Hironari Tamiya
YOU?
Author Swipe
View article: Chondrosarcoma organoids reveal SHH pathway activation driven by PTCH1 and BCOR alterations
Chondrosarcoma organoids reveal SHH pathway activation driven by PTCH1 and BCOR alterations Open
Chondrosarcoma is the second most common malignant bone tumor, characterized by the production of cartilaginous matrix and a high degree of resistance to conventional therapies such as chemotherapy and radiotherapy. Effective treatment opt…
View article: Utility of Same-Modality, Cross-Domain Transfer Learning for Malignant Bone Tumor Detection on Radiographs: A Multi-Faceted Performance Comparison with a Scratch-Trained Model
Utility of Same-Modality, Cross-Domain Transfer Learning for Malignant Bone Tumor Detection on Radiographs: A Multi-Faceted Performance Comparison with a Scratch-Trained Model Open
Background/Objectives: Developing high-performance artificial intelligence (AI) models for rare diseases like malignant bone tumors is limited by scarce annotated data. This study evaluates same-modality cross-domain transfer learning by c…
View article: Utility of Same-Modality, Cross-Domain Transfer Learning for Malignant Bone Tumor Detection on Radiographs: A Multi-Faceted Performance Comparison with a Scratch-Trained Model
Utility of Same-Modality, Cross-Domain Transfer Learning for Malignant Bone Tumor Detection on Radiographs: A Multi-Faceted Performance Comparison with a Scratch-Trained Model Open
Background/Objectives: Developing high-performance artificial intelligence (AI) models for rare diseases like malignant bone tumors is limited by scarce annotated data. This study evaluates same-modality cross-domain transfer learning by c…
View article: Development of synovial sarcoma organoids exhibiting ferroptosis resistance despite low malic enzyme 1 expression
Development of synovial sarcoma organoids exhibiting ferroptosis resistance despite low malic enzyme 1 expression Open
Although several studies have investigated synovial sarcoma using established cell lines and mouse models, effective treatments remain limited. We treated five patients with synovial sarcoma at our institute between 2022 and 2023, and rese…
View article: Impact of Bone-Modifying Agents on Post-Bone Metastasis Survival Across Cancer Types
Impact of Bone-Modifying Agents on Post-Bone Metastasis Survival Across Cancer Types Open
Background: Bone metastasis is associated with a poor prognosis. Bone-modifying agents (BMA) are commonly used for the prevention or treatment of skeletal-related events (SRE) in patients with bone metastasis; however, whether or not treat…
View article: The treatment efficacy of complete decongestive therapy for breast cancer-related lymphedema from the perspective of skin mechanical properties: a case study
The treatment efficacy of complete decongestive therapy for breast cancer-related lymphedema from the perspective of skin mechanical properties: a case study Open
[Purpose] To quantitatively assess skin mechanical properties in a case of breast cancer-related lymphedema (BCRL) and examine their clinical utility. [Participant and Methods] A 69-year-old female was diagnosed with BCRL of the left upper…
View article: Reliability and validity of skin elasticity meter to measure skin mechanical properties in patients with lower extremity cancer-related edema
Reliability and validity of skin elasticity meter to measure skin mechanical properties in patients with lower extremity cancer-related edema Open
[Purpose] This study aimed to clarify the reliability and validity of a skin elasticity meter for evaluating the skin mechanical properties. [Participants and Methods] We conducted a prospective observational study using data from 35 patie…
View article: The Three-Class Annotation Method Improves the AI Detection of Early-Stage Osteosarcoma on Plain Radiographs: A Novel Approach for Rare Cancer Diagnosis
The Three-Class Annotation Method Improves the AI Detection of Early-Stage Osteosarcoma on Plain Radiographs: A Novel Approach for Rare Cancer Diagnosis Open
