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View article: Myeloid specific PD-L1 deletion promotes cardiac dysfunction and myocardial inflammation 2162
Myeloid specific PD-L1 deletion promotes cardiac dysfunction and myocardial inflammation 2162 Open
Description PD-L1 inhibitors are effective in cancer treatment but can cause fatal heart issues. Despite the significant impact of these adverse events, there is limited research underlying mechanisms of immune checkpoint inhibitor-mediate…
View article: CXCR3 promotes development of heart failure following severe pneumococcal disease 2625
CXCR3 promotes development of heart failure following severe pneumococcal disease 2625 Open
Description Severe infection with Streptococcus pneumoniae (Spn), the leading cause of community-acquired pneumonia (CAP), is a significant long-term risk factor for major adverse cardiac events (MACE) such as heart failure (HF). Pulmonary…
View article: S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease
S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease Open
Streptococcus pneumoniae ( Spn ) is the leading cause of community-acquired pneumonia (CAP). A quarter of hospitalized patients with CAP experience a major adverse cardiac event (MACE), raising their mortality by four to five times compare…
View article: Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan
Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan Open
Our study demonstrates that Elmsan1, a unique component of the mitotic deacetylase complex (MiDAC), is essential for maintaining cardiac function. Loss of Elmsan1 in cardiomyocytes leads to age-related cardiac dysfunction and mitochondrial…
View article: Hypertrophic heart failure promotes gut dysbiosis and gut leakage in interleukin 10-deficient mice
Hypertrophic heart failure promotes gut dysbiosis and gut leakage in interleukin 10-deficient mice Open
IL-10, crucial for systemic inflammation regulation and gut mucosal homeostasis, was investigated using IL-10 knockout (KO) mice. Exacerbated gut inflammation was observed post-transverse aortic constriction (TAC) in IL-10-depleted mice, w…
View article: Animal models of haploinsufficiency revealed the isoform-specific role of GSK-3 in HFD-induced obesity and glucose intolerance
Animal models of haploinsufficiency revealed the isoform-specific role of GSK-3 in HFD-induced obesity and glucose intolerance Open
The precise isoform-specific role of GSK-3 in obesity-induced glucose intolerance is unclear. To overcome the limitations of pharmacological GSK-3 inhibitors (not isoform-specific) and tissue-specific genetic models, in the present study, …
View article: Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress
Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress Open
Cardiac fibrosis can be mitigated by limiting fibroblast-to-myofibroblast differentiation and proliferation. Human antigen R (HuR) modulates messenger RNA stability and expression of multiple genes. However, the direct role of cardiac myof…
View article: Bone marrow‐fibroblast progenitor cell‐derived small extracellular vesicles promote cardiac fibrosis via miR‐21‐5p and integrin subunit αV signalling
Bone marrow‐fibroblast progenitor cell‐derived small extracellular vesicles promote cardiac fibrosis via miR‐21‐5p and integrin subunit αV signalling Open
Cardiac fibrosis is the hallmark of cardiovascular disease (CVD), which is leading cause of death worldwide. Previously, we have shown that interleukin‐10 (IL10) reduces pressure overload (PO)‐induced cardiac fibrosis by inhibiting the rec…
View article: Circadian Rhythms in Cardiovascular Metabolism
Circadian Rhythms in Cardiovascular Metabolism Open
Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations in numerous cardiovascular functional parameters…
View article: Sustained Increases in Cardiomyocyte Protein <i>O</i> ‐Linked β‐N‐Acetylglucosamine Levels Lead to Cardiac Hypertrophy and Reduced Mitochondrial Function Without Systolic Contractile Impairment
Sustained Increases in Cardiomyocyte Protein <i>O</i> ‐Linked β‐N‐Acetylglucosamine Levels Lead to Cardiac Hypertrophy and Reduced Mitochondrial Function Without Systolic Contractile Impairment Open
Background Lifestyle and metabolic diseases influence the severity and pathogenesis of cardiovascular disease through numerous mechanisms, including regulation via posttranslational modifications. A specific posttranslational modification,…
View article: Cardiac fibroblast GSK-3α aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis
Cardiac fibroblast GSK-3α aggravates ischemic cardiac injury by promoting fibrosis, inflammation, and impairing angiogenesis Open
View article: GSK-3 at the heart of cardiometabolic diseases: Isoform-specific targeting is critical to therapeutic benefit
GSK-3 at the heart of cardiometabolic diseases: Isoform-specific targeting is critical to therapeutic benefit Open
View article: Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation
Ponatinib Drives Cardiotoxicity by S100A8/A9-NLRP3-IL-1β Mediated Inflammation Open
Background: The tyrosine kinase inhibitor ponatinib is the only treatment option for chronic myelogenous leukemia patients with T315I (gatekeeper) mutation. Pharmacovigilance analysis of Food and Drug Administration and World Health Organi…
View article: Metabolic labeling of cardiomyocyte‐derived small extracellular‐vesicle (sEV) miRNAs identifies miR‐208a in cardiac regulation of lung gene expression
Metabolic labeling of cardiomyocyte‐derived small extracellular‐vesicle (sEV) miRNAs identifies miR‐208a in cardiac regulation of lung gene expression Open
Toxoplasma gondii uracil phosphoribosyltransferase (UPRT) converts 4‐thiouracil (4TUc) into 4‐thiouridine (4TUd), which is incorporated into nascent RNAs and can be biotinylated, then labelled with streptavidin conjugates or isolated via s…
