Carlos Henrique Tomich de Paula da Silva
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View article: ANESTESIA EM PACIENTES COM NECESSIDADES ESPECIAIS: UMA REVISÃO BIBLIOGRÁFICA
ANESTESIA EM PACIENTES COM NECESSIDADES ESPECIAIS: UMA REVISÃO BIBLIOGRÁFICA Open
O artigo "ANESTESIA EM PACIENTES COM NECESSIDADES ESPECIAIS: UMA REVISÃO BIBLIOGRÁFICA" realiza uma revisão para abordar o manejo anestésico em indivíduos com necessidades especiais, focando nas particularidades de pacientes com Paralisia …
View article: Medicina regenerativa na ortopedia: avanços em biomateriais e terapias celulares
Medicina regenerativa na ortopedia: avanços em biomateriais e terapias celulares Open
This article presents a literature review on the advances of regenerative medicine applied to orthopedics, focusing on the use of biomaterials, cell therapies, and nanotechnology for bone and cartilage regeneration. Studies published betwe…
View article: TECNOLOGIA INCLUSIVA: REDEFININDO O FAZER PEDAGÓGICO EM AMBIENTES DIGITAIS EDUCACIONAIS
TECNOLOGIA INCLUSIVA: REDEFININDO O FAZER PEDAGÓGICO EM AMBIENTES DIGITAIS EDUCACIONAIS Open
A integração das tecnologias digitais à educação tem impulsionado profundas mudanças no cotidiano escolar, especialmente no que se refere à inclusão de estudantes com deficiência. Este artigo tem como objetivo geral analisar como se config…
View article: Pharmacophore-Based Virtual Screening of Alkaloids and Flavonoids for Designing Drugs with Inhibitory Activity on the Enzyme Monoamine Oxidase B
Pharmacophore-Based Virtual Screening of Alkaloids and Flavonoids for Designing Drugs with Inhibitory Activity on the Enzyme Monoamine Oxidase B Open
Parkinson’s disease is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons, resulting in multiple motor and cognitive impairments. Among the hypotheses proposed for its etiology, oxidative stress mediated…
View article: Agrobiologia: avaliação do potencial de novas bactérias fixadoras de nitrogênio e/ou promotoras do crescimento vegetal para inoculação na cana-de-açúcar
Agrobiologia: avaliação do potencial de novas bactérias fixadoras de nitrogênio e/ou promotoras do crescimento vegetal para inoculação na cana-de-açúcar Open
A cana-de-açúcar (Saccharum L.) é uma Poaceae (gramínea) de grande importância na agricultura brasileira, com produtos derivados tais como: açúcar, etanol, metanol, biodiesel, biogás, bioplásticos e produção de energia. Com a pandemia do C…
View article: Agrobiologia avaliação do potencial de novas bactérias fixadoras de nitrogênio e comparação com a bactéria (Nitrospirillum amazonense estirpe CBAmC) recomendada pelo mapa promotoras de crescimento vegetal para inoculação na cana-de-açúcar
Agrobiologia avaliação do potencial de novas bactérias fixadoras de nitrogênio e comparação com a bactéria (Nitrospirillum amazonense estirpe CBAmC) recomendada pelo mapa promotoras de crescimento vegetal para inoculação na cana-de-açúcar Open
As bactérias endofíticas têm sido isoladas e estudadas via metodologias que utilizam meios de cultivo, já se sabe que a maioria dessas bactérias ainda não são cultiváveis e permanecem à disposição da pesquisa, afim de ser conhecido o seu p…
View article: O uso da pomada de barbatimão em feridas não iatrogênicas em cães
O uso da pomada de barbatimão em feridas não iatrogênicas em cães Open
As lesões cutâneas são uma das ocorrências mais comuns na clínica veterinária de pequenos. Devido à sua exposição a riscos como atropelamentos e disputas com outros animais, o cão é especialmente propenso a se machucar. Frequentemente, ele…
View article: IMPACTO DAS TECNOLOGIAS DE INFORMAÇÃO E COMUNICAÇÃO NAS PRÁTICAS CONTÁBEIS E ADMINISTRATIVAS
IMPACTO DAS TECNOLOGIAS DE INFORMAÇÃO E COMUNICAÇÃO NAS PRÁTICAS CONTÁBEIS E ADMINISTRATIVAS Open
Este estudo tem como objetivo investigar o impacto das Tecnologias da Informação e Comunicação (TIC) nas práticas contábeis e administrativas, destacando sua relevância no contexto atual das organizações com uma abordagem qualitativa, por …
View article: Synthesis of Quinic Acid‐Derived Sialylmimetics and Their Effects on <i>T. cruzi</i> and <i>Trans</i> ‐ <i>Sialidase</i>
Synthesis of Quinic Acid‐Derived Sialylmimetics and Their Effects on <i>T. cruzi</i> and <i>Trans</i> ‐ <i>Sialidase</i> Open
Chagas disease, caused by the protozoan Trypanosoma cruzi , affects 6–7 million people worldwide, mainly in South and Central America. A key enzyme in the disease's progression is Trypanosoma cruzi trans‐sialidase ( TcTS ), which facilitat…
