Benoit H. Mulsant
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View article: Multiscale dispersion entropy of resting-state EEG in older adults with Alzheimer's disease, mild cognitive impairment, and remitted major depressive disorder
Multiscale dispersion entropy of resting-state EEG in older adults with Alzheimer's disease, mild cognitive impairment, and remitted major depressive disorder Open
Background Multiscale dispersion entropy (MDEnt) is a nonlinear EEG measure that quantifies brain complexity across time scales, reflecting both local and global brain dynamics. Previous research indicates lower complexity at short time sc…
View article: Trajectories of Cognitive Decline over 24 months in Older Adults with Treatment‐Resistant Late‐life Depression at risk for Dementia
Trajectories of Cognitive Decline over 24 months in Older Adults with Treatment‐Resistant Late‐life Depression at risk for Dementia Open
Background Individuals with Late‐life depression (LLD) are at elevated dementia‐risk and those with treatment‐resistant LLD (TRLLD), defined by failing at least two treatment regimens, may be at especially high dementia‐risk. We examined h…
View article: Assessing hyperexcitability in the context of cortical gray matter structures and white matter integrity in the dorsolateral prefrontal cortex and motor cortex of Alzheimer’s dementia patients
Assessing hyperexcitability in the context of cortical gray matter structures and white matter integrity in the dorsolateral prefrontal cortex and motor cortex of Alzheimer’s dementia patients Open
Background Abnormal cortical excitability is a marker of neurodegeneration in Alzheimer’s dementia (AD). However, the link between cortical excitability and structural changes in AD is not well understood. The objective of this study is to…
View article: Assessing hyperexcitability in the context of cortical gray matter structures and white matter integrity in the dorsolateral prefrontal cortex and motor cortex of Alzheimer's dementia patients
Assessing hyperexcitability in the context of cortical gray matter structures and white matter integrity in the dorsolateral prefrontal cortex and motor cortex of Alzheimer's dementia patients Open
Background Abnormal cortical excitability is a marker of neurodegeneration in Alzheimer's dementia (AD). However, the link between cortical excitability and structural changes in AD is not well understood. The objective of this study is to…
View article: Fall Risk and Psychotropic and General Medication Use in Dementia with Neuropsychiatric Symptoms
Fall Risk and Psychotropic and General Medication Use in Dementia with Neuropsychiatric Symptoms Open
Background Polypharmacy is common in older individuals with Alzheimer's disease and related dementia (ADRD) who present with neuropsychiatric symptoms (NPS). While it is associated with increased fall risk, specific impact of psychotropic …
View article: Executive Function Among Older Adults With Bipolar Disorder: A GAGE-BD Analysis
Executive Function Among Older Adults With Bipolar Disorder: A GAGE-BD Analysis Open
Executive dysfunction is a prominent feature of OABD, associated with several demographic and clinical characteristics. Future longitudinal studies of executive function and OABD need to assess the individual impact of impairment in execut…
View article: Trajectories of response to bilateral rTMS in late-life depression
Trajectories of response to bilateral rTMS in late-life depression Open
gov identifier NCT02998580.
View article: Sex Differences in Phenomenology of Behavioral and Psychological Symptoms of Dementia
Sex Differences in Phenomenology of Behavioral and Psychological Symptoms of Dementia Open
Introduction: Behavioral and psychological symptoms in dementia (BPSD) are highly prevalent in patients with Alzheimer’s dementia (AD). We examined sex differences in the frequency and severity of BPSD in patients with AD living in long-te…
View article: Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial
Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial Open
The US National Institute of Mental Health and the Patient-Centered Outcomes Research Institute.
View article: Biological markers of treatment response to serotonergic psychedelic therapies: a systematic review
Biological markers of treatment response to serotonergic psychedelic therapies: a systematic review Open
Background: Results from contemporary clinical trials of serotonergic psychedelic therapies have led to an increasing focus on their potential clinical use across mental disorders. However, studies examining mechanisms of clinical response…
View article: Effects of Comorbid Anxiety on Treatment Outcomes After Accelerated Theta Burst Stimulation for Late-Life Depression
Effects of Comorbid Anxiety on Treatment Outcomes After Accelerated Theta Burst Stimulation for Late-Life Depression Open
Comorbid anxiety symptoms may reduce the effectiveness of accelerated TBS for treating depressive symptoms in older adults.
