Houssein H. Ayoub
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View article: Global Estimates of COVID‐19 Morbidity and Mortality: A Cohort Study and Mathematical Model Analysis
Global Estimates of COVID‐19 Morbidity and Mortality: A Cohort Study and Mathematical Model Analysis Open
Background The true extent of the severity and fatality caused by the COVID‐19 pandemic remains uncertain. This study provides an approximate estimate of the global disease burden from the pandemic. Methods A cohort study followed the Qata…
View article: Estimating SARS-CoV-2 infection incidence and detection rates: Demonstrating a novel surveillance method
Estimating SARS-CoV-2 infection incidence and detection rates: Demonstrating a novel surveillance method Open
Leveraging readily available testing data, the introduced method was validated in a real-world setting and has the potential for diverse applications to enhance infectious disease surveillance for both emerging and endemic infections.
View article: Diagnostic Challenges in HSV-2 Serology: Comparative Performance of ELISA and Western Blot Assays and the Need for Confirmatory Testing
Diagnostic Challenges in HSV-2 Serology: Comparative Performance of ELISA and Western Blot Assays and the Need for Confirmatory Testing Open
Background Herpes simplex virus type 2 (HSV-2) is a highly prevalent sexually transmitted infection, underscoring the importance of accurate serodiagnosis. While enzyme-linked immunosorbent assays (ELISAs) are commonly used clinically, the…
View article: Effectiveness and durability of a fourth dose of ancestral-strain mRNA vaccines against SARS-CoV-2 infection: a nationwide matched cohort study in Qatar
Effectiveness and durability of a fourth dose of ancestral-strain mRNA vaccines against SARS-CoV-2 infection: a nationwide matched cohort study in Qatar Open
Concerns about waning immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the emergence of new variants underscore the need for booster doses. Using a matched cohort design, this study evaluated the …
View article: Quantifying population-level sexual risk behavior through HSV-2 transmission dynamics in the United States, 1950–2020
Quantifying population-level sexual risk behavior through HSV-2 transmission dynamics in the United States, 1950–2020 Open
The risk of acquiring a sexually transmitted infection, such as herpes simplex virus type 2 (HSV-2), is shaped by sexual risk behavior-an aggregate measure influenced not only by an individual's sexual behavior but also by the broader sexu…
View article: Evaluating the cost-effectiveness of COVID-19 mRNA primary-series vaccination in Qatar: An integrated epidemiological and economic analysis
Evaluating the cost-effectiveness of COVID-19 mRNA primary-series vaccination in Qatar: An integrated epidemiological and economic analysis Open
Qatar implemented a mass primary-series vaccination campaign to mitigate the impact of the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to retrospectively evaluate the cost-effectiveness of this program both before and af…
View article: Effectiveness of ChAdOx1 nCoV-19 (Vaxzevria) primary series vaccine against SARS-CoV-2 beta and delta variants: a nationwide study
Effectiveness of ChAdOx1 nCoV-19 (Vaxzevria) primary series vaccine against SARS-CoV-2 beta and delta variants: a nationwide study Open
Background This study assessed the real-world effectiveness of the ChAdOx1 nCoV-19 vaccine in adults against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, symptomatic infection, and severe coronavirus disease 2019…
View article: Comparative effectiveness of one versus two doses of COVID-19 vaccines in Qatar: Evidence of converging protection over time
Comparative effectiveness of one versus two doses of COVID-19 vaccines in Qatar: Evidence of converging protection over time Open
A single COVID-19 vaccine dose provides rapid, strong protection against severe outcomes, supporting first-dose prioritization during supply constraints. The slower development of protection against infection highlights the second dose's r…
View article: Immune histories and natural infection protection during the omicron era
Immune histories and natural infection protection during the omicron era Open
View article: Poster #43 - Seroprevalence of Hepatitis E Virus (HEV) among craft and manual workers in Qatar (2020–2021)
