Hithanadura Janaka de Silva
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View article: Management of Irritable Bowel Syndrome: The Role of Digital Health Technologies
Management of Irritable Bowel Syndrome: The Role of Digital Health Technologies Open
Functional Gastrointestinal Disorders (FGIDs), including conditions such as irritable bowel syndrome (IBS) and functional dyspepsia, affect millions worldwide, significantly impairing quality of life and increasing healthcare utilization. …
View article: Comparison of gastric emptying of solid and semi-solid meals using real-time ultrasonography in healthy Sri Lankan adults
Comparison of gastric emptying of solid and semi-solid meals using real-time ultrasonography in healthy Sri Lankan adults Open
BACKGROUND Routine assessment of solid gastric emptying is challenging due to the prolonged test duration and complex meal preparation. Replacing solid test meals with easily prepared, commercially available semisolid meals and shortening …
View article: Gilbert’s syndrome: The good, the bad and the ugly
Gilbert’s syndrome: The good, the bad and the ugly Open
Gilbert’s syndrome (GS) is a common hereditary condition characterized by mild increases in serum bilirubin levels due to inherited defects in bilirubin metabolism. This review, based on peer-reviewed articles spanning from 1977 to January…
View article: "Clinical epidemiology of inflammatory bowel disease among adults in the South Asian region: A systematic review and meta-analysis"
"Clinical epidemiology of inflammatory bowel disease among adults in the South Asian region: A systematic review and meta-analysis" Open
This study provides an epidemiological overview of adult IBD characteristics, phenotypes, and treatment patterns in the South Asian region. There were epidemiological, clinical, phenotypic and treatment differences compared to western IBD.
View article: Comparison of cardiovascular risk prediction models developed using machine learning based on data from a Sri Lankan cohort with World Health Organization risk charts for predicting cardiovascular risk among Sri Lankans: a cohort study
Comparison of cardiovascular risk prediction models developed using machine learning based on data from a Sri Lankan cohort with World Health Organization risk charts for predicting cardiovascular risk among Sri Lankans: a cohort study Open
Introduction Models derived from non-Sri Lankan cohorts are used for cardiovascular (CV) risk stratification of Sri Lankans. Objective To develop a CV risk prediction model using machine learning (ML) based on data from a Sri Lankan cohort…
View article: Effects of global change on snakebite envenoming incidence up to 2050: a modelling assessment
Effects of global change on snakebite envenoming incidence up to 2050: a modelling assessment Open
UK Medical Research Council.
View article: Identification of patients with type 2 diabetes with non-alcoholic fatty liver disease who are at increased risk of progressing to advanced fibrosis: a cross-sectional study
Identification of patients with type 2 diabetes with non-alcoholic fatty liver disease who are at increased risk of progressing to advanced fibrosis: a cross-sectional study Open
Introduction Identification of advanced hepatic fibrosis in non-alcoholic fatty liver disease (NAFLD) is important as this may progress to cirrhosis and hepatocellular carcinoma. The risk of hepatic fibrosis is especially high among patien…
View article: Liver abscess in patients with thalassaemia: case series and a mini-review of the literature
Liver abscess in patients with thalassaemia: case series and a mini-review of the literature Open
Management of liver abscesses in patients with thalassaemia is a challenge due to difficult venous access, other organ dysfunction, diabetes mellitus and etc. Here we report four thalassaemia patients with liver abscess where three of them…
View article: Alcohol use and alcoholic fatty liver disease: a prospective, communitybased study among adults in an urban community in Sri Lanka
Alcohol use and alcoholic fatty liver disease: a prospective, communitybased study among adults in an urban community in Sri Lanka Open
In conclusion, in this community-based study among urban Sri Lankan adults, the annual incidence of AFL among unsafe alcohol users was 7.7%. Furthermore, new-onset AFL was associated with males.