View article: Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d’anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d’un échantillon mondial provenant du projet GAGE-BD
Anticonvulsant Use in Older Age Bipolar Disorder in a Global Sample from the Global Aging and Geriatric Experiments in Bipolar Disorder Project: Utilisation d’anticonvulsivants pour le traitement des troubles bipolaires du sujet âgé auprès d’un échantillon mondial provenant du projet GAGE-BD Open
Background Anticonvulsants are an essential treatment for bipolar disorder; however, there is relatively little known about their use in older age bipolar disorder (OABD). In this paper, which leverages a large international dataset, we ai…
View article: Improving adherence to physical activity in treatment-resistant depression: Protocol for a pilot randomized controlled trial of a remotely delivered program
Improving adherence to physical activity in treatment-resistant depression: Protocol for a pilot randomized controlled trial of a remotely delivered program Open
Background At least 30% of individuals with major depressive disorder do not respond to conventional treatments (i.e., they meet the criteria for treatment-resistant depression [TRD]). Alternative therapeutic modalities are needed. Some st…
View article: Measurement-Based Care to Enhance Antidepressant Treatment Outcomes in Major Depressive Disorder
Measurement-Based Care to Enhance Antidepressant Treatment Outcomes in Major Depressive Disorder Open
Importance Measurement-based care (MBC) guides clinical decisions through structured monitoring of symptoms and adverse effects. Although MBC has been associated with improved outcomes in major depressive disorder (MDD), its effectiveness …
View article: Effect of psilocybin therapy on suicidal ideation, attempts, and deaths in people with psychiatric diagnoses: a systematic review and meta-analysis
Effect of psilocybin therapy on suicidal ideation, attempts, and deaths in people with psychiatric diagnoses: a systematic review and meta-analysis Open
Background: Suicidal ideation, attempts, and deaths present a major and tragic public health concern. Recent trials of psilocybin therapy (PT) have shown promise in treating treatment-resistant depression and have found a reduction in suic…
View article: Understanding Canadian experiences of suicidality during the COVID-19 pandemic: protocol of a pan-Canadian qualitative study
Understanding Canadian experiences of suicidality during the COVID-19 pandemic: protocol of a pan-Canadian qualitative study Open
Introduction The COVID-19 pandemic led to major disruptions in society across many spheres, including healthcare, the economy and social behaviours. While early predictions warned of an increased risk of suicide during and after the COVID-…
View article: Feasibility, efficacy, and perceptions of an online writing intervention in patients with depressive disorders: A randomized, multi-methods pilot study
Feasibility, efficacy, and perceptions of an online writing intervention in patients with depressive disorders: A randomized, multi-methods pilot study Open
Barriers to accessing treatment for Depressive Disorders highlight a need for scalable interventions. Expressive writing (EW), which involves daily writing about a personal issue, has been shown to alleviate depressive symptoms in various …
View article: Analysis of Demographic and Practice Characteristics of Psychiatrists in Three Canadian Provinces: Analyse des caractéristiques démographiques et de la pratique des psychiatres dans trois provinces canadiennes
Analysis of Demographic and Practice Characteristics of Psychiatrists in Three Canadian Provinces: Analyse des caractéristiques démographiques et de la pratique des psychiatres dans trois provinces canadiennes Open
Objective To describe demographic and practice characteristics of psychiatrists in British Columbia (BC), Manitoba (MB) and Ontario (ON) and explore how practice characteristics change by psychiatrist sex/gender and years since medical sch…
View article: Mapping psilocybin therapy: A systematic review of therapeutic frameworks, adaptations, and standardization across contemporary clinical trials
Mapping psilocybin therapy: A systematic review of therapeutic frameworks, adaptations, and standardization across contemporary clinical trials Open
Accumulating evidence suggests that psilocybin can produce rapid and sustained clinical benefits when administered in conjunction with psychological support. Though non-pharmacological procedures are considered integral, the field lacks th…
View article: The Senescence Associated Secretory Phenotype, a key marker of cellular senescence, is elevated in depression and moderated by sex
The Senescence Associated Secretory Phenotype, a key marker of cellular senescence, is elevated in depression and moderated by sex Open
In older adults, sex plays a significant role in senescence-related changes in depression. A higher senescence burden in males with depression may be an indicator of greater vulnerability to accelerated biological aging and a marker of ele…