Background/Objectives: Developing high-performance artificial intelligence (AI) models for rare diseases is challenging owing to limited data availability. This study aimed to evaluate whether a novel three-class annotation method for prep…
View article: The Effect of Bone-Modifying Agents on Post-Bone Metastasis Survival
The Effect of Bone-Modifying Agents on Post-Bone Metastasis Survival Open
Background: Bone metastasis is associated with a poor prognosis. Bone-modifying agents (BMA) are commonly used for the prevention or treatment of skeletal-related events (SRE) in patients with bone metastasis; however, whether or not treat…
View article: Factors Predicting Treatment Adherence in Outpatients with Cancer-Related Edema: Decision Tree Analysis
Factors Predicting Treatment Adherence in Outpatients with Cancer-Related Edema: Decision Tree Analysis Open
Yudai Fujimoto,1,2 Yoshimi Yuri,2 Miki Fujii,1 Hironari Tamiya1,3 1Department of Rehabilitation, Osaka International Cancer Institute, Osaka, Japan; 2Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Jap…
View article: Skin mechanical properties measured with skin elasticity measurement device in patients with lymphedema: Scoping review
Skin mechanical properties measured with skin elasticity measurement device in patients with lymphedema: Scoping review Open
Background Skin conditions in patients with lymphedema have been identified according to changes in skin mechanical properties. The skin elasticity meter is a non‐invasive tool for measuring the mechanical properties of the skin; however, …
View article: Successful pazopanib treatment of undifferentiated pleomorphic sarcoma with coamplification of <i>PDGFRA</i>, <i>VEGFR2</i> and <i>KIT</i>: A case report
Successful pazopanib treatment of undifferentiated pleomorphic sarcoma with coamplification of <i>PDGFRA</i>, <i>VEGFR2</i> and <i>KIT</i>: A case report Open
Undifferentiated pleomorphic sarcoma (UPS) is a high-grade, aggressive soft tissue sarcoma (STS) with a poor prognosis, and no definitive or effective treatment is currently available for it. Pazopanib, an orally available multiple tyrosin…
View article: Lorlatinib for the Treatment of Inflammatory Myofibroblastic Tumor after Allogeneic Hematopoietic Stem Cell Transplantation
Lorlatinib for the Treatment of Inflammatory Myofibroblastic Tumor after Allogeneic Hematopoietic Stem Cell Transplantation Open
Inflammatory myofibroblastic tumors (IMTs) are rare sarcomas composed of myofibroblastic and fibroblastic cells, accompanied by inflammatory cell infiltration. Many IMTs exhibit clonal rearrangement of anaplastic lymphoma kinase (ALK). We …
View article: Efficacy of surgery in the management of multiple recurrences of retroperitoneal dedifferentiated liposarcoma
Efficacy of surgery in the management of multiple recurrences of retroperitoneal dedifferentiated liposarcoma Open
BACKGROUND: Retroperitoneal dedifferentiated liposarcoma is associated with a high risk of recurrence; however, treatment strategies that are more effective than surgery remain to be established. This study aimed to determine the optimal n…
View article: Physical function assessment scales used in rehabilitation for upper limb lymphedema: a scoping review
Physical function assessment scales used in rehabilitation for upper limb lymphedema: a scoping review Open
Purpose: The aim of this scoping review was to identify the physical function assessment scales for the rehabilitation treatment of upper limb lymphedema. This review was conducted to establish a consensus on assessment scales for use in c…
View article: Prognostic nutrition index as a predictive factor for overall survival in trabectedin-treated advanced soft tissue sarcoma
Prognostic nutrition index as a predictive factor for overall survival in trabectedin-treated advanced soft tissue sarcoma Open
The study results indicate pretreatment PNI and CRP levels as prognostic factors for trabectedin treatment in advanced STS.
