Explanipedia

Next-generation precision medicine for pain Open

R. Bhagar, H Le-Niculescu, S. Corey, A. S. Gettelfinger, Martha Schmitz , et al. · 2025

Chronic pain remains a massive problem in society in general, and in mental health patients in particular, being strongly bi-directionally connected to mental health. Lack of widespread use of objective information has hampered treatment a…

Next-generation precision medicine for suicidality prevention Open

R. Bhagar, Sapna Gill, H Le-Niculescu, Yin Chen, K. Roseberry , et al. · 2024

Temporal effects on death by suicide: empirical evidence and possible molecular correlates Open

R. Bhagar, H Le-Niculescu, K. Roseberry, K. Kosary, Christine Daly , et al. · 2023

Towards precision medicine for anxiety disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs Open

K. Roseberry, H Le-Niculescu, Daniel F. Levey, R. Bhagar, Katherine C. Soe , et al. · 2023

Precision medicine in psychiatry: biomarkers to the forefront Open

Alexander B. Niculescu, H Le-Niculescu · 2021

Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs Open

H Le-Niculescu, K. Roseberry, Sapna Gill, Daniel F. Levey, Peter Phalen , et al. · 2021

Blood biomarkers for memory: toward early detection of risk for Alzheimer disease, pharmacogenomics, and repurposed drugs Open

Alexander B. Niculescu, H Le-Niculescu, K. Roseberry, Songlin Wang, Jaynee E. Hart , et al. · 2019

Short-term memory dysfunction is a key early feature of Alzheimer’s disease (AD). Psychiatric patients may be at higher risk for memory dysfunction and subsequent AD due to the negative effects of stress and depression on the brain. We car…

P2‐260: BLOOD BIOMARKERS FOR MEMORY: TOWARDS EARLY DETECTION OF RISK FOR ALZHEIMER DISEASE, PHARMACOGENOMICS, AND REPURPOSED DRUGS Open

Alexander B. Niculescu, H Le-Niculescu, Sophia Wang, Bruce T. Lamb, Debomoy K. Lahiri , et al. · 2019

Early identification of individuals at risk for AD may open the door to preventive approaches. Memory dysfunction is a key feature of AD. We proposed to identify blood biomarkers that track a relevant related quantitative phenotype, the re…

Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs Open

H Le-Niculescu, K. Roseberry, Daniel F. Levey, Jesse D. Rogers, K. Kosary , et al. · 2019

Towards precision medicine for pain: diagnostic biomarkers and repurposed drugs Open

Alexander B. Niculescu, H Le-Niculescu, Daniel F. Levey, K. Roseberry, Katherine C. Soe , et al. · 2019

Assessing Risk of Future Suicidality in Emergency Department Patients Open

Krista Brucker, Carter Duggan, Joseph Niezer, Kyle Roseberry, H Le-Niculescu , et al. · 2018

Background Emergency departments ( ED ) are the first line of evaluation for patients at risk and in crisis, with or without overt suicidality (ideation, attempts). Currently employed triage and assessments methods miss some of the individ…

Precision medicine for suicidality: from universality to subtypes and personalization Open

Alexander B. Niculescu, H Le-Niculescu, Daniel F. Levey, Peter Phalen, H L Dainton , et al. · 2017

Dissecting Suicidality Using a Combined Genomic and Clinical Approach Open

Alexander B. Niculescu, H Le-Niculescu · 2016

Mood, stress and longevity: convergence on ANK3 Open

Sunitha Rangaraju, Daniel F. Levey, Kwangsik Nho, Neha Jain, Katharine D. Andrews , et al. · 2016

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach Open

Alexander B. Niculescu, Daniel F. Levey, Peter Phalen, H Le-Niculescu, Helen Dainton‐Howard , et al. · 2015

Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions Open

Alexander B. Niculescu, Daniel F. Levey, H Le-Niculescu, E M Niculescu, Sunil M. Kurian , et al. · 2015

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