Donghai Lin
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View article: Machine Learning-Based Implied Volatility Prediction and Trading Models for Options
Machine Learning-Based Implied Volatility Prediction and Trading Models for Options Open
The occurrence of a series of major emergencies, such as the Russian-Ukrainian conflict and the COVID-19 epidemic, has caused a huge impact on the financial market, and the volatility of the global market has increased significantly. Facin…
View article: The Protective Mechanism of Moderate Intensity Continuous Training on TMAO-Induced Myocardial Injury Based on NMR Metabolomics
The Protective Mechanism of Moderate Intensity Continuous Training on TMAO-Induced Myocardial Injury Based on NMR Metabolomics Open
The purpose of this study was to explore the protective effect of 8 weeks of Moderate Intensity Continuous Training (MICT) on TMAO-induced myocardial injury in mice and its metabolic regulatory mechanism based on nuclear magnetic resonance…
View article: Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways
Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways Open
Disused muscle atrophy (DMA) is characterized by skeletal muscle loss and functional decline due to prolonged inactivity. Though evidence remains limited, recent studies suggest that ferroptosis, an iron-dependent, lipid peroxidation-drive…
View article: Metabolomic Profiling of Osteoblasts in Rat Subchondral Bone Following Anterior Cruciate Ligament Injury
Metabolomic Profiling of Osteoblasts in Rat Subchondral Bone Following Anterior Cruciate Ligament Injury Open
Objectives: Osteoarthritis (OA) is a prevalent chronic degenerative joint disorder marked by cartilage degradation, subchondral bone remodeling, and synovial inflammation. Despite its widespread occurrence, effective pharmacological interv…
View article: Engineered <i>Lactobacillus rhamnosus</i> Producing 3‐Hydroxybutyrate: A Dual‐Action Therapeutic Strategy for Colon Cancer Cachexia
Engineered <i>Lactobacillus rhamnosus</i> Producing 3‐Hydroxybutyrate: A Dual‐Action Therapeutic Strategy for Colon Cancer Cachexia Open
3‐hydroxybutyrate (3‐HB), an essential endogenous metabolite, shows significant therapeutic potential in several disease contexts. However, its clinical application has been hampered by limitations, such as adverse effects on the gut micro…
View article: Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection
Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection Open
Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling. Supplementation with taurine, a safe nonessential amino acid, may be a potential therapeutic strategy for OA.
View article: New Horizons in Health and Metabolism Research
New Horizons in Health and Metabolism Research Open
Editorial New Horizons in Health and Metabolism Research Donghai Lin 1, *, Shen Hu 2, Peng Huang 3, Jianbo Wan 4 and Yulan Wang 5 1 Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, C…
View article: Deciphering the Therapeutic Role of Lactate in Combating Disuse-Induced Muscle Atrophy: An NMR-Based Metabolomic Study in Mice
Deciphering the Therapeutic Role of Lactate in Combating Disuse-Induced Muscle Atrophy: An NMR-Based Metabolomic Study in Mice Open
Disuse muscle atrophy (DMA) is a significant healthcare challenge characterized by progressive loss of muscle mass and function resulting from prolonged inactivity. The development of effective strategies for muscle recovery is essential. …
View article: Metabolomics‐driven discovery of therapeutic targets for cancer cachexia
Metabolomics‐driven discovery of therapeutic targets for cancer cachexia Open
Cancer cachexia (CC) is a devastating metabolic syndrome characterized by skeletal muscle wasting and body weight loss, posing a significant burden on the health and survival of cancer patients. Despite ongoing efforts, effective treatment…
View article: Trimethylamine N-Oxide Improves Exercise Performance by Reducing Oxidative Stress through Activation of the Nrf2 Signaling Pathway
Trimethylamine N-Oxide Improves Exercise Performance by Reducing Oxidative Stress through Activation of the Nrf2 Signaling Pathway Open
Trimethylamine N-oxide (TMAO) has attracted interest because of its association with cardiovascular disease and diabetes, and evidence for the beneficial effects of TMAO is accumulating. This study investigates the role of TMAO in improvin…
View article: Metabolic adaptations of Microbacterium sediminis YLB-01 in deep-sea high-pressure environments
Metabolic adaptations of Microbacterium sediminis YLB-01 in deep-sea high-pressure environments Open
The deep-sea environment is an extremely difficult habitat for microorganisms to survive in due to its intense hydrostatic pressure. However, the mechanisms by which these organisms adapt to such extreme conditions remain poorly understood…