View article: The Combined Use of Inflammation Markers, Modified Glasgow Prognostic Score, and Sarculator Nomogram in Extremity Soft Tissue Sarcoma: A Multicenter Observational Study
The Combined Use of Inflammation Markers, Modified Glasgow Prognostic Score, and Sarculator Nomogram in Extremity Soft Tissue Sarcoma: A Multicenter Observational Study Open
Background: Sarculator is a validated nomogram designed to predict overall survival (OS) in extremity soft tissue sarcoma (STS). Inflammation plays a critical role in cancer development and progression. There were no reports which investig…
View article: Impact of Nodal Metastasis on Survival in Clear Cell Sarcoma
Impact of Nodal Metastasis on Survival in Clear Cell Sarcoma Open
Aim: Clear Cell Sarcoma (CCS) of soft tissue is a high-grade malignancy that often occurs on the distal extremities. The five-year overall survival is reported to be around 40%. Lymph node metastasis, that is categorized into stage IV in t…
View article: Intra- and inter-rater reliabilities of skin mechanical properties measured in healthy individuals using skin elasticity meter
Intra- and inter-rater reliabilities of skin mechanical properties measured in healthy individuals using skin elasticity meter Open
In this study, intra- and inter-reliabilities were measured at "excellent" and more than "moderate" levels, respectively. However, because some proportional errors were observed, the limits of reliability agreement should be considered whe…
View article: Current status and short‐term results of frailty in patients undergoing gastrointestinal cancer resection
Current status and short‐term results of frailty in patients undergoing gastrointestinal cancer resection Open
フレイル (Frailty) は健康な状態と要介護状態の中間に位置し, 身体および認知機能の低下が見られる状態を指す. 癌領域においてフレイルは高率に発生し, せん妄や感染をはじめとする術後合併症, ならびに生存期間の短縮, 施設退院, 再入院に影響することが報告されている. 本検討では, 消化器癌に対し外科療法を施行された症例を対象に, フレイルの発生頻度, 手術成績を調査することを目的に検討を実施した. 2021年7月から9月に大阪国際がんセンターにおいて6分間歩行距離…
View article: Post-bone metastasis survival and performance status in lung cancer patients with bone metastasis
Post-bone metastasis survival and performance status in lung cancer patients with bone metastasis Open
Lung cancer is one of the most frequent primary origins to develop bone metastases that deteriorate physical function and quality of life. Antitumor agents, including molecular-targeted drugs and immune checkpoint inhibitors, have been dev…
View article: Secondary leiomyosarcoma of the nasal cavity in a treated patient with possible hereditary retinoblastoma with germline reciprocal translocation of RB1 and DMXL1 and somatic TP53 mutation: A case report
Secondary leiomyosarcoma of the nasal cavity in a treated patient with possible hereditary retinoblastoma with germline reciprocal translocation of RB1 and DMXL1 and somatic TP53 mutation: A case report Open
Retinoblastoma is a common primary intraocular malignant tumor that affects infants and young children. Radiation therapy for hereditary retinoblastoma increases the risk of secondary malignancy. The present report discusses the case of a …
View article: SHARPIN Enhances Ferroptosis in Synovial Sarcoma Cells via NF-κB- and PRMT5-Mediated PGC1α Reduction
SHARPIN Enhances Ferroptosis in Synovial Sarcoma Cells via NF-κB- and PRMT5-Mediated PGC1α Reduction Open
Sarcoma is a rare type of cancer for which new therapeutic agents are required. Ferroptosis is a nonapoptotic cell death triggered by iron-mediated lipid peroxidation. We found that TFRC, an iron uptake protein, was expressed at higher lev…
View article: Osteolytic lesions caused by hyperparathyroidism mimicking multiple bone metastases
Osteolytic lesions caused by hyperparathyroidism mimicking multiple bone metastases Open
Multiple osteolytic lesions in elderly patients are usually metastatic bone tumors, while brown tumor is a rare disease featuring osteolytic lesions associated with hyperparathyroidism. In this report, we present the case of a 62-year-old …
View article: Physical function of allogeneic hematopoietic stem cell transplantation recipients with anxiety during the spread of COVID-19 infection.
Physical function of allogeneic hematopoietic stem cell transplantation recipients with anxiety during the spread of COVID-19 infection. Open
【目的】同種造血幹細胞移植(以下:移植)患者は身体機能低下が問題となる。新型コロナウィルス感染症(coronavirus disease 2019 : 以下,COVID-19)の感染拡大期において,感染に対する不安が大きいと活動時間が減少すると報告されているが,移植患者への関連は明らかになっていない。今回,COVID-19感染拡大期における同種造血幹細胞移植患者の不安と身体機能回復との関連について検討した。【方法】対象は当院で移植を施行した25名とし,身体機能は6分間歩行距…