Helen R. Griffiths
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View article: Disrupted adipokine secretion and inflammatory responses in human adipocyte hypertrophy
Disrupted adipokine secretion and inflammatory responses in human adipocyte hypertrophy Open
Adipocyte hypertrophy is a critical contributor to obesity-induced inflammation and insulin resistance. This study employed a human adipocyte hypertrophy model to investigate the adipokine release, inflammatory responses, and the intracell…
View article: Integration of Low Intensity Psychological Support for Children and Young People Receiving Cancer Services: A Qualitative Study of Staff Perspectives
Integration of Low Intensity Psychological Support for Children and Young People Receiving Cancer Services: A Qualitative Study of Staff Perspectives Open
Objective Despite children and young people (CYP) with cancer having elevated mental health needs, accessing evidence‐based psychological support remains difficult. Delivering low‐intensity cognitive behavioural therapy (LICBT) to CYP with…
View article: SARS-CoV-2 Infection and Childhood Islet Autoimmunity
SARS-CoV-2 Infection and Childhood Islet Autoimmunity Open
This cohort study examines whether there is a temporal association between SARS-CoV-2 infection and the development of islet autoimmunity among Australian children with a first-degree relative with type 1 diabetes.
View article: Exploring the Interplay between Carotenoids, Lipid Oxidation, and Cognitive Impairment in Aging
Exploring the Interplay between Carotenoids, Lipid Oxidation, and Cognitive Impairment in Aging Open
Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, memory loss, and impaired daily functioning. As the global population ages, the prevalence of AD continues to rise, emphasi…
View article: Pragmatic implementation of low-intensity psychological treatment for children and young people: the reality
Pragmatic implementation of low-intensity psychological treatment for children and young people: the reality Open
Background and aims: Low-intensity psychological interventions are effective for children and young people (CYP) with mental health difficulties and can help bridge the demand–capacity gap. Despite increasing awareness, training and use of…
View article: BVX001, a Bispecific ADC Targeting CD7-Positive AML with Favorable Toxicity Profile, Exhibits Significant Efficacy in Primary Patient Samples and PDX-Models
BVX001, a Bispecific ADC Targeting CD7-Positive AML with Favorable Toxicity Profile, Exhibits Significant Efficacy in Primary Patient Samples and PDX-Models Open
Background Acute myeloid leukemia (AML) is a heterogeneous and aggressive hematologic malignancy with limited treatment options. CD7-positive AML has emerged as an aggressive and treatment -resistant subtype of AML, with shorter overall su…
View article: Early Dysglycemia Is Detectable Using Continuous Glucose Monitoring in Very Young Children at Risk of Type 1 Diabetes
Early Dysglycemia Is Detectable Using Continuous Glucose Monitoring in Very Young Children at Risk of Type 1 Diabetes Open
OBJECTIVE Continuous glucose monitoring (CGM) can detect early dysglycemia in older children and adults with presymptomatic type 1 diabetes (T1D) and predict risk of progression to clinical onset. However, CGM data for very young children …
View article: National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barrett’s oesophagus and stage I oesophageal adenocarcinoma
National Institute for Health and Care Excellence (NICE) guidance on monitoring and management of Barrett’s oesophagus and stage I oesophageal adenocarcinoma Open
Barrett’s oesophagus is the only known precursor to oesophageal adenocarcinoma, a cancer with very poor prognosis. The main risk factors for Barrett’s oesophagus are a history of gastro-oesophageal acid reflux symptoms and obesity. Men, sm…
View article: Effects of carotenoids on mitochondrial dysfunction
Effects of carotenoids on mitochondrial dysfunction Open
Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the pro-oxidant state is a result of increased production of reactive oxygen species (ROS) or inadequate antioxidant protection. ROS are produced through …
View article: Mental health interventions for children and young people with long-term health conditions in Children and Young People’s Mental Health Services in England
Mental health interventions for children and young people with long-term health conditions in Children and Young People’s Mental Health Services in England Open
Background Almost a quarter of children and young people (CYP) in England have a long-term health condition (LTC), which increases the risk of developing mental health difficulties. There is a lack of understanding regarding the routine pr…
View article: APOE genotypes and oxidized lipids in Alzheimer’s Disease
APOE genotypes and oxidized lipids in Alzheimer’s Disease Open
Background The APOE4 allele is a strong risk factor for late‐onset and early‐onset forms but APOE4 is neither a prerequisite for, nor sufficient to cause, AD. Despite decades of research, the exact mechanisms underlying how ApoE4 contribut…
View article: Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Adipose tissue macrophages as potential targets for obesity and metabolic diseases Open
Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders. In this review, we aim to present the most recent resear…
View article: TNF-α-Mediated Endothelial Cell Apoptosis Is Rescued by Hydrogen Sulfide
TNF-α-Mediated Endothelial Cell Apoptosis Is Rescued by Hydrogen Sulfide Open
Endothelial dysfunction is implicated in the development and aggravation of cardiovascular complications. Among the endothelium-released vasoactive factors, hydrogen sulfide (H2S) has been investigated for its beneficial effects on the vas…
View article: Pre‐conditioning of gingival epithelial cells with sub‐apoptotic concentrations of curcumin prevents pro‐inflammatory cytokine release
Pre‐conditioning of gingival epithelial cells with sub‐apoptotic concentrations of curcumin prevents pro‐inflammatory cytokine release Open
Background and Objective Plaque‐induced gingival inflammation (gingivitis) is ubiquitous in humans. The epithelial barrier reacts to the presence of oral bacteria and induces inflammatory cascades. The objective of this study was to invest…
View article: Individualised consent for endoscopy: update on the 2016 BSG guidelines
Individualised consent for endoscopy: update on the 2016 BSG guidelines Open
In 2016, the British Society of Gastroenterology (BSG) published comprehensive guidelines for obtaining consent for endoscopic procedures. In November 2020, the General Medical Council (GMC) introduced updated guidelines on shared decision…
View article: Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation
Adipokines, Hepatokines and Myokines: Focus on Their Role and Molecular Mechanisms in Adipose Tissue Inflammation Open
Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular diseases. Inflammation in ATs is characterized by macrophage infiltra…
View article: Trajectories of screen time across adolescence and their associations with adulthood mental health and behavioural outcomes
Trajectories of screen time across adolescence and their associations with adulthood mental health and behavioural outcomes Open
Excessive screen time among adolescents is discussed as a significant public health concern. Identifying adolescent longitudinal patterns of time spent on regularly-used media screens and understanding their adulthood mental health and beh…
View article: Developmental Relations Between Bullying Victimization and Suicidal Ideation in Middle Adolescence and Emerging Adulthood: Do Internalizing Problems and Substance Use Mediate Their Links?