View article: Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart
Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart Open
Background: Heart failure is the leading cause of mortality, morbidity, and health care expenditures worldwide. Numerous studies have implicated GSK-3 (glycogen synthase kinase-3) as a promising therapeutic target for cardiovascular diseas…
View article: Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose Intolerance
Isoform-Specific Role of GSK-3 in High Fat Diet Induced Obesity and Glucose Intolerance Open
Obesity-associated metabolic disorders are rising to pandemic proportions; hence, there is an urgent need to identify underlying molecular mechanisms. Glycogen synthase kinase-3 (GSK-3) signaling is highly implicated in metabolic diseases.…
View article: Mechanisms of Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models
Mechanisms of Fibroblast Activation and Myocardial Fibrosis: Lessons Learned from FB-Specific Conditional Mouse Models Open
Heart failure (HF) is a leading cause of morbidity and mortality across the world. Cardiac fibrosis is associated with HF progression. Fibrosis is characterized by the excessive accumulation of extracellular matrix components. This is a ph…
View article: Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling
Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling Open
Aims The cardiac natriuretic peptides [atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP)] are important regulators of cardiovascular physiology, with reduced natriuretic peptide (NP) activity linked to multiple human ca…
View article: Repurposing Nintedanib for pathological cardiac remodeling and dysfunction
Repurposing Nintedanib for pathological cardiac remodeling and dysfunction Open
View article: Cardiac fibroblast GSK-3α mediates adverse myocardial fibrosis via IL-11 and ERK pathway
Cardiac fibroblast GSK-3α mediates adverse myocardial fibrosis via IL-11 and ERK pathway Open
Background Heart failure is the leading cause of mortality, morbidity, and healthcare expenditures worldwide. Numerous studies have implicated Glycogen Synthase Kinase-3 (GSK-3) as a promising therapeutic target for cardiovascular diseases…
View article: Targeting 5-HT <sub>2B</sub> Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling After Myocardial Infarction
Targeting 5-HT <sub>2B</sub> Receptor Signaling Prevents Border Zone Expansion and Improves Microstructural Remodeling After Myocardial Infarction Open
Background: Myocardial infarction (MI) induces an intense injury response that ultimately generates a collagen-dominated scar. Although required to prevent ventricular rupture, the fibrotic process is often sustained in a manner detrimenta…
View article: Repurposing Nintedanib for Pathological Cardiac Remodeling and Dysfunction
Repurposing Nintedanib for Pathological Cardiac Remodeling and Dysfunction Open
Background Heart Failure (HF) is the leading cause of death worldwide. Myocardial fibrosis, one of the clinical manifestations implicated in almost every form of heart disease, contributes significantly to HF development. However, there is…
View article: Tom Force (1951–2020)
Tom Force (1951–2020) Open
View article: The BDNF rs6265 Polymorphism is a Modifier of Cardiomyocyte Contractility and Dilated Cardiomyopathy
The BDNF rs6265 Polymorphism is a Modifier of Cardiomyocyte Contractility and Dilated Cardiomyopathy Open
Brain-derived neurotrophic factor (BDNF) is a neuronal growth and survival factor that harbors cardioprotective qualities that may attenuate dilated cardiomyopathy. In ~30% of the population, BDNF has a common, nonsynonymous single nucleot…
View article: A Pharmacovigilance Study of Hydroxychloroquine Cardiac Safety Profile: Potential Implication in COVID-19 Mitigation
A Pharmacovigilance Study of Hydroxychloroquine Cardiac Safety Profile: Potential Implication in COVID-19 Mitigation Open
In light of the favorable outcomes of few small, non-randomized clinical studies, the Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) to Hydroxychloroquine (HCQ) for hospitalized coronavirus disease 2019 …
View article: Cardiotoxicity of the BCR-ABL1 tyrosine kinase inhibitors: Emphasis on ponatinib
Cardiotoxicity of the BCR-ABL1 tyrosine kinase inhibitors: Emphasis on ponatinib Open
View article: Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity
Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity Open
Obesity is an independent risk factor for cardiovascular diseases (CVD), including heart failure. Thus, there is an urgent need to understand the molecular mechanism of obesity-associated cardiac dysfunction. We recently reported the criti…
View article: Mouse Models of Heart Failure with Preserved or Reduced Ejection Fraction
Mouse Models of Heart Failure with Preserved or Reduced Ejection Fraction Open
View article: Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction
Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction Open
Background: Myocardial infarction (MI) triggers myelopoiesis, resulting in heightened production of neutrophils. However, the mechanisms that sustain their production and recruitment to the injured heart are unclear. Methods: Using a mouse…
View article: Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase Signaling
Cardiomyocyte Homeodomain-Interacting Protein Kinase 2 Maintains Basal Cardiac Function via Extracellular Signal-Regulated Kinase Signaling Open
Background: Cardiac kinases play a critical role in the development of heart failure, and represent potential tractable therapeutic targets. However, only a very small fraction of the cardiac kinome has been investigated. To identify novel…