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View article: P92 Benefits of a specialist multidisciplinary team approach to the management of <i>Aspergillus</i> -related chronic lung disease
P92 Benefits of a specialist multidisciplinary team approach to the management of <i>Aspergillus</i> -related chronic lung disease Open
Background In June 2024, we established a monthly cross-site multidisciplinary team (MDT) to guide management of chronic fungal lung disease, consisting of respiratory and infectious diseases/microbiology physicians and highly specialist r…
View article: 445 A community-based intervention to promote influenza vaccine uptake among East London minority ethnicity (ME) populations and persons with low income: randomised pilot and feasibility trial
445 A community-based intervention to promote influenza vaccine uptake among East London minority ethnicity (ME) populations and persons with low income: randomised pilot and feasibility trial Open
OP 33: Diseases and Interventions 1, B304 (FCSH), September 5, 2025, 09:00 - 10:00 Aims Influenza vaccination among underserved groups remains lower than in general populations. We co-designed a multilingual patient engagement tool (PET) w…
View article: Barriers to and enablers of adherence to the treatment of active drug-sensitive tuberculosis in people living with HIV: a mixed method systematic review
Barriers to and enablers of adherence to the treatment of active drug-sensitive tuberculosis in people living with HIV: a mixed method systematic review Open
Adherence to TB treatment among individuals with HIV/TB coinfection is significantly influenced by social determinants, including educational level, socioeconomic status, and the quality of healthcare service delivery. Targeted interventio…
View article: Long-term follow-up of treatment comparisons in RECOVERY: a randomised, open-label, platform trial for patients hospitalised with COVID-19
Long-term follow-up of treatment comparisons in RECOVERY: a randomised, open-label, platform trial for patients hospitalised with COVID-19 Open
SUMMARY Background The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial evaluated the effects of sixteen potential treatments for patients hospitalised with COVID-19. Dexamethasone (at a dose of 6mg daily), tocilizumab, baricitin…
View article: Type I interferon responses contribute to immune protection against mycobacterial infection
Type I interferon responses contribute to immune protection against mycobacterial infection Open
Type I interferon responses have been considered detrimental to host protection in tuberculosis (TB). We provide novel data to challenge this paradigm, derived from transcriptional profiling of human in vivo immune responses to discover as…
View article: Type I interferon responses contribute to immune protection against mycobacterial infection
Type I interferon responses contribute to immune protection against mycobacterial infection Open
Type I interferon responses have been considered detrimental to host protection in tuberculosis (TB). We provide novel data to challenge this paradigm, derived from transcriptional profiling of human in vivo immune responses to discover as…
View article: Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones
Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones Open
T cells contribute to immune protection and pathogenesis in tuberculosis, but measurements of polyclonal responses have failed to resolve correlates of outcome. We report the first temporal evaluation of the human in vivo clonal repertoire…
View article: Global maternal mortality associated with SARS-CoV-2 infection: a systematic review and meta-analysis
Global maternal mortality associated with SARS-CoV-2 infection: a systematic review and meta-analysis Open
Background Pregnant and recently pregnant women infected with SARS-CoV-2 are at increased risk of death and serious complications than those without the infection. The extent of variation in mortality rates in pregnant women with SARS-CoV-…
View article: COVER-ME: developing and evaluating community-based interventions to promote vaccine uptake for COVID-19 and influenza in East London minority ethnicity (ME) and underserved individuals - protocol for a pilot randomised controlled trial
COVER-ME: developing and evaluating community-based interventions to promote vaccine uptake for COVID-19 and influenza in East London minority ethnicity (ME) and underserved individuals - protocol for a pilot randomised controlled trial Open
Introduction Under-vaccination among underserved groups remains low due to existing disparities. This is particularly the case with postpandemic COVID-19 vaccinations and other vaccine-preventable diseases, including measles, mumps, rubell…
View article: A micro-costing of latent tuberculosis infection testing and treatment in adults in secondary care in England
A micro-costing of latent tuberculosis infection testing and treatment in adults in secondary care in England Open
Background Latent TB infection (LTBI) screening and treatment of population groups at high risk for TB is part of England’s Tuberculosis Action Plan, which has succeeded in increasing testing volumes. However, analysis of the cost-effectiv…
View article: Tuberculosis in adult migrants in Europe: a TBnet consensus statement
Tuberculosis in adult migrants in Europe: a TBnet consensus statement Open
Introduction Global migration has increased in recent decades owing to war, conflict, persecution and natural disasters, but also secondary to increased opportunities related to work or study. Migrants’ risk of tuberculosis (TB) differs de…
View article: Drug-resistant tuberculosis treatments, the case for a phase III platform trial
Drug-resistant tuberculosis treatments, the case for a phase III platform trial Open
