H. Richard Koerber
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View article: Kappa opioids inhibit spinal output neurons to suppress itch
Kappa opioids inhibit spinal output neurons to suppress itch Open
Itch is a protective sensation that drives scratching. Although specific cell types have been proposed to underlie itch, the neural basis for itch remains unclear. Here, we used two-photon Ca 2+ imaging of the dorsal horn to visualize neur…
View article: Identification of a convergent spinal neuron population that encodes itch
Identification of a convergent spinal neuron population that encodes itch Open
Summary Itch is a protective sensation that drives scratching. Although specific cell types have been proposed to underlie itch, the neural circuit basis for itch remains unclear. Here, we used two-photon Ca 2+ imaging of the dorsal horn t…
View article: Neuronally expressed PDL1, not PD1, suppresses acute nociception
Neuronally expressed PDL1, not PD1, suppresses acute nociception Open
View article: Cell type-specific calcium imaging of central sensitization in mouse dorsal horn
Cell type-specific calcium imaging of central sensitization in mouse dorsal horn Open
View article: Population Imaging of Central Sensitization
Population Imaging of Central Sensitization Open
Capsaicin applied locally to the skin causes central sensitization that results in allodynia, a state in which pain is elicited by innocuous stimuli. Here, we used two-photon calcium imaging of neurons in the dorsal spinal cord to visualiz…
View article: Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis Open
View article: Mrgprd Cre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit
Mrgprd Cre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit Open
Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, nonpeptidergic C fibers also respond to mecha…
View article: Decision letter: Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates
Decision letter: Pruriception and neuronal coding in nociceptor subtypes in human and nonhuman primates Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract In humans, intradermal administration of β…
View article: Parallel ascending spinal pathways for affective touch and pain
Parallel ascending spinal pathways for affective touch and pain Open
View article: Optogenetic evaluation of the ability of different cutaneous C-fiber afferents to evoke aversive behaviors
Optogenetic evaluation of the ability of different cutaneous C-fiber afferents to evoke aversive behaviors Open
Most cutaneous C-fibers, including both peptidergic and non-peptidergic subtypes are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, non-peptidergic C-fibers also respond to mech…
View article: Unique Molecular Characteristics of Visceral Afferents Arising from Different Levels of the Neuraxis: Location of Afferent Somata Predicts Function and Stimulus Detection Modalities
Unique Molecular Characteristics of Visceral Afferents Arising from Different Levels of the Neuraxis: Location of Afferent Somata Predicts Function and Stimulus Detection Modalities Open
Viscera receive innervation from sensory ganglia located adjacent to multiple levels of the brainstem and spinal cord. Here we examined whether molecular profiling could be used to identify functional clusters of colon afferents from thora…
View article: Unique molecular characteristics of visceral afferents arising from different levels of the neuraxis: location of afferent somata predicts function and stimulus detection modalities
Unique molecular characteristics of visceral afferents arising from different levels of the neuraxis: location of afferent somata predicts function and stimulus detection modalities Open
Visceral organs receive neural innervation from sensory ganglia located adjacent to multiple levels of the brainstem and spinal cord. Here we examined whether molecular profiling could be used to identify functional clusters of colon affer…
View article: Distribution of functional opioid receptors in human dorsal root ganglion neurons
Distribution of functional opioid receptors in human dorsal root ganglion neurons Open
Preclinical evidence has highlighted the importance of the μ-opioid peptide (MOP) receptor on primary afferents for both the analgesic actions of MOP receptor agonists, as well as the development of tolerance, if not opioid-induced hyperal…
View article: Extracellular ATP released from<i>Candida albicans</i>activates non-peptidergic neurons to augment host defense
Extracellular ATP released from<i>Candida albicans</i>activates non-peptidergic neurons to augment host defense Open
Intestinal microbes release ATP to modulate local immune responses. Herein we demonstrates that Candida albicans , an opportunistic commensal fungus, also modulates immune responses via secretion of ATP. We found that ATP secretion from C.…
View article: Selective-cold output through a distinct subset of lamina I spinoparabrachial neurons
Selective-cold output through a distinct subset of lamina I spinoparabrachial neurons Open
