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View article: P-600 Loss of nucleoporin NUP210L and chromatin protein BAF-L together, but not separately cause male infertility in the mouse revealing their redundant roles in nuclear integrity
P-600 Loss of nucleoporin NUP210L and chromatin protein BAF-L together, but not separately cause male infertility in the mouse revealing their redundant roles in nuclear integrity Open
Study question Could colocalised spermatid-specific genes Banf2 and Nup210l, whose individual loss has no effect on male fertility, have redundant functions at the caudal nuclear envelope? Summary answer Banf2 and Nup210l are required toge…
View article: Nucleoporin NUP210L and BAF-paralogue BAF-L together ensure microtubule organization and nuclear integrity in spermatids
Nucleoporin NUP210L and BAF-paralogue BAF-L together ensure microtubule organization and nuclear integrity in spermatids Open
During spermiogenesis, haploid round spermatids differentiate into spermatozoa. This involves nuclear elongation, chromatin compaction, cytoplasm reduction, and formation of the acrosome and the flagellum. These events are orchestrated by …
View article: Spermatozoa in mice lacking the nucleoporin <scp>NUP210L</scp> show defects in head shape and motility but not in nuclear compaction or histone replacement
Spermatozoa in mice lacking the nucleoporin <span>NUP210L</span> show defects in head shape and motility but not in nuclear compaction or histone replacement Open
Biallelic loss‐of‐function mutation of NUP210L , encoding a testis‐specific nucleoporin, has been reported in an infertile man whose spermatozoa show uncondensed heads and histone retention. Mice with a homozygous transgene intronic insert…
View article: The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review
The involvement of the nuclear lamina in human and rodent spermiogenesis: a systematic review Open
The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. The NL is a component of the nuclear envelope, interacts with a wide range of protein…
View article: LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist
LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist Open
During spermiogenesis the spermatid nucleus is elongated, and dramatically reduced in size with protamines replacing histones to produce a highly compacted chromatin. After fertilisation, this process is reversed in the oocyte to form the …
View article: Homozygous deletion of SUN5 in three men with decapitated spermatozoa
Homozygous deletion of SUN5 in three men with decapitated spermatozoa Open
A recent study of 17 men with decapitated spermatozoa found that 8 carried two rare SUN5 alleles, and concluded that loss of SUN5 function causes the acephalic spermatozoa syndrome. Consistent with this, the SUN5 protein localises to the h…
View article: Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development
Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development Open
A previous study indicated that genetic information encoded on the mouse Y chromosome short arm (Yp) is required for efficient completion of the second meiotic division (that generates haploid round spermatids), restructuring of the sperm …