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View article: Metabolic Heterogeneity in High-Grade Glioma Assessed by Multi-Tracer PET and Ex Vivo Metabolomics: A Systematic Review and Meta-Analysis
Metabolic Heterogeneity in High-Grade Glioma Assessed by Multi-Tracer PET and Ex Vivo Metabolomics: A Systematic Review and Meta-Analysis Open
Background/Objectives: High-grade glioma shows marked metabolic heterogeneity. We performed a PRISMA-guided systematic review and meta-analysis to quantify PET accuracy for pseudoprogression (PsP) and for recurrence/progression versus trea…
View article: Synergistic Effects of Cryotherapy and Radiotherapy in Glioblastoma Treatment: Evidence from a Murine Model
Synergistic Effects of Cryotherapy and Radiotherapy in Glioblastoma Treatment: Evidence from a Murine Model Open
Background/Objectives: Cryotherapy involves the insertion of cryoprobes into tumors to induce cell destruction through exposure to extremely low temperatures over several minutes. This localized treatment modality may enhance the efficacy …
View article: Radiation therapy in functioning and no functioning pituitary neuroendocrine tumor: systematic review of the recent literature after 2011
Radiation therapy in functioning and no functioning pituitary neuroendocrine tumor: systematic review of the recent literature after 2011 Open
Summary Neuroendocrine pituitary tumor, a benign cells proliferation, can cause significant morbidity due to its local invasiveness and secretory properties. Historically, radiotherapy has been employed as a second or third-line treatment …
View article: Fulminant leptomeningeal disease diagnosed as comutant <i>H3F3A</i> and <i>FGFR</i> diffuse midline glioma
Fulminant leptomeningeal disease diagnosed as comutant <i>H3F3A</i> and <i>FGFR</i> diffuse midline glioma Open
Diffuse midline gliomas present a particularly intricate and challenging clinical scenario. This rare case involves a patient with comutant H3F3A and FGFR diffuse midline glioma with a clinical presentation of fulminant leptomeningitis. A …
View article: Minimally Invasive Management of Cervical Spondylodiscitis. A Multicenter Experience
Minimally Invasive Management of Cervical Spondylodiscitis. A Multicenter Experience Open
Background The urgent etiological diagnosis represents the main management objective of cervical spondylodiscitis (CSD) to start as soon as possible antibiotic treatment to prevent neurological deterioration. The present study aimed to eva…
View article: Supplementary Table S3 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Table S3 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Sporadic ependymomas characteristics
View article: Data from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Data from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Purpose:Multiple endocrine neoplasia type 1 (MEN1) is thought to increase the risk of meningioma and ependymoma. Thus, we aimed to describe the frequency, incidence, and specific clinical and histological features of central nervous system…
View article: Supplementary Table S2 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Table S2 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Sporadic non-meningothelial meningiomas characteristics
View article: Supplementary Data S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Data S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Detailed including criteria, Registering process, and Legal aspects
View article: Supplementary Figure S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Figure S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
MEN1 loss of heterozygosity in meningiomas of patients #8, #15 and #16. Electropherogram of Sanger sequencing on tumor DNA showing falsely homozygous MEN1 pathogenic variants due to loss of heterozygosity at a somatic level. Patient #8: c.…
View article: Supplementary Table S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Table S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Sporadic meningothelial meningiomas characteristics
View article: Supplementary Data S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Data S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Detailed including criteria, Registering process, and Legal aspects
View article: Data from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Data from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Purpose:Multiple endocrine neoplasia type 1 (MEN1) is thought to increase the risk of meningioma and ependymoma. Thus, we aimed to describe the frequency, incidence, and specific clinical and histological features of central nervous system…
View article: Supplementary Table S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Table S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Sporadic meningothelial meningiomas characteristics
