Lois E. H. Smith
YOU?
Author Swipe
View article: <scp>TREM2</scp> ‐Mediated Myeloid Cells Protect Against Pathological Choroidal Neovascularization
<span>TREM2</span> ‐Mediated Myeloid Cells Protect Against Pathological Choroidal Neovascularization Open
Choroidal neovascularization (CNV) is a hallmark of neovascular age‐related macular degeneration, a leading cause of irreversible vision loss in the elderly. While immune dysregulation and myeloid cell activation have been implicated in CN…
ApoM-bound S1P acts via endothelial S1PR1 to suppress choroidal neovascularization and vascular leakage Open
Neovascular age-related macular degeneration (nAMD) is a major cause of vision loss worldwide. Current standard of care is repetitive intraocular injections of vascular endothelial growth factor (VEGF) inhibitors, although responses may be…
Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes—Brief Report Open
BACKGROUND: Mononuclear phagocytes contribute to pathological angiogenesis in age-related macular degeneration, a leading worldwide cause of visual impairment. However, the mechanisms that orchestrate the functions of mononuclear phagocyte…
Optimisation of the preparation phase for orthopaedic surgery: Study protocol for a student-led multimodal prehabilitation feasibility trial (BoneFit) Open
Background Since the Covid-19 pandemic, a surgical backlog for total hip replacement (THR) and total knee replacement (TKR) surgery remains in the United Kingdom. Multimodal prehabilitation pathways (encompassing exercise, nutritional supp…
Association between Early Postnatal Hydrocortisone and Retinopathy of Prematurity in Extremely Preterm Infants Open
Introduction: Retinopathy of prematurity (ROP) is a leading cause of preventable childhood blindness. We investigated the association of early postnatal low-dose intravenous hydrocortisone used for the prevention of bronchopulmonary dyspla…
Platelet characteristics in extremely preterm infants after fatty acid supplementation: a randomized controlled trial Open
Background Two risk factors for severe retinopathy of prematurity (ROP) in extremely preterm infants are thrombocytopenia and low levels of arachidonic acid (AA) and docosahexaenoic acid (DHA). To date, these risk factors have not been lin…
Increased risk of autism in extremely preterm children with a history of retinopathy of prematurity Open
Aim To investigate the association between retinopathy of prematurity and autism spectrum disorder in extremely preterm children. Methods Data in children born extremely preterm at <28 weeks’ gestational age in the Region Västra Götaland, …
View article: Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases
Therapeutic Effects of Taurine and Histidine Supplementation in Retinal Diseases Open
Amino acids are basic building blocks of structural proteins and enzymes. They also act as signaling molecules and as fuel. They are characterized as essential if sufficient quantities must be supplied exogenously or as non-essential if th…
The wind in the willows effect: Does age affect human versus animal faux pas recognition? Open
Children's literature is rife with anthropomorphic or non-human characters that may be used as a scaffold to teach children about theory of mind (ToM) or the ways in which people think or feel about the social world. In this study, 107 typ…
Relationship between Capillary Wettability, Mass, and Momentum Transfer in Nanoconfined Water: The Case of Water in Nanoslits of Graphite and Hexagonal Boron Nitride Open
The flow of water confined in nanosize capillaries is subject of intense research due to its relevance in the fabrication of nanofluidic devices and in the development of theories for fluid transport in porous media. Here, using molecular …
View article: Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity Open
Pathological neovascularization in retinopathy of prematurity (ROP) can cause visual impairment in preterm infants. Current ROP treatments which are not preventative and only address late neovascular ROP, are costly and can lead to severe …
Mitochondrial control of hypoxia-induced pathological retinal angiogenesis Open
Objective Pathological retinal neovascularization is vision-threatening. In mouse oxygen-induced retinopathy (OIR) we sought to define mitochondrial respiration changes longitudinally during hyperoxia-induced vessel loss and hypoxia-induce…
eLife Assessment: Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy Open
Autosomal dominant optic atrophy (DOA) is a progressive form of blindness caused by degeneration of retinal ganglion cells and their axons, mainly caused by mutations in the OPA1 mitochondrial dynamin like GTPase (OPA1) gene. OPA1 encodes …
View article: Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3 Open
Background Pathological angiogenesis causes significant vision loss in neovascular age-related macular degeneration and other retinopathies with neovascularization (NV). Neuronal/glial-vascular interactions influence the release of angioge…
ROP: 80 Years after Its Detection – Where Do We Stand and How Long Will We Continue to Laser? Open
Background: Retinopathy of prematurity (ROP), a potentially blinding disease, is increasing worldwide because of the increased survival of extremely preterm and preterm infants born where oxygen monitoring and ROP screening programs are in…
View article: Therapeutic Effects of Anti-Inflammatory and Anti-Oxidant Nutritional Supplementation in Retinal Ischemic Diseases
Therapeutic Effects of Anti-Inflammatory and Anti-Oxidant Nutritional Supplementation in Retinal Ischemic Diseases Open
Appropriate nutrients are essential for cellular function. Dietary components can alter the risk of systemic metabolic diseases, including cardiovascular diseases, cancer, diabetes, and obesity, and can also affect retinal diseases, includ…
A Framework for a High Throughput Screening Method to Assess Polymer/Plasticizer Miscibility Open
Polymer composite materials require softening to reduce their glass transition temperature and improve processability. To this end, plasticizers, which are small organic molecules, are added to the polymer matrix. The miscibility of these …
View article: Arachidonic acid and docosahexaenoic acid levels correlate with the inflammation proteome in extremely preterm infants
Arachidonic acid and docosahexaenoic acid levels correlate with the inflammation proteome in extremely preterm infants Open
ClinicalTrials.gov (NCT03201588).
View article: Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy
Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy Open
Healthy blood vessels supply neurons to preserve metabolic function. In blinding proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological revascularization of the ischemic neuroretina. …
View article: Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy
Metabolic Reprogramming of the Neovascular Niche Promotes Regenerative Angiogenesis in Proliferative Retinopathy Open
Healthy blood vessels supply neurons to preserve metabolic function. In blinding ischemic proliferative retinopathies (PRs), pathological neovascular tufts often emerge in lieu of needed physiological neuroretina revascularization. We show…
A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells Open
To address the needs of the life sciences community and the pharmaceutical industry in pre-clinical drug development to both maintain and continuously assess tissue metabolism and function with simple and rapid systems, we improved on the …