View article: A Protocol for the Characterization of Diatom Communities in Mountain Glaciers
A Protocol for the Characterization of Diatom Communities in Mountain Glaciers Open
This research presents a significant contribution to the methodologies and protocols for studying diatom communities in cryoconite holes on glaciers. Cryoconite holes are unique microenvironments found on glacial surfaces that support intr…
View article: In silico Screening of Monamine Oxidase B Inhibitors for the Treatment of Central Nervous System Disorders
In silico Screening of Monamine Oxidase B Inhibitors for the Treatment of Central Nervous System Disorders Open
Worldwide, millions of people suffer from neurological and psychiatric conditions, such as schizophrenia, depression, and neurodegenerative diseases. These conditions are often linked to hyperactivity of monoamine oxidase B (MAO-B) in the …
View article: Expression of Truncated Products at the 5′-Terminal Region of <i>RIPK2</i> and Evolutive Aspects that Support Their Biological Importance
Expression of Truncated Products at the 5′-Terminal Region of <i>RIPK2</i> and Evolutive Aspects that Support Their Biological Importance Open
Alternative splicing is the process of generating different mRNAs from the same primary transcript, which contributes to increase the transcriptome and proteome diversity. Abnormal splicing has been associated with the development of sever…
View article: GDP-mannose pyrophosphorylase is an efficient target in <i>Xanthomonas citri</i> for citrus canker control
GDP-mannose pyrophosphorylase is an efficient target in <i>Xanthomonas citri</i> for citrus canker control Open
Xanthomonas citri subsp. citri (Xcc) is a bacterium that causes citrus canker, an economically important disease that results in premature fruit drop and reduced yield of fresh fruit. In this study, we demonstrated the involvement of XanB,…
View article: Vicia sativa subsp. sativa native to the Middle East comprises Pea Albumin1 b-like homologs: A promising natural biopesticide
Vicia sativa subsp. sativa native to the Middle East comprises Pea Albumin1 b-like homologs: A promising natural biopesticide Open
View article: Structure-based drug design for protein arginine deiminase Type IV (PAD4) receptor: Chemoinformatics approach
Structure-based drug design for protein arginine deiminase Type IV (PAD4) receptor: Chemoinformatics approach Open
Rheumatoid Arthritis (RA) is the second most common type of arthritis with symptoms first appearing in patients between 40 and 60 years of age. The number of older persons is projected to double to 1.5 billion in 2050, globally. Peptidylar…
View article: Eventos adversos do ciclo do sangue notificados em Minas Gerais, 2013 – 2022
Eventos adversos do ciclo do sangue notificados em Minas Gerais, 2013 – 2022 Open
View article: Diversity of Insecticidal PA1b Homologs among Legume Seeds from Middle Eastern Region
Diversity of Insecticidal PA1b Homologs among Legume Seeds from Middle Eastern Region Open
Legumes play a central role in various food systems, with significant socio-economic and environmental impacts. Their high protein content, composed mainly of globulins and albumins, makes them valuable for human food and animal feed. Amon…
View article: New Records of Helminth Infection in Bothrops Atrox Linnaeus, 1758 from Marajó Island-Brazil and a Survey of Parasitic Helminths in Bothrops Species (Squamata, Viperidae) from Neotropical Region
New Records of Helminth Infection in Bothrops Atrox Linnaeus, 1758 from Marajó Island-Brazil and a Survey of Parasitic Helminths in Bothrops Species (Squamata, Viperidae) from Neotropical Region Open
View article: New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling
New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling Open
Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing a 1,2,4-triazole-3-carboxamide moiety, is a first-line drug for its treatment, …
View article: Hierarchical Virtual Screening Based on Rocaglamide Derivatives to Discover New Potential Anti-Skin Cancer Agents
Hierarchical Virtual Screening Based on Rocaglamide Derivatives to Discover New Potential Anti-Skin Cancer Agents Open
