Richard H. Guy
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View article: Assessment of microneedle array insertion into skin using Raman spectroscopic techniques
Assessment of microneedle array insertion into skin using Raman spectroscopic techniques Open
Microneedle (MN) arrays bypass the skin’s stratum corneum barrier to deliver drugs directly into the viable tissue. The skin disposition of three types of MNs—dissolvable, degradable and hydrogel-forming, fabricated using different polymer…
View article: Raman spectroscopy as a tool to accelerate development of complex medicinal products
Raman spectroscopy as a tool to accelerate development of complex medicinal products Open
Regulatory approval of complex generic drug products that are applied topically to treat skin disease can be challenging because a standard method to assess cutaneous pharmacokinetics in vivo is not available. As a result, expensive and pr…
View article: Cutaneous pharmacokinetics of a volatile drug post-application to the skin
Cutaneous pharmacokinetics of a volatile drug post-application to the skin Open
This research explored whether in vitro release and skin permeation tests, combined with in vitro and in vivo stratum corneum (SC) sampling, can quantify the “input rate” of a volatile drug into and through the skin. Two topical methyl sal…
View article: Physicochemical characterization of the metamorphosis of film-forming formulations of betamethasone-17-valerate
Physicochemical characterization of the metamorphosis of film-forming formulations of betamethasone-17-valerate Open
Following topical application of a dermatological product, the loss (by evaporation and/or absorption through the skin) of volatile excipients will alter the composition of the formulation remaining on the tissue. This so-called metamorpho…
View article: Evaluation of chemical disposition in skin by stimulated Raman scattering microscopy
Evaluation of chemical disposition in skin by stimulated Raman scattering microscopy Open
Tracking drug disposition in the skin in a non-destructive and at least semi-quantitative fashion is a relevant objective for the assessment of local (cutaneous) bioavailability. Confocal Raman spectroscopy has been shown potentially usefu…
View article: Correction to “Reverse Iontophoresis: Noninvasive Assessment of Topical Drug Bioavailability”
Correction to “Reverse Iontophoresis: Noninvasive Assessment of Topical Drug Bioavailability” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition and Correct...Addition and CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Reverse Iontophoresis: Noninvasive Assessment of Topical Drug Bioavailability"Kieran Moore…
View article: Reverse Iontophoresis: Noninvasive Assessment of Topical Drug Bioavailability
Reverse Iontophoresis: Noninvasive Assessment of Topical Drug Bioavailability Open
Assessing drug disposition in the skin after the application of a topical formulation is difficult. It is hypothesized that reverse iontophoresis (RI), which can extract charged/polar molecules for monitoring purposes, may provide a noninv…
View article: Visualisation of drug distribution in skin using correlative optical spectroscopy and mass spectrometry imaging
Visualisation of drug distribution in skin using correlative optical spectroscopy and mass spectrometry imaging Open
A correlative methodology for label-free chemical imaging of soft tissue has been developed, combining non-linear optical spectroscopies and mass spectrometry to achieve sub-micron spatial resolution and critically improved drug detection …
View article: Confocal Raman Spectroscopic Characterization of Dermatopharmacokinetics Ex Vivo
Confocal Raman Spectroscopic Characterization of Dermatopharmacokinetics Ex Vivo Open
Confocal Raman spectroscopy is being assessed as a tool with which to quantify the rate and extent of drug uptake to and its clearance from target sites of action within the viable epidermis below the skin's stratum corneum (SC) barrier. T…
View article: Quantification of Chemical Uptake into the Skin by Vibrational Spectroscopies and Stratum Corneum Sampling
Quantification of Chemical Uptake into the Skin by Vibrational Spectroscopies and Stratum Corneum Sampling Open
Evaluation of the bioavailability of drugs intended to act within the skin following the application of complex topical products requires the application of multiple experimental tools, which must be quantitative, validated, and, ideally a…
