Robert G. Griffin
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View article: Aducanumab binding to Aβ <sub>1-42</sub> fibrils alters dynamics of the N-terminal tail while preserving the fibril core
Aducanumab binding to Aβ <sub>1-42</sub> fibrils alters dynamics of the N-terminal tail while preserving the fibril core Open
Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ 1-42 fibrils remain unresol…
View article: Aducanumab Binding to Aβ1-42 Fibrils Alters Dynamics of the N-Terminal Tail While Preserving the Fibril Core
Aducanumab Binding to Aβ1-42 Fibrils Alters Dynamics of the N-Terminal Tail While Preserving the Fibril Core Open
Aducanumab, a human IgG1 antibody with plaque-clearing effects and modest clinical benefit, binds selectively to aggregated Aβ via the N-terminal region. Yet, the molecular details of how the antibody engages Aβ 1-42 fibrils remain unresol…
View article: Diboron-Incorporated Indenofluorene: Isolation of Crystalline Neutral and Reduced States of 6,12-Diboraindeno[1,2-<i>b</i>]fluorene
Diboron-Incorporated Indenofluorene: Isolation of Crystalline Neutral and Reduced States of 6,12-Diboraindeno[1,2-<i>b</i>]fluorene Open
The synthesis and redox transformations of 6,12-diboraindeno[1,2-b]fluorene (DBIF)─a pentacyclic π-system with diboron incorporation─are reported. In notable contrast to the all-hydrocarbon indenofluorenes, a ligand coordination and reduct…
View article: Dynamic Nuclear Polarization with P1 Centers in Diamond
Dynamic Nuclear Polarization with P1 Centers in Diamond Open
Substitutional nitrogen impurities within the diamond lattice, known as P1 centers, have unpaired electrons that can mediate microwave driven dynamic nuclear polarization (DNP). In this paper we explore DNP of the bulk 13C spins in microme…
View article: Dipolar Recoupling in Rotating Solids
Dipolar Recoupling in Rotating Solids Open
Magic angle spinning (MAS) nuclear magnetic resonance (NMR) has evolved significantly over the past three decades and established itself as a vital tool for the structural analysis of biological macromolecules and materials. This review de…
View article: Peptidic “Molecular Beacon” for Collagen
Peptidic “Molecular Beacon” for Collagen Open
Collagen-mimetic peptides (CMP) have been invaluable tools for understanding the structure and function of collagen, which is the most abundant protein in animals. CMPs have also been developed as probes that detect damaged collagen becaus…
View article: Design and optimization of THz coupling in zirconia MAS rotors for dynamic nuclear polarization NMR
Design and optimization of THz coupling in zirconia MAS rotors for dynamic nuclear polarization NMR Open
We present 3D electromagnetic simulations of the coupling of a 250 GHz beam to the sample in a 380 MHz DNP NMR spectrometer. To obtain accurate results for magic angle spinning (MAS) geometries, we first measured the complex dielectric con…
View article: Structural characterization of E22G Aβ<sub>1–42</sub> fibrils <i>via</i><sup>1</sup>H detected MAS NMR
Structural characterization of E22G Aβ<sub>1–42</sub> fibrils <i>via</i><sup>1</sup>H detected MAS NMR Open
Amyloid fibrils have been implicated in the pathogenesis of several neurodegenerative diseases, the most prevalent example being Alzheimer's disease (AD).
