Joel H. Kramer
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View article: Tablet‐based Cognitive Assessment Tool (TabCAT) in a multisite study of early‐onset Alzheimer's disease
Tablet‐based Cognitive Assessment Tool (TabCAT) in a multisite study of early‐onset Alzheimer's disease Open
INTRODUCTION Brief digital cognitive measures may be a valuable and scalable alternative to traditional tests for improving early detection and disease monitoring in patients with early‐onset Alzheimer's disease (EOAD). METHODS We examined…
View article: Longitudinal functional network connectivity changes across the clinical stages of <i>C9orf72</i> hexanucleotide repeat expansion carriers
Longitudinal functional network connectivity changes across the clinical stages of <i>C9orf72</i> hexanucleotide repeat expansion carriers Open
INTRODUCTION Intrinsic functional connectivity network abnormalities in C9orf72 hexanucleotide repeat expansion carriers emerge during the asymptomatic phase, yet longitudinal studies remain limited. We examined cross-sectional abnormaliti…
View article: Functional network collapse in neurodegenerative disease
Functional network collapse in neurodegenerative disease Open
Cognitive and behavioral deficits in Alzheimer’s disease (AD) and frontotemporal dementia (FTD) arise alongside gray matter atrophy and altered functional connectivity, yet the structure-function relationship across the dementia spectrum r…
View article: Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings
Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings Open
Background Remote, smartphone-based cognitive testing may improve access to cognitive assessments for Alzheimer’s disease and related dementias. We evaluated the feasibility, reliability, and validity of unsupervised smartphone-based cogni…
View article: A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brain
A proteomic signature of vascular dysfunction linked to tauopathy and degeneration in the aging brain Open
Small vessel disease (SVD) impacts healthy aging of organs across the body, yet its contributions to adverse brain aging remain poorly defined. Here we show thromboinflammation, a core feature of SVD, as a driver of adverse brain aging. We…
View article: Burden of psychiatric disease inversely correlates with Alzheimer's age at onset
Burden of psychiatric disease inversely correlates with Alzheimer's age at onset Open
INTRODUCTION Depression is regarded as a risk factor for Alzheimer's disease (AD). Associations between AD and other psychiatric disorders are less clear. METHODS We screened 1,500 AD UCSF Memory and Aging Center patients for prevalence of…
View article: Combining plasma neurofilament light chain and frontotemporal atrophy improves differentiation of bvFTD from primary psychiatric disorders
Combining plasma neurofilament light chain and frontotemporal atrophy improves differentiation of bvFTD from primary psychiatric disorders Open
INTRODUCTION Distinguishing behavioral variant frontotemporal dementia (bvFTD) from primary psychiatric disorders (PPDs) remains challenging due to overlapping clinical presentation. Neurofilament light chain (NfL) is a biomarker of neuron…
View article: Moderating effects of plasma glial fibrillary acidic protein along the Alzheimer's disease continuum
Moderating effects of plasma glial fibrillary acidic protein along the Alzheimer's disease continuum Open
INTRODUCTION Glial fibrillary acidic protein (GFAP) may contribute to Alzheimer's pathology at early disease stages. GFAP moderation of Alzheimer's disease (AD)‐related neurodegeneration and cognition is unclear. METHODS We examined plasma…
View article: Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype
Neurodevelopment and neural environment inform Alzheimer's disease age at onset and phenotype Open
INTRODUCTION Risk factors associated with sporadic non‐amnestic and early‐onset Alzheimer's disease (AD) remain underexamined. METHODS We investigated a large, clinically heterogeneous, AD cohort for frequencies of established risk factors…
View article: Enhancing early detection of cognitive impairment in primary care with the TabCAT‐BHA
Enhancing early detection of cognitive impairment in primary care with the TabCAT‐BHA Open
INTRODUCTION As dementia cases increase and new therapies become available, timely diagnosis is critical yet challenging in primary care. We evaluated the TabCAT‐Brain Health Assessment (TabCAT‐BHA) digital paradigm to assist with early de…
View article: 0042 Rest-activity-patterns and Daytime Napping Differ Across Alzheimer’s Disease Phenotypes
0042 Rest-activity-patterns and Daytime Napping Differ Across Alzheimer’s Disease Phenotypes Open
Introduction Sleep disruption in Alzheimer’s disease (AD) is common, linked to cognitive decline, and a major cause of institutionalization. While AD is associated with increased daytime napping, nocturnal wakefulness, and disrupted rest-a…
View article: 0043 Sex Differences in Circadian Behavior and GFAP Expression in Cognitively Unimpaired Older Adults
0043 Sex Differences in Circadian Behavior and GFAP Expression in Cognitively Unimpaired Older Adults Open
Introduction Glial fibrillary acidic protein (GFAP, marker of astrocyte activation) expression is associated with disrupted circadian rhythms and increased risk of cognitive impairment. The risk of cognitive impairment also increases with …
View article: <i>BDNF</i> Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults
<i>BDNF</i> Val66Met polymorphism moderates associations between physical activity and neurocognitive outcomes in older adults Open
INTRODUCTION Increased brain‐derived neurotrophic factor (BDNF) release through physical activity (PA) is thought to underlie protective effects of PA on brain aging. The BDNF Val66Met single‐nucleotide polymorphism (rs6265) reduces activi…
View article: Caregiver Assessment of Socioemotional Functioning in People Living With Neurodegenerative Disease (Part 1): Construct Validity of a New Measure
Caregiver Assessment of Socioemotional Functioning in People Living With Neurodegenerative Disease (Part 1): Construct Validity of a New Measure Open