View article: Geographically regulated designs of incidence surveys can match the precision of classical survey designs whilst requiring smaller sample sizes: the case of snakebite envenoming in Sri Lanka
Geographically regulated designs of incidence surveys can match the precision of classical survey designs whilst requiring smaller sample sizes: the case of snakebite envenoming in Sri Lanka Open
Background Snakebite envenoming is a neglected tropical disease. Data from the worst affected countries are limited because conducting epidemiological surveys is challenging. We assessed the utility of inhibitory geostatistical design with…
View article: Non-alcoholic fatty liver disease in the South Asian Region: A systematic review and meta-analysis
Non-alcoholic fatty liver disease in the South Asian Region: A systematic review and meta-analysis Open
Objectives We estimated the prevalence and effect sizes of associations for NAFLD, the commonest chronic liver disease worldwide, among South-Asian adults. Design We searched the PubMed database, using search terms “Prevalence of NAFLD (No…
View article: Prevalence of childhood obesity and its associations among adolescents: a cross-sectional, urban, community-based, birth cohort study from South Asia
Prevalence of childhood obesity and its associations among adolescents: a cross-sectional, urban, community-based, birth cohort study from South Asia Open
BackgroundThere are few community-based data on childhood obesity. We investigated the community prevalence and associations of adolescent obesity in a birth cohort from an urban community in Sri Lanka.MethodsThe study population consisted…
View article: Late-onset neurodegenerative manifestations in patients with cirrhosis: acquired hepatocerebral degeneration - a neglected diagnosis
Late-onset neurodegenerative manifestations in patients with cirrhosis: acquired hepatocerebral degeneration - a neglected diagnosis Open
Acquired hepatocerebral degeneration (AHCD) is an acquired, extrapyramidal, neurodegenerative condition, encountered in patients with cirrhosis. It is an uncommon and usually irreversible condition, resulting in widespread cerebral, basal …
View article: Spatially regulated designs of incidence surveys can match the precision of classical survey designs whilst requiring smaller sample sizes: the case of snakebite in Sri Lanka
Spatially regulated designs of incidence surveys can match the precision of classical survey designs whilst requiring smaller sample sizes: the case of snakebite in Sri Lanka Open
Background Snakebite envenoming is a neglected tropical disease. Data from the worst affected countries are limited because conducting epidemiological surveys is challenging. We assessed the utility of inhibitory geostatistical design with…
View article: Effects of probiotics combined with dietary and lifestyle modification on clinical, biochemical, and radiological parameters in obese children with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: a randomized clinical trial
Effects of probiotics combined with dietary and lifestyle modification on clinical, biochemical, and radiological parameters in obese children with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis: a randomized clinical trial Open
Background: Childhood obesity is a global problem associated with metabolic abnormalities. The gut-liver axis is thought to play a major role in its pathogenesis. Probiotics are known to alter the gut microbiota and, therefore, could be a …
View article: Redefining snakebite envenoming as a zoonosis: disease incidence is driven by snake ecology, socioeconomics and anthropogenic impacts
Redefining snakebite envenoming as a zoonosis: disease incidence is driven by snake ecology, socioeconomics and anthropogenic impacts Open
Snakebite is the only WHO-listed, not infectious neglected tropical disease (NTD), although its eco-epidemiology is similar to that of zoonotic infections: envenoming occurs after a vertebrate host contacts a human. Accordingly, snakebite …
View article: Evaluating spatiotemporal dynamics of snakebite in Sri Lanka: Monthly incidence mapping from a national representative survey sample
Evaluating spatiotemporal dynamics of snakebite in Sri Lanka: Monthly incidence mapping from a national representative survey sample Open
Background Snakebite incidence shows both spatial and temporal variation. However, no study has evaluated spatiotemporal patterns of snakebites across a country or region in detail. We used a nationally representative population sample to …
View article: Development of in-house ELISAs as an alternative method for the serodiagnosis of leptospirosis
Development of in-house ELISAs as an alternative method for the serodiagnosis of leptospirosis Open
The serovar-specific in-house ELISA could be used for the laboratory diagnosis of leptospirosis in endemic settings. The high levels of anti-leptospiral IgG observed suggest its value as a predictor of disease severity.
View article: Outcomes of NAFLD and MAFLD: Results from a community-based, prospective cohort study
Outcomes of NAFLD and MAFLD: Results from a community-based, prospective cohort study Open
Background The term “metabolic (dysfunction)-associated fatty liver disease” (MAFLD) is suggested alternative for “non-alcoholic fatty liver disease” (NAFLD), as it better reflects metabolic dysfunction. No study has compared outcomes of t…
View article: Integrating human behavior and snake ecology with agent-based models to predict snakebite in high risk landscapes
Integrating human behavior and snake ecology with agent-based models to predict snakebite in high risk landscapes Open
Snakebite causes more than 1.8 million envenoming cases annually and is a major cause of death in the tropics especially for poor farmers. While both social and ecological factors influence the chance encounter between snakes and people, t…
View article: Features of Covid-19 patients detected during community screening: A study from a rural hospital in Sri Lanka.
Features of Covid-19 patients detected during community screening: A study from a rural hospital in Sri Lanka. Open
We studied the clinical course and virus shedding of all patients referred to Welikanda Hospital, in one month. There were 53 positives for Covid-19 by PCR. 24 (45%) were male, with an age range of 11-94 years. Of these, 41 (77%) were asym…
View article: Outcomes of NAFLD and MAFLD: Results from a community-based, prospective cohort study
Outcomes of NAFLD and MAFLD: Results from a community-based, prospective cohort study Open
Introduction Metabolic (dysfunction)-associated fatty liver disease (MAFLD) is a recently suggested alternative to Non-alcoholic fatty liver disease (NAFLD). We compared baseline metabolic traits and outcomes of NAFLD and MAFLD. Methods In…