View article: Resonant Mixing Dynamic Nuclear Polarization
Resonant Mixing Dynamic Nuclear Polarization Open
We propose a mechanism for dynamic nuclear polarization that is different from the well-known Overhauser effect, solid effect, cross effect, and thermal mixing processes. We term it Resonant Mixing (RM), and we show that it arises from the…
High aspect ratio diamond nanosecond laser machining Open
Laser processing of diamond has become an important technique for fabricating next generation microelectronic and quantum devices. However, the realization of low taper, high aspect ratio structures in diamond remains a challenge. We demon…
View article: Coherent Dynamic Nuclear Polarization using Chirped Pulses
Coherent Dynamic Nuclear Polarization using Chirped Pulses Open
This paper presents a study of coherent dynamic nuclear polarization (DNP) using frequency swept pulses at 94 GHz which optimize the polarization transfer efficiency. Accordingly, an enhancement ε ∼ 496 was observed using 10 mM trityl-OX06…
View article: Coherent Dynamic Nuclear Polarization using Chirped Pulses
Coherent Dynamic Nuclear Polarization using Chirped Pulses Open
This paper presents a study of coherent dynamic nuclear polarization (DNP) using frequency swept pulses at 94 GHz which optimize the polarization transfer efficiency. Accordingly, an enhancement ℇ∼496 was observed using 10mM trityl-OX063 a…
View article: Resonant Mixing Dynamic Nuclear Polarization
Resonant Mixing Dynamic Nuclear Polarization Open
We propose a new mechanism for dynamic nuclear polarization that is different from the well-known Overhauser effect, solid effect, cross effect and thermal mixing processes. In particular, we discovered that the evolution of the density ma…
View article: Frontiers in the Application of RF Vacuum Electronics
Frontiers in the Application of RF Vacuum Electronics Open
The application of radio frequency (RF) vacuum electronics for the betterment of the human condition began soon after the invention of the first vacuum tubes in the 1920s and has not stopped since. Today, microwave vacuum devices are power…
View article: Characterization of peptide O⋯HN hydrogen bonds <i>via</i> <sup>1</sup> H-detected <sup>15</sup> N/ <sup>17</sup> O solid-state NMR spectroscopy
Characterization of peptide O⋯HN hydrogen bonds <i>via</i> <sup>1</sup> H-detected <sup>15</sup> N/ <sup>17</sup> O solid-state NMR spectroscopy Open
Sensitive high-resolution multidimensional solid-state NMR method is reported for facile identification of hydrogen-bonded 15 N– 17 O pairs in peptides.
View article: TRACER-MAP AMS Measurement
TRACER-MAP AMS Measurement Open
Aerosol composition was measured by using the high resolution time-of-flight aerosol mass spectrometer (HR ToF-AMS). The data were collected at five different sites (AMF1, Aldine, University of Houston (UH), Jones Forest (JF), San Jacinto …
View article: Amplified Overhauser DNP with Selective Deuteration: Attenuation of Double-Quantum Cross-Relaxation
Amplified Overhauser DNP with Selective Deuteration: Attenuation of Double-Quantum Cross-Relaxation Open
We recently used selective 2H labeling of BDPA to investigate the Overhauser Effect (OE) dynamic nuclear polarization (DNP) mechanism in insulating solids doped with 1,3-bis(diphenylene)-2-phenylallyl (BDPA), and established that the α and…
View article: Characterization of peptide O∙∙∙HN hydrogen bonds via multidimensional 1H-detected 15N/17O solid-state nuclear magnetic resonance spectroscopy
Characterization of peptide O∙∙∙HN hydrogen bonds via multidimensional 1H-detected 15N/17O solid-state nuclear magnetic resonance spectroscopy Open
Solid-state NMR methods with high resolution and sensitivity are presented for identification and charaterization of hydrogen-bonded 15N/17O atomic pairs in peptide samples. Indirect 1H detection under fast magic-angle spinning, and the st…
View article: Making Education More Brain-Friendly through Gamified Instruction
Making Education More Brain-Friendly through Gamified Instruction Open
Just because you can does not mean you should. Although gamified instruction is being widely adopted, there needs to be compelling research that supports gamification as an effective educational modality. Without this support, gamification…
View article: Room-Temperature Quantitative Quantum Sensing of Lithium Ions with a Radical-Embedded Metal–Organic Framework
Room-Temperature Quantitative Quantum Sensing of Lithium Ions with a Radical-Embedded Metal–Organic Framework Open
Recent advancements in quantum sensing have sparked transformative detection technologies with high sensitivity, precision, and spatial resolution. Owing to their atomic-level tunability, molecular qubits and ensembles thereof are promisin…
View article: Biradical Polarizing Agents at High Fields
Biradical Polarizing Agents at High Fields Open
The sensitivity enhancements available from dynamic nuclear polarization (DNP) are rapidly reshaping the research landscape and expanding the field of nuclear magnetic resonance (NMR) spectroscopy as a tool for solving complex chemical and…
View article: Observing Nearby Nuclei on Paramagnetic Trityls and MOFs via DNP and Electron Decoupling
Observing Nearby Nuclei on Paramagnetic Trityls and MOFs via DNP and Electron Decoupling Open
Dynamic nuclear polarization (DNP) is an NMR sensitivity enhancement technique that mediates polarization transfer from unpaired electrons to NMR‐active nuclei. Despite its success in elucidating important structural information on biologi…