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View article: Sc(III) Complexes of Pyclen Derivative Ligands as Probes for Hypoxia: Synthesis, Chemical Characterization, <sup>44</sup> Sc‐Radiolabeling, and Preclinical Assessment
Sc(III) Complexes of Pyclen Derivative Ligands as Probes for Hypoxia: Synthesis, Chemical Characterization, <sup>44</sup> Sc‐Radiolabeling, and Preclinical Assessment Open
Rigid pyclen derivative ligands bearing hypoxia‐sensitive nitroimidazole (NI) pendants, PC2A‐Ph‐NI (hexadentate) and PC2AM‐NI (heptadentate), were synthesized, radiolabeled with 44 Sc(III), and evaluated under preclinical circumstances. Ph…
View article: Decadentate Acyclic Chelators for Lanthanum Radiopharmaceuticals
Decadentate Acyclic Chelators for Lanthanum Radiopharmaceuticals Open
Two decadentate acyclic chelators bearing four picolinic acid groups appended on either an ethylenediamine (H4TPAEN) or a trans-1,2-cyclohexyldiamine (H4TPADAC) unit were explored as candidates for lanthanum-ba…
View article: Relaxation-Based In Vivo Discrimination of Oxidized and Reduced States of a Redox-Switchable <sup>19</sup>F MRI Probe
Relaxation-Based In Vivo Discrimination of Oxidized and Reduced States of a Redox-Switchable <sup>19</sup>F MRI Probe Open
MRI assessment of the tissue redox state is important for revealing and understanding various pathologies, and redox-responsive imaging probes capable of generating discrete and quantifiable signals in both their reduced and oxidized forms…
View article: HER2 expression in different cell lines at different inoculation sites assessed by [52Mn]Mn-DOTAGA(anhydride)-trastuzumab
HER2 expression in different cell lines at different inoculation sites assessed by [52Mn]Mn-DOTAGA(anhydride)-trastuzumab Open
Purpose Positron emission tomography (PET) hybrid imaging targeting HER2 requires antibodies labelled with longer half-life isotopes. With a suitable radiation profile, 52 Mn coupled with DOTAGA as a bifunctional chelator is a potential ca…
View article: Mn(II)-alapú diagnosztikai szerek: az alapkutatástól a célzott diagnosztikai eljárásokig
Mn(II)-alapú diagnosztikai szerek: az alapkutatástól a célzott diagnosztikai eljárásokig Open
A célzott molekuláris képalkotás egy új, ígéretes módszer a nukleáris medicinában a diagnosztika és a terápia területén. A mangánizotópok sokszínűsége elérhető közelségbe hozta a bimodális képalkotásokat, mivel az 52 Mn pozitront emittáló …
View article: Small, Fluorinated Mn<sup>2+</sup> Chelate as an Efficient <sup>1</sup>H and <sup>19</sup>F MRI Probe
Small, Fluorinated Mn<sup>2+</sup> Chelate as an Efficient <sup>1</sup>H and <sup>19</sup>F MRI Probe Open
We explore the potential of fluorine‐containing small Mn 2+ chelates as alternatives to perfluorinated nanoparticles, widely used as 19 F MRI probes. In MnL1 , the cyclohexanediamine skeleton and two piperidine rings, involving each a meta…
View article: Small, Fluorinated Mn<sup>2+</sup> Chelate as an Efficient <sup>1</sup>H and <sup>19</sup>F MRI Probe
Small, Fluorinated Mn<sup>2+</sup> Chelate as an Efficient <sup>1</sup>H and <sup>19</sup>F MRI Probe Open
We explore the potential of fluorine‐containing small Mn 2+ chelates as alternatives to perfluorinated nanoparticles, widely used as 19 F MRI probes. In MnL1 , the cyclohexanediamine skeleton and two piperidine rings, involving each a meta…
View article: Structural, stability and relaxation features of lanthanide‐complexes designed for multimodal imaging detection of enzyme activities
Structural, stability and relaxation features of lanthanide‐complexes designed for multimodal imaging detection of enzyme activities Open
Lanthanide complexes of DO3A‐derivative ligands bearing a pyridine‐carbamate ( L1 ) or pyridine‐amine ( L2 ) arm have potential interest in the design of enzymatically activated imaging probes. Solid‐state X‐ray structures for CeL1 and YbL…
View article: CCDC 2291722: Experimental Crystal Structure Determination
CCDC 2291722: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2291723: Experimental Crystal Structure Determination
CCDC 2291723: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2291721: Experimental Crystal Structure Determination
CCDC 2291721: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Gd<sup>3+</sup> Complexes for MRI Detection of Zn<sup>2+</sup> in the Presence of Human Serum Albumin: Structure–Activity Relationships
Gd<sup>3+</sup> Complexes for MRI Detection of Zn<sup>2+</sup> in the Presence of Human Serum Albumin: Structure–Activity Relationships Open
