Anthony G Marson
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View article: Developing and validating a clinical prediction model to predict epilepsy-related emergency department attendance, hospital admission, or death: A cohort study protocol
Developing and validating a clinical prediction model to predict epilepsy-related emergency department attendance, hospital admission, or death: A cohort study protocol Open
Introduction This retrospective open cohort study develops and externally validates a clinical prediction model (CPM) to predict the joint risk of two important outcomes occurring within the next year in people with epilepsy (PWE). These a…
View article: Seizure prophylaxis in glioma surgery (SPRING): a multi-Centre, unblinded, randomised trial
Seizure prophylaxis in glioma surgery (SPRING): a multi-Centre, unblinded, randomised trial Open
Background 50-80% of glioma patients will have seizures. Guidelines recommend against prophylactic anti-seizure medication, but levetiracetam is frequently prescribed. Our aim was to determine the effectiveness of 12-months prophylactic le…
View article: A review of use of external data and update on reporting standards in Sequential Multiple-Assignment Randomised Trials
A review of use of external data and update on reporting standards in Sequential Multiple-Assignment Randomised Trials Open
Background: The Sequential Multiple-Assignment Randomised Trial (SMART) design is considered the gold standard for developing adaptive interventions, which tailor treatments to individual patient characteristics and responses. While SMART …
View article: Service delivery, behavioural, and self-management interventions for children with epilepsy
Service delivery, behavioural, and self-management interventions for children with epilepsy Open
We included six studies in this review, each examining a different intervention, reporting on different outcomes, and involving varied populations. All studies had several limitations, including small sample sizes, lack of blinding, and in…
View article: Prognostic factors predicting an unprovoked seizure recurrence in children and adults following a first unprovoked seizure
Prognostic factors predicting an unprovoked seizure recurrence in children and adults following a first unprovoked seizure Open
We aimed to identify prognostic factors predicting seizure recurrence after a first unprovoked seizure. Considerable heterogeneity and inconsistency in how the included studies defined, measured, and reported prognostic factors significant…
View article: Service delivery, behavioural, and self-management interventions for adults with epilepsy
Service delivery, behavioural, and self-management interventions for adults with epilepsy Open
There is no high-certainty evidence that service delivery, behavioural, and self-management interventions improve seizure control or quality of life outcomes for adults with epilepsy. There were wide variations in the size of the effect es…
View article: A retrospective cohort study of valproate and infertility in men with epilepsy or bipolar disorder using international health data
A retrospective cohort study of valproate and infertility in men with epilepsy or bipolar disorder using international health data Open
Valproate is highly effective at treating epilepsy and bipolar disorder. It faces prescribing restrictions in men due to concerns it causes testicular dysfunction and infertility. These mostly stem from animal models – the human evidence i…
View article: How accurate are witnesses of first suspected seizures in recalling semiology at clinically relevant timepoints? A <scp>UK</scp> experimental study with a pilot intervention
How accurate are witnesses of first suspected seizures in recalling semiology at clinically relevant timepoints? A <span>UK</span> experimental study with a pilot intervention Open
Objective A key diagnostic challenge at “first seizure” clinic appointments is determining whether the reported event was epileptic. Witness accounts are often critical, yet such appointments typically occur weeks after the event. Guidelin…
View article: Seizure prophylaxis in glioma surgery (SPRING): a multi-centre, unblinded, randomised trial
Seizure prophylaxis in glioma surgery (SPRING): a multi-centre, unblinded, randomised trial Open
Background 50-80% of all glioma patients will have seizures. Guidelines recommend against prophylactic anti-seizure medication, but levetiracetam is frequently prescribed. Our aim was to determine the effectiveness of 12-months prophylacti…
View article: Epilepsy as a dynamic disease: Toward actionable, individualized seizure risk prediction
Epilepsy as a dynamic disease: Toward actionable, individualized seizure risk prediction Open
The current definition of epilepsy allows diagnosis after a single unprovoked seizure if the estimated 10‐year recurrence risk is ≥60%. While this framework is grounded in epidemiological evidence, it does not align with the shorter time h…
View article: The role of third-sector helplines in epilepsy support: Insights from a retrospective analysis of routine data from a UK service (2020–2024)
The role of third-sector helplines in epilepsy support: Insights from a retrospective analysis of routine data from a UK service (2020–2024) Open
This first systematic examination of a third-sector epilepsy helpline reveals high and growing demand, broad reach, and access inequities. Routine helpline data may offer a novel, real-time lens on community needs. Our analytic method coul…
View article: Predicting Drug Response with Multi-Task Gradient-Boosted Trees in Epilepsy
Predicting Drug Response with Multi-Task Gradient-Boosted Trees in Epilepsy Open
Motivation Despite the availability of numerous anti-seizure medications (ASMs), drug resistance remains a major issue for people with epilepsy. The probability of achieving seizure freedom diminishes with each unsuccessful drug trial, and…
View article: What matters most to people living with epilepsy? A rapid review of qualitative research relating to health outcomes
What matters most to people living with epilepsy? A rapid review of qualitative research relating to health outcomes Open
At present, the outcomes measured and reported in clinical trials for adults with epilepsy are heterogenous and have often not been selected in consultation with people living with epilepsy. As part of a wider project developing a core out…
View article: Epileptogenesis in meningioma: Theories, putative biomarkers, and postoperative risk
Epileptogenesis in meningioma: Theories, putative biomarkers, and postoperative risk Open
Cranial meningioma are the most common type of primary brain tumor, and focal onset, tumor‐related seizures affect a significant proportion of patients. Seizures affect 30% of symptomatic preoperative patients and a further 12% of postoper…
