Alon Friedman
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View article: Paroxysmal slow wave events as a diagnostic biomarker for epilepsy: Lessons from rural Zambia
Paroxysmal slow wave events as a diagnostic biomarker for epilepsy: Lessons from rural Zambia Open
Objective Epilepsy affects more than 50 million people globally, with low‐ and middle‐income countries (LMICs) bearing the greatest burden due to limited medical resources and stigma. Electroencephalography (EEG) is a cost‐effective diagno…
View article: Transcranial Magnetic Stimulation Enhances the Therapeutic Effect of IGF-Trap in Intracerebral Glioma Models
Transcranial Magnetic Stimulation Enhances the Therapeutic Effect of IGF-Trap in Intracerebral Glioma Models Open
Background: Glioblastoma multiforme is an aggressive malignancy with a dismal 5-year survival rate of 5–10%. Current therapeutic options are limited, due in part to drug exclusion by the blood–brain barrier (BBB). We have previously shown …
View article: Imaging blood–brain barrier dysfunction in drug‐resistant epilepsy: A multi‐center feasibility study
Imaging blood–brain barrier dysfunction in drug‐resistant epilepsy: A multi‐center feasibility study Open
Objective Blood–brain barrier dysfunction (BBBD) has been linked to various neurological disorders, including epilepsy. This study aims to utilize dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) to identify and compare brain…
View article: Amygdala self-neuromodulation capacity as a window for process-related network recruitment
Amygdala self-neuromodulation capacity as a window for process-related network recruitment Open
Neurofeedback (NF) has emerged as a promising avenue for demonstrating process-related neuroplasticity, enabling self-regulation of brain function. NF targeting the amygdala has drawn attention to therapeutic potential in psychiatry, by po…
View article: Paroxysmal Slow Wave Events as a diagnostic and predictive biomarker for post-traumatic epilepsy
Paroxysmal Slow Wave Events as a diagnostic and predictive biomarker for post-traumatic epilepsy Open
Traumatic brain injury (TBI) is a major global health concern, affecting more than 40 million people annually. While most cases are mild and present with light symptoms, repeated mild injuries can result in delayed brain pathologies, inclu…
View article: Using Textual Analysis to Examine Student Engagement in Online Undergraduate Science Education
Using Textual Analysis to Examine Student Engagement in Online Undergraduate Science Education Open
This study investigates the relationship between student engagement and peer review performance in an online data science course. Employing a mixed-methods approach, we analyzed quantitative data on peer review metrics (word count, sentime…
View article: Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial
Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic resonance imaging randomized controlled trial Open
Glycemic control contributes to the neuroprotective effects of the MED and green-MED diets on brain age. Polyphenols-rich diet components as Mankai and green tea may contribute to a more youthful brain age. This trial was registered at cli…
View article: Cortical plasticity is associated with blood–brain barrier modulation
Cortical plasticity is associated with blood–brain barrier modulation Open
Brain microvessels possess the unique properties of a blood–brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…
View article: Author response: Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Author response: Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open
Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…
View article: Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open
Summary Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the as…
View article: Amygdala Self-Neuromodulation Capacity as a Window for Process-Related Network Recruitment
Amygdala Self-Neuromodulation Capacity as a Window for Process-Related Network Recruitment Open
Neurofeedback (NF) has emerged as a promising avenue for demonstrating process-related neuroplasticity, enabling self-regulation of brain function. NF targeting the amygdala has drawn attention for therapeutic potential in psychiatry, by p…
View article: Blood‐brain barrier dysfunction and decreased transcription of tight junction proteins in epileptic dogs
Blood‐brain barrier dysfunction and decreased transcription of tight junction proteins in epileptic dogs Open
Background Epilepsy in dogs and humans is associated with blood‐brain barrier (BBB) dysfunction (BBBD), which may involve dysfunction of tight junction (TJ) proteins, matrix metalloproteases, and astrocytes. Imaging techniques to assess BB…
View article: Enhancing Student Feedback Using Predictive Models in Visual Literacy Courses
Enhancing Student Feedback Using Predictive Models in Visual Literacy Courses Open
Peer review is a popular feedback mechanism in higher education that actively engages students and provides researchers with a means to assess student engagement. However, there is little empirical support for the durability of peer review…
View article: 302 Resting state functional connectivity in SLE patients and association with cognitive impairment and blood-brain barrier permeability
302 Resting state functional connectivity in SLE patients and association with cognitive impairment and blood-brain barrier permeability Open
Objective Cognitive impairment (CI) is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. We have previously reported an association between …
View article: Contrast-Induced Encephalopathy and the Blood-Brain Barrier
Contrast-Induced Encephalopathy and the Blood-Brain Barrier Open
Background: Contrast-induced encephalopathy (CIE) is an adverse event associated with diagnostic and therapeutic endovascular procedures. Decades of animal and human research support a mechanistic role for pathological blood-brain barrier …
View article: Evidence for interictal blood–brain barrier dysfunction in people with epilepsy
Evidence for interictal blood–brain barrier dysfunction in people with epilepsy Open
Objective Interictal blood–brain barrier dysfunction in chronic epilepsy has been demonstrated in animal models and pathological specimens. Ictal blood–brain barrier dysfunction has been shown in humans in vivo using an experimental quanti…
View article: Reviewer #3 (Public Review): Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Reviewer #3 (Public Review): Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open
Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…
View article: Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open
Summary Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the as…
View article: Reviewer #1 (Public Review): Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Reviewer #1 (Public Review): Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open
Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…
View article: Reviewer #2 (Public Review): Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Reviewer #2 (Public Review): Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open
Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…
View article: Author Response: Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Author Response: Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open
Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…
View article: Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance
Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance Open
Paroxysmal patterns of slow cortical activity have been detected in EEG recordings from individuals with age-related neuropathology and have been shown to be correlated with cognitive dysfunction and blood-brain barrier disruption in these…
View article: Mechanisms of blood-retinal barrier disruption related to intraocular inflammation and malignancy
Mechanisms of blood-retinal barrier disruption related to intraocular inflammation and malignancy Open
Blood-retinal barrier (BRB) disruption is a common accompaniment of intermediate, posterior and panuveitis causing leakage into the retina and macular oedema resulting in vision loss. It is much less common in anterior uveitis or in patien…
View article: Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury
Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury Open
Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on electrically triggered CSDs in healthy and brain-injured anima…
View article: Cortical Plasticity is associated with Blood-Brain-Barrier Modulation
Cortical Plasticity is associated with Blood-Brain-Barrier Modulation Open
Summary Brain microvessels possess the unique properties of a blood-brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the as…
View article: Cortical plasticity is associated with blood–brain barrier modulation
Cortical plasticity is associated with blood–brain barrier modulation Open
Brain microvessels possess the unique properties of a blood–brain barrier (BBB), tightly regulating the passage of molecules from the blood to the brain neuropil and vice versa. In models of brain injury, BBB dysfunction and the associated…