Guy Touchard
YOU?
Author Swipe
View article: Randall-Type Monoclonal IgE Kappa Light-Heavy Chain Deposition Disease
Randall-Type Monoclonal IgE Kappa Light-Heavy Chain Deposition Disease Open
View article: A gain-of-function variant in the Wiskott-Aldrich syndrome gene is associated with a MYH9-related disease-like syndrome
A gain-of-function variant in the Wiskott-Aldrich syndrome gene is associated with a MYH9-related disease-like syndrome Open
While loss-of-function variants in the WAS gene are associated with Wiskott-Aldrich syndrome and lead to microthrombocytopenia, gain-of-function variants of WAS are associated with X-linked neutropenia (XLN) and the absence of microthrombo…
View article: Crystalglobulin-Associated Kidney Disease: A Case Report and Literature Review
Crystalglobulin-Associated Kidney Disease: A Case Report and Literature Review Open
The kidney is commonly involved in multiple myeloma and other disorders producing monoclonal immunoglobulins. Crystalglobulinemia is a rare condition characterized by spontaneous crystallization and deposition of monoclonal immunoglobulins…
View article: Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma
Crystalline podocytopathy and tubulopathy linked to kappa light chain deposits in a context of smoldering multiple myeloma Open
A 42-year-old man with smoldering immunoglobulin G kappa multiple myeloma showed a heavy proteinuria composed of free light chain, prompting performance of a kidney biopsy. Electron microscopy revealed numerous rhomboid-shaped crystals lab…
View article: Atypical focal segmental glomerulosclerosis associated with a new <i>PODXL</i> nonsense variant
Atypical focal segmental glomerulosclerosis associated with a new <i>PODXL</i> nonsense variant Open
Background Podocalyxin (PODXL) is a highly sialylated adhesion glycoprotein that plays an important role in podocyte's physiology. Recently, missense and nonsense dominant variants in the PODXL gene have been associated with focal segmenta…
View article: Randall-Type Monoclonal Immunoglobulin Deposition Disease: New Insights into the Pathogenesis, Diagnosis and Management
Randall-Type Monoclonal Immunoglobulin Deposition Disease: New Insights into the Pathogenesis, Diagnosis and Management Open
Randall-type monoclonal immunoglobulin deposition disease (MIDD) is a rare disease that belongs to the spectrum of monoclonal gammopathy of renal significance (MGRS). Renal involvement is prominent in MIDD, but extra-renal manifestations c…
View article: Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures
Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures Open
Background The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI). Methods Kidney biopsy samples in two Caucasian patients and one…
View article: First phenotypic description of a female patient with c.610 T > C variant of GLA: a renal-predominant presentation of Fabry disease
First phenotypic description of a female patient with c.610 T > C variant of GLA: a renal-predominant presentation of Fabry disease Open
View article: Immunoglobulin light chain toxicity in a mouse model of monoclonal immunoglobulin light-chain deposition disease
Immunoglobulin light chain toxicity in a mouse model of monoclonal immunoglobulin light-chain deposition disease Open
Light chain deposition disease (LCDD) is a rare disorder characterized by glomerular and peritubular amorphous deposits of a monoclonal immunoglobulin (Ig) light chain (LC), leading to nodular glomerulosclerosis and nephrotic syndrome. We …
View article: Clinicopathologic predictors of renal outcomes in light chain cast nephropathy: a multicenter retrospective study
Clinicopathologic predictors of renal outcomes in light chain cast nephropathy: a multicenter retrospective study Open
Light chain cast nephropathy (LCCN) in multiple myeloma often leads to severe and poorly reversible acute kidney injury. Severe renal impairment influences the allocation of chemotherapy and its tolerability; it also affects patient surviv…
View article: Monoclonal Gammopathy of Renal Significance
Monoclonal Gammopathy of Renal Significance Open
Monoclonal gammopathy of renal significance. The term "monoclonal gammopathy of renal significance" regroups all renal disorders caused by a monoclonal immunoglobulin (Ig) secreted by a nonmalignant B-cell clone. However, a small clone can…
View article: Ifosfamide nephrotoxicity in adult patients
Ifosfamide nephrotoxicity in adult patients Open
Background Ifosfamide, a widely prescribed antineoplasic agent, is frequently associated with kidney dysfunction. Its nephrotoxicity is well documented in children, but data are lacking in adult patients. Methods The aim of this retrospect…
View article: Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease
Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease Open
Light chain deposition disease (LCDD) is a rare disorder characterized by glomerular and peritubular amorphous deposits of a monoclonal immunoglobulin (Ig) light chain (LC), leading to nodular glomerulosclerosis and nephrotic syndrome. We …
View article: Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study
Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study Open
Monoclonal immunoglobulin deposition disease (MIDD) is a rare complication of B-cell clonal disorders, defined by Congo red negative–deposits of monoclonal light chain (LCDD), heavy chain (HCDD), or both (LHCDD). MIDD is a systemic disorde…