Zn2+-responsive magnetic resonance imaging (MRI) contrast agents are typically composed of a Gd chelate conjugated to a Zn2+-binding moiety via a linker. They allow for Zn2+ detection in the presence of hum…
View article: CCDC 2256758: Experimental Crystal Structure Determination
CCDC 2256758: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2218897: Experimental Crystal Structure Determination
CCDC 2218897: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2218896: Experimental Crystal Structure Determination
CCDC 2218896: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193088: Experimental Crystal Structure Determination
CCDC 2193088: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193095: Experimental Crystal Structure Determination
CCDC 2193095: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193093: Experimental Crystal Structure Determination
CCDC 2193093: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2193094: Experimental Crystal Structure Determination
CCDC 2193094: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis and characterization of two piperazine containing macrocycles and their transition metal complexes
Synthesis and characterization of two piperazine containing macrocycles and their transition metal complexes Open
View article: Improving the potential of paraCEST through magnetic-coupling induced line sharpening
Improving the potential of paraCEST through magnetic-coupling induced line sharpening Open
A paramagnetic chemical exchange saturation transfer (paraCEST) imaging agent based on a homodinuclear Ni( ii ) complex exhibits enhanced CEST efficiency due to magnetic-coupling induced line sharpening effect.
View article: Synthesis, Physicochemical, Labeling and In Vivo Characterization of 44Sc-Labeled DO3AM-NI as a Hypoxia-Sensitive PET Probe
Synthesis, Physicochemical, Labeling and In Vivo Characterization of 44Sc-Labeled DO3AM-NI as a Hypoxia-Sensitive PET Probe Open
Hypoxia promotes angiogenesis, which is crucial for tumor growth, and induces malignant progression and increases the therapeutic resistance. Positron emission tomography (PET) enables the detection of the hypoxic regions in tumors using 2…
View article: Rigidified Derivative of the Non-macrocyclic Ligand H<sub>4</sub>OCTAPA for Stable Lanthanide(III) Complexation
Rigidified Derivative of the Non-macrocyclic Ligand H<sub>4</sub>OCTAPA for Stable Lanthanide(III) Complexation Open
The stability constants of lanthanide complexes with the potentially octadentate ligand CHXOCTAPA4-, which contains a rigid 1,2-diaminocyclohexane scaffold functionalized with two acetate and two picolinate pendant arms, …
View article: CCDC 2108175: Experimental Crystal Structure Determination
CCDC 2108175: Experimental Crystal Structure Determination Open
View article: CCDC 2108178: Experimental Crystal Structure Determination
CCDC 2108178: Experimental Crystal Structure Determination Open
View article: A New Oxygen Containing Pyclen-Type Ligand as a Manganese(II) Binder for MRI and 52Mn PET Applications: Equilibrium, Kinetic, Relaxometric, Structural and Radiochemical Studies
A New Oxygen Containing Pyclen-Type Ligand as a Manganese(II) Binder for MRI and 52Mn PET Applications: Equilibrium, Kinetic, Relaxometric, Structural and Radiochemical Studies Open
A new pyclen-3,9-diacetate derivative ligand (H23,9-OPC2A) was synthesized possessing an etheric O-atom opposite to the pyridine ring, to improve the dissociation kinetics of its Mn(II) complex (pyclen = 3,6,9,15-tetraazabicyclo(9.3.1)pent…
View article: CCDC 2108177: Experimental Crystal Structure Determination
CCDC 2108177: Experimental Crystal Structure Determination Open
View article: CCDC 2108176: Experimental Crystal Structure Determination
CCDC 2108176: Experimental Crystal Structure Determination Open
View article: How the Chemical Properties of GBCAs Influence Their Safety Profiles In Vivo
How the Chemical Properties of GBCAs Influence Their Safety Profiles In Vivo Open
The extracellular class of gadolinium-based contrast agents (GBCAs) is an essential tool for clinical diagnosis and disease management. In order to better understand the issues associated with GBCA administration and gadolinium retention a…
View article: Stable and inert macrocyclic cobalt(<scp>ii</scp>) and nickel(<scp>ii</scp>) complexes with paraCEST response
Stable and inert macrocyclic cobalt(<span>ii</span>) and nickel(<span>ii</span>) complexes with paraCEST response Open
Saturation of the paramagnetically shifted amide 1 H NMR signals of Co( ii ) and Ni( ii ) macrocyclic pyclen derivatives provides an efficient pathway for the saturation of bulk water.