected from acid attack by salivary proteins that make up the acq…
View article: Salivary Adiponectin and Albumin Levels on the Gingival Conditions of Patients Undergoing Bariatric Surgery: A Cohort Study
Salivary Adiponectin and Albumin Levels on the Gingival Conditions of Patients Undergoing Bariatric Surgery: A Cohort Study Open
This study analyzed the salivary proteomics, adiponectin and albumin, related to weight loss and periodontitis in patients undergoing bariatric surgery. This study included fourteen patients with morbid obesity (body mass index, BMI > 40 k…
View article: The Role of mTOR and Injury in Developing Salispheres
The Role of mTOR and Injury in Developing Salispheres Open
Salispheres are the representative primitive cells of salivary glands grown in vitro in a nonadherent system. In this study, we used the ligation model for salisphere isolation after seven days of obstruction of the main excretory duct of …
View article: Label-Free Quantitative Proteomic Analysis Reveals Inflammatory Pattern Associated with Obesity and Periodontitis in Pregnant Women
Label-Free Quantitative Proteomic Analysis Reveals Inflammatory Pattern Associated with Obesity and Periodontitis in Pregnant Women Open
Obesity and pregnancy may have synergistic effects on periodontal condition, and proteomics could be an ideal approach to highlight the pathophysiological mechanisms associated with these outcomes. This study analyzed the salivary proteomi…
View article: Metabolomic Profiles Associated with Obesity and Periodontitis during Pregnancy: Cross-Sectional Study with Proton Nuclear Magnetic Resonance (1H-NMR)-Based Analysis
Metabolomic Profiles Associated with Obesity and Periodontitis during Pregnancy: Cross-Sectional Study with Proton Nuclear Magnetic Resonance (1H-NMR)-Based Analysis Open
This study aimed to elucidate the metabolomic signature associated with obesity and periodontitis during pregnancy in plasma and saliva biofluids. Ninety-eight pregnant women were divided into: with obesity and periodontitis (OP = 20), wit…
View article: Protein-induced delubrication: How plant-based and dairy proteins affect mouthfeel
Protein-induced delubrication: How plant-based and dairy proteins affect mouthfeel Open
Understanding how certain proteins cause astringency is necessary in order to improve the mouthfeel and popularity of plant-based foods. To this end, we studied protein interactions during oral processes using a PDMS-PDMS interface lubrica…
View article: Duration of canine retraction with fixed appliances: A systematic review and meta-analysis
Duration of canine retraction with fixed appliances: A systematic review and meta-analysis Open
Dataset for all analyses
View article: Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation
Molecular and cellular insight into Escherichia coli SslE and its role during biofilm maturation Open
Escherichia coli is a Gram-negative bacterium that colonizes the human intestine and virulent strains can cause severe diarrhoeal and extraintestinal diseases. The protein SslE is secreted by a range of pathogenic and some commensal E. col…
View article: Duration of canine retraction with fixed appliances: A systematic review and meta-analysis
Duration of canine retraction with fixed appliances: A systematic review and meta-analysis Open
Dataset for all analyses
View article: Protein-Induced Delubrication: How plant-based and dairy proteins affect mouthfeel
Protein-Induced Delubrication: How plant-based and dairy proteins affect mouthfeel Open
Understanding how certain proteins cause astringency is necessary in order to improve the mouthfeel and popularity of plant-based foods. To this end, we studied protein interactions during oral processes using a PDMS-PDMS interface lubrica…
View article: Salivary bacterial community profile in normal‐weight and obese adolescent patients prior to orthodontic treatment with fixed appliances
Salivary bacterial community profile in normal‐weight and obese adolescent patients prior to orthodontic treatment with fixed appliances Open
Objectives The aim of this study was to compare the intra‐oral bacterial profile of normal‐weight and obese adolescents prior to orthodontic treatment with fixed appliances. Materials and methods Nineteen adolescent patients were recruited…
View article: Molecular and cellular insight into <i>Escherichia coli</i> SslE and its role during biofilm maturation
Molecular and cellular insight into <i>Escherichia coli</i> SslE and its role during biofilm maturation Open
Escherichia coli is a Gram-negative bacterium that colonizes the human intestine and virulent strains can cause severe diarrhoeal and extraintestinal diseases. The protein SslE is secreted by a range of pathogenic and some commensal E. col…
View article: Evidence for Proline Utilization by Oral Bacterial Biofilms Grown in Saliva
Evidence for Proline Utilization by Oral Bacterial Biofilms Grown in Saliva Open
Within the mouth bacteria are starved of saccharides as their main nutrient source between meals and it is unclear what drives their metabolism. Previously oral in vitro biofilms grown in saliva have shown proteolytic degradation of saliva…
View article: The Origins of Salivary Vitamin A, Vitamin B12 and Vitamin D-Binding Proteins
The Origins of Salivary Vitamin A, Vitamin B12 and Vitamin D-Binding Proteins Open
Vitamin A- (retinol), vitamin B12- (haptocorrin) and vitamin D-binding proteins are the major circulatory transporters of their respective ligands; they are also constituents of the salivary proteome, the origins of which, remain unclear. …
View article: Duration of tooth alignment with fixed appliances: a with meta-analysis
Duration of tooth alignment with fixed appliances: a with meta-analysis Open
Datasets for all analyses
View article: Agonists of orally expressed TRP channels stimulate salivary secretion and modify the salivary proteome
Agonists of orally expressed TRP channels stimulate salivary secretion and modify the salivary proteome Open
Natural compounds that can stimulate salivary secretion are of interest in developing treatments for xerostomia, the perception of a dry mouth, that affects between 10 and 30% of the adult and elderly population. Chemesthetic transient rec…