Hiroyuki Ono
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View article: Safety Profile of Low‐Power Pure‐Cut Hot Snare Polypectomy for 10–14 mm Nonpedunculated Colorectal Neoplasms
Safety Profile of Low‐Power Pure‐Cut Hot Snare Polypectomy for 10–14 mm Nonpedunculated Colorectal Neoplasms Open
Objectives The reported rate of delayed bleeding (DB) after hot snare polypectomy (HSP) for 10–19‐mm polyps is 2.1%–2.8%, which is non‐negligible. We hypothesized that a low‐power pure‐cut current (LPPC) yields a lower risk of DB than a co…
View article: Factors influencing steroid withdrawal syndrome in very-low-birth-weight infants
Factors influencing steroid withdrawal syndrome in very-low-birth-weight infants Open
Systemic steroid therapy is frequently used in very-low-birth-weight infants to manage bronchopulmonary dysplasia and refractory hypotension and to facilitate extubation by preventing reintubation. However, because the hypothalamic-pituita…
View article: Ultra‐Sensitive Quantification of Indoxyl Sulfate and 3‐Carboxy‐4‐Methyl‐5‐Propyl‐2‐Furanpropanoic Acid in Plasma Using Ultra‐Performance Liquid Chromatography Coupled to Quadrupole Time‐of‐Flight Mass Spectrometry
Ultra‐Sensitive Quantification of Indoxyl Sulfate and 3‐Carboxy‐4‐Methyl‐5‐Propyl‐2‐Furanpropanoic Acid in Plasma Using Ultra‐Performance Liquid Chromatography Coupled to Quadrupole Time‐of‐Flight Mass Spectrometry Open
Background Uremic toxins such as indoxyl sulfate and 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF) are accumulated in patients with chronic kidney disease (CKD). Recent studies have shown that the accumulation of indoxyl sulfate…
View article: Small Duodenal Adenocarcinoma with Peritoneal Dissemination Mimicking Duodenal Brunner’s Gland Hyperplasia
Small Duodenal Adenocarcinoma with Peritoneal Dissemination Mimicking Duodenal Brunner’s Gland Hyperplasia Open
Introduction: Gastric-phenotype non-ampullary duodenal carcinomas are rare but potentially aggressive tumors. Case Presentation: A 52-year-old woman was referred for a duodenal polyp. Endoscopy revealed multiple duodenal bulb polyps sugges…
View article: Efficacy and safety of remimazolam for sedation during endoscopic procedures in Japanese: A prospective phase III clinical trial
Efficacy and safety of remimazolam for sedation during endoscopic procedures in Japanese: A prospective phase III clinical trial Open
Objectives Remimazolam is a general anesthetic with a short elimination half‐life and its pharmacokinetics are less affected by liver and kidney function. It may be useful for sedation during endoscopic procedures in patients. This single‐…
View article: Usefulness and safety of remimazolam in upper gastrointestinal endoscopy: A comparative study between elderly and non‐elderly patients
Usefulness and safety of remimazolam in upper gastrointestinal endoscopy: A comparative study between elderly and non‐elderly patients Open
Objectives In gastroenterology, sedation demand is increasing, although elderly patients are more prone to experiencing adverse events. Remimazolam, a novel ultra‐short‐acting benzodiazepine, may reduce recovery time after endoscopic proce…
View article: Genetic medicine of familial and hereditary pancreatic cancer: Recent update in the era of precision cancer medicine
Genetic medicine of familial and hereditary pancreatic cancer: Recent update in the era of precision cancer medicine Open
In Japan, 5 years have passed since the initiation of precision cancer medicine, and recent data accumulation in familial pancreatic cancer (FPC) and hereditary pancreatic cancer is outstanding. Multigene germline panel tests (MGPTs) have …
View article: Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis
Comparative Study of Remimazolam and Midazolam During Sedated Upper Gastrointestinal Endoscopy: A Propensity Score Matching Analysis Open
Aim This study aimed to compare the use of remimazolam and midazolam in upper gastrointestinal endoscopy in Japan as a sub‐analysis of data from an investigator‐initiated clinical trial of remimazolam. Methods and Results Patients in two g…
View article: Enhancing visibility in gastric endoscopic dissection: Red dichromatic imaging in managing submucosal fatty tissue
Enhancing visibility in gastric endoscopic dissection: Red dichromatic imaging in managing submucosal fatty tissue Open