Developmental Relations Between Bullying Victimization and Suicidal Ideation in Middle Adolescence and Emerging Adulthood: Do Internalizing Problems and Substance Use Mediate Their Links? Open
Previous research has suggested that bullying victimization is associated with higher suicidal risk among young people; however, the mechanisms underlying this relation have not been well examined. The current study aimed to illuminate the…
View article: Co-developmental trajectories of parental psychological distress and child internalizing and externalizing problems in childhood and adolescence: Associations with self-harm and suicide attempts
Co-developmental trajectories of parental psychological distress and child internalizing and externalizing problems in childhood and adolescence: Associations with self-harm and suicide attempts Open
Growing evidence has suggested that parental mental illness and child internalizing and externalizing problems tend to co-occur and engender risk for adverse child outcomes; however, there is considerable heterogeneity in their joint devel…
View article: Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation
Lower polyunsaturated fatty acid levels and FADS2 expression in adult compared to neonatal keratinocytes are associated with FADS2 promotor hypermethylation Open
Keratinocytes produce lipids that are critical for the skin barrier, however, little is known about the impact of age on fatty acid (FA) biosynthesis in these cells. We have examined the relationship between keratinocyte FA composition, li…
View article: Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases
Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases Open
Hydrogen sulfide (H2S), a gaseous signalling molecule, is important in numerous physiological and pathophysiological processes. Despite its initial identification as an environmental toxin, H2S is now well described as an essential physiol…
View article: Odd chain fatty acid metabolism in mice after a high fat diet
Odd chain fatty acid metabolism in mice after a high fat diet Open
Epidemiological studies show that higher circulating levels of odd chain saturated fatty acids (FA: C15:0 and C17:0) are associated with lower risk of metabolic disease. These odd chain saturated fatty acids (OCSFA) are produced by α-oxida…
View article: Patient reported experiences and treatment outcomes of orthodontic patients treated within secondary care settings in the South West of England during the COVID-19 pandemic
Patient reported experiences and treatment outcomes of orthodontic patients treated within secondary care settings in the South West of England during the COVID-19 pandemic Open
Objective: To assess the impact of the temporary cessation of orthodontic services on patients undergoing treatment during the COVID-19 pandemic. Design: Two-phase multicentre service evaluation. Setting: Secondary care orthodontic departm…
View article: Developmental associations between bullying victimization and suicidal ideation and direct self-injurious behavior in adolescence and early adulthood
Developmental associations between bullying victimization and suicidal ideation and direct self-injurious behavior in adolescence and early adulthood Open
Background: Bullying, suicide, and self-injury are significant public health issues among young people. Extensive research has documented bullying victimization associations with suicidal ideation and self-injury; however, the modeling app…
View article: P71 A national survey of safety across UK endoscopy services
P71 A national survey of safety across UK endoscopy services Open
Introduction The 'Improving Safety and Reducing Error in Endoscopy' (ISREE) strategy has highlighted the need to improve our understanding of factors related to safety across UK endoscopy. This study assesses aspects of safety that were in…
View article: P70 The JAG survey of UK endoscopy services: results from the 2019 census
P70 The JAG survey of UK endoscopy services: results from the 2019 census Open
Introduction The Joint Advisory Group on Gastrointestinal endoscopy (JAG) conduct a biennial census to understand factors related to endoscopy quality, workforce and training across services in the UK. The study reports the results of the …
View article: Oxidative stress links periodontal inflammation and renal function
Oxidative stress links periodontal inflammation and renal function Open
Aims Patients with chronic kidney disease (CKD) are also susceptible to periodontitis. The causal link between periodontitis and CKD may be mediated via systemic inflammation/oxidative stress. Using structural equation modelling (SEM), thi…