Gyde Nissen
YOU?
Author Swipe
View article: 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma
17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma Open
Rationale: The strongest genetic risk factor for childhood-onset asthma, the 17q21 locus, is associated with increased viral susceptibility and disease-promoting processes.Objectives: To identify biological targets underlying…
View article: Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort
Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort Open
View article: TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease
TRACK-CF prospective cohort study: Understanding early cystic fibrosis lung disease Open
Background Lung disease as major cause for morbidity in patients with cystic fibrosis (CF) starts early in life. Its large phenotypic heterogeneity is partially explained by the genotype but other contributing factors are not well delineat…
View article: In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma
In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma Open
Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high phenotype is linked to severe, therapy-refractory asthma, subclinical infections and neutrophil inflammation. Previously, we found neutrophil granulocyte…
View article: IgA<sup>+</sup>memory B-cells are significantly increased in patients with asthma and small airway dysfunction
IgA<sup>+</sup>memory B-cells are significantly increased in patients with asthma and small airway dysfunction Open
Background Comprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B-cells to this chronic inflam…
View article: T2-high asthma phenotypes across lifespan
T2-high asthma phenotypes across lifespan Open
Rationale In adults, personalised asthma treatment targets patients with type 2 (T2)-high and eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in children. Objectives To define T2-high asthma with eas…
View article: Two Beer(s) or Not Two Beer(s): The eNose as an Instrument to Pacify the World
Two Beer(s) or Not Two Beer(s): The eNose as an Instrument to Pacify the World Open
Background Science prizes that are not meant to be very serious, stand-up evenings, science slams or publications with a scientific twist: science comedy comes in very different forms. But all variants have one thing in common: humour. It …
View article: Erratum zu: „Gemeinsam stark – für eine bessere Kinder- und Jugendmedizin!“
Erratum zu: „Gemeinsam stark – für eine bessere Kinder- und Jugendmedizin!“ Open
View article: „Gemeinsam stark – für eine bessere Kinder- und Jugendmedizin!“
„Gemeinsam stark – für eine bessere Kinder- und Jugendmedizin!“ Open
View article: Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation
Tumstatin fragment selectively inhibits neutrophil infiltration in experimental asthma exacerbation Open
Summary Background Asthma is a chronic inflammatory disease with structural changes present. Burgess and colleagues recently found tumstatin markedly reduced in adult asthmatic lung tissue compared with nonasthmatics. ECM fragments such as…
View article: <scp>S</scp>i<scp>MA</scp>: A simplified migration assay for analyzing neutrophil migration
<span>S</span>i<span>MA</span>: A simplified migration assay for analyzing neutrophil migration Open
In lung inflammation, neutrophils are the first leukocytes migrating to an inflammatory site, eliminating pathogens by multiple mechanisms. The term “migration” describes several stages of neutrophil movement to reach the site of inflammat…