Poster #43 - Seroprevalence of Hepatitis E Virus (HEV) among craft and manual workers in Qatar (2020–2021) Open
View article: Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar
Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar Open
Background: This study investigated the presence of the healthy vaccinee effect—the imbalance in health status between vaccinated and unvaccinated individuals—in two rigorously conducted COVID-19 vaccine effectiveness studies involving pri…
View article: Age-Dependent Assortativeness in Herpes Simplex Virus Type 1 Oral Transmission in the United States: A Mathematical Modeling Analysis
Age-Dependent Assortativeness in Herpes Simplex Virus Type 1 Oral Transmission in the United States: A Mathematical Modeling Analysis Open
Background Herpes simplex virus type 1 (HSV-1) is a highly infectious, globally prevalent lifelong infection. Despite advancements in understanding its epidemiology, the assortativeness in the age-dependent transmission patterns remains un…
View article: Author response: Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar
Author response: Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar Open
View article: Evaluating chemiluminescent immunoassays for syphilis detection: A comparative analysis
Evaluating chemiluminescent immunoassays for syphilis detection: A comparative analysis Open
This study highlights the high diagnostic accuracy of the Mindray-TP assay, positioning it as a reliable and efficient tool for syphilis screening in high-volume laboratories. Given its operational efficiency and strong agreement with gold…
View article: Protection conferred by SARS-CoV-2 infection across a spectrum of reinfection symptoms and severities
Protection conferred by SARS-CoV-2 infection across a spectrum of reinfection symptoms and severities Open
Background SARS-CoV-2 infection is associated with protection against reinfection. This study analysed this protection across different reinfection symptoms and severities, comparing the preomicron and omicron eras. Methods A nationwide, m…
View article: Evaluating Hospital Admission Data as Indicators of COVID-19 Severity: A National Assessment in Qatar
Evaluating Hospital Admission Data as Indicators of COVID-19 Severity: A National Assessment in Qatar Open
Background Accurately assessing SARS-CoV-2 infection severity is essential for understanding the health impact of the infection and evaluating the effectiveness of interventions. This study investigated whether SARS-CoV-2–associated hospit…
View article: Differential protection against SARS-CoV-2 reinfection pre- and post-Omicron
Differential protection against SARS-CoV-2 reinfection pre- and post-Omicron Open
View article: P-1948. Differential Patterns of Protection from Natural Infection against SARS-CoV-2 Reinfection in the Pre-Omicron and Omicron Eras
P-1948. Differential Patterns of Protection from Natural Infection against SARS-CoV-2 Reinfection in the Pre-Omicron and Omicron Eras Open
Background SARS-CoV-2 infection protection against reinfection can be compromised by emergence of immune-evasive variants. Methods A national, matched, test-negative, case-control study was conducted on Qatar's population between February …
View article: Hepatitis C virus transmission among people who inject drugs in the Middle East and North Africa: mathematical modeling analyses of incidence and intervention impact
Hepatitis C virus transmission among people who inject drugs in the Middle East and North Africa: mathematical modeling analyses of incidence and intervention impact Open
This publication was made possible by NPRP grant number 12S-0216-190,094 from the Qatar National Research Fund (a member of Qatar Foundation). The authors alone are responsible for the views expressed in this publication and they do not ne…
View article: Epidemiologic research on childhood obesity and cardiovascular risk factors
Epidemiologic research on childhood obesity and cardiovascular risk factors Open
Childhood obesity has emerged as one of the most sizeable public health challenges of the 21st century, with far-achieving implications for cardiovascular health. This complete evaluation explores the epidemiological patterns, threat eleme…