View article: Supplementary Table S3 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Table S3 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Sporadic ependymomas characteristics
View article: Supplementary Figure S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Figure S1 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
MEN1 loss of heterozygosity in meningiomas of patients #8, #15 and #16. Electropherogram of Sanger sequencing on tumor DNA showing falsely homozygous MEN1 pathogenic variants due to loss of heterozygosity at a somatic level. Patient #8: c.…
View article: Supplementary Table S2 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
Supplementary Table S2 from A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Sporadic non-meningothelial meningiomas characteristics
View article: Central Nervous System Siderosis Associated with Multiple Cerebral Aneurysms: Literature Review and Description of an Additional Case
Central Nervous System Siderosis Associated with Multiple Cerebral Aneurysms: Literature Review and Description of an Additional Case Open
Our literature review found 24 reported cases of unruptured IA associated with cortical SS. The possible source for leakages could be neovessels visible in IA walls. The case reported illustrates an uncommon presentation of recurrent bleed…
View article: A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1
A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1 Open
Purpose: Multiple endocrine neoplasia type 1 (MEN1) is thought to increase the risk of meningioma and ependymoma. Thus, we aimed to describe the frequency, incidence, and specific clinical and histological features of central nervous syste…
View article: Repeated Stereotactic Radiotherapy for Local Brain Metastases Failure or Distant Brain Recurrent: A Retrospective Study of 184 Patients
Repeated Stereotactic Radiotherapy for Local Brain Metastases Failure or Distant Brain Recurrent: A Retrospective Study of 184 Patients Open
Background: The main advantages of stereotactic radiotherapy (SRT) are to delay whole-brain radiotherapy (WBRT) and to deliver ablative doses. Despite this efficacy, the risk of distant brain metastases (BM) one year after SRT ranges from …
View article: Is the OCT a predictive tool to assess visual impairment in optic chiasm compressing syndrome? A prospective longitudinal study
Is the OCT a predictive tool to assess visual impairment in optic chiasm compressing syndrome? A prospective longitudinal study Open
Background: Visual dysfunction is a prevalent symptom in patients with non-functioning pituitary macroadenoma (NFPM); the role of OCT is such patients has not been yet determined. Method: This is a prospective longitudinal observational st…
View article: DIPG-33. P16 IMMUNOHISTOCHEMICAL EXPRESSION AS A SURROGATE ASSESSMENT OF CDKN2A ALTERATION IN GLIOMAS LEADING TO PROGNOSTIC SIGNIFICANCES
DIPG-33. P16 IMMUNOHISTOCHEMICAL EXPRESSION AS A SURROGATE ASSESSMENT OF CDKN2A ALTERATION IN GLIOMAS LEADING TO PROGNOSTIC SIGNIFICANCES Open
CDKN2A is a tumor suppressor gene encoding for p16 protein. Its homozygous deletion is a central prognostic factor for numerous brain cancers. This deletion can be detected by several techniques. Up to now, immunohistochemistry (IHC) using…
View article: Pituitary Abscess: A Challenging Preoperative Diagnosis—A Multicenter Study
Pituitary Abscess: A Challenging Preoperative Diagnosis—A Multicenter Study Open
Background and Objectives: Pituitary abscess (PA) is a rare occurrence, representing less than 1% of pituitary lesions, and is defined by the presence of an infected purulent collection within the sella turcica. Pas can be classified as ei…
View article: p16 Immunohistochemical Expression as a Surrogate Assessment of CDKN2A Alteration in Gliomas Leading to Prognostic Significances
p16 Immunohistochemical Expression as a Surrogate Assessment of CDKN2A Alteration in Gliomas Leading to Prognostic Significances Open
CDKN2A is a tumor suppressor gene encoding the p16 protein, a key regulator of the cell cycle. CDKN2A homozygous deletion is a central prognostic factor for numerous tumors and can be detected by several techniques. This study aims to eval…
View article: Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic radiotherapy (SRT) for brain metastases: a retrospective study of 184 patients
Acute toxicities and cumulative dose to the brain of repeated sessions of stereotactic radiotherapy (SRT) for brain metastases: a retrospective study of 184 patients Open
Background Stereotactic radiation therapy (SRT) is a focal treatment for brain metastases (BMs); thus, 20 to 40% of patients will require salvage treatment after an initial SRT session, either because of local or distant failure. SRT is no…