Explanipedia

Multimodal learning on RGB-D image for precise litchi phenotyping and weight estimation Open

Mingchao Yang, Rongzhou Chen, Chen Ding, Huicong Wang, Xianghe Wang , et al. · 2025

Plasma Proteomic Characterization of Adolescent Idiopathic Scoliosis Open

Jiacheng Lyu, Tianyuan Zhang, Tao Ji, Zeya Xu, Xiexiang Shao , et al. · 2025

Serum Proteomics Reveals Diagnostic Biomarkers and Molecular Pathways in Cerebral Palsy Open

Yiran Xu, Chi Ma, Shiman He, Lingling Zhang, Jinwen Feng , et al. · 2025

Cerebral palsy (CP), a prevalent non-progressive neurological disorder in children, lacks reliable biomarkers for early diagnosis, and its molecular mechanisms remain poorly understood. In this study, we conducted serum proteomic profiling…

Author Correction: Proteogenomic insights into the biology and treatment of pan-melanoma Open

Rongkui Luo, Bing Yang, Sha Xu, Wen Huang, Shaoshuai Tang , et al. · 2025

Performance and stability of the prototype stereoscopic water Cherenkov detector array experiment Open

Chen Ding, J. Huang, Liuming Zhai, Ying Zhang, Yiming Zou , et al. · 2025

Development of wide-field stereoscopic water Cherenkov detector for 100GeV - 100 TeV energy range at high altitude Open

Chen Ding, J. Huang, L. M. Zhai, Ying Zhang, Yiming Zou , et al. · 2025

Author Correction: Cancer biomarkers discovered using pan-cancer plasma proteomic profiling Open

Lin Bai, Jiacheng Lyu, Jinwen Feng, Xiaoqiang Qiao, Yuanyuan Qu , et al. · 2025

Multi-omics integration of epigenetics, proteomics, and metabolomics identifies putative drug targets and improves early prediction for diabetes Open

Wenran Li, Yingyu Cheng, Aoyuan Cui, Mengyao Huang, Qingxia Huang , et al. · 2025

Diabetes holds significant social importance due to its high incidence rate and the multitude of associated complications. The identification of diabetes biomarkers and the understanding of the intricate biological mechanisms underlying di…

Enhancing chemosensitivity in pancreatic cancer: Novel strategies to overcome therapeutic resistance Open

Wenhao Luo, Menggang Zhang, Hao Chen, Jun Wang, Zhe Cao , et al. · 2025

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and fatal malignancies, with a 5-year survival rate of <15%. Despite significant advancements in targeted therapies and immunotherapy, these approaches benefit only a li…

TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity Open

Yinan Niu, Chen Ding, Quansheng Wang, Jingyi Yin, Lingmeng Li , et al. · 2025

Integrating 7-day D-dimer exposure into deep vein thrombosis risk prediction after gastrointestinal surgery Open

Shuwei Weng, Chen Ding, Die Hu, Likui Huang, Daoquan Peng · 2025

Deep vein thrombosis (DVT) is a serious complication following gastrointestinal surgery. While D-dimer is a widely used biomarker for thrombosis, its postoperative specificity is limited due to inflammatory interference. This study introdu…

Risk Assessment of Precancers and Cancers in Women with Atypical Glandular Cells of Endocervical, Endometrial, and Unknown Origin Open

Chen Ding, Qin Liu, Xin Zhou, Qiuqin Zou, Wanrun Lin , et al. · 2025

Objective: To assess the risk of precancers [high-grade squamous intraepithelial lesions (HSIL), adenocarcinoma in situ (AIS) and atypical endometrial hyperplasia (AEH)] and cancers [squamous cell carcinoma (SCC) and adenocar…

Author Correction: Spatial immune scoring system predicts hepatocellular carcinoma recurrence Open

Gengjie Jia, Peiqi He, Tianli Dai, Denise Goh, Jiabei Wang , et al. · 2025

Lipid droplet clearance inhibits esophageal cancer growth via metabolic reprogramming Open

Pu Yan, Yi Wan, Yuhua Fu, Kai Li, Yijiao Chen , et al. · 2025

Advancing global antifungal development to combat invasive fungal infection Open

Xiuli Wang, Jun Ding, Koon Ho Wong, Chen Ding, Chider Chen , et al. · 2025

Baseline Plasma GPX3 Level Predicts Efficacy of Insulin-Sensitization Drug Chiglitazar in Type 2 Diabetes Open

