Hideo Utsumi
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View article: Role of Reactive Oxygen Species in Collagen-Induced Platelet Activation and the Protective Effects of Antioxidants
Role of Reactive Oxygen Species in Collagen-Induced Platelet Activation and the Protective Effects of Antioxidants Open
Collagen plays a crucial role in platelet activation and thrombosis, yet the underlying mechanisms involving reactive oxygen species (ROS) remain incompletely understood. This study investigated how collagen modulates ROS generation and pl…
View article: Redox imaging of dextran sodium sulfate-induced colitis mice treated with nitric oxide synthase inhibitors
Redox imaging of dextran sodium sulfate-induced colitis mice treated with nitric oxide synthase inhibitors Open
Ulcerative colitis (UC) is an inflammatory bowel disease of unknown cause. Redox imbalance, as characterized by excessive production of reactive oxygen species (ROS) and nitric oxide (NO), and deficient levels of endogenous antioxidants, i…
View article: Electricity use is associated with residents’ vital data and lifestyles: observational study using an IT health support system in Japan
Electricity use is associated with residents’ vital data and lifestyles: observational study using an IT health support system in Japan Open
Motivated by developments in information technology, recording personal parameters with health devices is effective in health promotion. Today’s indoor individual lifestyles often involve using electrical appliances. We developed a health …
View article: <i>In Vivo</i> Application of Proton-Electron Double-Resonance Imaging
<i>In Vivo</i> Application of Proton-Electron Double-Resonance Imaging Open
PEDRI has similarities with electron paramagnetic resonance imaging (EPRI) because both techniques observe the EPR signal, directly in the case of EPRI and indirectly with PEDRI. PEDRI provides information that is vital to research on home…
View article: Dataset for: Electron Spin Resonance Studies on Deuterated Nitroxyl Spin Probes Used in Overhauser-enhanced Magnetic Resonance Imaging
Dataset for: Electron Spin Resonance Studies on Deuterated Nitroxyl Spin Probes Used in Overhauser-enhanced Magnetic Resonance Imaging Open
The Electron Spin Resonance studies were carried out for 2 mM concentration of 14N and 15N -labeled 3-carbamoyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl, 3-carboxy-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl, 3-methoxycarbonyl-2,2,5,5-tetramethyl…
View article: Dataset for: Dynamic Nuclear Polarization Studies of Nitroxyl Spin Probes in Agarose gel Using Overhauser-enhanced Magnetic Resonance Imaging
Dataset for: Dynamic Nuclear Polarization Studies of Nitroxyl Spin Probes in Agarose gel Using Overhauser-enhanced Magnetic Resonance Imaging Open
Agarose is a tissue-equivalent material and its imaging characteristics similar to those of real tissues. Hence the dynamic nuclear polarization studies of carboxy-PROXYL in agarose gel were carried out. The DNP parameters such as spin lat…
View article: Development of Redox Metabolic Imaging Using Endogenous Molecules
Development of Redox Metabolic Imaging Using Endogenous Molecules Open
Redox metabolism plays a central role in maintaining homeostasis in living organisms. The electron transfer system in mitochondria produces ATP via endogenous redox molecules such as flavin mononucleotide (FMN), flavin adenine dinucleotide…
View article: Evaluation of Brain Redox Status and Its Association with Cognitive Dysfunction in Diabetic Animal Models by Redox Molecular Imaging (ReMI)
Evaluation of Brain Redox Status and Its Association with Cognitive Dysfunction in Diabetic Animal Models by Redox Molecular Imaging (ReMI) Open
Oxidative stress contributes to the development of diabetic complications. Increasing epidemiologic evidence suggests that diabetes mellitus is associated with dementia and cognitive decline. However, the underlying mechanisms are not full…
View article: Imaging Reactive Oxygen Species-Induced Modifications in Living Systems
Imaging Reactive Oxygen Species-Induced Modifications in Living Systems Open
None of the presented techniques fulfill all requirements for clinical translation. The obvious way forward is to incorporate anatomical and functional imaging into a common hybrid-imaging platform. Antioxid. Redox Signal. 24, 939-958.
View article: Redox Molecular Imaging Using ReMI
Redox Molecular Imaging Using ReMI Open
Tissue redox status is one of the most important parameters to maintain homeostasis in the living body. Numerous redox reactions are involved in metabolic processes, such as energy production in the mitochondrial electron transfer system. …
View article: Development of a New Redox Molecular Imaging Method
Development of a New Redox Molecular Imaging Method Open
For indirect tissue observation, electron-spin, Overhauser-enhanced, dynamic nuclear polarization magnetic resonance imaging (DNP-MRI) is a useful technique. However, its sensitivity and resolution are low compared with the clinical MRI ap…
View article: Redox and Microglia in the Pathophysiology of Schizophrenia
Redox and Microglia in the Pathophysiology of Schizophrenia Open
Altered antioxidant status has been implicated in schizophrenia. Microglia are major sources of free radicals such as superoxide in the brain, and play crucial roles in various brain diseases. Recent postmortem and imaging studies have ind…