H. Mannem
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View article: The Role of Endoscopic Sleeve Gastroplasty for the Treatment of Obesity Limiting Candidacy for Lung Transplantation
The Role of Endoscopic Sleeve Gastroplasty for the Treatment of Obesity Limiting Candidacy for Lung Transplantation Open
The role of endoscopic sleeve gastroplasty (ESG) in managing obesity among potential organ transplant candidates with end-stage organ disease remains largely unexplored. We report a case of a 69-year-old man with end-stage chronic obstruct…
View article: Machine Learning of Plasma Proteomics Classifies Diagnosis of Interstitial Lung Disease
Machine Learning of Plasma Proteomics Classifies Diagnosis of Interstitial Lung Disease Open
Rationale: Distinguishing connective tissue disease-associated interstitial lung disease (CTD-ILD) from idiopathic pulmonary fibrosis (IPF) can be clinically challenging. Objectives: To identify proteins that separate and classify patients…
View article: ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements
ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part II: Cardiac, surgical, perioperative, operative, and post-operative challenges and management statements Open
Patients with connective tissue disease (CTD) present unique surgical, perioperative, operative, and postoperative challenges related to the often underlying severe pulmonary hypertension and right ventricular dysfunction. The Internationa…
View article: Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres
Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres Open
Because the short telomere defect has been linked to the pathogenesis of IPF in some cases, our data indicate that impaired CMV immunity may be a systemic manifestation of telomere-mediated disease in these patients. Identifying this high-…
View article: IL-12–Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control
IL-12–Dependent Cytomegalovirus-Specific CD4+ T Cell Proliferation, T-bet Induction, and Effector Multifunction during Primary Infection Are Key Determinants for Early Immune Control Open
CMV remains an important opportunistic pathogen in solid organ and hematopoietic cell transplantation, particularly in lung transplant recipients (LTRs). LTRs mismatched for CMV (donor+/recipient−; D+R−) are at high risk for active CMV inf…