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View article: Ultra-Sensitive Quantification of Coproporphyrin-I and -III in Human Plasma Using Ultra-Performance Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry
Ultra-Sensitive Quantification of Coproporphyrin-I and -III in Human Plasma Using Ultra-Performance Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry Open
Organic anion transporting polypeptides (OATP) 1B1 and 1B3 are expressed in liver cells and are involved in drug uptake in the liver. OATP1B activity varies due to polymorphisms and is decreased by OATP1B inhibitors. Variability of OATP1B …
View article: Evaluation of intra‐ and inter‐individual variations in plasma belimumab concentrations in adult patients with systemic lupus erythematosus
Evaluation of intra‐ and inter‐individual variations in plasma belimumab concentrations in adult patients with systemic lupus erythematosus Open
In this study, plasma belimumab concentrations were measured over the course of treatment in systemic lupus erythematosus (SLE) patients on belimumab therapy, and intra‐ and interindividual variations in plasma belimumab concentration were…
View article: Randomized Controlled Trial of Remimazolam Compared with Placebo in Japanese Patients Undergoing Colonoscopy: A Phase III, Investigator-Initiated Trial
Randomized Controlled Trial of Remimazolam Compared with Placebo in Japanese Patients Undergoing Colonoscopy: A Phase III, Investigator-Initiated Trial Open
Introduction: We conducted an investigator-initiated clinical trial in which remimazolam was used to achieve sedation in patients undergoing colonoscopies. Methods: This multicenter, double-blind, placebo-controlled, phase III investigator…
View article: Comparison of remimazolam and midazolam for sedation during colonoscopy in Japanese patients: A propensity score matching analysis
Comparison of remimazolam and midazolam for sedation during colonoscopy in Japanese patients: A propensity score matching analysis Open
Objectives To compare the efficacy and safety of sedation with midazolam and remimazolam for colorectal endoscopy. Methods This single‐center, two‐arm, post‐hoc analysis of the REM‐IICTJP01 study investigated the efficacy and safety of rem…
View article: Efficacy of texture and color enhancement imaging for the visibility and diagnostic accuracy of non‐polypoid colorectal lesions
Efficacy of texture and color enhancement imaging for the visibility and diagnostic accuracy of non‐polypoid colorectal lesions Open
Objective A newly launched endoscopy system (EVIS X1, CV‐1500; Olympus) is equipped with texture and color enhancement imaging (TXI). We aimed to investigate the efficacy of TXI for the visibility and diagnostic accuracy of non‐polypoid co…
View article: Endoscopic hand suturing using a modified through‐the‐scope needle holder for mucosal closure after colorectal endoscopic submucosal dissection: Prospective multicenter study (with video)
Endoscopic hand suturing using a modified through‐the‐scope needle holder for mucosal closure after colorectal endoscopic submucosal dissection: Prospective multicenter study (with video) Open
Objectives Endoscopic hand suturing (EHS) is a novel technique for closing a mucosal defect after endoscopic submucosal dissection (ESD). We investigated the technical feasibility of colorectal EHS using a modified flexible through‐the‐sco…
View article: Novel clip closure technique for a large mucosal defect with anchor‐pronged clips after duodenal endoscopic submucosal dissection
Novel clip closure technique for a large mucosal defect with anchor‐pronged clips after duodenal endoscopic submucosal dissection Open
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View article: Current status of preoperative endoscopic biliary drainage for distal and hilar biliary obstruction
Current status of preoperative endoscopic biliary drainage for distal and hilar biliary obstruction Open
The purpose of preoperative biliary drainage (PBD) is to reduce complications during the perioperative period. The extrahepatic bile duct comprises distal and hilar bile ducts and assessing the need for PBD must be considered separately fo…
View article: Ring-string traction for successful endoscopic clip closure to treat delayed perforation of the ulcer bed after colorectal endoscopic submucosal dissection