Skin Cancer (SC) is among the most common type of cancers worldwide. The search for SC therapeutics using molecular modeling strategies as well as considering natural plant-derived products seems to be a promising strategy. The phytochemic…
View article: Chromatographic profile, in silico and in vivo study of the pharmacokinetic and toxicological properties of major constituent present in kefir, the kefiran
Chromatographic profile, in silico and in vivo study of the pharmacokinetic and toxicological properties of major constituent present in kefir, the kefiran Open
Kefiran is a polysaccharide present in kefir grains that have been widely explored due to its potential health benefits. The objective of this work was to characterize and quantify the components present in the ethanolic extract of milk ke…
View article: New triazole triterpene derivative exhibits anti-RSV activity synthesis biological evaluation and molecular modeling
New triazole triterpene derivative exhibits anti-RSV activity synthesis biological evaluation and molecular modeling Open
Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing 1,2,4-triazole-3-carboxamide moiety, is a first-line drug for its treatment, ho…
View article: Natural Products-Based Drug Design against SARS-CoV-2 Mpro 3CLpro
Natural Products-Based Drug Design against SARS-CoV-2 Mpro 3CLpro Open
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has received global attention due to the serious threat it poses to public health. Since the outbreak in December 2019, millions o…
View article: Revisiting the Proposition of Binding Pockets and Bioactive Poses for GSK-3β Allosteric Modulators Addressed to Neurodegenerative Diseases
Revisiting the Proposition of Binding Pockets and Bioactive Poses for GSK-3β Allosteric Modulators Addressed to Neurodegenerative Diseases Open
Glycogen synthase kinase-3 beta (GSK-3β) is an enzyme pertinently linked to neurodegenerative diseases since it is associated with the regulation of key neuropathological features in the central nervous system. Among the different kinds of…
View article: Pharmacophore-based Virtual Screening From Phytocannabinoids for Anti-obesity Activity
Pharmacophore-based Virtual Screening From Phytocannabinoids for Anti-obesity Activity Open
Search for new pharmacological alternatives for obesity is based on the design and development of compounds that can aid in weight loss so that they can be used safely and effectively over a long period while maintaining their function. Th…
View article: Identification of Known Drugs As Potential SARS-CoV-2 Mpro Inhibitors Using ligand- and Structure-Based Virtual Screening
Identification of Known Drugs As Potential SARS-CoV-2 Mpro Inhibitors Using ligand- and Structure-Based Virtual Screening Open
Background: The new coronavirus pandemic has had a significant impact worldwide, and therapeutic treatment for this viral infection is being strongly pursued. Efforts have been undertaken by medicinal chemists to discover molecules …
View article: Identification of novel potential cyclooxygenase-2 inhibitors using ligand- and structure-based virtual screening approaches
Identification of novel potential cyclooxygenase-2 inhibitors using ligand- and structure-based virtual screening approaches Open
Cyclooxygenase 2 (COX-2) is a well-established target for the design of anti-inflammatory intermediates. Celecoxib was selected as a template molecule to perform ligand-based virtual screening, i.e. to search for structures with similarity…
View article: Virtual screening, ADME/Tox predictions and the drug repurposing concept for future use of old drugs against the COVID-19
Virtual screening, ADME/Tox predictions and the drug repurposing concept for future use of old drugs against the COVID-19 Open
View article: Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches
Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches Open
Adenosine Receptor Type 2A (A2AAR) plays a role in important processes, such as anti-inflammatory ones. In this way, the present work aimed to search for compounds by pharmacophore-based virtual screening. The pharmacokinetic/toxicological…
View article: The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance
The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance Open
Aspergillus fumigatus is an opportunistic human pathogen causing allergic reactions or systemic infections, such as invasive pulmonary aspergillosis in immunocompromised patients. The mitogen-activated protein kinase (MAPK) signaling pathw…