Hartwig R. Siebner
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View article: Non-inferiority of Rituximab versus OCrelizumab in Multiple Sclerosis (ROC-MS)—an individual participant data meta-analysis
Non-inferiority of Rituximab versus OCrelizumab in Multiple Sclerosis (ROC-MS)—an individual participant data meta-analysis Open
This ROC-MS collaboration will improve the precision of the estimates, increase statistical power for outcomes and assessment of rare events and facilitate subgroup analyses, ultimately providing robust evidence on the efficacy and safety …
View article: Profiling the Cerebrospinal Fluid Proteome in Progressive Multiple Sclerosis: Treatment Effects and Associations with IgM Oligoclonal Bands
Profiling the Cerebrospinal Fluid Proteome in Progressive Multiple Sclerosis: Treatment Effects and Associations with IgM Oligoclonal Bands Open
View article: Paired-pulse TMS of premotor cortex produces non-linear suppressive effects on neural activity in the targeted network - a TMS-fMRI study
Paired-pulse TMS of premotor cortex produces non-linear suppressive effects on neural activity in the targeted network - a TMS-fMRI study Open
Focal ppTMS may exert a net suppressive effect on neural activity within the targeted network. Network effects may follow a non-linear response pattern and may peak at relatively low stimulation intensities. These findings highlight the va…
View article: Reply to Han et al.
Reply to Han et al. Open
View article: Rostro-caudal TMS mapping of immediate transcranial evoked potentials reveals a pericentral crescendo-decrescendo pattern
Rostro-caudal TMS mapping of immediate transcranial evoked potentials reveals a pericentral crescendo-decrescendo pattern Open
These findings support the idea that pericentral iTEPs reflect a direct response signature of the pericentral cortex, possibly involving a synchronized TMS-induced excitation of cortical pyramidal tract neurons. Similar but non-identical r…
View article: No changes in weight, body composition or metabolic parameters after the switch to dolutegravir and lamivudine compared to continued treatment with dolutegravir, abacavir and lamivudine for virologically suppressed HIV infection (The AVERTAS trial)
No changes in weight, body composition or metabolic parameters after the switch to dolutegravir and lamivudine compared to continued treatment with dolutegravir, abacavir and lamivudine for virologically suppressed HIV infection (The AVERTAS trial) Open
Continuing or discontinuing abacavir for 48 weeks was associated with modest gains in weight that did not differ between groups. Similarly, fat distribution, or metabolic parameters were comparable between groups.
View article: Blunted response of caudal locus coeruleus to arousing stimuli in Parkinson’s Disease
Blunted response of caudal locus coeruleus to arousing stimuli in Parkinson’s Disease Open
Parkinson’s disease (PD) causes progressive degeneration of noradrenergic neurons in the locus coeruleus (LC), contributing to non-motor symptoms. Using neuromelanin-sensitive ultra-high field (7T) MRI, we previously identified a reduction…
View article: Family-based cognitive behavioral therapy versus family-based psychoeducation and relaxation training for obsessive-compulsive disorder in children and adolescents: a randomized clinical trial (TECTO)
Family-based cognitive behavioral therapy versus family-based psychoeducation and relaxation training for obsessive-compulsive disorder in children and adolescents: a randomized clinical trial (TECTO) Open
Few randomized clinical trials (RCTs) have compared cognitive behavioral therapy (CBT) versus active control interventions for pediatric obsessive-compulsive disorder (OCD), and the range of investigated outcomes has been limited. We inves…
View article: Tadalafil Treatment in Patients With Cerebral Small Vessel Disease: The ETLAS-2 Randomized Clinical Trial
Tadalafil Treatment in Patients With Cerebral Small Vessel Disease: The ETLAS-2 Randomized Clinical Trial Open
BACKGROUND: White matter hyperintensities and reduced cerebral blood flow are hallmarks of cerebral small vessel disease (CSVD). We tested the feasibility of daily treatment with the vasoactive drug tadalafil in patients with CSVD and its …
View article: Emergent technologies in clinical neurophysiology to study the central nervous system: IFCN handbook chapter
Emergent technologies in clinical neurophysiology to study the central nervous system: IFCN handbook chapter Open
View article: Effects of Acute Iso- and Hypocaloric Carbohydrate Restriction on Liver Fat and Glucose and Lipid Metabolism
Effects of Acute Iso- and Hypocaloric Carbohydrate Restriction on Liver Fat and Glucose and Lipid Metabolism Open
Context Liver fat is reduced within days after a low-carbohydrate diet substituted with fat to maintain isocaloric conditions. Objective Investigate the effect of matched carbohydrate restriction during isocaloric and hypocaloric condition…
View article: No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts
No significant association between self-reported physical activity and brain volumes in women and men from five European cohorts Open
View article: Mapping the hemodynamic effects of terlipressin in patients with hepatorenal syndrome using advanced magnetic resonance imaging
Mapping the hemodynamic effects of terlipressin in patients with hepatorenal syndrome using advanced magnetic resonance imaging Open
View article: High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging
High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging Open
View article: Sex-specific cortical brain differences in children at familial high risk for schizophrenia or bipolar disorder
Sex-specific cortical brain differences in children at familial high risk for schizophrenia or bipolar disorder Open
Background Schizophrenia (SZ) and bipolar disorder (BP) are severe psychiatric disorders with neurodevelopmental underpinnings. Familial high risk (FHR) is the strongest predictor of developing SZ and BP. Children at FHR offer a unique opp…
View article: Comparable 40 Hz Auditory Steady-State Responses in Children at Familial High Risk for Schizophrenia or Bipolar Disorder and Population-Based Controls
Comparable 40 Hz Auditory Steady-State Responses in Children at Familial High Risk for Schizophrenia or Bipolar Disorder and Population-Based Controls Open
Background The 40-Hz auditory steady state response (ASSR) is reduced in patients with schizophrenia and bipolar disorder. Recent evidence suggests that ASSR may be altered in clinical high risk and familial high-risk populations. Here, we…
View article: Phase Locking of 40 Hz Auditory Steady State Responses Is Modulated by Sensory Predictability and Linked to Cerebellar Myelination
Phase Locking of 40 Hz Auditory Steady State Responses Is Modulated by Sensory Predictability and Linked to Cerebellar Myelination Open
40 Hz auditory steady‐state responses (ASSR) can be evoked by brief auditory clicks delivered at 40 Hz. While the neuropharmacology behind the generation of ASSR is well examined, the link between ASSR and microstructural properties of the…
View article: No long-term benefits from resistance training on brain grey matter volumes in active older adults at retirement age
No long-term benefits from resistance training on brain grey matter volumes in active older adults at retirement age Open
The study was approved by the regional ethics committee and registered on clinicaltrials.gov 2014-04-24 (NCT02123641).
View article: A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium
A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium Open
Low-intensity Transcranial Ultrasonic Stimulation (TUS) is a non-invasive brain stimulation technique enabling cortical and deep brain targeting with unprecedented spatial accuracy. Given the high rate of adoption by new users with varying…
View article: Mapping the rostro-caudal expression of immediate transcranial evoked potentials (i-TEPs) revealed a neural response signature of the pericentral sensorimotor cortex
Mapping the rostro-caudal expression of immediate transcranial evoked potentials (i-TEPs) revealed a neural response signature of the pericentral sensorimotor cortex Open
View article: Pharmacological Applications of fMRI
Pharmacological Applications of fMRI Open
View article: Ernie Extended - an extended head model to simulate and optimize noninvasive brain stimulation and its implications for extracephalic transcranial electrical stimulation
Ernie Extended - an extended head model to simulate and optimize noninvasive brain stimulation and its implications for extracephalic transcranial electrical stimulation Open
View article: Has white noise acoustic stimulation a modulatory effect on the aperiodic component of EEG activity?
Has white noise acoustic stimulation a modulatory effect on the aperiodic component of EEG activity? Open
View article: Corrigendum to “Comparable 40 Hz auditory steady-state responses in children at familial high risk for schizophrenia or bipolar disorder and population-based controls” [NeuroImage Clin. 48 (2025) 103841]
Corrigendum to “Comparable 40 Hz auditory steady-state responses in children at familial high risk for schizophrenia or bipolar disorder and population-based controls” [NeuroImage Clin. 48 (2025) 103841] Open
View article: An EEG signature of immediate motor cortex activity evoked by single-pulse TMS
An EEG signature of immediate motor cortex activity evoked by single-pulse TMS Open
View article: Immediate transcranial evoked potentials (i-TEPs) are evoked by magnetic stimulation of the motor cortical leg representation
Immediate transcranial evoked potentials (i-TEPs) are evoked by magnetic stimulation of the motor cortical leg representation Open
View article: Regional glutamate but not GABA concentration scales with TMS-based measures of cortical excitability – a combined 7T MR spectroscopy and TMS study of the human primary motor hand area
Regional glutamate but not GABA concentration scales with TMS-based measures of cortical excitability – a combined 7T MR spectroscopy and TMS study of the human primary motor hand area Open
View article: Comparable 40 Hz auditory steady-state responses in children at familial high risk for schizophrenia or bipolar disorder and population-based controls
Comparable 40 Hz auditory steady-state responses in children at familial high risk for schizophrenia or bipolar disorder and population-based controls Open
View article: Spatial relation between the N15 source location of the transcranial evoked potential peak (TEP) and the induced electrical field distribution: a TMS-EEG modelling study
Spatial relation between the N15 source location of the transcranial evoked potential peak (TEP) and the induced electrical field distribution: a TMS-EEG modelling study Open
View article: Focal iTBS of left DLPFC reduces regional alpha power between consecutive burst trains compared to sham iTBS
Focal iTBS of left DLPFC reduces regional alpha power between consecutive burst trains compared to sham iTBS Open