Jun Lyu
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View article: From glycemic variability to digital signal biomarker: a prognostic and precision medicine framework for sepsis-associated acute kidney injury
From glycemic variability to digital signal biomarker: a prognostic and precision medicine framework for sepsis-associated acute kidney injury Open
Sepsis, a condition with substantial global morbidity and mortality, frequently leads to sepsis-associated acute kidney injury (SA-AKI). While glycemic variability (GV) correlates with adverse outcomes in critically ill populations, its pr…
View article: Virtual Element Method for Piezoelasticity
Virtual Element Method for Piezoelasticity Open
This paper presents a Virtual Element Method (VEM) for the simulation of 2D and 3D piezoelectric problems. Piezoelectric materials exhibit strong multiphysics coupling behavior and have the ability to convert mechanical energy into electri…
View article: Whole genome transcriptome sequencing in inherited bone marrow failure syndromes and related diseases – the ibmdx study
Whole genome transcriptome sequencing in inherited bone marrow failure syndromes and related diseases – the ibmdx study Open
Inherited bone marrow failure syndromes (IBMFS) are a group of monogenic diseases of diverse pathogenesis manifesting as single or multilineage cytopenia typically due to hypoproliferative dyshematopoiesis. Accurately diagnosing IBMFS is c…
View article: Digital finance for economic resilience: the uneven impact of Fintech across urban China
Digital finance for economic resilience: the uneven impact of Fintech across urban China Open
Introduction This study examines the uneven impact of financial technology (Fintech) on economic resilience with empirical case of Chinese cities. Results The results reveal a U-shaped relationship between Fintech development and economic …
View article: Liraglutide in Acute Minor Ischemic Stroke or High-Risk Transient Ischemic Attack With Type 2 Diabetes
Liraglutide in Acute Minor Ischemic Stroke or High-Risk Transient Ischemic Attack With Type 2 Diabetes Open
Importance Glucagon-like peptide–1 receptor agonists can reduce the risk of cardiovascular events in patients with high-risk type 2 diabetes (T2D). However, dedicated randomized clinical trials that evaluate their efficacy in acute ischemi…
View article: Baitong Decoction Ameliorates DSS-Induced Colitis via Modulation of STING and JAK/STAT Pathways
Baitong Decoction Ameliorates DSS-Induced Colitis via Modulation of STING and JAK/STAT Pathways Open
Baitong decoction (BTD), a classical traditional Chinese medicine formulation, is widely recognized for its pharmacological potential in treating digestive diseases, yet its mechanisms of action in ulcerative colitis (UC) remain unclear. T…
View article: Butyrate blocks specific histone acetylation by preventing recruitment of p300 to acetylated histones
Butyrate blocks specific histone acetylation by preventing recruitment of p300 to acetylated histones Open
Butyrate, a short-chain fatty acid (SCFA) produced by microbial fermentation of dietary fiber, exerts beneficial metabolic and immunomodulatory functions through hyperactivation of the histone acetylase (HAT) p300 and inhibition of histone…
View article: A phenome-wide spectrum of morbidity and mortality risks related to the number of offspring among 0.5 million Chinese men and women: A prospective cohort study
A phenome-wide spectrum of morbidity and mortality risks related to the number of offspring among 0.5 million Chinese men and women: A prospective cohort study Open
Background: Prospective evidence on how offspring number influences morbidity and mortality remains limited. This study investigated the associations between number of offspring and morbidity and mortality risks among 0.5 million Chinese a…
View article: XYZCylinder: Towards Compatible Feed-Forward 3D Gaussian Splatting for Driving Scenes via Unified Cylinder Lifting Method
XYZCylinder: Towards Compatible Feed-Forward 3D Gaussian Splatting for Driving Scenes via Unified Cylinder Lifting Method Open
Feed-forward paradigms for 3D reconstruction have become a focus of recent research, which learn implicit, fixed view transformations to generate a single scene representation. However, their application to complex driving scenes reveals s…
View article: Endometriosis-associated infertility: Multi-omics insights into pathogenesis and precision therapeutics
Endometriosis-associated infertility: Multi-omics insights into pathogenesis and precision therapeutics Open
Introduction Endometriosis is a prevalent, estrogen-dependent, inflammatory disease that impairs fertility via hormonal dysregulation, immune dysfunction, oxidative stress/ferroptosis, genetic and epigenetic alterations, and microbiome imb…
View article: #1023 Association between baseline serum creatinine/cystatin C (SCr/CYS) ratio and adverse events in patients receiving cisplatin or carboplatin: a prospective cohort study
#1023 Association between baseline serum creatinine/cystatin C (SCr/CYS) ratio and adverse events in patients receiving cisplatin or carboplatin: a prospective cohort study Open
Background and Aims Large discrepancies between serum creatinine (SCr) and cystatin C (CYS) have been used to identify frailty. Having a low SCr/CYS ratio is associated with sarcopenia and has been used to predict mortality in patients wit…
View article: Global Epidemiology and Burden of Migraine in Children and Adolescents from 1990 to 2021: Insights from the Global Burden of Disease Study 2021
Global Epidemiology and Burden of Migraine in Children and Adolescents from 1990 to 2021: Insights from the Global Burden of Disease Study 2021 Open
The global burden of migraine in children and adolescents has increased substantially, disproportionately affecting females, adolescents aged 15-19 years, and low-middle SDI regions, while the greatest potential for improvement lies in mid…
View article: #1061 Re-defining carboplatin dosage using eGFR-CR-CYS compared to Cockcroft Gault and impact on platinum-associated adverse events
#1061 Re-defining carboplatin dosage using eGFR-CR-CYS compared to Cockcroft Gault and impact on platinum-associated adverse events Open
Background and Aims Carboplatin is first-line chemotherapy for numerous cancers. However, it is primarily really excreted, has a narrow therapeutic index, and high rate of adverse events (AEs), including cytopenias, acute kidney injury (AK…
View article: Integrating nutritional and immune-inflammation-based index predicts disease-free survival of colorectal cancer patients undergoing radical surgery
Integrating nutritional and immune-inflammation-based index predicts disease-free survival of colorectal cancer patients undergoing radical surgery Open
The integrated scores of N-SII and N-SIRI complemented the limitation of each individual index, demonstrating superior accuracy in predicting long-term DFS in CRC patients.
