Dhimant Desai
YOU?
Author Swipe
View article: Impact of Soil Quality on Cannabinoid and Terpenoid Content of Cannabis sativa L.
Impact of Soil Quality on Cannabinoid and Terpenoid Content of Cannabis sativa L. Open
Cannabis sativa L., or ‘hemp,’ is an expanding commodity that relies heavily on its chemical constituents for its therapeutic effects and legal status. Growing conditions are critical for obtaining an anticipated chemical profile for any g…
View article: The effects of Co-exposure of tobacco smoke with Dibenzo[a,l]pyrene diol epoxide on molecular targets and immune cells in the mouse oral cavity
The effects of Co-exposure of tobacco smoke with Dibenzo[a,l]pyrene diol epoxide on molecular targets and immune cells in the mouse oral cavity Open
Tobacco smoking (TS) is an established etiological factor in the development of head and neck squamous cell carcinoma (HNSCC). We previously developed a mouse model using a select tobacco carcinogen, dibenzo[a,l]pyrene (DB[a,l]P, and its u…
View article: Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia
Critical roles of IKAROS and HDAC1 in regulation of heterochromatin and tumor suppression in T-cell acute lymphoblastic leukemia Open
The IKZF1 gene encodes IKAROS – a DNA binding protein that acts as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL). IKAROS can act as a transcriptional repressor via recruitment of histone deacetylase 1 (HDAC1) and chroma…
View article: [Corrigendum] Chemopreventive effects of PBI‑Se, a selenium‑containing analog of PBIT, on AOM‑induced aberrant crypt foci in F344 rats
[Corrigendum] Chemopreventive effects of PBI‑Se, a selenium‑containing analog of PBIT, on AOM‑induced aberrant crypt foci in F344 rats Open
Following the publication of the above article, an interested reader drew to the authors' attention that the RT‑PCR data panels shown in Fig. 3C, showing the effects of PBIT and PBI‑Se treatment on endogenous IL‑8 mRNA expression levels in…
View article: Current challenges and potential opportunities for interception and prevention of head and neck cancer
Current challenges and potential opportunities for interception and prevention of head and neck cancer Open
Globally, the incidence of head and neck squamous cell carcinoma (HNSCC) has increased over recent decades and is projected to continue to rise, largely driven by increases in oropharyngeal squamous cell carcinoma (OPSCC), which is linked …
View article: Discovering Potential in Non-Cancer Medications: A Promising Breakthrough for Multiple Myeloma Patients
Discovering Potential in Non-Cancer Medications: A Promising Breakthrough for Multiple Myeloma Patients Open
MM is a common type of cancer that unfortunately leads to a significant number of deaths each year. The majority of the reported MM cases are detected in the advanced stages, posing significant challenges for treatment. Additionally, all M…
View article: A New Hope for Multiple Myeloma: Harnessing the Power of Non-Cancer Medications
A New Hope for Multiple Myeloma: Harnessing the Power of Non-Cancer Medications Open
Multiple myeloma (MM) is a common type of cancer that unfortunately leads to a significant number of deaths each year. The majority of the reported MM cases are detected in the advanced stages, posing significant challenges for treatment. …
View article: The Potential of Cannabichromene (CBC) as a Therapeutic Agent
The Potential of Cannabichromene (CBC) as a Therapeutic Agent Open
There is a growing interest in the use of medicinal plants to treat a variety of diseases, and one of the most commonly used medicinal plants globally is Cannabis sativa The two most abundant cannabinoids (Δ9-tetrahydrocannabinol and canna…
View article: The underappreciated diversity of bile acid modifications
The underappreciated diversity of bile acid modifications Open
The repertoire of modifications to bile acids and related steroidal lipids by host and microbial metabolism remains incompletely characterized. To address this knowledge gap, we created a reusable resource of tandem mass spectrometry (MS/M…
View article: Effect of mechanical scarification and biofertilizer treatments on seed quality enhancement in Senna (Senna alexandrina Mill.)