Spinal projection neurons are a major pathway through which somatic stimuli are conveyed to the brain. However, the manner in which this information is coded is poorly understood. Here, we report the identification of a modality-selective …
View article: A labeled-line for cold from the periphery to the parabrachial nucleus
A labeled-line for cold from the periphery to the parabrachial nucleus Open
Spinal projection neurons are a major pathway through which somatic stimuli are conveyed to the brain. However, the manner in which this information is coded is poorly understood. Here, we report the identification of a modality-selective …
View article: Single cell q-PCR derived expression profiles of identified sensory neurons
Single cell q-PCR derived expression profiles of identified sensory neurons Open
Sensory neurons are chemically and functionally heterogeneous and this heterogeneity has been examined extensively over the last several decades. These studies have employed a variety of different methodologies, including anatomical, elect…
View article: Nicotine Evoked Currents in Human Primary Sensory Neurons
Nicotine Evoked Currents in Human Primary Sensory Neurons Open
View article: Single-cell q-PCR derived expression profiles of identified sensory neurons
Single-cell q-PCR derived expression profiles of identified sensory neurons Open
Sensory neurons are chemically and functionally heterogeneous, and this heterogeneity has been examined extensively over the last several decades. These studies have employed a variety of different methodologies, including anatomical, elec…
View article: Kappa Opioid Receptor Distribution and Function in Primary Afferents
Kappa Opioid Receptor Distribution and Function in Primary Afferents Open
View article: Wind-up in lamina I spinoparabrachial neurons: a role for reverberatory circuits
Wind-up in lamina I spinoparabrachial neurons: a role for reverberatory circuits Open
Wind-up is a frequency-dependent increase in the response of spinal cord neurons, which is believed to underlie temporal summation of nociceptive input. However, whether spinoparabrachial neurons, which likely contribute to the affective c…
View article: Cutaneous TRPM8-expressing sensory afferents are a small population of neurons with unique firing properties
Cutaneous TRPM8-expressing sensory afferents are a small population of neurons with unique firing properties Open
It has been well documented that the transient receptor potential melastatin 8 (TRPM8) receptor is involved in environmental cold detection. The role that this receptor plays in nociception however, has been somewhat controversial since co…
View article: Cutaneous neurturin overexpression alters mechanical, thermal, and cold responsiveness in physiologically identified primary afferents
Cutaneous neurturin overexpression alters mechanical, thermal, and cold responsiveness in physiologically identified primary afferents Open
Neurotrophic factors play an important role in the regulation of functional properties of sensory neurons under normal and pathological conditions. The GDNF family member neurturin is one such factor that has been linked to modulating resp…
View article: Semi-intact ex vivo approach to investigate spinal somatosensory circuits
Semi-intact ex vivo approach to investigate spinal somatosensory circuits Open
The somatosensory input that gives rise to the perceptions of pain, itch, cold and heat are initially integrated in the superficial dorsal horn of the spinal cord. Here, we describe a new approach to investigate these neural circuits in mo…
View article: Author response: Semi-intact ex vivo approach to investigate spinal somatosensory circuits
Author response: Semi-intact ex vivo approach to investigate spinal somatosensory circuits Open
View article: Deletion of the murine ATP/UTP receptor P2Y2 alters mechanical and thermal response properties in polymodal cutaneous afferents
Deletion of the murine ATP/UTP receptor P2Y2 alters mechanical and thermal response properties in polymodal cutaneous afferents Open
View article: Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes
Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes Open
The extent to which the skin instructs peripheral somatosensory neuron maturation is unknown. We studied this question in Merkel cell–neurite complexes, where slowly adapting type I (SAI) neurons innervate skin-derived Merkel cells. Transg…
View article: Keratinocytes can modulate and directly initiate nociceptive responses
Keratinocytes can modulate and directly initiate nociceptive responses Open
How thermal, mechanical and chemical stimuli applied to the skin are transduced into signals transmitted by peripheral neurons to the CNS is an area of intense study. Several studies indicate that transduction mechanisms are intrinsic to c…
View article: Author response: Keratinocytes can modulate and directly initiate nociceptive responses
Author response: Keratinocytes can modulate and directly initiate nociceptive responses Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract How thermal, mechanical and chemical stimuli ap…