Most phase III trials in drug-resistant tuberculosis have either been underpowered to quantify differences in microbiological endpoints or have taken up to a decade to complete. Composite primary endpoints, dominated by differences in trea…
View article: Treatment of latent tuberculosis infection in migrants in primary care<i>versus</i>secondary care
Treatment of latent tuberculosis infection in migrants in primary care<i>versus</i>secondary care Open
Background Control of latent tuberculosis infection (LTBI) is a priority in the World Health Organization strategy to eliminate TB. Many high-income, low TB incidence countries have prioritised LTBI screening and treatment in recent migran…
View article: COVER-ME: Developing and Evaluating community-based interventions to promote vaccine uptake in East London minority ethnicity (ME) populations; underserved migrants and persons with low income: protocol for a pilot randomised controlled trial
COVER-ME: Developing and Evaluating community-based interventions to promote vaccine uptake in East London minority ethnicity (ME) populations; underserved migrants and persons with low income: protocol for a pilot randomised controlled trial Open
Introduction Under vaccination amongst underserved groups remains low due to existing disparities. This is particularly the case with post-pandemic COVID-19 vaccinations, and other vaccine-preventable diseases including measles, Mumps and …
View article: Type I interferon responses contribute to immune protection against mycobacterial infection
Type I interferon responses contribute to immune protection against mycobacterial infection Open
Type I interferon responses have been considered detrimental to host protection in tuberculosis (TB). We provide novel data to challenge this paradigm, derived from transcriptional profiling of human in vivo immune responses to discover as…
View article: Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis
Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis Open
Objective To assess the effects of COVID-19 vaccines in women before or during pregnancy on SARS-CoV-2 infection-related, pregnancy, offspring and reactogenicity outcomes. Design Systematic review and meta-analysis. Data sources Major data…
View article: COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss
COVID-19 in pregnant women: a systematic review and meta-analysis on the risk and prevalence of pregnancy loss Open
BACKGROUND Pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are more likely to experience preterm birth and their neonates are more likely to be stillborn or admitted to a neonatal unit. The World H…
View article: Development and description of a theory-driven, evidence-based, complex intervention to improve adherence to treatment for tuberculosis in the UK: the IMPACT study
Development and description of a theory-driven, evidence-based, complex intervention to improve adherence to treatment for tuberculosis in the UK: the IMPACT study Open
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View article: S123 Mycobacterium tuberculosis (M.tb) and bacterial co-infection in BAL samples in a multi-centre UK cohort
S123 Mycobacterium tuberculosis (M.tb) and bacterial co-infection in BAL samples in a multi-centre UK cohort Open
Background M.tb and bacterial co-infection can complicate the clinical presentation of tuberculosis (TB) and may require additional antibiotic therapy. Yet there are limited data describing M.tb with bacterial co-infection in BAL samples i…
View article: P92 Outcomes of non-tuberculous mycobacterial pulmonary disease in an East London cohort
P92 Outcomes of non-tuberculous mycobacterial pulmonary disease in an East London cohort Open
Introduction Prevalence of non-tuberculous mycobacterial pulmonary disease (NTM-PD) is increasing. The diagnosis and treatment of NTM-PD present challenges as long treatment regimens with multiple agents can induce intolerable side effects…
View article: P139 Adverse effects of drugs used in the treatment of multi-drug resistant tuberculosis
P139 Adverse effects of drugs used in the treatment of multi-drug resistant tuberculosis Open
Introduction Multi-drug resistant tuberculosis (MDR-TB) remains a challenge despite shorter treatment regimes, with significant adverse effects that can impact psychological and physical aspects of health, potentially affecting treatment o…
View article: P136 Treatment outcomes of spinal tuberculosis patients
P136 Treatment outcomes of spinal tuberculosis patients Open
Introduction The diagnosis of spinal tuberculosis (TB) is often delayed, which may affect treatment outcomes. NICE Guidelines suggest to treat spinal TB for 6 months however it does not take into account severity of disease (multi-level in…
View article: Tuberculosis incidence in foreign-born people residing in European countries in 2020
Tuberculosis incidence in foreign-born people residing in European countries in 2020 Open
Background European-specific policies for tuberculosis (TB) elimination require identification of key populations that benefit from TB screening. Aim We aimed to identify groups of foreign-born individuals residing in European countries th…
View article: Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial
Evaluating the effect of short-course rifapentine-based regimens with or without enhanced behaviour-targeted treatment support on adherence and completion of treatment for latent tuberculosis infection among adults in the UK (RID-TB: Treat): protocol for an open-label, multicentre, randomised controlled trial Open
Introduction The successful scale-up of a latent tuberculosis (TB) infection testing and treatment programme is essential to achieve TB elimination. However, poor adherence compromises its therapeutic effectiveness. Novel rifapentine-based…