View article: Non‐destructive, reverse iontophoretic extraction of phytochemicals from <scp><i>Mangifera indica</i></scp>, <scp><i>Centella asiatica</i></scp>, <scp><i>Punica granatum</i></scp>, and <scp><i>Citrus sinensis</i></scp>
Non‐destructive, reverse iontophoretic extraction of phytochemicals from <span><i>Mangifera indica</i></span>, <span><i>Centella asiatica</i></span>, <span><i>Punica granatum</i></span>, and <span><i>Citrus sinensis</i></span> Open
For the commercial‐scale isolation of phytochemicals, a suitable plant biomass source (including species, origin, growing season, etc.) must be identified, and frequent analytical verification is required to ensure that the phytochemicals …
View article: Extraction of phytochemicals from the pomegranate (<i>Punica granatum</i> L., <i>Punicaceae</i>) by reverse iontophoresis
Extraction of phytochemicals from the pomegranate (<i>Punica granatum</i> L., <i>Punicaceae</i>) by reverse iontophoresis Open
Reverse iontophoresis facilitated the extraction of phytochemicals from intact pomegranates in a non-destructive manner. These phytochemicals were subsequently identified using liquid chromatography coupled to untargeted mass spectrometry …
View article: Development and validation of a minimally invasive and image-guided tape stripping method to sample atopic skin in children
Development and validation of a minimally invasive and image-guided tape stripping method to sample atopic skin in children Open
Background Molecular skin profiling techniques, typically performed on skin samples taken by punch biopsy, have enhanced the understanding of the pathophysiology of atopic dermatitis (AD), thereby enabling the development of novel targeted…
View article: Raman Spectroscopic Tools to Probe the Skin–(Trans)dermal Formulation Interface
Raman Spectroscopic Tools to Probe the Skin–(Trans)dermal Formulation Interface Open
Medicines designed to deliver the active pharmaceutical ingredient either into or through the skin─often referred to as topicals and transdermals, respectively─are generally considered to be complex drug products. A particular challenge fa…
View article: Skin pharmacokinetics of diclofenac and co-delivered functional excipients
Skin pharmacokinetics of diclofenac and co-delivered functional excipients Open
An important question in the development of a dermatological drug product is whether a target concentration has been achieved in, for example, the viable epidermis following topical administration. When attempting to address this challenge…
View article: Reverse Iontophoretic Extraction of Skin Cancer-Related Biomarkers
Reverse Iontophoretic Extraction of Skin Cancer-Related Biomarkers Open
Non-invasive methods for early diagnosis of skin cancer are highly valued. One possible approach is to monitor relevant biomarkers such as tryptophan (Trp) and kynurenine (Kyn), on the skin surface. The primary aim of this in vitro investi…
View article: Skin Pharmacokinetics of Transdermal Scopolamine: Measurements and Modeling
Skin Pharmacokinetics of Transdermal Scopolamine: Measurements and Modeling Open
Prediction of skin absorption and local bioavailability from topical formulations remains a difficult task. An important challenge in forecasting topical bioavailability is the limited information available about local and systemic drug co…
View article: Stratum Corneum Sampling to Assess Bioequivalence between Topical Acyclovir Products
Stratum Corneum Sampling to Assess Bioequivalence between Topical Acyclovir Products Open
Purpose To examine the potential of stratum corneum (SC) sampling via tape-stripping in humans to assess bioequivalence of topical acyclovir drug products, and to explore the potential value of alternative metrics of local skin bioavailabi…
View article: Regulatory Science and Innovation Programme for Europe (ReScIPE): A proposed model
Regulatory Science and Innovation Programme for Europe (ReScIPE): A proposed model Open
Regulatory science underpins the objective evaluation of medicinal products. It is therefore imperative that regulatory science and expertise remain at the cutting edge so that innovations of ever‐increasing complexity are translated safel…
View article: Scanning the horizon: a systematic literature review of methodologies
Scanning the horizon: a systematic literature review of methodologies Open
Objectives Society is confronted with the rapid emergence of innovation in science and technology. To manage this, horizon scanning is being adopted globally to identify, assess and prioritise innovations and trends at an early stage of th…