Background and Objectives Neurodegenerative diseases cause socioemotional changes that are commonly measured using laboratory-based assessments. However, these assessments can be labor-, cost-, and time-intensive. We aim to establish the p…
View article: Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration <scp>TDP</scp>‐43 A and B
Clinical and Imaging Features of Sporadic and Genetic Frontotemporal Lobar Degeneration <span>TDP</span>‐43 A and B Open
Objective Certain frontotemporal lobar degeneration subtypes, including TDP‐A and B, can either occur sporadically or in association with specific genetic mutations. It is uncertain whether syndromic or imaging features previously associat…
View article: Validation of the Cognitive-Emotional Perspective Taking test in patients with neurodegeneration
Validation of the Cognitive-Emotional Perspective Taking test in patients with neurodegeneration Open
Background Theory of mind (ToM) is crucial for socioemotional interaction. ToM deficits may explain behavioral changes in dementia, especially Alzheimer's disease (AD) and frontotemporal dementia (FTD). Objective This study examined the ps…
View article: Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer's Disease for use in clinical trials
Characterizing and validating 12-month reliable cognitive change in Early-Onset Alzheimer's Disease for use in clinical trials Open
The current results support including EOAD patients in longitudinal clinical trials, and generate evidence of validation for using 12-month reliable cognitive change as a clinical outcome metric in clinical trials in EOAD cohorts like LEAD…
View article: Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo
Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo Open
Objective The 2024 Alzheimer’s Association (AA) research diagnostic criteria for Alzheimer’s Disease (AD) considers fluid biomarkers, including promising blood-based biomarkers for detecting AD. This study aims to identify dementia subtype…
View article: Detection of Alzheimer Neuropathology in Alzheimer and Non-Alzheimer Clinical Syndromes With Blood-Based Biomarkers
Detection of Alzheimer Neuropathology in Alzheimer and Non-Alzheimer Clinical Syndromes With Blood-Based Biomarkers Open
Importance Blood-based biomarkers for Alzheimer disease (AD) are clinically available, but their value is not well understood in syndromes typically associated with frontotemporal lobar degeneration syndromes (FTLD). Objective To investiga…
View article: Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer's disease: A head‐to‐head comparison of the LEADS and ADNI cohorts
Dissociable spatial topography of cortical atrophy in early‐onset and late‐onset Alzheimer's disease: A head‐to‐head comparison of the LEADS and ADNI cohorts Open
INTRODUCTION Early‐onset and late‐onset Alzheimer's disease (EOAD and LOAD, respectively) have distinct clinical manifestations, with prior work based on small samples suggesting unique patterns of neurodegeneration. The current study perf…
View article: Neurophysiological signatures of ageing: compensatory and compromised neural mechanisms
Neurophysiological signatures of ageing: compensatory and compromised neural mechanisms Open
Spatiotemporal patterns of neural oscillations change with ageing, even in the cognitively unimpaired individual. Whether these neurophysiological changes represent ageing-related vulnerabilities or mechanisms that support cognitive resili…
View article: Network changes associated with right anterior temporal lobe atrophy: insight into unique symptoms
Network changes associated with right anterior temporal lobe atrophy: insight into unique symptoms Open
Semantic behavioural variant (also referred to as right temporal) frontotemporal dementia is a newly described syndrome associated with predominant right anterior temporal lobe atrophy and a distinctive combination of behavioural and seman…
View article: MRI free water mediates the association between diffusion tensor image analysis along the perivascular space and executive function in four independent middle to aged cohorts
MRI free water mediates the association between diffusion tensor image analysis along the perivascular space and executive function in four independent middle to aged cohorts Open
INTRODUCTION Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index was proposed for assessing glymphatic clearance function. This study evaluated DTI‐ALPS as a biomarker for cerebral small vessel disease (cSVD) rela…
View article: THE DYNAMIC AFFECT RECOGNITION TEST: CONSTRUCTION AND VALIDATION IN NEURODEGENERATIVE SYNDROMES
THE DYNAMIC AFFECT RECOGNITION TEST: CONSTRUCTION AND VALIDATION IN NEURODEGENERATIVE SYNDROMES Open
Learning objective To validate a novel video-based emotion identification measure in persons with neurodegeneration and show correspondence to emotion-relevant brain systems Background Given advances in disease-modifying therapies for deme…
View article: Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease
Brain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease Open
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate ‘pro-aging’ or ‘pro-youthful’ effects on the mouse brain. The clinical relevance and combined effec…
View article: Exploring Cognitive and Neuroimaging Profiles of Dementia Subtypes of Individuals with Dementia in the Democratic Republic of Congo
Exploring Cognitive and Neuroimaging Profiles of Dementia Subtypes of Individuals with Dementia in the Democratic Republic of Congo Open
Objective The 2024 Alzheimer’s Association (AA) research diagnostic criteria for Alzheimer’s Disease (AD) considers fluid biomarkers, including promising blood-based biomarkers for detecting AD. This study aims to identify dementia subtype…
View article: White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status
White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status Open
INTRODUCTION Placental growth factor (PlGF) may regulate cerebrovascular permeability. We hypothesized that white matter interstitial fluid accumulation, estimated via magnetic resonance imaging (MRI) free water (FW), would explain the ass…