View article: Development and Validation of a Nomogram Model for Predicting Non-keratinizing Nasopharyngeal Carcinoma by Combining Sex and Three EB Virus Antibodies
Development and Validation of a Nomogram Model for Predicting Non-keratinizing Nasopharyngeal Carcinoma by Combining Sex and Three EB Virus Antibodies Open
Introduction Early diagnosis of non-keratinizing nasopharyngeal carcinoma (NK-NPC) is a significant clinical challenge. This study assessed combined antibodies and built a nomogram for more accurate NK-NPC screening. Methods Clinical data …
View article: Individualized Reconstruction Of Infective Segmental Mandibular Defects Via IMT
Individualized Reconstruction Of Infective Segmental Mandibular Defects Via IMT Open
Introduction: By using CAD/CAM-assisted induced membrane technology (IMT), personalized restoration was achieved in this case with a segmental mandibular defect caused by mandibular osteomyelitis and pathological fracture. It is expected t…
View article: Lung function as a modifiable risk factor for Ischemic Stroke: Evidence from the UK biobank
Lung function as a modifiable risk factor for Ischemic Stroke: Evidence from the UK biobank Open
This study underscores the importance of monitoring lung function, particularly at the community level, as a preventive measure against ischemic stroke. Given the aging global population, early detection and management of declining lung fu…
View article: The molecular mechanisms and therapeutic implications of PANoptosis in ischemic diseases
The molecular mechanisms and therapeutic implications of PANoptosis in ischemic diseases Open
The singular forms of programmed cell death (PCD), including pyroptosis, apoptosis, and necroptosis, are inadequate for comprehensively elucidating the complex pathological mechanisms underlying ischemic diseases. PANoptosis is a unique ly…
View article: Retrospective cohort study on the correlation between serum 25(OH)D, vitamin A and neonatal respiratory distress syndrome (NRDS) in premature infants
Retrospective cohort study on the correlation between serum 25(OH)D, vitamin A and neonatal respiratory distress syndrome (NRDS) in premature infants Open
The findings suggest that adequate serum levels of 25(OH)D and vitamin A may play a crucial role in mitigating the risk of NRDS in premature infants. Monitoring and intervention strategies regarding these vitamins could enhance clinical ou…
View article: Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates
Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates Open
[This corrects the article DOI: 10.1016/j.omtm.2023.101154.].
View article: Global burden of aortic aneurysm attributable to high-sodium diet from 1990 to 2021
Global burden of aortic aneurysm attributable to high-sodium diet from 1990 to 2021 Open
Background This study aims to investigate the impact of high-sodium diet (HSD) on the global burden of aortic aneurysm (AA), analyze its epidemiological trends across different regions, sexes, and age groups, and project future trends. Met…
View article: Association between long-term (current) aspirin use and sepsis-related delirium in elderly patients: a retrospective cohort study
Association between long-term (current) aspirin use and sepsis-related delirium in elderly patients: a retrospective cohort study Open
In elderly patients, long-term (current) aspirin use is negatively associated with the incidence of SAD and is also linked to improved clinical outcomes.
View article: Physician turnover in China, 2011–2021: a nationwide longitudinal study
Physician turnover in China, 2011–2021: a nationwide longitudinal study Open
This study suggests that the physician turnover rate is rising in China. Polices should pay more attention to physician retention in less-developed regions. The underlying causes of physician turnover should be thoroughly investigated. Con…
View article: Accelerated biological aging as a potential mediator mediates the relationship between metabolic syndrome and the risk of psoriasis: a prospective analysis from the UK biobank
Accelerated biological aging as a potential mediator mediates the relationship between metabolic syndrome and the risk of psoriasis: a prospective analysis from the UK biobank Open
Background Increasing evidence suggests that metabolic syndrome (MetS) may contribute to the development of psoriasis. However, the mediating role of accelerated aging in this association remains unclear. Methods This study utilized data f…
View article: The Evolving Landscape of Immunotherapy in Triple-negative Breast Cancer: Mechanisms, Biomarkers, and Future Horizons
The Evolving Landscape of Immunotherapy in Triple-negative Breast Cancer: Mechanisms, Biomarkers, and Future Horizons Open
Triple-negative breast carcinoma (TNBC) is an aggressive malignancy with a historical paucity of targeted therapies, but recent years have seen a therapeutic revolution. Its distinct immunogenic profile, with an elevated tumor mutational b…