Lan Xiao
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View article: Post-translational modifications in ovarian cancer: implications for immunotherapy: a mini-review
Post-translational modifications in ovarian cancer: implications for immunotherapy: a mini-review Open
Ovarian cancer (OC) is the most lethal gynecologic malignancies worldwide, is characterized by poor prognosis and limited treatment options. While immunotherapy has shown promise in treating gynecologic cancers, particularly OC, its effica…
View article: Heparin administration at first medical contact vs immediately before primary percutaneous coronary intervention: the HELP-PCI trial
Heparin administration at first medical contact vs immediately before primary percutaneous coronary intervention: the HELP-PCI trial Open
Background and Aims The beneficial effect of pre-treatment with unfractionated heparin (UFH) at first medical contact (FMC) before primary percutaneous coronary intervention (PPCI) in all-comers with ST-elevation myocardial infarction (STE…
View article: A 3R (remove-remodel-repair)-integrated self-assembled Chlorella-gelatin-PEG hydrogel for diabetic wound healing
A 3R (remove-remodel-repair)-integrated self-assembled Chlorella-gelatin-PEG hydrogel for diabetic wound healing Open
View article: Novel <scp><i>ABCD1</i></scp> Variants in X‐Linked Adrenoleukodystrophy
Novel <span><i>ABCD1</i></span> Variants in X‐Linked Adrenoleukodystrophy Open
X‐linked adrenoleukodystrophy (X‐ALD) is a neurodegenerative disorder caused by mutations in the ABCD1 gene. We reported the clinical features and genetic findings of 17 X‐ALD patients. Fifteen variants were identified, including five nove…
View article: Fatigue in the Preataxic and Ataxic Stages of Spinocerebellar Ataxia Type 3
Fatigue in the Preataxic and Ataxic Stages of Spinocerebellar Ataxia Type 3 Open
Objective Fatigue is a significant symptom in patients with spinocerebellar ataxia type 3 (SCA3). This study explores the role of fatigue in SCA3, examining its impact on quality of life and its potential as an indicator of disease progres…
View article: Bacteria‐Derived Extracellular Vesicle as A “Trojan Horse” for Selective M1 Macrophage‐Targeting in A Multi‐Cellular Entanglement Environment
Bacteria‐Derived Extracellular Vesicle as A “Trojan Horse” for Selective M1 Macrophage‐Targeting in A Multi‐Cellular Entanglement Environment Open
The temporary transition of macrophages from a pro‐inflammatory macrophages (M1) to an anti‐inflammatory macrophages (M2) is crucial for tissue repair and regeneration processes. Selectively targeting M1 macrophages is preferred to modulat…
View article: Survival of Endodontically Treated Teeth with Direct and Indirect Posts: A 5-Year Retrospective Evaluation at an Australian University Dental Clinic
Survival of Endodontically Treated Teeth with Direct and Indirect Posts: A 5-Year Retrospective Evaluation at an Australian University Dental Clinic Open
Restoring endodontically treated teeth has always been a challenge in dentistry. Dental posts are used when further retention is required for the final restoration, indicating that the tooth is already structurally compromised. Varying sur…
View article: Insights into Bioengineering Approaches for Aging Bone Regeneration: Strategies to Target Osteoimmunosenescence
Insights into Bioengineering Approaches for Aging Bone Regeneration: Strategies to Target Osteoimmunosenescence Open
Review Insights into Bioengineering Approaches for Aging Bone Regeneration: Strategies to Target Osteoimmunosenescence Lan Xiao 1,2,†, Wendong Gao 1,2,†, Jinfu Wu 3, Itsasne Erezuma 4, Alireza Dolatshahi-Pirouz 5, Joana Silva-Correia 6,7, …
View article: Muscle Fibrous Porous Microspheres Boost Rotator Cuff Regeneration within a Biomimetic Dynamic Mechanical Niche
Muscle Fibrous Porous Microspheres Boost Rotator Cuff Regeneration within a Biomimetic Dynamic Mechanical Niche Open
View article: Food insecurity among older adult Asian Americans: concerning trends
Food insecurity among older adult Asian Americans: concerning trends Open
