Gyöngyi Szabó
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View article: MicroRNA-21 is a potential therapeutic agent targeting Tgfbi and mitigating high-fat-diet-induced liver disease and cancer
MicroRNA-21 is a potential therapeutic agent targeting Tgfbi and mitigating high-fat-diet-induced liver disease and cancer Open
View article: Comprehensive assessment of erenumab efficacy in participants with high‐frequency episodic migraine with at least one previously failed preventive treatment: The <scp>EMBRACE</scp> study
Comprehensive assessment of erenumab efficacy in participants with high‐frequency episodic migraine with at least one previously failed preventive treatment: The <span>EMBRACE</span> study Open
Objective To evaluate the effect of erenumab treatment beyond monthly migraine days in patients with high‐frequency episodic migraine who did not respond to at least one previous migraine preventive treatment. Background Reduction in month…
View article: Transcriptome of monocytes from liver, brain and bone marrow reveals organ-specific features in aging and alcohol misuse
Transcriptome of monocytes from liver, brain and bone marrow reveals organ-specific features in aging and alcohol misuse Open
Background & Aims: Aging and alcohol misuse independently alter monocyte (MO) and macrophage (MØ) function, leading to impaired antimicrobial responses. However, how alcohol misuse contributes to impaired MO/MØ function during aging remain…
View article: Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache: Final Results From a Phase 4 Randomized Placebo‐Controlled Study
Efficacy and Safety of Erenumab in Adults With Medication Overuse Headache: Final Results From a Phase 4 Randomized Placebo‐Controlled Study Open
Background Erenumab‐induced medication overuse headache (MOH) remission in participants with chronic migraine (CM) in a prospective, Phase 4, randomized, placebo‐controlled trial with an open‐label treatment period (OLTP). We present 1‐yea…
View article: The efficacy of rosuvastatin to reduce circulating tissue factor extracellular vesicles after ovarian cancer surgery
The efficacy of rosuvastatin to reduce circulating tissue factor extracellular vesicles after ovarian cancer surgery Open
View article: Parental liver disease mortality is associated with unfavorable outcomes in patients with alcohol-associated hepatitis
Parental liver disease mortality is associated with unfavorable outcomes in patients with alcohol-associated hepatitis Open
Background: How parental alcohol use disorder and liver disease-related mortality influence the risk and the outcomes of alcohol-associated hepatitis (AH) in the offspring is unknown. Methods: We analyzed data from 2 prospective observatio…
View article: Acute-on-chronic liver failure (ACLF): the ‘Kyoto Consensus’—steps from Asia
Acute-on-chronic liver failure (ACLF): the ‘Kyoto Consensus’—steps from Asia Open
Acute-on-chronic liver failure (ACLF) is a condition associated with high mortality in the absence of liver transplantation. There have been various definitions proposed worldwide. The first consensus report of the working party of the Asi…
View article: Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF
Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF Open
Background Gasdermin D (GSDM-D), a key executor of pyroptosis, is increased in various liver diseases and contributes to disease progression. Alcohol induces inflammasome activation and cell death, which are both linked to GSDM-D activatio…
View article: A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition
A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition Open
Our novel ACLF model triggered by alcohol binge mimics key features of pathophysiology and multi-organ impairment in human ACLF. Our results indicate that neutrophil infiltration and NETs contribute to hepatocyte cell death via pyroptosis …
View article: miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice
miR-21: A therapeutic target for delaying severe liver disease and hepatocellular carcinoma in high-fat-diet-fed mice Open
Liver disease, including hepatocellular carcinoma (HCC), is a major global health concern, claiming approximately 2 million lives worldwide annually, yet curative treatments remain elusive. In this study, we aimed to investigate the role o…
View article: Efficacy and Safety of Erenumab for Nonopioid Medication Overuse Headache in Chronic Migraine
Efficacy and Safety of Erenumab for Nonopioid Medication Overuse Headache in Chronic Migraine Open
Importance Patients with chronic migraine and medication overuse headaches (CM-MOH) represent a particularly burdened subpopulation. This trial provides first, to our knowledge, American Academy of Neurology class I evidence for a preventi…
View article: In vivo Bruton’s tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis
In vivo Bruton’s tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis Open
Severe alcohol-associated hepatitis (AH) is a life-threatening form of alcohol-associated liver disease. Liver neutrophil infiltration is a hallmark of AH, yet the effects of alcohol on neutrophil functions remain elusive. Identifying ther…
View article: Inflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation
Inflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation Open
View article: A novel experimental model of MetALD in male mice recapitulates key features of severe alcohol-associated hepatitis
A novel experimental model of MetALD in male mice recapitulates key features of severe alcohol-associated hepatitis Open
Background: The recent increase in the incidence of alcohol-associated hepatitis (AH) coincides with the obesity epidemic in the United States. However, current mouse models do not fully replicate the combined insults of obesity, metabolic…
View article: Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver
