Harold S. Margolis
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View article: Burden of Dengue Infection and Disease in a Pediatric Cohort in Urban Sri Lanka
Burden of Dengue Infection and Disease in a Pediatric Cohort in Urban Sri Lanka Open
Dengue is the most significant arthropod-borne viral infection of humans. Persons infected with dengue viruses (DENV) have subclinical or clinically apparent infections ranging from undifferentiated fever to dengue hemorrhagic fever/shock …
View article: Estimates of Dengue Force of Infection in Children in Colombo, Sri Lanka
Estimates of Dengue Force of Infection in Children in Colombo, Sri Lanka Open
Dengue is the most important vector-borne viral disease worldwide and a major cause of childhood fever burden in Sri Lanka, which has experienced a number of large epidemics in the past decade. Despite this, data on the burden and transmis…
View article: New Dengue Virus Type 1 Genotype in Colombo, Sri Lanka
New Dengue Virus Type 1 Genotype in Colombo, Sri Lanka Open
The number of cases and severity of disease associated with dengue infection in Sri Lanka has been increasing since 1989, when the first epidemic of dengue hemorrhagic fever was recorded. We identified a new dengue virus 1 strain circulati…
View article: No Evidence of Acute Dengue Virus Infections at a Rural Site in Western Kenya, 2011 and 2013
No Evidence of Acute Dengue Virus Infections at a Rural Site in Western Kenya, 2011 and 2013 Open
The incidence and spread of dengue virus (DENV) have increased rapidly in recent decades. Dengue is underreported in Africa, but recent outbreaks and seroprevalence data suggest that DENV is widespread there. A lack of ongoing surveillance…
View article: Extramedullary hematopoiesis causing spinal cord compression with excellent durable response after radiation therapy: Case report and review of the literature
Extramedullary hematopoiesis causing spinal cord compression with excellent durable response after radiation therapy: Case report and review of the literature Open
Extramedullary hematopoiesis (EMH) is a rare occurrence in the setting of spinal cord compression. We report on a 72-year-old who was initially diagnosed with polycythemia vera (PV) which after approximately 15 years converted to myelofibr…
View article: An open challenge to advance probabilistic forecasting for dengue epidemics
An open challenge to advance probabilistic forecasting for dengue epidemics Open
A wide range of research has promised new tools for forecasting infectious disease dynamics, but little of that research is currently being applied in practice, because tools do not address key public health needs, do not produce probabili…
View article: Genetic relatedness of hepatitis A virus strains recovered from different geographical regions
Genetic relatedness of hepatitis A virus strains recovered from different geographical regions Open
A pairwise comparison of the nucleic acid sequence of 168 bases from 152 wild-type or unique cell culture-adapted strains of hepatitis A virus (HAV) revealed that HAV strains can be differentiated genetically into seven unique genotypes (I…
View article: Autocidal gravid ovitraps protect humans from chikungunya virus infection by reducing Aedes aegypti mosquito populations
Autocidal gravid ovitraps protect humans from chikungunya virus infection by reducing Aedes aegypti mosquito populations Open
These findings indicate that AGO traps are an effective tool that protects humans from infection with a virus transmitted by Ae. aegypti mosquitos. Future studies should evaluate their protective effectiveness in large, urban communities.
View article: Lessons Learned from Dengue Surveillance and Research, Puerto Rico, 1899–2013
Lessons Learned from Dengue Surveillance and Research, Puerto Rico, 1899–2013 Open
Dengue was first reported in Puerto Rico in 1899 and sporadically thereafter. Following outbreaks in 1963 and 1969, the Centers for Disease Control and Prevention has worked closely with the Puerto Rico Department of Health to monitor and …
View article: Estimating dengue under-reporting in Puerto Rico using a multiplier model
Estimating dengue under-reporting in Puerto Rico using a multiplier model Open
Dengue is a mosquito-borne viral illness that causes a variety of health outcomes, from a mild acute febrile illness to potentially fatal severe dengue. Between 2005 and 2010, the annual number of suspected dengue cases reported to the Pas…
View article: Clinical and epidemiologic characteristics of dengue and other etiologic agents among patients with acute febrile illness, Puerto Rico, 2012–2015
Clinical and epidemiologic characteristics of dengue and other etiologic agents among patients with acute febrile illness, Puerto Rico, 2012–2015 Open
Identifying etiologies of acute febrile illnesses (AFI) is challenging due to non-specific presentation and limited availability of diagnostics. Prospective AFI studies provide a methodology to describe the syndrome by age and etiology, fi…
View article: A New Look at an Old Disease: Recent Insights into the Global Epidemiology of Dengue
A New Look at an Old Disease: Recent Insights into the Global Epidemiology of Dengue Open
View article: Surveillance for Chikungunya and Dengue During the First Year of Chikungunya Virus Circulation in Puerto Rico
Surveillance for Chikungunya and Dengue During the First Year of Chikungunya Virus Circulation in Puerto Rico Open
After chikungunya virus (CHIKV) transmission was detected in Puerto Rico in May 2014, multiple surveillance systems were used to describe epidemiologic trends and CHIKV-associated disease. Of 28 327 cases reported via passive surveillance,…
View article: Enhanced Surveillance for Fatal Dengue-Like Acute Febrile Illness in Puerto Rico, 2010-2012
Enhanced Surveillance for Fatal Dengue-Like Acute Febrile Illness in Puerto Rico, 2010-2012 Open
EFASS showed that dengue mortality rates among adults were higher than reported for influenza, and identified a leptospirosis outbreak and index cases of melioidosis and meningitis.