View article: Evaluation of the mindray CL900i CLIA HIV Ag/Ab combo assay for sensitive and specific HIV screening compared to established methods
Evaluation of the mindray CL900i CLIA HIV Ag/Ab combo assay for sensitive and specific HIV screening compared to established methods Open
Architect-HIV Ag/Ab combo chemiluminescence assay is globally recognized for its sensitivity but has a notable false-positive rate. In this study, we aim to evaluate the performance of a new cost-effective screening alternative, the chemil…
View article: Prevalence of syphilis infection among migrant workers in Qatar: a nationwide cross-sectional survey
Prevalence of syphilis infection among migrant workers in Qatar: a nationwide cross-sectional survey Open
Objectives Scant data are available on syphilis infection within migrant populations worldwide and in the population of the Middle East and North Africa region. This study investigated the prevalence of both lifetime and recent syphilis in…
View article: BNT162b2 Versus mRNA‐1273 Vaccines: Comparative Analysis of Long‐Term Protection Against SARS‐CoV‐2 Infection and Severe COVID‐19 in Qatar
BNT162b2 Versus mRNA‐1273 Vaccines: Comparative Analysis of Long‐Term Protection Against SARS‐CoV‐2 Infection and Severe COVID‐19 in Qatar Open
Background This study provides a head‐to‐head comparison of the protection provided by the BNT162b2 and mRNA‐1273 vaccines against SARS‐CoV‐2 infection and against severe COVID‐19, covering primary series and third dose/booster vaccination…
View article: Dynamics of Neisseria gonorrhoeae transmission among female sex workers and clients: A mathematical modeling study
Dynamics of Neisseria gonorrhoeae transmission among female sex workers and clients: A mathematical modeling study Open
NG epidemiology in HSWNs is typically a "fragile epidemiology" that is responsive to a range of interventions even if the interventions are incremental, partially efficacious, and only applied to FSWs.
View article: Assessing Healthy Vaccinee Effect in COVID-19 Vaccine Effectiveness Studies: A National Cohort Study in Qatar
Assessing Healthy Vaccinee Effect in COVID-19 Vaccine Effectiveness Studies: A National Cohort Study in Qatar Open
Background This study investigated the presence of the healthy vaccinee effect—the imbalance in health status between vaccinated and unvaccinated individuals—in two COVID-19 vaccine effectiveness studies involving primary series and booste…
View article: Comparative analysis and evolution of civilian versus combatant mortality ratios in Israel-Gaza conflicts, 2008–2023
Comparative analysis and evolution of civilian versus combatant mortality ratios in Israel-Gaza conflicts, 2008–2023 Open
Background There is a need for statistical methodologies that scrutinize civilian casualties in conflicts, evaluating the degree to which the conduct of war affects civilians and breaches the laws of war. Employing an epidemiological metho…
View article: Mindray CL900i CLIA HIV Ag/Ab Combo assay: a reliable solution for highly sensitive and specific HIV screening
Mindray CL900i CLIA HIV Ag/Ab Combo assay: a reliable solution for highly sensitive and specific HIV screening Open
Background: Architect-HIV Ag/Ab combo chemiluminescence assay is globally recognized for its sensitivity but has a notable false-positive rate. Aim:To evaluate the performance of a new cost-effective screening alternative, the chemilumines…
View article: Prevalence of hepatitis B and C viruses among migrant workers in Qatar
Prevalence of hepatitis B and C viruses among migrant workers in Qatar Open
View article: Effectiveness of two and three doses of COVID-19 mRNA vaccines against infection, symptoms, and severity in the pre-omicron era: A time-dependent gradient
Effectiveness of two and three doses of COVID-19 mRNA vaccines against infection, symptoms, and severity in the pre-omicron era: A time-dependent gradient Open
View article: Protection of natural infection against reinfection with SARS-CoV-2 JN.1 variant
Protection of natural infection against reinfection with SARS-CoV-2 JN.1 variant Open
Overall effectiveness of infection in preventing reinfection with SARS-CoV-2 JN.1 variant was estimated at 1.8% (95% CI: −9.3to 12.6%), and demonstrated rapid decline over time since the previous infection, decreasing from 82.4% (95% CI: 4…