Objective: Little is known about food insecurity in Asian Americans (AA). We examined age/ethnic subgroup differences in food insecurity among AA in California. Design: We examined associations between food insecurity and socio-demographic…
View article: Self-powered hydrogel improves bone regeneration via bone drived biomechanical piezoelectricity
Self-powered hydrogel improves bone regeneration via bone drived biomechanical piezoelectricity Open
Large bone defect healing remains a challenge in current clinical treatment, which suggests the need for functional bone repair materials. Piezoelectric materials can generate electrical stimulation under mechanical stress to improve the t…
View article: Multifunctional Bone Regeneration Membrane with Flexibility, Electrical Stimulation Activity and Osteoinductive Activity
Multifunctional Bone Regeneration Membrane with Flexibility, Electrical Stimulation Activity and Osteoinductive Activity Open
The use of membrane‐based guided bone regeneration techniques has great potential for single‐stage reconstruction of critical‐sized bone defects. Here, a multifunctional bone regeneration membrane combining flexible elasticity, electrical …
View article: Corrigendum to ‘Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects’ [Mater. Today Bio 26, June 2024, 101092]
Corrigendum to ‘Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects’ [Mater. Today Bio 26, June 2024, 101092] Open
[This corrects the article DOI: 10.1016/j.mtbio.2024.101092.].
View article: Peripheral sensory nerve regeneration: Novel target in bone tissue engineering
Peripheral sensory nerve regeneration: Novel target in bone tissue engineering Open
Synthetic biomaterials are emerging candidate solutions for treating large bone defects. However, the clinical performances of most synthetic materials are not satisfactory, with the need for improvement in design and synthesis. Although b…
View article: A Glycoprotein-Based Surface-Enhanced Raman Spectroscopy–Lateral Flow Assay Method for Abrin and Ricin Detection
A Glycoprotein-Based Surface-Enhanced Raman Spectroscopy–Lateral Flow Assay Method for Abrin and Ricin Detection Open
Abrin and ricin, both type II ribosome-inactivating proteins, are toxins of significant concern and are under international restriction by the Chemical Weapons Convention and the Biological and Toxin Weapons Convention. The development of …
View article: Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon‐to‐Bone Healing: A Large Animal Study and Short‐Term Outcome of a Clinical Trial
Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon‐to‐Bone Healing: A Large Animal Study and Short‐Term Outcome of a Clinical Trial Open
Tissue engineering has demonstrated its efficacy in promoting tissue regeneration, and extensive research has explored its application in rotator cuff (RC) tears. However, there remains a paucity of research translating from bench to clini…
View article: Impact of nursing interventions in obstetric and gynecological surgery: A bibliometric and visual analysis
Impact of nursing interventions in obstetric and gynecological surgery: A bibliometric and visual analysis Open
View article: Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects
Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects Open
Osteoporosis (OP) can result in slower bone regeneration than the normal condition due to the imbalance between osteogenesis and osteoclastogenesis, making osteoporotic bone defects healing a significant clinical challenge. Calcium phospha…
View article: The decisive early phase of biomaterial-induced bone regeneration
The decisive early phase of biomaterial-induced bone regeneration Open
View article: Gold Nanoparticles Confined in Mesoporous Bioactive Glass for Periodontitis Therapy
Gold Nanoparticles Confined in Mesoporous Bioactive Glass for Periodontitis Therapy Open
Periodontitis is a chronic disease caused by bacterial infection and is characterized with alveolar bone resorption. Bone regeneration in periodontitis remains a critical challenge because bacterial infection induced an unfavorable microen…