View article: Multiple myeloma with crystal-storing histiocytosis, crystalline podocytopathy, and light chain proximal tubulopathy, revealed by retinal abnormalities
Multiple myeloma with crystal-storing histiocytosis, crystalline podocytopathy, and light chain proximal tubulopathy, revealed by retinal abnormalities Open
Rationale: Crystal sorting histiocytosis (CSH) is a rare disorder that is morphologically characterized by the accumulation of monoclonal immunoglobulin crystals, predominantly of a kappa light chain type, within lysosomes of macrophages. …
View article: Comprehensive molecular characterization of a heavy chain deposition disease case
Comprehensive molecular characterization of a heavy chain deposition disease case Open
International audience
View article: Endogenous IL-33 Contributes to Kidney Ischemia-Reperfusion Injury as an Alarmin
Endogenous IL-33 Contributes to Kidney Ischemia-Reperfusion Injury as an Alarmin Open
Inflammation is a prominent feature of ischemia-reperfusion injury (IRI), which is characterized by leukocyte infiltration and renal tubular injury. However, signals that initiate these events remain poorly understood. We examined the role…
View article: Proliferative lupus nephritis in the absence of overt systemic lupus erythematosus
Proliferative lupus nephritis in the absence of overt systemic lupus erythematosus Open
Severe lupus nephritis in the absence of systemic lupus erythematosus (SLE) is a rare condition with an unclear clinical presentation and outcome.We conducted a historical observational study of 12 adult (age >18 years) patients with biops…
View article: IL-33 receptor ST2 deficiency attenuates renal ischaemia–reperfusion injury in euglycaemic, but not streptozotocin-induced hyperglycaemic mice
IL-33 receptor ST2 deficiency attenuates renal ischaemia–reperfusion injury in euglycaemic, but not streptozotocin-induced hyperglycaemic mice Open
View article: Treatment of B-cell disorder improves renal outcome of patients with monoclonal gammopathy–associated C3 glomerulopathy
Treatment of B-cell disorder improves renal outcome of patients with monoclonal gammopathy–associated C3 glomerulopathy Open
Key Points Monoclonal gammopathy is associated with C3 glomerulopathy. Specific treatment of the underlying B-cell clone improves renal survival.
View article: Warfarin-related nephropathy induced by three different vitamin K antagonists: analysis of 13 biopsy-proven cases
Warfarin-related nephropathy induced by three different vitamin K antagonists: analysis of 13 biopsy-proven cases Open
Background: Acute kidney injury (AKI) with renal tubular obstruction by red blood cell casts (RBCC) has been described in patients treated with warfarin and is known as warfarin-related nephropathy (WRN). Methods: To determin…
View article: Genome-Wide Association Study of Acute Renal Graft Rejection
Genome-Wide Association Study of Acute Renal Graft Rejection Open
View article: SP121RANDALL-TYPE MIDD: THE DISEASE SPECTRUM
SP121RANDALL-TYPE MIDD: THE DISEASE SPECTRUM Open
View article: Prognostic value of kidney biopsy in myeloma cast nephropathy: a retrospective study of 70 patients
Prognostic value of kidney biopsy in myeloma cast nephropathy: a retrospective study of 70 patients Open
In the published version of this paper the first and second sentences of the 'Patients' section ('This study was done in accordance with the Declaration of Helsinki.Written informed consent was obtained from all study participants.Seventy …
View article: A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H
A Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor H Open
C3 glomerulopathy is a recently described form of CKD. C3GN is a subtype of C3 glomerulopathy characterized by predominant C3 deposits in the glomeruli and is commonly the result of acquired or genetic abnormalities in the alternative path…
View article: Prognostic value of kidney biopsy in myeloma cast nephropathy: a retrospective study of 70 patients
Prognostic value of kidney biopsy in myeloma cast nephropathy: a retrospective study of 70 patients Open
In MCN, the presence of numerous casts and diffuse tubular atrophy is associated with poor renal prognosis. These data suggest that additional strategies to reduce FLC burden should be considered in patients with extensive cast formation.
View article: The Authors Reply
The Authors Reply Open
View article: A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy
A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy Open
Key Points We created the first transgenic mouse model recapitulating the early pathologic features of Randall-type heavy chain deposition disease. Production of a truncated immunoglobulin heavy chain heightens plasma cell sensitivity to b…
View article: Fibrosis Progression According to Epithelial-Mesenchymal Transition Profile: A Randomized Trial of Everolimus Versus CsA
Fibrosis Progression According to Epithelial-Mesenchymal Transition Profile: A Randomized Trial of Everolimus Versus CsA Open
Markers of epithelial-mesenchymal transition (EMT) may identify patients at high risk of graft fibrogenesis who could benefit from early calcineurin inhibitor (CNI) withdrawal. In a randomized, open-label, 12-month trial, de novo kidney tr…
View article: Daclizumab Versus Rabbit Antithymocyte Globulin in High-Risk Renal Transplants: Five-Year Follow-up of a Randomized Study
Daclizumab Versus Rabbit Antithymocyte Globulin in High-Risk Renal Transplants: Five-Year Follow-up of a Randomized Study Open