View article: Home-based cognitive remediation and transcranial direct current stimulation to enhance cognition in older adults with major depressive disorder or mild cognitive impairment: An open label study
Home-based cognitive remediation and transcranial direct current stimulation to enhance cognition in older adults with major depressive disorder or mild cognitive impairment: An open label study Open
This study demonstrates that home-based CR+tDCS is feasible and safe in patients with MCI or rMDD, and could improve cognition in patients and quality of life in study partners. Randomized controlled trials are needed to confirm these find…
View article: Neuropsychiatric Symptoms Present Differently in Individuals with Different High-Risk States of Dementia
Neuropsychiatric Symptoms Present Differently in Individuals with Different High-Risk States of Dementia Open
Introduction: Neuropsychiatric symptoms (NPS) are common in neurocognitive disorders. However, the differences in presentation of NPS in high-risk states for dementia such as mild neurocognitive disorder (Mild NCD) and remitted major depre…
View article: Moderators of antidepressant augmentation versus switch in the OPTIMUM randomised controlled trial
Moderators of antidepressant augmentation versus switch in the OPTIMUM randomised controlled trial Open
Background Older adults with treatment-resistant depression (TRD) benefit more from treatment augmentation than switching. It is useful to identify moderators that influence these treatment strategies for personalised medicine. Aims Our ob…
View article: Assessing Motor Cortex Excitability and Its Relationship with Cortical Atrophy in Alzheimer’s Dementia
Assessing Motor Cortex Excitability and Its Relationship with Cortical Atrophy in Alzheimer’s Dementia Open
Background: Cortical excitability has been proposed as a novel neurophysiological marker of neurodegeneration in Alzheimer’s dementia (AD). However, the link between cortical excitability and structural changes in AD is not well understood…
View article: A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain
A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain Open
This study suggests potential benefits of SSM for individuals with comorbid CP and depression. Future trials should include larger sample sizes in non-pandemic conditions to better evaluate the effectiveness of SSM. Further research should…
View article: A Longitudinal Study of the Relationship Among Cognition, Mood Symptoms, and Markers of Brain Health in Older Age Bipolar Disorder: Une étude longitudinale de la relation entre la cognition, les symptômes thymiques, et les marqueurs de la santé du cerveau en présence de troubles bipolaires du sujet âgé
A Longitudinal Study of the Relationship Among Cognition, Mood Symptoms, and Markers of Brain Health in Older Age Bipolar Disorder: Une étude longitudinale de la relation entre la cognition, les symptômes thymiques, et les marqueurs de la santé du cerveau en présence de troubles bipolaires du sujet âgé Open
Objectives An emerging literature has assessed cognition or imaging markers of brain health in in older age bipolar disorder (OABD). In this context, we conducted the first longitudinal study (to our knowledge) that assessed the relationsh…
View article: A Digital Dialectical Behaviour Therapy Intervention for Acute Suicidality in Psychiatric Inpatients: A Feasibility Randomised Controlled Study: Intervention numérique en thérapie comportementale dialectique en cas de suicidabilité aiguë de patients hospitalisés en psychiatrie : Étude de faisabilité contrôlée à répartition aléatoire
A Digital Dialectical Behaviour Therapy Intervention for Acute Suicidality in Psychiatric Inpatients: A Feasibility Randomised Controlled Study: Intervention numérique en thérapie comportementale dialectique en cas de suicidabilité aiguë de patients hospitalisés en psychiatrie : Étude de faisabilité contrôlée à répartition aléatoire Open
Objective: To evaluate the feasibility and preliminary efficacy of a digital dialectical behaviour therapy (d-DBT) skills intervention in suicidal psychiatric inpatients. Methods: A parallel arm, assessor-blinded, randomized controlled tri…
View article: Relationship of the revised anticholinergic drug scale with cultured cell‐based serum anticholinergic activity and cognitive measures in older adults with mild cognitive impairment or remitted depression
Relationship of the revised anticholinergic drug scale with cultured cell‐based serum anticholinergic activity and cognitive measures in older adults with mild cognitive impairment or remitted depression Open
Objective The Anticholinergic Drug Scale (ADS) is a commonly used measure of anticholinergic exposure. This study describes an expanded and revised version of the ADS (rADS) and its relationship with cultured cell‐based serum anticholinerg…