Ring-string traction for successful endoscopic clip closure to treat delayed perforation of the ulcer bed after colorectal endoscopic submucosal dissection Open
Endoscopic closure of delayed perforations after colorectal endoscopic submucosal dissection (ESD) is challenging due to the fragility of the ulcer bed and the stiffness of the surrounding tissue [1] [2] [3] [4]. The case presented here il…
View article: Closing the defect after gastric endoscopic full‐thickness resection with a novel closure device
Closing the defect after gastric endoscopic full‐thickness resection with a novel closure device Open
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View article: Risk factors for intraoperative and delayed perforation related with gastric endoscopic submucosal dissection
Risk factors for intraoperative and delayed perforation related with gastric endoscopic submucosal dissection Open
Background and Aim Perforation is one of the most important complications of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Several studies have examined risk factors for intraoperative and delayed perforations, but…
View article: Impact of a new dedicated sheath device for tissue sampling of biliary stricture on pathological diagnostic yield: Retrospective study
Impact of a new dedicated sheath device for tissue sampling of biliary stricture on pathological diagnostic yield: Retrospective study Open
Background and study aims Endoscopic transpapillary biliary forceps biopsy (TBFB) is a common method for obtaining specimens from biliary lesions. Its diagnostic yield is unsatisfactory; to overcome this disadvantage, a dedicated sheath ha…
View article: Evaluation of the usefulness of plasma 4β‐hydroxycholesterol concentration normalized by 4α‐hydroxycholesterol for accurate CYP3A phenotyping
Evaluation of the usefulness of plasma 4β‐hydroxycholesterol concentration normalized by 4α‐hydroxycholesterol for accurate CYP3A phenotyping Open
Plasma 4β‐hydroxycholesterol (OHC) has drawn attention as an endogenous substrate indicating CYP3A activity. Plasma 4β‐OHC is produced by hydroxylation by CYP3A4 and CYP3A5 and by cholesterol autoxidation. Plasma 4α‐OHC is produced by chol…
View article: Randomized controlled trial of remimazolam compared with placebo in Japanese patients undergoing upper gastrointestinal endoscopy: Phase III investigator‐initiated clinical trial
Randomized controlled trial of remimazolam compared with placebo in Japanese patients undergoing upper gastrointestinal endoscopy: Phase III investigator‐initiated clinical trial Open
Objectives To assess the effectiveness of remimazolam against normal saline (placebo) as a sedative agent for endoscopy in a multicenter, randomized, double‐blind, investigator‐initiated phase III controlled trial. Methods We included 48 J…
View article: Gel immersion endoscopic mucosal resection for early gastric neoplasms: a multicenter case series study
Gel immersion endoscopic mucosal resection for early gastric neoplasms: a multicenter case series study Open
Several cases have been reported that suggest the efficacy of gel immersion endoscopic mucosal resection (GI-EMR) for gastric neoplasms. However, no study has evaluated treatment outcomes of GI-EMR for gastric neoplasms. This study aimed t…
View article: Relationship of plasma 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid concentration with <scp>OATP1B</scp> activity in patients with chronic kidney disease
Relationship of plasma 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid concentration with <span>OATP1B</span> activity in patients with chronic kidney disease Open
Organic anion‐transporting polypeptides (OATP)1B are drug transporters mainly expressed in the sinusoidal membrane. Many studies have suggested that OATP1B activity is affected by genetic factor, the uremic toxin 3‐carboxy‐4‐methyl‐5‐propy…
View article: Evaluating false‐positive detection in a computer‐aided detection system for colonoscopy
Evaluating false‐positive detection in a computer‐aided detection system for colonoscopy Open
Background and Aim Computer‐aided detection (CADe) systems can efficiently detect polyps during colonoscopy. However, false‐positive (FP) activation is a major limitation of CADe. We aimed to compare the rate and causes of FP using CADe be…