Zehui Cao, Haonan Chen, Qiaochu Chen, Chen Ding, Leming Shi , et al. · 2025

POS0406 ASSOCIATIONS BETWEEN THE TRIGLYCERIDE-GLUCOSE INDEX AND THE RISKS OF INCIDENT DIABETES AND CARDIOVASCULAR DISEASES IN INDIVIDUALS WITH OSTEOARTHRITIS: A LARGE-SCALE PROSPECTIVE COHORT STUDY Open

Wei Wu, Hua Zhang, Muhui Zeng, Junya Jia, Shiwen Yuan , et al. · 2025

Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment Open

Shiman He, Xuejiao Hu, Jiajun Zhu, Weiteng Wang, Chi Ma , et al. · 2025

Integrated clinical and proteomic-based model for diagnostic and prognostic prediction in pRCC Open

Zeya Xu, Linhui Zhang, J Lyu, Maoping Cai, Tao Ji , et al. · 2025

Panoramic spatial enhanced resolution proteomics (PSERP) reveals tumor architecture and heterogeneity in gliomas Open

Ziyan Xu, Yunzhi Wang, Tao Xie, Rongkui Luo, Hengli Ni , et al. · 2025

The spatial proteomic profiling of complex tissues is essential for investigating cellular function in physiological and pathological states. However, the imbalance among resolution, protein coverage, and expense precludes their systematic…

AI in fungal drug development: opportunities, challenges, and future outlook Open

Yanjian Li, Qiao Yue, Yuanyuan Ma, Peng Xue, Chen Ding · 2025

The application of artificial intelligence (AI) in fungal drug development offers innovative strategies to address the escalating threat of fungal infections and the challenge of antifungal resistance. This review evaluates the current lan…

Enhancing proton kinetics in Bi 2O 2Se nanosheets via polymer coating for high-performance aqueous zinc metal batteries Open

Bin Wang, Peng Chen, Siyuan Wang, Chao Yang, Peng Xie , et al. · 2025

NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming Open

Xiping Wang, Li Wang, Linxi Zhou, Lu Chen, Jiayi Shi , et al. · 2025

Integrative proteogenomic characterization reveals therapeutic targets in poorly differentiated and anaplastic thyroid cancers Open

Zongfu Pan, Zhuo Tan, Ning Xu, Zhenmei Yao, Chuanming Zheng , et al. · 2025

Time‐restricted feeding mitigates Alzheimer's disease‐associated cognitive impairments via a B. pseudolongum‐propionic acid‐FFAR3 axis Open

Yihang Zhao, Mengzhen Jia, Chen Ding, Bin Bao, Hangqi Li , et al. · 2025

Time‐restricted feeding (TRF) holds promise for alleviating cognitive decline in aging, albeit the precise mechanism via the gut‐brain axis remains elusive. In a clinical trial, we observed, for the first time, that a 4‐month TRF ameliorat…

RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus Open

Xiaoyu Ding, Yonggang Zhou, Xiaofeng Qiu, Xiuxiu Xu, Xinyu Hu , et al. · 2025

Region- and Cell-type–Resolved Multiomic Atlas of the Heart Open

Fan Zhang, Yunzhi Wang, Jiajun Zhu, Jinxi Wang, Qiang Li , et al. · 2025

The heart is a vital muscular organ in vertebrate animals, responsible for maintaining blood circulation through rhythmic contraction. Although previous studies have investigated the heart proteome, the full hierarchical molecular network …

[Construction and Validation of A Prognostic Model for Lung Adenocarcinoma  Based on Ferroptosis-related Genes]. Open

Zhanrui Zhang, Wenhao Zhao, Zixuan Hu, Chen Ding, Hua Huang , et al. · 2025

This study successfully established a LUAD risk scoring model composed of 12 ferroptosis-related genes. In the future, this model is expected to be used in conjunction with the tumor-node-metastasis (TNM) staging system for prognostic pred…

Integrated proteogenomic characterization of ampullary adenocarcinoma Open

Qiao Zhang, Xiaomeng Xu, Dongxian Jiang, Yunzhi Wang, Hai Wang , et al. · 2025

Proteogenomic Analysis Identifies Clinically Relevant Subgroups of Collecting Duct Carcinoma Open

Yuanyuan Qu, Xiaoru Pei, Jinwen Feng, Xin Yan, Linhui Zhang , et al. · 2025

Collecting duct carcinoma (CDC) is a rare but aggressive form of renal cell carcinoma (RCC) that has limited understanding and an undefined systemic therapeutic regimen. Herein, we conducted a comprehensive proteogenomic analysis of CDC tu…

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