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View article: Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay
Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay Open
Kaposi’s sarcoma-associated herpesvirus (KSHV, HHV-8) is associated with several human malignancies. During latency, the viral genomes reside in the nucleus of infected cells as large non-integrated plasmids, known as episomes. To ensure e…
View article: Unidirectional protein recruitment is essential for viral latency
Unidirectional protein recruitment is essential for viral latency Open
Kaposi’s sarcoma associated herpesvirus (KSHV, HHV-8) is associated with several human malignancies. During latency the viral genomes reside in the nucleus of infected cells as large non-integrated plasmids, known as episomes. All KSHV inf…
View article: Global CpG DNA Methylation Footprint in Kaposi’s Sarcoma
Global CpG DNA Methylation Footprint in Kaposi’s Sarcoma Open
Kaposi’s sarcoma-associated herpesvirus (KSHV), also familiar as human herpesvirus 8 (HHV-8), is one of the well-known human cancer-causing viruses. KSHV was originally discovered by its association with Kaposi’s sarcoma (KS), a common AID…
View article: High-throughput sequencing analysis of a “hit and run” cell and animal model of KSHV tumorigenesis
High-throughput sequencing analysis of a “hit and run” cell and animal model of KSHV tumorigenesis Open
Kaposi's sarcoma (KS), is an AIDS-associated neoplasm caused by the KS herpesvirus (KSHV/ HHV-8). KSHV-induced sarcomagenesis is the consequence of oncogenic viral gene expression as well as host genetic and epigenetic alterations. Althoug…
CpG methylation in cell-free Epstein-Barr virus DNA in patients with EBV-Hodgkin lymphoma Open
Epstein-Barr virus (EBV) is associated with a variety of tumors and nonmalignant conditions. Latent EBV genomes in cells, including tumor cells, are often CpG methylated, whereas virion DNA is not CpG methylated. We demonstrate that methyl…
View article: RNA-sequencing analysis of a multistep and hit-and-run cell and animal model of KSHV tumorigenesis reveal the roles of mutations, CpG methylation, and viral-infection footprints in oncogenesis
RNA-sequencing analysis of a multistep and hit-and-run cell and animal model of KSHV tumorigenesis reveal the roles of mutations, CpG methylation, and viral-infection footprints in oncogenesis Open
Human viral oncogenesis is the consequence of cell transformation mediated by virally encoded oncogenes in combination with host oncogenic alterations. Kaposi’s sarcoma (KS), caused by the Kaposi’s sarcoma-associated herpes virus (KSHV), i…
View article: Modulation of Cellular CpG DNA Methylation by Kaposi's Sarcoma-Associated Herpesvirus
Modulation of Cellular CpG DNA Methylation by Kaposi's Sarcoma-Associated Herpesvirus Open
In cancer cells, certain promoters become aberrantly methylated, contributing to the phenotype of the tumor. KSHV infection seems to modify cellular CpG methylation, but only a few methylated promoters have been identified in KSHV-infected…