View article: Antiseizure medications for preventing a first seizure in adults with a brain tumour
Antiseizure medications for preventing a first seizure in adults with a brain tumour Open
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the efficacy and tolerability of antiseizure medications (ASMs) in preventing a first seizure in people with brain tumours compared with plac…
View article: A qualitative study of experiencing cauda equina syndrome and its aftercare in the UK
A qualitative study of experiencing cauda equina syndrome and its aftercare in the UK Open
Study design Qualitative, semi structured interviews. Objectives Cauda Equina Syndrome (CES) is a neurological emergency that can cause permanent disability to the lower limbs, including pain, weakness, and bladder, bowel and sexual dysfun…
View article: Prospective neuroimaging and neuropsychological evaluation in adults with newly diagnosed focal epilepsy
Prospective neuroimaging and neuropsychological evaluation in adults with newly diagnosed focal epilepsy Open
Objective Few prospective studies exist on newly diagnosed focal epilepsy (NDFE), a critical period for understanding epilepsy's biology and identifying biomarkers and potential interventions. We report a prospective cohort study in patien…
View article: Guide to evaluating performance of prediction models for recurrent clinical events
Guide to evaluating performance of prediction models for recurrent clinical events Open
Background Many chronic conditions, such as epilepsy and asthma, are typified by recurrent events—repeated acute deterioration events of a similar type. Statistical models for these conditions often focus on evaluating the time to the firs…
View article: Epilepsy–heart syndrome: Concept, clinical context, and opportunity for integrated care
Epilepsy–heart syndrome: Concept, clinical context, and opportunity for integrated care Open
In this concept paper, we introduce epilepsy‐heart syndrome as a shared burden of illness between epilepsy and cardiac disorders. This pragmatic definition is agnostic of which condition came first (the epilepsy or the cardiac disorder), r…
View article: Virtually the same, but remotely different: health professionals, parents and children’s experiences of remote out-patient consultations
Virtually the same, but remotely different: health professionals, parents and children’s experiences of remote out-patient consultations Open
Objective To explore experiences, benefits and concerns associated with remote (telephone/video) consultations from the perspectives of children and young people with juvenile idiopathic arthritis (JIA), their parents and health profession…
View article: Core Outcome Sets for Meningioma In Clinical studies (COSMIC): An international patient and healthcare professional consensus for research studies
Core Outcome Sets for Meningioma In Clinical studies (COSMIC): An international patient and healthcare professional consensus for research studies Open
Background Core Outcome Sets (COS) define the minimum outcomes that should be measured and reported in all clinical trials for a specific health condition or health area. The aim was to develop 2 COS for intracranial meningioma to be used …
View article: A roadmap toward promoting and improving brain health in Europe and closing the awareness and funding gap
A roadmap toward promoting and improving brain health in Europe and closing the awareness and funding gap Open
Background and Purpose The global burden of neurological diseases exceeds 43.1%, imposing a significant burden on patients, caregivers and society. This paper presents a roadmap to reduce this burden and improve brain health (BH) in Europe…
View article: Machine learning-based reconstruction of 2D MRI for quantitative morphometry in epilepsy
Machine learning-based reconstruction of 2D MRI for quantitative morphometry in epilepsy Open
Structural neuroimaging analyses require “research quality” images, procured with costly MRI acquisitions. Isotropic (3D-T1) images are desirable for quantitative analyses, however, a routine compromise in the clinical setting is to acquir…
View article: Top Ten epilepsy research priorities: A UK priority setting partnership
Top Ten epilepsy research priorities: A UK priority setting partnership Open
The aim of the UK Epilepsy PSP is to encourage and inspire researchers to investigate the research areas prioritised by those most affected by the condition and provide the evidence of need to aid future policy making discussions and suppo…
View article: Use of sodium valproate and other antiseizure drug treatments in England and Wales: quantitative analysis of nationwide linked electronic health records
Use of sodium valproate and other antiseizure drug treatments in England and Wales: quantitative analysis of nationwide linked electronic health records Open
Objective To investigate the use of sodium valproate in England and Wales, including during pregnancy, compared with other antiseizure drug treatments, based on national level electronic health records. Design Quantitative analysis of nati…
View article: PD222 Balancing Patient Preferences With Feasible Healthcare Delivery: Using Discrete Choice Experiments Alongside Knowledge Exchange To Inform Care Pathways
PD222 Balancing Patient Preferences With Feasible Healthcare Delivery: Using Discrete Choice Experiments Alongside Knowledge Exchange To Inform Care Pathways Open
Introduction Emergency department (ED) visits for epilepsy are common, costly, and often clinically unnecessary. Configuration of care pathways (CPs) that could divert people away from ED offer an alternative. The aim was to measure patien…
View article: Epilepsy core outcome set for effectiveness trials (EPSET): A systematic review of outcomes measured in registered phase III and IV clinical trials for adults with epilepsy
Epilepsy core outcome set for effectiveness trials (EPSET): A systematic review of outcomes measured in registered phase III and IV clinical trials for adults with epilepsy Open
At present, little is known about the outcomes measured in studies assessing the effectiveness of treatments for adults with epilepsy. As part of a wider project developing a Core Outcome Set for clinical trials for adults with epilepsy, w…
View article: ‘Blue-lighting’ seizure-related needs in care homes: a retrospective analysis of ambulance call-outs for seizures in North West England (2014–2021), their management and costs, with community comparisons
‘Blue-lighting’ seizure-related needs in care homes: a retrospective analysis of ambulance call-outs for seizures in North West England (2014–2021), their management and costs, with community comparisons Open
Objectives With a projected rise in care home residency and the disproportionate impact of epilepsy and seizures on older adults, understanding seizure-related needs in this population is crucial. Data silos and inconsistent recording of r…