Combined Insults of a MASH Diet and Alcohol Binges Activate Intercellular Communication and Neutrophil Recruitment via the NLRP3-IL-1β Axis in the Liver Open
Binge drinking in obese patients positively correlates with accelerated liver damage and liver-related death. However, the underlying mechanism and the effect of alcohol use on the progression of metabolic-dysfunction-associated steatotic …
View article: Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression
Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression Open
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirr…
View article: IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s disease
IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer’s disease Open
Summary The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF…
View article: A novel score of IL-13 and age predicts 90-day mortality in severe alcohol-associated hepatitis: A multicenter plasma biomarker analysis
A novel score of IL-13 and age predicts 90-day mortality in severe alcohol-associated hepatitis: A multicenter plasma biomarker analysis Open
Background: Severe alcoholic hepatitis (AH) has a high short-term mortality rate. The MELD assesses disease severity and mortality; however, it is not specific for AH. We screened plasma samples from patients with severe AH for biomarkers …
View article: Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease
Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease Open
Background: Chronic alcohol consumption impairs gut barrier function and perturbs the gut microbiome. Although shifts in bacterial communities in patients with alcohol-associated liver disease (ALD) have been characterized, less is known a…
View article: Bile acid–induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1
Bile acid–induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1 Open
Background and Aims: Cell death and inflammation play critical roles in chronic tissue damage caused by cholestatic liver injury leading to fibrosis and cirrhosis. Liver cirrhosis is often associated with kidney damage, which is a severe c…
View article: Protective role of <scp>cGAS</scp> in <scp>NASH</scp> is related to the maintenance of intestinal homeostasis
Protective role of <span>cGAS</span> in <span>NASH</span> is related to the maintenance of intestinal homeostasis Open
Background & Aims Various intracellular pathways regulate inflammation in NASH. Cyclic GMP‐AMP synthase (cGAS) is a DNA sensor that activates STING and plays a role in inflammatory diseases. Here, we explored the role of cGAS in hepatic da…
View article: The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis
The Beneficial Effects of Lactobacillus GG Therapy on Liver and Drinking Assessments in Patients with Moderate Alcohol-Associated Hepatitis Open
INTRODUCTION: We investigated the effect of daily oral Lactobacillus rhamnosus GG (LGG) in reducing liver injury/severity and drinking in patients with alcohol use disorder and moderately severe alcohol-associated hepatitis. METHODS: Forty…
View article: Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis
Safety, Pharmacokinetics, and Efficacy Signals of Larsucosterol (DUR-928) in Alcohol-Associated Hepatitis Open
INTRODUCTION: This study is to evaluate the safety and pharmacokinetics (PK) of larsucosterol (DUR-928 or 25HC3S) in subjects with alcohol-associated hepatitis (AH), a devastating acute illness without US Food and Drug Administration–appro…
View article: Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation
Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation Open
Background & Aims: Prolonged systemic inflammation contributes to poor clinical outcomes in severe alcohol-associated hepatitis (AH) even after the cessation of alcohol use. However, mechanisms leading to this persistent inflammation remai…
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We appreciate the points made by Malkebe et al in their Letter to the Editor about survival in placebo-treated patients with severe alcohol-associated hepatitis (AH). Clinical trial design in AH has been challenging due to several factors.…
View article: Differential role of MLKL in alcohol-associated and non–alcohol-associated fatty liver diseases in mice and humans
Differential role of MLKL in alcohol-associated and non–alcohol-associated fatty liver diseases in mice and humans Open
View article: A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients
A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients Open
The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we performed single-nucleus RNA-seq and spati…
View article: Innate immune activation: Parallels in alcohol use disorder and Alzheimer’s disease
Innate immune activation: Parallels in alcohol use disorder and Alzheimer’s disease Open
Alcohol use disorder is associated with systemic inflammation and organ dysfunction especially in the liver and the brain. For more than a decade, studies have highlighted alcohol abuse-mediated impairment of brain function and acceleratio…
View article: Granulocyte colony‐stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice
Granulocyte colony‐stimulating factor attenuates liver damage by M2 macrophage polarization and hepatocyte proliferation in alcoholic hepatitis in mice Open
Massive inflammation and liver failure are main contributors to the high mortality in alcohol‐associated hepatitis (AH). In recent clinical trials, granulocyte colony‐stimulating factor (G‐CSF) therapy improved liver function and survival …
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Gyongyi Szabo, Mack Mitchell, Craig J McClain, and Srinivasan Dasarathy contributed equally to this work. We appreciate the comments from Singh, Mishra, and Jindal, as well as from Gupta, Nath, and Anand. We were also disappointed that the…