View article: Injectable, anti-collapse, adhesive, plastic and bioactive bone graft substitute promotes bone regeneration by moderating oxidative stress in osteoporotic bone defect
Injectable, anti-collapse, adhesive, plastic and bioactive bone graft substitute promotes bone regeneration by moderating oxidative stress in osteoporotic bone defect Open
The treatment of osteoporotic bone defect remains a big clinical challenge because osteoporosis (OP) is associated with oxidative stress and high levels of reactive oxygen species (ROS), a condition detrimental for bone formation. Anti-oxi…
View article: Gold capped mesoporous bioactive glass guides bone regeneration via BMSCs recruitment and drug adaptive release
Gold capped mesoporous bioactive glass guides bone regeneration via BMSCs recruitment and drug adaptive release Open
View article: Abstract 21: Examining the Impact of Food as Medicine on Heart Health
Abstract 21: Examining the Impact of Food as Medicine on Heart Health Open
Introduction: The recent White House Conference on Hunger, Nutrition, and Health in October 2022 made it a national priority to address food and nutrition insecurity and reduce inequities in nutrition-related chronic conditions such as hea…
View article: Editorial: The interplay between endocrine and immune systems in metabolic diseases
Editorial: The interplay between endocrine and immune systems in metabolic diseases Open
Citation: Xiao L, Wang W and Han P (2024) Editorial: The interplay between endocrine and immune systems in metabolic diseases. Front. Endocrinol. 15:1385271. doi: 10.3389/fendo.2024.1385271
View article: Remodeling of the Intra‐Conduit Inflammatory Microenvironment to Improve Peripheral Nerve Regeneration with a Neuromechanical Matching Protein‐Based Conduit
Remodeling of the Intra‐Conduit Inflammatory Microenvironment to Improve Peripheral Nerve Regeneration with a Neuromechanical Matching Protein‐Based Conduit Open
Peripheral nerve injury (PNI) remains a challenging area in regenerative medicine. Nerve guide conduit (NGC) transplantation is a common treatment for PNI, but the prognosis of NGC treatment is unsatisfactory due to 1) neuromechanical unma…
View article: Photo-triggered multifunctional gold-based hybrid nanoflowers promote infectious skin regeneration
Photo-triggered multifunctional gold-based hybrid nanoflowers promote infectious skin regeneration Open
The skin wound-healing under infectious conditions remains challenging owing to the lack of efficient strategies to inhibit drug-resistant bacteria growth and control inflammation. Photothermal therapy shows efficient antimicrobial effects…
View article: A Self-Gelling Hemostatic Powder Boosts Radiotherapy-Elicited Nk Cell Immunity to Combat Postoperative Hepatocellular Carcinoma Relapse
A Self-Gelling Hemostatic Powder Boosts Radiotherapy-Elicited Nk Cell Immunity to Combat Postoperative Hepatocellular Carcinoma Relapse Open
View article: Four‐Arm Polymer‐Guided Formation of Curcumin‐Loaded Flower‐Like Porous Microspheres as Injectable Cell Carriers for Diabetic Wound Healing (Adv. Healthcare Mater. 30/2023)
Four‐Arm Polymer‐Guided Formation of Curcumin‐Loaded Flower‐Like Porous Microspheres as Injectable Cell Carriers for Diabetic Wound Healing (Adv. Healthcare Mater. 30/2023) Open
View article: The effect of a bionic bone ionic environment on osteogenesis, osteoimmunology, and in situ bone tissue engineering
The effect of a bionic bone ionic environment on osteogenesis, osteoimmunology, and in situ bone tissue engineering Open
View article: Biomimetic Structural Protein Based Magnetic Responsive Scaffold for Enhancing Bone Regeneration by Physical Stimulation on Intracellular Calcium Homeostasis
Biomimetic Structural Protein Based Magnetic Responsive Scaffold for Enhancing Bone Regeneration by Physical Stimulation on Intracellular Calcium Homeostasis Open
The bone matrix has distinct architecture and biochemistry which present a barrier to synthesizing bone‐mimetic regenerative scaffolds. To mimic the natural structures and components of bone, biomimetic structural decellularized extracellu…