View article: Structural and Functional Insights into the Stealth Protein CpsY of Mycobacterium tuberculosis
Structural and Functional Insights into the Stealth Protein CpsY of Mycobacterium tuberculosis Open
Mycobacterium tuberculosis (Mtb) is an important and harmful intracellular pathogen that is responsible for the cause of tuberculosis (TB). Mtb capsular polysaccharides can misdirect the host’s immune response pathways, resulting in additi…
View article: Author Response: Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress
Author Response: Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Appendix 1 Data availability References Peer review Author response Article and author information Metrics Abstract Acc…
View article: Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress Open
Accumulating evidence indicates that acetate is increased under energy stress conditions such as those that occur in diabetes mellitus and prolonged starvation. However, how and where acetate is produced and the nature of its biological si…
View article: Reviewer #2 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Reviewer #2 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses Open
Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We o…
View article: Reviewer #1 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Reviewer #1 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses Open
Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We o…
View article: Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses Open
Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We o…
View article: Author Response: Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Author Response: Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses Open
Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We o…
View article: Reviewer #3 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Reviewer #3 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses Open
Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We o…
View article: CloudBrain-NMR: An Intelligent Cloud Computing Platform for NMR Spectroscopy Processing, Reconstruction and Analysis
CloudBrain-NMR: An Intelligent Cloud Computing Platform for NMR Spectroscopy Processing, Reconstruction and Analysis Open
Nuclear Magnetic Resonance (NMR) spectroscopy has served as a powerful analytical tool for studying molecular structure and dynamics in chemistry and biology. However, the processing of raw data acquired from NMR spectrometers and subseque…
View article: Exploring the Therapeutic Potential of Ethyl 3-Hydroxybutyrate in Alleviating Skeletal Muscle Wasting in Cancer Cachexia
Exploring the Therapeutic Potential of Ethyl 3-Hydroxybutyrate in Alleviating Skeletal Muscle Wasting in Cancer Cachexia Open
Cachexia (CAC) is a debilitating metabolic syndrome. Although dietary interventions are attractive, long-term adherence to specific diets is difficult to maintain and can lead to systemic side effects. Ethyl 3-hydroxybutyrate (EHB) is a co…
View article: Metabolomic Analysis of Trehalose Alleviating Oxidative Stress in Myoblasts
Metabolomic Analysis of Trehalose Alleviating Oxidative Stress in Myoblasts Open
Trehalose, a naturally occurring non-toxic disaccharide, has attracted considerable attention for its potential in alleviating oxidative stress in skeletal muscle. In this study, our aim was to elucidate the metabolic mechanisms underlying…
View article: Metabolic signatures and potential biomarkers for the diagnosis and treatment of colon cancer cachexia
Metabolic signatures and potential biomarkers for the diagnosis and treatment of colon cancer cachexia Open
Cancer cachexia (CAC) is a debilitating condition that often arises from noncachexia cancer (NCAC), with distinct metabolic characteristics and medical treatments. However, the metabolic changes and underlying molecular mechanisms during c…
View article: Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses Open
Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We o…
View article: Reviewer #2 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Reviewer #2 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses Open
Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We o…
View article: Reviewer #1 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Reviewer #1 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses Open
Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We o…
View article: Reviewer #3 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
Reviewer #3 (Public Review): Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses Open
Accumulating evidences indicate that acetate is increased in energy stresses such as diabetes mellitus and prolonged starvation. However, it is largely unknown how and where acetate is produced and what is its biological significance. We o…