View article: Effect of a Dengue Clinical Case Management Course on Physician Practices in Puerto Rico
Effect of a Dengue Clinical Case Management Course on Physician Practices in Puerto Rico Open
Management of dengue inpatients significantly improved following implementation of a classroom-style course taught by master trainers. An online version of the course was launched in 2014 to expand its reach and sustainability.
View article: Evidence-based risk assessment and communication: a new global dengue-risk map for travellers and clinicians<sup>#</sup>
Evidence-based risk assessment and communication: a new global dengue-risk map for travellers and clinicians<sup>#</sup> Open
These new risk classifications enable detailed consideration of dengue risk, with clearer meaning and a direct link to the evidence that supports the specific classification. Since many infectious diseases have dynamic risk, strong geograp…
View article: Use of a Rapid Test for Diagnosis of Dengue during Suspected Dengue Outbreaks in Resource-Limited Regions
Use of a Rapid Test for Diagnosis of Dengue during Suspected Dengue Outbreaks in Resource-Limited Regions Open
Dengue is major public health problem, globally. Timely verification of suspected dengue outbreaks allows for public health response, leading to the initiation of appropriate clinical care. Because the clinical presentation of dengue is no…
View article: Performance of Dengue Diagnostic Tests in a Single-Specimen Diagnostic Algorithm
Performance of Dengue Diagnostic Tests in a Single-Specimen Diagnostic Algorithm Open
The use of molecular or NS1 antigen tests to detect DENV and one to detect anti-DENV IgM in a single serum specimen collected during the first 10 days of illness accurately identified ≥90% of dengue primary and secondary cases.
View article: Epidemiology of Dengue Among Children Aged < 18 Months—Puerto Rico, 1999–2011
Epidemiology of Dengue Among Children Aged < 18 Months—Puerto Rico, 1999–2011 Open
Dengue, a mosquito-borne viral illness caused by dengue virus types (DENV)-1 to DENV-4, is endemic in Puerto Rico. Severe dengue usually occurs in individuals previously infected with DENV or among infants born to previously infected mothe…
View article: Epidemic curve of suspected dengue cases by week of illness onset, Puerto Rico, 2010.
Epidemic curve of suspected dengue cases by week of illness onset, Puerto Rico, 2010. Open
Surveillance data from cases reported via the Passive Dengue Surveillance System, Enhanced Dengue Surveillance System, Notifiable Diseases Surveillance System, or private laboratory dengue diagnostic test results were compiled and grouped …
View article: Underrecognition of Dengue during 2013 Epidemic in Luanda, Angola
Underrecognition of Dengue during 2013 Epidemic in Luanda, Angola Open
During the 2013 dengue epidemic in Luanda, Angola, 811 dengue rapid diagnostic test-positive cases were reported to the Ministry of Health. To better understand the magnitude of the epidemic and identify risk factors for dengue virus (DENV…
View article: A Household Serosurvey to Estimate the Magnitude of a Dengue Outbreak in Mombasa, Kenya, 2013
A Household Serosurvey to Estimate the Magnitude of a Dengue Outbreak in Mombasa, Kenya, 2013 Open
Dengue appears to be endemic in Africa with a number of reported outbreaks. In February 2013, several individuals with dengue-like illnesses and negative malaria blood smears were identified in Mombasa, Kenya. Dengue was laboratory confirm…
View article: Clinicopathologic Characteristics and Immunolocalization of Viral Antigens in Chikungunya-Associated Fatal Cases—Puerto Rico, 2014
Clinicopathologic Characteristics and Immunolocalization of Viral Antigens in Chikungunya-Associated Fatal Cases—Puerto Rico, 2014 Open