Gwenaëlle Douaud
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View article: Genome-wide analysis identifies 66 variants underlying anatomical variation in human neuroendocrine structures and reveals links to testosterone
Genome-wide analysis identifies 66 variants underlying anatomical variation in human neuroendocrine structures and reveals links to testosterone Open
The hypothalamus, pituitary gland and olfactory bulbs are neuroanatom-ical structures key to the regulation of the endocrine system. Variation in their anatomy can affect the function of the reproductive system. To investigate this relatio…
View article: The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease
The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease Open
We have previously identified a network of higher-order brain regions particularly vulnerable to the ageing process, schizophrenia and Alzheimer’s disease. However, it remains unknown what the genetic influences on this fragile brain netwo…
View article: MMORF—FSL’s MultiMOdal Registration Framework
MMORF—FSL’s MultiMOdal Registration Framework Open
We present MMORF—FSL’s MultiMOdal Registration Framework—a newly released nonlinear image registration tool designed primarily for application to magnetic resonance imaging (MRI) images of the brain. MMORF is capable of simultaneously opti…
View article: Internally consistent and fully unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM
Internally consistent and fully unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM Open
Anatomical magnetic resonance imaging (MRI) templates of the brain are essential to group-level analyses and image processing pipelines, as they provide a reference space for spatial normalisation. While it has become common for studies to…
View article: Internally-consistent and fully-unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM
Internally-consistent and fully-unbiased multimodal MRI brain template construction from UK Biobank: Oxford-MM Open
Anatomical MRI templates of the brain are essential to group-level analyses and image processing pipelines, as they provide a reference space for spatial normalisation. While it has become common for studies to acquire multimodal MRI data,…
View article: MMORF—FSL’s MultiMOdal Registration Framework
MMORF—FSL’s MultiMOdal Registration Framework Open
We present MMORF—FSL’s MultiMOdal Registration Framework—a newly released nonlinear image registration tool designed primarily for application to MRI images of the brain. MMORF is capable of simultaneously optimising both displacement and …
View article: Subthalamic nucleus shows opposite functional connectivity pattern in Huntington’s and Parkinson’s disease
Subthalamic nucleus shows opposite functional connectivity pattern in Huntington’s and Parkinson’s disease Open
Huntington’s and Parkinson’s disease are two movement disorders representing mainly opposite states of the basal ganglia inhibitory function. Despite being an integral part of the cortico-subcortico-cortical circuitry, the subthalamic nucl…
View article: Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads study
Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads study Open
Introduction Magnetic resonance imaging (MRI) of the brain could be a key diagnostic and research tool for understanding the neuropsychiatric complications of COVID-19. For maximum impact, multi-modal MRI protocols will be needed to measur…
View article: Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood
Individual differences in slow wave sleep architecture relate to variation in white matter microstructure across adulthood Open
Sleep plays a key role in supporting brain function and resilience to brain decline. It is well known that sleep changes substantially with aging and that aging is associated with deterioration of brain structure. In this study, we sought …
View article: SARS-CoV-2 is associated with changes in brain structure in UK Biobank
SARS-CoV-2 is associated with changes in brain structure in UK Biobank Open
There is strong evidence of brain-related abnormalities in COVID-19 1–13 . However, it remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing…
View article: Early brain injury and cognitive impairment after aneurysmal subarachnoid haemorrhage
Early brain injury and cognitive impairment after aneurysmal subarachnoid haemorrhage Open
The first 72 h following aneurysm rupture play a key role in determining clinical and cognitive outcomes after subarachnoid haemorrhage (SAH). Yet, very little is known about the impact of so called “early brain injury” on patents with cli…
View article: Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging
Phenotypic and genetic associations of quantitative magnetic susceptibility in UK Biobank brain imaging Open
A key aim in epidemiological neuroscience is identification of markers to assess brain health and monitor therapeutic interventions. Quantitative susceptibility mapping (QSM) is an emerging MRI technique that measures tissue magnetic susce…
View article: SARS-CoV-2 is associated with changes in brain structure in UK Biobank
SARS-CoV-2 is associated with changes in brain structure in UK Biobank Open
There is strong evidence for brain-related abnormalities in COVID-19 1–13 . It remains unknown however whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing…
View article: Multimodal Imaging Brain Markers in Early Adolescence Are Linked with a Physically Active Lifestyle
Multimodal Imaging Brain Markers in Early Adolescence Are Linked with a Physically Active Lifestyle Open
The World Health Organization promotes physical exercise and a healthy lifestyle as means to improve youth development. However, relationships between physical lifestyle and human brain development are not fully understood. Here, we asked …
View article: Multimodal imaging brain markers in early adolescence are linked with a physically active lifestyle
Multimodal imaging brain markers in early adolescence are linked with a physically active lifestyle Open
The World Health Organization (WHO) promotes physical exercise and a healthy lifestyle as means to improve youth development. However, relationships between physical lifestyle and brain development are not fully understood. Here, we asked …
View article: Enhanced Brain Imaging Genetics in UK Biobank
Enhanced Brain Imaging Genetics in UK Biobank Open
UK Biobank is a major prospective epidemiological study that is carrying out detailed multimodal brain imaging on 100,000 participants, and includes genetics and ongoing health outcomes. As a step forwards in understanding genetic influenc…
View article: Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations
Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations Open
Brain imaging can be used to study how individuals’ brains are aging, compared against population norms. This can inform on aspects of brain health; for example, smoking and blood pressure can be seen to accelerate brain aging. Typically, …
View article: Population-based neuroimaging reveals traces of childbirth in the maternal brain
Population-based neuroimaging reveals traces of childbirth in the maternal brain Open
Significance Pregnancy is one of the most dynamic periods in a woman’s life, involving a remarkable potential for brain plasticity that promotes cognitive and emotional adjustments to the newborn. We provide evidence for a relationship bet…
View article: Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations
Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations Open
Brain imaging can be used to study how individuals’ brains are aging, compared against population norms. This can inform on aspects of brain health; for example, smoking and blood pressure can be seen to accelerate brain aging. Typically, …
View article: Handedness, language areas and neuropsychiatric diseases: insights from brain imaging and genetics
Handedness, language areas and neuropsychiatric diseases: insights from brain imaging and genetics Open
The brain signature and genetic basis of handedness are unclear. Wiberg et al. show that left-handers have higher functional connectivity between language networks, and identify four genomic regions associated with handedness. Variants wit…
View article: Structural Variability in the Human Brain Reflects Fine-Grained Functional Architecture at the Population Level
Structural Variability in the Human Brain Reflects Fine-Grained Functional Architecture at the Population Level Open
Human brain structure topography is thought to be related in part to functional specialization. However, the extent of such relationships is unclear. Here, using a data-driven, multimodal approach for studying brain structure across the li…
View article: Population-based neuroimaging reveals traces of childbirth in the maternal brain
Population-based neuroimaging reveals traces of childbirth in the maternal brain Open
Pregnancy and childbirth involve maternal brain adaptations that promote attachment to and protection of the newborn. Using brain imaging and machine learning, we provide evidence for a positive relationship between number of childbirths a…