Effect of mechanical scarification and biofertilizer treatments on seed quality enhancement in Senna (Senna alexandrina Mill.) Open
Senna (Senna alexandrina Mill.) is an annual medicinal plant commonly known as “senna” or “Alexandrian senna” primarily known for its agricultural, industrial and ethno-medicinal purposes which belong to family leguminoceae. Senna seeds us…
View article: S32 Implementing lung cancer screening in the UK: baseline results from the NHS England national ‘targeted lung health check’ programme
S32 Implementing lung cancer screening in the UK: baseline results from the NHS England national ‘targeted lung health check’ programme Open
Background Lung cancer screening (LCS) with low-dose CT (LDCT) reduces lung cancer mortality. National implementation is now recommended in England, with government support announced. Following successful UK pilot studies between 2016–2019…
View article: Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases
Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases Open
The Rho associated coiled-coil containing protein kinase (ROCK1 and ROCK2) and myotonic dystrophy-related Cdc-42 binding kinases (MRCKα and MRCKβ) are critical regulators of cell proliferation and cell plasticity, a process intimately invo…
View article: Complex chemical signals dictate Ah receptor activation through the gut–lung axis
Complex chemical signals dictate Ah receptor activation through the gut–lung axis Open
The aryl hydrocarbon receptor (AHR) mediates intestinal barrier homeostasis. Many AHR ligands are also CYP1A1/1B1 substrates, which can result in rapid clearance within the intestinal tract, limiting systemic exposure and subsequent AHR ac…
View article: Supplementary Figure 2 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Supplementary Figure 2 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma Open
PDF file - 104K, Selenocoxib-1-GSH inhibits the generation of ROS
View article: Supplementary Appendix including cell line RRIDs and supplementary figures from Ceramide Analogue SACLAC Modulates Sphingolipid Levels and <i>MCL-1</i> Splicing to Induce Apoptosis in Acute Myeloid Leukemia
Supplementary Appendix including cell line RRIDs and supplementary figures from Ceramide Analogue SACLAC Modulates Sphingolipid Levels and <i>MCL-1</i> Splicing to Induce Apoptosis in Acute Myeloid Leukemia Open
Figure S1. SACLAC reduces AC activity at lower doses than LCL204. Figure S2. SACLAC treatment increases production of multiple ceramide species in human AML cell lines. Figure S3. SACLAC is more toxic to AML cells than normal cells. Figure…
View article: Supplementary Table 1 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Supplementary Table 1 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma Open
PDF file - 60K, Selenocoxib-1-GSH is not toxic to mice
View article: Supplementary Appendix including cell line RRIDs and supplementary figures from Ceramide Analogue SACLAC Modulates Sphingolipid Levels and <i>MCL-1</i> Splicing to Induce Apoptosis in Acute Myeloid Leukemia
Supplementary Appendix including cell line RRIDs and supplementary figures from Ceramide Analogue SACLAC Modulates Sphingolipid Levels and <i>MCL-1</i> Splicing to Induce Apoptosis in Acute Myeloid Leukemia Open
Figure S1. SACLAC reduces AC activity at lower doses than LCL204. Figure S2. SACLAC treatment increases production of multiple ceramide species in human AML cell lines. Figure S3. SACLAC is more toxic to AML cells than normal cells. Figure…
View article: Data from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Data from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma Open
Melanoma is a highly metastatic and deadly disease. An agent simultaneously targeting the COX-2, PI3K/Akt, and mitogen-activated protein kinase (MAPK) signaling pathways that are deregulated in up to 70% of sporadic melanomas might be an e…
View article: Supplementary Figure 1 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Supplementary Figure 1 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma Open
PDF file - 132K, Selenocoxib-1-GSH does not alter the cellular or morphological organization of organs in animals following treatment
View article: Supplementary Figure Legend from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Supplementary Figure Legend from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma Open
PDF file - 57K
View article: Supplementary Table 1 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Supplementary Table 1 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma Open
PDF file - 60K, Selenocoxib-1-GSH is not toxic to mice
View article: Supplementary Figure 2 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Supplementary Figure 2 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma Open
PDF file - 104K, Selenocoxib-1-GSH inhibits the generation of ROS
View article: Supplementary Figure 1 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Supplementary Figure 1 from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma Open
PDF file - 132K, Selenocoxib-1-GSH does not alter the cellular or morphological organization of organs in animals following treatment
View article: Data from Ceramide Analogue SACLAC Modulates Sphingolipid Levels and <i>MCL-1</i> Splicing to Induce Apoptosis in Acute Myeloid Leukemia
Data from Ceramide Analogue SACLAC Modulates Sphingolipid Levels and <i>MCL-1</i> Splicing to Induce Apoptosis in Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation of immature myeloid cells in the blood and bone marrow. The 5-year survival rate is approximately 25%, and recent therapeutic developments have yielded l…
View article: Supplementary Figure Legend from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma
Supplementary Figure Legend from Simultaneous Targeting of COX-2 and AKT Using Selenocoxib-1-GSH to Inhibit Melanoma Open
PDF file - 57K
View article: Data from Ceramide Analogue SACLAC Modulates Sphingolipid Levels and <i>MCL-1</i> Splicing to Induce Apoptosis in Acute Myeloid Leukemia
Data from Ceramide Analogue SACLAC Modulates Sphingolipid Levels and <i>MCL-1</i> Splicing to Induce Apoptosis in Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is a disease characterized by uncontrolled proliferation of immature myeloid cells in the blood and bone marrow. The 5-year survival rate is approximately 25%, and recent therapeutic developments have yielded l…